A hipotermia bem-sucedida em primatas não humanos abre caminho para futuras aplicações no torpor humano durante voos espaciais
A hibernação é um estado adotado por certos mamíferos como uma adaptação às condições adversas do inverno. As características típicas da hibernação incluem atividade metabólica muito reduzida e temperatura corporal reduzida.
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)
Ilustração de como os neurônios pré-ópticos impulsionam a hipotermia e a defesa contra o frio, juntamente com um exemplo da aplicação potencial em voos espaciais. Crédito: SIAT
A hibernação é um estado adotado por certos mamíferos como uma adaptação às condições adversas do inverno. As características típicas da hibernação incluem atividade metabólica muito reduzida e temperatura corporal reduzida.
Como animais de sangue quente, os primatas (exceto os lêmures) não hibernam naturalmente nem experimentam torpor. Mas podemos manipular a temperatura corporal dos primatas e fazê-los cair em um estado hipometabólico ou mesmo em hibernação artificial?
Uma equipe de pesquisa liderada pelo Dr. Wang Hong e pelo Dr. Dai Ji, do Instituto de Tecnologia Avançada de Shenzhen (SIAT) da Academia Chinesa de Ciências, relatou recentemente a primeira hipotermia confiável em primatas não humanos causada pela ativação de um grupo de neurônios hipotalâmicos.
O estudo foi publicado no The Innovation .
Os pesquisadores exploraram a termorregulação no primata não humano Macaca fascicularis combinando manipulação quimiogenética, ressonância magnética funcional (fMRI), análise comportamental e monitoramento de um conjunto abrangente de parâmetros fisiológicos e bioquímicos.
"Para investigar a rede cerebral como consequência da ativação da área pré-óptica (POA), realizamos varreduras de fMRI e identificamos várias regiões envolvidas na termorregulação e interocepção", disse o Dr. Dai, um dos autores correspondentes. “Este é o primeiro estudo de fMRI a investigar as conexões funcionais em todo o cérebro reveladas pela ativação quimiogenética”.
Os pesquisadores visaram seletivamente os neurônios excitatórios no POA do hipotálamo no cérebro do macaco, infectando localmente os neurônios com vírus codificadores de DREADD conduzidos pelo promotor CAMKII. "DREADD" refere-se a receptores de design ativados exclusivamente por drogas de design. Eles descobriram que a ativação do subconjunto de neurônios POA pelo agonista cognato DREADD N-óxido de clozapina (CNO) desencadeou hipotermia de forma confiável em macacos anestesiados e acordados.
Nos experimentos anestesiados, surpreendentemente, a atividade neuronal induzida por CNO induziu uma diminuição na temperatura corporal central, antagonizando o aquecimento externo. Isso demonstra que os neurônios excitatórios conservados evolutivamente no POA também são funcionalmente conservados e desempenham um papel crítico na termorregulação no cérebro dos primatas.
Os pesquisadores examinaram as respostas autonômicas e comportamentais à hipotermia induzida no modelo do macaco. Em contraste com os camundongos, que normalmente diminuem a atividade e a frequência cardíaca, os macacos defendem sua temperatura corporal aumentando a frequência cardíaca, tremendo os músculos esqueléticos e aumentando a locomoção. Todos os dados apontam para a noção de que o mecanismo de termorregulação dos primatas é mais complexo do que o dos camundongos. Tipos de células anatomicamente conservadas podem divergir em suas conexões e funções.
"Este trabalho fornece a primeira demonstração bem-sucedida de hipotermia em um primata com base na manipulação neuronal direcionada", disse o Dr. Wang. “Com a crescente paixão pelo voo espacial humano , este modelo de macaco hipotérmico é um marco no longo caminho em direção à hibernação artificial”.
Mais informações: Zhiting Zhang et al, Primate preopticneurons drive hypothermia and cold defense, The Innovation (2022). DOI: 10.1016/j.xinn.2022.100358