Pesquisadores da UC Riverside estão abrindo caminho para que pacientes com diabetes e câncer esqueçam agulhas e injeções e, em vez disso, tomem pílulas para controlar suas condições.
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)
Imagens de PET scan mostram EPP6 administrado oralmente acumulado nos intestinos e chegou ao cérebro e à bexiga através da circulação sanguínea. Crédito: Min Xue/UCR
Pesquisadores da UC Riverside estão abrindo caminho para que pacientes com diabetes e câncer esqueçam agulhas e injeções e, em vez disso, tomem pílulas para controlar suas condições.
Alguns medicamentos para essas doenças se dissolvem na água, portanto, não é viável transportá-los pelos intestinos, que recebem o que bebemos e comemos. Como resultado, esses medicamentos não podem ser administrados por via oral. No entanto, os cientistas da UCR criaram uma "marca" química que pode ser adicionada a esses medicamentos, permitindo que eles entrem na circulação sanguínea através dos intestinos.
Os detalhes de como eles encontraram a etiqueta e as demonstrações de sua eficácia são descritos em um novo artigo do Journal of the American Chemical Society .
A etiqueta é composta por um pequeno peptídeo, que é como um fragmento de proteína. "Por serem moléculas relativamente pequenas , você pode anexá-las quimicamente a drogas ou outras moléculas de interesse e usá-las para administrar essas drogas por via oral", disse Min Xue, professor de química da UCR que liderou a pesquisa.
O laboratório de Xue estava testando algo não relacionado quando os pesquisadores observaram esses peptídeos entrando nas células.
"Nós não esperávamos encontrar esse peptídeo entrando nas células. Ele nos pegou de surpresa", disse Xue. "Sempre quisemos encontrar esse tipo de etiqueta química, e finalmente aconteceu por acaso."
Imagens de microscopia mostram que EPP6 pode fornecer diferentes tipos de moléculas
de corante fluorescente nas células. Crédito: Min Xue/UCR
Essa observação foi inesperada, disse Xue, porque anteriormente os pesquisadores acreditavam que esse tipo de etiqueta de entrega precisava carregar cargas positivas para ser aceita nas células carregadas negativamente. O trabalho deles com essa marca peptídica neutra, chamada EPP6, mostra que essa crença não era precisa.
Testando a capacidade do peptídeo de se mover através de um corpo, o grupo Xue juntou-se ao grupo de Kai Chen na Keck School of Medicine da Universidade do Sul da Califórnia e alimentou camundongos com o peptídeo. Usando um PET scan - uma técnica semelhante a um raio-X de corpo inteiro disponível na USC, a equipe observou o peptídeo se acumulando nos intestinos e documentou sua transferência final para os órgãos dos animais através do sangue.
Tendo provado que a etiqueta navegou com sucesso nos sistemas circulatórios através da administração oral, a equipe agora planeja demonstrar que a etiqueta pode fazer a mesma coisa quando anexada a uma seleção de medicamentos. "Resultados preliminares bastante convincentes nos fazem pensar que podemos levar isso adiante", disse Xue.
Muitos medicamentos, incluindo insulina, devem ser injetados. Os pesquisadores esperam que seu próximo conjunto de experimentos mude isso, permitindo que eles adicionem essa marca a uma ampla variedade de drogas e produtos químicos, mudando a maneira como essas moléculas se movem pelo corpo.
"Esta descoberta pode aliviar o fardo das pessoas que já estão sobrecarregadas com doenças", disse Xue.