Cientistas em Cingapura e na Espanha obtiveram novos insights sobre a atividade de uma proteína supressora de tumor em moscas da fruta que podem ajudar na compreensão de alguns cânceres humanos. O estudo, publicado na PLOS Biology...
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)
A perda de Parafibromina/Hyrax resulta na perda da polaridade das células-tronco neurais (NSC), levando a uma mudança da divisão assimétrica para simétrica. Painéis superiores: Dividindo NSCs de controle (esquerda) e knockdown Hyrax (direita) foram marcados com uma proteína de polaridade celular aPKC (cinza) e DNA (ciano). A localização assimétrica de aPKC é perdida no knockdown. Painéis inferiores: NSCs telófases do cérebro foram marcados com um marcador mitótico fosfo-histona H3 (PH3 em magenta) e um marcador de membrana GFP (verde) marcando o contorno da célula. As linhas azuis e vermelhas indicam o diâmetro de duas células filhas de NSCs. O controle NSC (esquerda) se divide assimetricamente para produzir duas células filhas com tamanhos distintos, enquanto o Hyrax knockdown NSC (direita) se divide simetricamente para gerar duas células filhas de tamanhos semelhantes. Barras de escala: 5 mm. Crédito:
Cientistas em Cingapura e na Espanha obtiveram novos insights sobre a atividade de uma proteína supressora de tumor em moscas da fruta que podem ajudar na compreensão de alguns cânceres humanos. O estudo, publicado na PLOS Biology , pode eventualmente levar os pesquisadores a novos tratamentos e prevenção do câncer.
Os cientistas da Duke-NUS Medical School colaboraram com colegas do Instituto de Pesquisa em Biomedicina do Instituto de Ciência e Tecnologia de Barcelona, ??do Instituto Genoma de Cingapura e do NUS para investigar uma proteína supressora de tumor humana chamada Parafibromina. As atividades normais da parafibromina impedem o desenvolvimento de tumores, mas deficiências nessas atividades têm sido associadas a vários tipos de câncer, incluindo síndrome do hiperparatireoidismo-tumor da mandíbula e câncer de mama, gástrico, colorretal e de pulmão. Até agora, o papel exato da proteína na saúde e na doença no sistema nervoso permaneceu desconhecido.
Embora as moscas da fruta e os humanos possam parecer muito diferentes, os pesquisadores geralmente descobrem que vias moleculares cruciais, sistemas de sinalização e controle são compartilhados por muitas espécies, tendo se originado no início da evolução de uma variedade diversificada de organismos.
"Como Hyrax - uma proteína evolutivamente relacionada - é o análogo da parafibromina, nós a examinamos no desenvolvimento de células cerebrais em moscas da fruta Drosophila como um primeiro passo para uma melhor compreensão", disse Deng Qiannan, primeiro autor do estudo e pesquisador. com o programa Neurociências e Distúrbios Comportamentais (NBD) na Duke-NUS.
"Descobrimos que a proteína Hyrax desempenha um papel essencial durante o desenvolvimento do sistema nervoso central da Drosophila , e por isso acreditamos que a parafibromina também pode desempenhar uma função semelhante em humanos", disse o Dr. Cayetano Gonzalez, coautor do estudo. e Chefe do Laboratório de Divisão Celular do Instituto de Pesquisa em Biomedicina, Barcelona.
Os resultados revelaram funções anteriormente desconhecidas para a proteína no controle da polaridade celular – a organização assimétrica das proteínas – nas células-tronco que geram células nervosas maduras. Descobriu-se que a perda da função de Hyrax levava ao crescimento excessivo de células- tronco neurais no cérebro de Drosophila. Isso estava ligado a influências nas estruturas celulares chamadas centrossomos, que coordenam a divisão celular, e à regulação de duas outras proteínas supressoras de tumor conhecidas, as quinases Polo e Aurora-A.
"A perda de polaridade celular e anormalidades centrossomais são características dos cânceres humanos", disse o professor Wang Hongyan, autor sênior correspondente do estudo e vice-diretor do programa NBD da Duke-NUS. "Estas novas descobertas surpreendentes podem ser muito relevantes para a compreensão do papel da parafibromina em cânceres humanos, talvez especialmente no cérebro".
Mais pesquisas serão necessárias para explorar se essas descobertas em moscas da fruta podem ser aplicadas à parafibromina em humanos e a equipe de pesquisa já iniciou novas investigações para esse objetivo.
"Traduzir a pesquisa científica básica em descobertas de importância clínica é o objetivo principal da pesquisa médica. A professora Wang e seus colegas deram um primeiro passo muito interessante que um dia poderá ter um impacto no tratamento e prevenção do câncer ", disse o professor Patrick Casey, Vice-reitor de pesquisa na Duke-NUS.