Uma vacina experimental contra o câncer de mama gerou com segurança uma forte resposta imune a uma proteína-chave do tumor, relatam pesquisadores da Universidade de Washington em Seattle em um artigo publicado pela revista JAMA Oncology
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)
Cultura tridimensional de células de câncer de mama humano, com DNA corado em azul e uma proteína na membrana da superfície celular corada em verde. Crédito: NCI Center for Cancer Research, National Cancer Institute, National Institutes of Health
Uma vacina experimental contra o câncer de mama gerou com segurança uma forte resposta imune a uma proteína-chave do tumor, relatam pesquisadores da Escola de Medicina da Universidade de Washington em Seattle em um artigo publicado pela revista JAMA Oncology . Os resultados sugerem que a vacina pode ser capaz de tratar diferentes tipos de câncer de mama.
"Como este não foi um ensaio clínico randomizado , os resultados devem ser considerados preliminares, mas os resultados são promissores o suficiente para que a vacina seja agora avaliada em um ensaio clínico randomizado maior", disse a principal autora, Dra. Mary "Nora" L. Disis, professor de medicina da UW, Divisão de Oncologia Médica e diretor do Instituto de Vacinas contra o Câncer.
O estudo de fase I foi projetado para avaliar a segurança de uma vacina que tem como alvo uma proteína chamada receptor 2 do fator de crescimento epidérmico humano (HER2) e para ver se gerou uma resposta imune à proteína.
HER2 é encontrado na superfície de muitas células, mas em até 30% dos cânceres de mama, HER2 é superproduzido em até cem vezes a quantidade observada em células normais . Esses cânceres "HER2-positivos" tendem a ser mais agressivos e mais propensos a recorrer após o tratamento, mas a superprodução de HER2 também desencadeia uma reação imunológica que pode ser benéfica.
Especificamente, pacientes com câncer de mama HER2-positivo que montam um tipo de resposta imune chamada imunidade citotóxica – ou de morte celular – são menos propensos a ver seu câncer se repetir após o tratamento e têm sobrevida geral mais longa do que aqueles que não montam essa resposta imune. .
Para estimular esse tipo de resposta, Disis e seus colegas criaram uma vacina de DNA. Ao contrário das vacinas de proteína, que normalmente contêm uma proteína ou parte de uma proteína que você deseja que o sistema imunológico alveje, as vacinas de DNA contêm as instruções de DNA para a proteína alvo.
Uma vez injetado, esse DNA é absorvido pelas células no local da injeção, que então começam a produzir a proteína codificada nas instruções de DNA da vacina. As células então apresentarão a proteína ao sistema imunológico, um processo com maior probabilidade de gerar uma resposta imune forte e citotóxica.
A vacina usada neste estudo continha as instruções de DNA para uma parte do HER2 que geralmente está localizada dentro da célula. Esta porção intracelular é conhecida por provocar respostas imunes citotóxicas mais fortes.
Sessenta e seis mulheres que tiveram câncer metastático foram incluídas no estudo. Todas as mulheres completaram um curso padrão de terapia e alcançaram remissão completa ou apenas tinham tumor remanescente em seu osso, que tende a crescer lentamente.
Os participantes do estudo foram divididos em três grupos com cada participante recebendo três injeções. Um grupo recebeu três injeções de baixa dose (10 mcg) da vacina, um grupo recebeu três injeções com dose intermediária de 100 mcg e um grupo, três injeções de alta dose, 500 mcg. Eles também receberam o fator estimulante de colônia de granulócitos-macrófagos (GM-CSF), que promove imunidade citotóxica.
Os participantes foram então acompanhados por três a 13 anos (o acompanhamento médio foi de quase 10 anos). Um longo acompanhamento foi importante porque o HER2 é encontrado em muitos outros tipos de células. Os pesquisadores queriam garantir que a vacinação não desencadeasse, ao longo do tempo, uma resposta autoimune contra outros tecidos saudáveis ??com HER2.
"Os resultados mostraram que a vacina era muito segura", disse Disis. “Na verdade, os efeitos colaterais mais comuns que vimos em cerca de metade dos pacientes foram muito semelhantes ao que você vê com as vacinas COVID: vermelhidão e inchaço no local da injeção e talvez febre, calafrios e sintomas semelhantes aos da gripe”.
A vacina também estimulou com sucesso a resposta imune citotóxica desejada sem desencadear efeitos colaterais graves , com a resposta imune mais forte aparecendo em pacientes que receberam a dose média.
Embora o estudo não tenha sido projetado para ver se a vacina poderia retardar ou prevenir a progressão do câncer, os pesquisadores observaram que os participantes se saíram muito melhor do que o esperado em pacientes com estágios semelhantes de câncer de mama, cerca de metade dos quais seria esperado. morrer dentro de 5 anos de tratamento.
"Nós já acompanhamos essas mulheres há dez anos e 80% delas ainda estão vivas", observou Disis.
"Se os resultados do novo ensaio clínico randomizado controlado de fase II da vacina forem positivos, será um forte sinal para avançarmos rapidamente para um ensaio de fase III definitivo", disse Disis. "Tenho grandes esperanças de que estejamos perto de ter uma vacina que possa efetivamente tratar pacientes com câncer de mama ".