As bactanãrias tornam-se resistentes aos antibia³ticos adquirindo ou mutando genes que lhes permitem sobreviver a administraz£o de antibia³ticos, que de outra forma os matariam.
Crédito: Joana Carvalho, 2020
![](data:image/jpeg;base64,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)
A resistência aos antibia³ticos éum desafio crescente no tratamento de doenças infecciosas em todo o mundo. As bactanãrias tornam-se resistentes aos antibia³ticos adquirindo ou mutando genes que lhes permitem sobreviver a administração de antibia³ticos, que de outra forma os matariam. No entanto, essa vantagem na presença de antibia³ticos pode implicar custos para as bactanãrias quando os medicamentos deixam de ser administrados. Isso ocorre porque a resistência geralmente afeta genes essenciais para a canãlula e, assim, de volta ao contexto original, sem antibia³ticos, as bactanãrias deixam de ser aptas para competir por sua própria sobrevivaªncia.
Atéagora, nosso conhecimento sobre esse processo vem de estudos realizados em sistemas artificiais que fornecem uma perspectiva incompleta da real complexidade desse fena´meno. Para preencher essa lacuna, uma equipe de pesquisadores liderada por Isabel Gordo, pesquisadora principal do IGC, usou camundongos como organismo modelo e identificou que no intestino, após a administração de antibia³ticos , a competição pela sobrevivaªncia mostra dina¢micas muito diferentes ao longo do tempo, dependendo do host onde ocorre. A mesma resistência tem interações diferentes que determinam que em um indivaduo uma bactanãria tem baixa capacidade de sobreviver na ausaªncia de antibia³ticos, enquanto em outro indivaduo essa capacidade éalta.
"encontrar o calcanhar de Aquiles de bactanãrias resistentes no intestino, uma linha de pesquisa que estamos desenvolvendo sob vários a¢ngulos", explica Isabel Gordo. "Pelo menos uma de nossas hipa³teses estãofornecendo a³timos resultados: mesmo ao colonizar o intestino nas condições menos favoráveis , somos capazes de elimina¡-los mais rapidamente!"
Usando a bactanãria Escherichia coli, os pesquisadores descobriram que as diferenças no custo de resistência a uma bactanãria são devidas a s diferenças na flora intestinal (ou microbiota) de cada hospedeiro. "Observamos que camundongos sem microbiota não mostram diferenças na dina¢mica de sobrevivaªncia de bactanãrias resistentes, que sempre sofrem danos e são incapazes de sobreviver", explica Isabel Gordo. Pelo contra¡rio, camundongos com flora intestinal diversa relataram "uma grande variabilidade na dina¢mica de sobrevivaªncia de bactanãrias resistentes, especaficas de cada hospedeiro, estabelecendo uma relação causal entre a microbiota individual e a sobrevivaªncia de bactanãrias resistentes a antibia³ticos", diz Gordo.
Para entender melhor esses resultados, eles usaram um modelo matema¡tico que simula como as propriedades individuais da microbiota podem explicar os diferentes custos da resistência a antibia³ticos em cada indivaduo. Além de explicar o efeito observado anteriormente no intestino do rato, o modelo prevaª que "ao longo do tempo e a medida que a microbiota se estabiliza após a administração de antibia³ticos, a resistência deve desaparecer são todos os hospedeiros, a menos que as bactanãrias compensem os efeitos negativos causados ​​pelo ganho de resistência. As previsaµes revelam que mesmo a aquisição de mecanismos de compensação depende da composição da microbiota de cada indivaduo ", esclarece Massimo Amicone, co-autor do estudo.
Esses resultados foram posteriormente confirmados experimentalmente em camundongos, destacando "as caracteristicas altamente personalizadas de como a sobrevivaªncia e a manutenção de bactanãrias resistentes a antibia³ticos podem ocorrer em cada um de nós", afirmam Luas Cardoso e Paulo Dura£o, também coautores do estudo.
Os pra³ximos passos incluem "encontrar o calcanhar de Aquiles de bactanãrias resistentes no intestino, uma linha de pesquisa que estamos desenvolvendo sob vários a¢ngulos", explica Isabel Gordo. "Pelo menos uma de nossas hipa³teses estãofornecendo a³timos resultados: mesmo ao colonizar o intestino nas condições menos favoráveis , somos capazes de elimina¡-los mais rapidamente!" revela Isabel com entusiasmo.