Uma equipe de pesquisadores afiliados a várias instituições no Japão, trabalhando com colegas do Vietnã, Camboja, Cingapura, Taiwan, Indonésia e Gana, encontrou evidências de mosquitos altamente resistentes a inseticidas comuns no Vietnã e no Camboja
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)
Primário vetor do mosquito da dengue, Aedes aegypti, que tem mostrado um nível extremamente alto de resistência a inseticidas na Ásia devido a mutações concomitantes. Crédito: Shinji Kasai
Uma equipe de pesquisadores afiliados a várias instituições no Japão, trabalhando com colegas do Vietnã, Camboja, Cingapura, Taiwan, Indonésia e Gana, encontrou evidências de mosquitos altamente resistentes a inseticidas comuns no Vietnã e no Camboja.
Insetos, como mosquitos, carregam uma série de doenças infecciosas, desde dengue e febre amarela até o vírus Zika e a malária. Assim, os cientistas desenvolveram uma série de produtos químicos destinados a matar ou repelir mosquitos, a maioria dos quais são chamados de piretróides e têm como alvo o sistema nervoso central do mosquito. Neste novo esforço, os pesquisadores encontraram evidências de mosquitos no Vietnã e no Camboja evoluindo para se tornarem altamente resistentes aos piretróides.
O trabalho envolveu ir a campo e coletar mosquitos no Vietnã, Indonésia, Gana e Taiwan. Os pesquisadores então pulverizaram cada uma das amostras com permetrina, um piretróide comumente usado em todas as áreas onde as amostras foram coletadas. Eles descobriram que apenas 20% dos mosquitos coletados no Vietnã morreram. As taxas de mortalidade por mosquitos nas outras amostras foram as esperadas.
Os pesquisadores então analisaram os genomas dos mosquitos que sobreviveram à exposição ao inseticida e encontraram uma mutação no gene L982W – um gene que já foi associado à resistência em mosquitos. A equipe então coletou mais amostras, desta vez de Cingapura e Camboja, e estudou seus genes, olhando especificamente para o L982W. Eles encontraram 10 cepas únicas com mutações semelhantes às observadas nos mosquitos vietnamitas – e quase todas elas estavam no Camboja.
Os pesquisadores estimaram que até 78% dos mosquitos nas amostras coletadas no Camboja ou no Vietnã eram resistentes ao piretróide – e aqueles com a mutação do piretróide apresentaram, em média, um aumento de resistência de 50 a 100 vezes. Eles também procuraram combinações de mutações que levam à resistência e descobriram que aqueles com uma combinação de L982W e outras mutações poderiam sobreviver a níveis de exposição a piretróides de 500 a 1.000 vezes mais do que a quantidade que normalmente mata os mosquitos.
Os pesquisadores concluem que outros países devem começar a testar a resistência para determinar a verdadeira magnitude do problema.
O trabalho foi publicado na revista Science Advances .
Mais informações: Shinji Kasai et al, Descoberta de mosquitos da dengue super-resistentes a inseticidas na Ásia: Ameaças de mutações de resistência concomitantes, Science Advances (2022). DOI: 10.1126/sciadv.abq7345
Informações da revista: Science Advances