Estudo revela idade média na concepção para homens versus mulheres nos últimos 250.000 anos
A duração de uma geração específica pode nos dizer muito sobre a biologia e a organização social dos humanos. Agora, pesquisadores da Universidade de Indiana podem determinar a idade média em que mulheres e homens tiveram filhos...
![](data:image/jpeg;base64,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)
Gráficos mostrando a idade média de concepção para homens versus mulheres nos últimos 250.000 anos. Crédito: Hahn, Wang, et. al., Universidade de Indiana
A duração de uma geração específica pode nos dizer muito sobre a biologia e a organização social dos humanos. Agora, pesquisadores da Universidade de Indiana podem determinar a idade média em que mulheres e homens tiveram filhos ao longo da história evolutiva humana com um novo método que desenvolveram usando mutações de DNA.
Os pesquisadores disseram que este trabalho pode nos ajudar a entender os desafios ambientais enfrentados por nossos ancestrais e também pode nos ajudar a prever os efeitos de futuras mudanças ambientais nas sociedades humanas .
“Através de nossa pesquisa com humanos modernos , percebemos que poderíamos prever a idade em que as pessoas tiveram filhos a partir dos tipos de mutações de DNA que deixaram para seus filhos”, disse o coautor do estudo, Matthew Hahn, distinto professor de biologia no College of Artes e Ciências e Ciência da Computação na Luddy School of Informatics, Computing and Engineering na IU Bloomington. “Em seguida, aplicamos esse modelo aos nossos ancestrais humanos para determinar em que idade nossos ancestrais procriaram”.
De acordo com o estudo, publicado hoje na Science Advances e coautoria do pesquisador de pós-doutorado da IU, Richard Wang, a idade média em que os humanos tiveram filhos nos últimos 250.000 anos é de 26,9 anos. Além disso, os pais eram consistentemente mais velhos, com 30,7 anos em média, do que as mães, com 23,2 anos em média, mas a diferença de idade diminuiu nos últimos 5.000 anos, com as estimativas mais recentes do estudo sobre a idade materna em média de 26,4 anos. A diferença cada vez menor parece dever-se em grande parte ao fato de as mães terem filhos em idades mais avançadas.
Além do recente aumento na idade materna no parto, os pesquisadores descobriram que a idade dos pais não aumentou constantemente em relação ao passado e pode ter caído cerca de 10.000 anos atrás devido ao crescimento populacional coincidindo com o surgimento da civilização.
“Essas mutações do passado se acumulam a cada geração e existem nos humanos hoje”, disse Wang. “Agora podemos identificar essas mutações, ver como elas diferem entre pais do sexo masculino e feminino e como mudam em função da idade dos pais”.
O DNA das crianças herdado de seus pais contém cerca de 25 a 75 novas mutações, o que permite aos cientistas comparar os pais e os filhos e, em seguida, classificar o tipo de mutação que ocorreu. Ao observar as mutações em milhares de crianças, os pesquisadores da IU notaram um padrão: os tipos de mutações que as crianças recebem dependem das idades da mãe e do pai.
Abordagens genéticas anteriores para determinar os tempos históricos de geração dependiam dos efeitos compostos de recombinação ou mutação da divergência da sequência de DNA humano moderno de amostras antigas. Mas os resultados foram calculados entre homens e mulheres e nos últimos 40.000 a 45.000 anos.
Hahn, Wang e seus coautores construíram um modelo que usa mutações de novo – uma alteração genética que está presente pela primeira vez em um membro da família como resultado de uma variante ou mutação em uma célula germinativa de um dos pais ou que surge no ovo fertilizado durante o início da embriogênese - para estimar separadamente os tempos de geração masculina e feminina em muitos pontos diferentes ao longo dos últimos 250.000 anos.
Os pesquisadores originalmente não estavam procurando entender a relação de gênero e idade na concepção ao longo do tempo; eles estavam conduzindo uma investigação mais ampla sobre o número de mutações passadas de pais para filhos . Eles só notaram os padrões de mutação com base na idade enquanto procuravam entender as diferenças e semelhanças entre esses padrões em humanos versus outros mamíferos, como gatos, ursos e macacos.
"A história da humanidade é reunida a partir de um conjunto diversificado de fontes: registros escritos, achados arqueológicos , fósseis etc.", disse Wang. "Nossos genomas, o DNA encontrado em cada uma de nossas células, oferecem uma espécie de manuscrito da história evolutiva humana. As descobertas de nossa análise genética confirmam algumas coisas que sabíamos de outras fontes (como o recente aumento da idade dos pais), mas também oferecem uma compreensão mais rica da demografia dos humanos antigos. Essas descobertas contribuem para uma melhor compreensão de nossa história compartilhada."
Colaboradores adicionais para esta pesquisa foram Samer I. Al-Saffar, um estudante de graduação da IU na época do estudo, e Jeffrey Rogers do Baylor College of Medicine.
Mais informações: Richard Wang, tempos de geração humana nos últimos 250.000 anos, Science Advances (2023). DOI: 10.1126/sciadv.abm7047 . www.science.org/doi/10.1126/sciadv.abm7047
Informações da revista: Science Advances