Uma área do cérebro pensada para transmitir consciência se comporta como um roteador de internet, diz estudo
Escondida sob o córtex externo e enrugado do cérebro está uma área profundamente misteriosa, conhecida como claustrum. Essa região é conhecida há muito tempo por trocar sinais com grande parte do córtex, responsável pelo raciocínio superior...
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6pZ9SsPJWNcDN4LMQckT6pZ9Us+qWHkifUrF5aiNz0Ie0MT/wDby1Oxfj2JFpZgePZggjyCtp0GMHHbBoMIwfHVoKHIFJMZGXzaNCMf4mivaUo05DZZFC221seRZVv48ZfVxu93JAaxEzY4FVt1e6eFNJnGRc343rpFtBq9DqUbwq45dePx0ZP7v469S+npnxWt2n02qvxWDEEH/AV6LK7FaXYcom83Tpmtd+UoW+U8exkpAQXalq1LMyqwKay5dbK03ams5rqFc1xOL2NlBEuQvXOKFNxJAO1PFXIa9SbbsPGUqYnHwvEybOWcXcnXo3ILK/BEZzRQUSqvbk3cZ1P/AHNI2tChrWbpwFla23qlLCTYxE5ynNAzb1rQteK5eChV3vKuHqwdeZOKvor2R7X0rUpyJx3r2vGamAMsGHQIJx3Vxd3UqNVOtVgBPKRdOOoNlRrMSvpuytYzKLaOmV43IrxP7prericZNVpJN3Lyp5fFVV/7jhfuhhm04tbOKnLgd2t+XKIaj9PrDHQB7u8vX7VQG9NeljgdTkqfpqKMUV0hDzGJX1K/EQtNlVTWhl6f8kJmUVFC+DKlYH3BoQS1dq+H2Su3EJBTAEq9uTuy3Uno8RA9rWMETCcQDCcr2Dq7chNLv5+DNczRvBU2jKV/h8dcVJU0xl9Qw4qZpQywAQ+scH012D0n3fVa+K1b0js6jvaftKgNYQTltiL7UnpzORrtLlX6hdmfGq7O3PVjvww4VwNVrJlGEpTV2f4u6ixD3uJED7TiKK1BSHXpH4PjV2xOeuH/AJOMxaiYaewqmgBPaUAPNMRK/t/SPsyNVO5nzhqGei0II/PQw6PE92cvbfkcfhA7u4olte0axVXjnaijLTk29GzmVHHGpAlVrLy7jo/IsVOOmOioJl1Z5HOe3pTlUdeun18b1bcl/wDk1P02j4rFVmLl7y5gtXV+1x2DAU4Ld6zln45LAqpvs0R+NYzKu090AGLm+wzYHKbLfx66toaJUirCyTBJAYTLHwBUTbWK9hmTHDkVYFvMcV+FFpBvCQofzcc4db0VHQGXnqV8U4nTFo5NmByyAvFbWxQVa9P+R0SYlQFa1gXvk282wZ4lm6VbCy3KQ+q1K2BfY0fCO5a3jk2RSdOQV1Vdba7lM5Oc8h8Di2aWs50psSZ1erUVHtOY+qcawV2VktY9wZa2LzkbQgIGOzfxkrzBUxnYTo5i0BYAJaVSbYNhy9CdQWVPKp1KxbZZ1FbcHBaYMLh5nLmDCmwZP5OMwdOM2UK4tZQEqASrk2AMzFmlNvVrDDkVozgtkhfs13WhITk1ua3rtBHU3gOT23a4s/Iu8OPe1LNdvx+zzArTqZrtfVXYu04/JDRMmYAbGsa5ag7F2lPJemJfvKrl3e+oRrXZf4gGZpiL3dVgaWK7W7x7e3V+5d6nBAWvSx6q1rGstrEtqINdhhIc9NxNu/bIPaEja2sYKn8lblGrvyxfZzeOpZf9u19m8K3KGm8GwsXgtBF/IyGYsfCuxqzTyEMe0IHvSPyCfIlrJK+Us+rAd+b2LE+RbHWNYzE32GE5/mUVgm4HqoIMTSGuMyotrV6CJTumO1P7nUCqvI6i1tbK22CichQli2akEhyaGVaLYSVhQmvd7CoWXJ+UXWAZOSSfN1rMZP8A2QmAJxs7P7ZmzRbCI1w1tOQcY/qr0Uf3U2Iw6kTVYler8dy7n0i9LC2ck1mYOw5VgL+sLWxgoEWpVBXMtTRv8Lif0F2SpNF94izXvp3sSdwxlAGbXW6JVkFQBWMFkXCe6dr7LRHtZpWhZtBreNJ8pt6ae8ufUbs0Gwlo3BGP8KPaccdu5iOxNjlK+KPtW2CsMQUb9yWWBq6hCQArHf8At2HR6uBsWQ5U7ZFSrXUTiXE49Sju04w1FveV4VTYoLLiX/L/AAY8PkUbpvUQZYO6/FW78gfeAYVtsGdE0VBj+0pXFyLUYC+tSDPVNLFWuen7cdVtJ7yz3u9qnIIsDRqxahrWpOSolbbJamQRg/4ICHtAnZa1sippH9tsI3pi+uyy1tn2Y0AGnbChxVF9QehmtfBfbWYMr48CZhri1SzCwDY8is446fbdSpW5kl9rXMDmNKv27x6v8F2EVllrh5xlADDDW/Cr4/N7FCoWy28qACIhsfogwqqrZY9rfFavUy4BLrlWwGvRI166+qw27U1tY9xrGqOAQx748BX9sYSWKGX/AKZKXefSPBw5dxdFqqNhfjus6LYKsP4ijJyglQDEDQ14WE7HAnI5ASUZxy2JsTi+m3XIyZxhoj34lvK3RcKhDmUoV8NJlgLNjOHVkY1HIbdePT6fSA7iH3AmCIHFqkklG7t8v+jStngpdTVFQPBQol65HF9L+iyXcdhMNK+ImLafvPTYg/gKDjpklHVYzdRkYhkuAa2+L6rFetRdY1jrc4GZU6zqdr8wdoCzgV+nE/vsFZ1y/vXZhXulS7lvQjk2QGekgHBNk7u68JQH42pb8dXFZotNQnIoCzU7VcKPwllvCKJ/AroewVVIqqOi9YS2JQFnZFs5nqfkNqj+qqw9TjnetkQC6ycamWlZaALPz1HWvINQMUtha9o1Pqesqh7RV2LgLEme8VtGy9zdN9KnWiGwal8ytcy8xVM6eQRiLVPgW9Y1VAe5hEb341gqs+qLtYPTf7/h4y7XlMp3DY6llqCuyrDDXEut3N3DAqPb8wGZxXTXpI0uoacWojw5jEAYn9U6BhXUZSoUMMr9M5stPSrtW14ePbGqdfz0YKmtkVR3TAiOu3acpl6RE9lT1THfEQbN9NDUFZLBpe+9o7hHBdH73e6Dt7QpkntGEziWDJCqUIeuf+hHerjgjGDU7OOQmV/BwuONL/t8jj2bLbTmV0azn/DiNhbO9XHr9Td35q4u/Lw6cB+N3qr18l1fUX6fWOwnS2KhhOODjwZQ0NQnRl1Q0sXR/wAtCx7AwnecbJsa09S/4tLXBrBxKnxKwpssws7mVIWe9cOo9d5bNbYer3f3XsC3qHxJ7mds47t2LOpVhqHU68f9hyWfihjbYna5dX81Kbvx+0uqnFPhZcBOVcrClsSg7VsBWoaOOo7UMzvW1Z/HTylCDlM7I7Y37hwfAHMuXKXkrZUYiCZCwHMJxOsmVtRjyOQa4eYDLGLv+VH1Qr2ZWWY7VDWFhoNmnS2RqjlqdQCRP7BxO5NVprPIbqOCwhDXV6BDUBhtVjWZiCPyCxVJcw6f9tZGIY7YmawN1sUO1ZuIM4mMZxOWPMO841Oq1jBsXYKNbm+AqLNdUsIGOJ7XglMHLrqtFc5VO6HsfxVMJVgG20mLY8ofJU9mbS1WDrzqfVwzmM4RSzWMnwcmMCRUGrZz1JZx1X8+fR4FstXZpL9HCHAVi0JxYzNnjtWwvr6VkKxJgTsz+ilZU5lo7KVBXQLfYhnWcjGJ/a09iiqjaMuAIgJfkjNan0IdLH7zkfDy8XjkpQ0HgVGZaplnaWAziriqaDJqBOuI+AORjrfiHpNYVh1FNmggsOa7jq67KGKm89Srhn0s27IsNncfchXEPvbY3Wax2/OhAMcKYVEb0n5Iy6ik4G3rts2mhE2JYVEwAr4NmamEnPualEts7nuQxWIilem+S2ZStbTdbDeD4PKL2V7WZoB3qGzdiOZ5al3sdygLsr0vsPEkYvx1a66yB28jviHax+dWqp+IVmUexKTdte2vUZRxbj1LEwS3ppJSmldpb7RrumTdYWLtHHpCloKGMZSp/KpxMdx6jWAx+n1UL21jH1BTEqDL0hB6JYvUjEhlyYMR1ycZgGhOZ3EVN50wDlgB3iZ2ramqPYpB7Gsdq3CXMRdVpqlfeDsOUfueT9PXNy46hqDSuvTxtuSqemxW4uxrq0nWrD+N4bNaYW3j7QjB/BTxgox2CDTMHh/VFPbHoWpZWtbVp8CIbWUvYGH9qfuEpOkrBKgg5uv50fEwjRHCRr+4tbItXD17uXxKrPUbtm3zA2AzKzhtZWckquQgEKZTBQtegFZwGJ2ALH6axZpHrZYozGWf+rIWNZ1WzuKB3s7LYdn8nBYrZdVtOPtiHw56dSV3WVGrnbLbzrHnFUvaD6fAjM1lvaW97fPxVDXa/bvLiKjkFSIPCiraKvZuy8uw9LhExDCsvqLHoHUjBr+bAK9ahYUzOYMj+CpMOFD4IXONEwQyRD3yFhb0n3VWE2EqJje1eZb7lRGIECsYlaqxvRyo74V1filAtDsUqwNBDXLMCJbqbeSW836cgKYGAoEsslbzIlibS3inbi8YGs8V5xuOUWO2i92FlllTU8jeW6POWoW3z00Piq3Es1ZTxmFlrHfHhTjpwzm/t8GL4GNLVy6pqF9dlSRzXLFXVhhv4A9+5lAWyXqFOzGMSDrDgzZlgIi2DXsQM79wLLSB1DCH1gzCGecfHUtOiUvtH+KHE29I7tmX/MdqvNwLdZ1e625UxRAcH+jLGaqxB2WOcKzE1qcqfZHGXdZa+9nmQbMigVHBKsyxbBYLtDAJXxUICBU9jtOZ+zwR2GRMwCWL4ESqoYuJClDln0Rjk/wdvTW+sZtonz0V1ep4PYiUsMvSyE2YVKiZvlbIMF9l0ADD4ypTAgU5BUgi8n0/1v6RtGJAzmWHz8FQztXKW7w/twfEy84dfiglntKxrWffprLqld7l0s83GGb2UmjHqVSYtE+kslfFIbUCGO0DZligrSiKpOCpg7zXt0hBUMy5tYbSZZUbTYur/wAGrBmirU3aKfT6gPqBltYq12yqvu1ZFFda4Dfa1cQCdpkibMYMz2g9mMHt1QJWMwgAllAc9Q4CxzlvN+nn12oWVKGqeN+0nussnNb7lRyo9jDON+yZWJYuH5P7/mobS2u141aNF44z7CWn1m+dTaXLcYTZU9nKZ1r5D1jS2ycYW42dILmlB9f93s6t1yIX2i12lbUKP/BBwUs2DdicZQMw6JJ6Q149DAqujGyFvWj9NmtyU4416In95gJ2NlkW7K7TfIFGYLNVa2DvNpbZ+DihtqrcS5dhjExmkNrFPZvbk1F5V2mwEawQguEXSs5nIJBL5rf5+bi/vIQiPblqrWB/qWO78pa1EGstaXlnsdCkHY08hcIkyMWVgyt3HJMZQ0PHTJSpIz5nJJ6v8IHEW6CsGCsiWizYZiviF8wQ1JlqVnRaLdXqzCN3bAmpyEnTgrWYnfwcelewts/DxB3btAzeD+ikWLYDnB5jKq8tdBy03Z+uT2lV46nuLrOnLXNgUWNORX038yMUZGa1RTK6Z2n92KATXtFJRmwVYlb8o86VAFg9FDDUDM7CClTZLrTnNkJbBvRUY7N/EqtxFtllgIaybtFsM6xnWi2gxzunZCAWPpytSgagTE1M0naGAYllgBNhP4uGuWSpVnVqE1Uzn8gm9VGn9cgZsgGZxmGJao0/TuQzWOisCaUnUTHIba3z8W7Ertyj3ExLCrK24buE7NekD+l7ALlKZxXGdrHorGla4XUZ8OQnqLFZtsOTjq/xtzPc47nt5KhmKohpBgqxBQNtJrO0zC4nckACW2/kptNTLa10rQZyEXk8au41Vrry+w2PgDgj34+HTloSv6fV0zyXwrZxZyDr+HjWlhrDOM3ciMMN8lNPflUygKY2onFrgRRGtULQ+7TMvY74zHYVoxyf5tB8czM2m82ncwCFgse7P5uCQUFYWWEQL6D6Ddd3b38EX0JYUnHHr5T+uwb8fbQXMGs/CjFGpbrAJWJVp4XCVWS5THLajuy0lmQDC1NORoJxMT+tyttrLl7UVLbDY385TqVOwmZgzEwJ2mYzYDvsfzUv03FwZXtBs6npsYkN7+PfAYhqbI3qte7Scm9Sv46rTXB65W2k+oisLFZNHsz0/uuOlmrjLpV02sFWyK7I5oQqxOI/TeFFxymBs/6BH1isD4Z8jWARmLfwgzIetZhL8wtUsY5PhToY9CZ6pVktIe27d/y1WMhC7KQNksVA/rWv4s7bIGzW3r1YKrgxq0WVtmWDta7pLeUWX/ogSILTOtOtDaYWJ/mZP8Lh8mdJWLqqrxz4O6rGC5tIqtq5HUdlzO2vTEHpHMvRR/l15NgiXLcmVrDHVOmWgoSuXkPyMmh6eQbJauy1WrVOTzCxJz/mQcSjktU3/kUM+vQpfzepXmFiZVyrKlbmXNCST/8Ajv8A/8QALxEAAgIABQMDBAEDBQAAAAAAAAECEQMQEiExICJBBDBREzJAUHEUM0JgYXCAkf/aAAgBAwEBPwH/AFxeV30KSfTaE7/QKKaNJoj4PGTVjXwdsh8CyXYKDTtsavLfwJQUbJJXYouqzq41Roj46JKMVXkV1v0J3x+GtfMUaqdS5G6VsfGW9WOejkc4oUk8sO/A8S23I+oqLF8HgWyzjLehT0vJfc8k9zyYktrMO0qY8oq+RyS2yXx+AuS4KSonhpu2TitNCVCVje2mh1u2VB7GGlHty1rTVE4asTUuCuImH2tpidiMRXGh7xIVWx5NDW+UYvVeahK92PjYg3rpjLqIl5RjQ1NNi4NVtda6F1QptE6/8KQj+C7yqj+Rx3sWJtvzkpd1UaRxsSvgZ/saSRGTusld5O2bxXAtzUm+cvkunvlG63NFfgpyXaS7iK3t5tLLkfAlRty82RXkp2Vk+BLyMTyvfLeytjY/gW2TX4klKkhFb3nwhO+hKutpPn2KK/4EqjS81BscGs6Y4tZ1+ljzZqtjmyW5H5FK2a65JfJH5YnvZqt0TjpYkQdJn3Z+Nxqs6/NuiK2NKqxbrY8FbWVsW2J0qYrRbuyTsklQiPI1bGmizwJWVRp99tI1oXG4qJT32Iu/ZrtE9hOyPGxXk54OOSi2XtQ3lIhFu8m6+4deCUKRGhZRQ+fddjiiMFJ7Gp8MnLDcaXIsGT3IYLjyjDhqnTJ+lXgnDS66o77ZPix7IgzdG7JbEWJ6TuluSZWsi3HY077kpWRSZblRxl2jltS9tcjzgo4auQ8PTvk0enlUqkzExJYctKML1Gl7mPjRcdvY1p8mpUN3lr+TVknRrNbqsk6NQ3ed+9F6UPOMU2Ys9TMTFrtWeFhzbtGLLvHocLfP6aC8k+M6IyjFUY0q7YmFD5PpN8Dwmmf1EkqyjdjVP9KnDRaJW+7OCt7nqZQiuwhvuyKtkpPC2iW+nW48iuQv0MUnySXwNuUayY9kaXLkS8Edhzb6pmDq8naNU/0MJUar3FyaYp9x6jGTlSINJEpLlF31St7Di4qy+0jL9Ciow7WSWlH0bkqPVQp6hpMWDKMLFzbFOLjSHprOxyomOLlycC2l+FJik10/XlKVRRq8exHkliaH3Ic9WwrwNxyWLyShHVsYeI/sPVP/ABowsF6bZJ28te9E+NiCfk2SL1OiMdJO9d/hQb1OyK7myF3njY6hsiOl9yW5hqWq5ezhyX2yFgRUtT4MTGjJibkuww4OWJUhxpWj1Uq8HpZNyeoxcLtc0YMtS3Eop2yTbYojnpMOm7N7/DXLGRjniYUXuQceImm0YD8ezZFJvcjgxgnpZbwz6ssOO4pxmtyXpotWjDr7KMfAhVR2FLTyWvBF2hpMUUuv1OI12ojjOCSebdKzCmp7jXXO4zL3rpd4c2YDm2zDhpXtLkhiNxMXB1d0S5FqjD9Q4Rowp6JaicdfcPDY8LS/a9T/AHCUbmlnJWqPR+SXW1YoJdMoRlyRgo8e4pNKhYzjwSk3u8lV7jaZbFjUhzg+R6b9n1Ue6yEeJPnNmFBQ2H+gsv22k+f+iv8A/8QALxEAAgIBBAAFAwMDBQAAAAAAAQIAEQMQEiExBBMgIjAyQVAjQGEUUXFSYHCAgf/aAAgBAgEBPwH/AH7Xpr8EMfFxgF0qtBKHUZRxqATLEr761cFKvGhJI12iAUKn20AuIUrnuGHVfcLEr9ljSxGst/eNxFo96F6Aj5FHMfIL5iuO9MZqZWVJYq4OdAsY6mop28y7h0YVB3OzG9F7dD8ZNelBzLUCow2ndMh8wzriILaMlrzGUdtG2txEXbxoHHQj47ybpXExqbIhFRZkXiEcVFWhoORpxoQIy1FHMYVFH94whEWtBXryXxXoy/T6cJAbmKfd7pl/tK8vjRYwI4abN3CwKDoGMDV1ptrX+IzX6OfSSIJZrToTdE4hEAH7HcajGzc/zr2ICR1DLrQVXMFXASDcMEDccd+kkwaVxenNyuJsI4hvSoFNcSj2f2Vz7xjeohP3+PiXqOJcY31qOIXJ9Fmq/wCAbGtzeNSalj8QYfp9sQce6I/uqVcYUvERLXmIeajX9o/CUZVgERTcckdR+xPcG/j0Kb/AZib4mOwomQmqMxcEQ5QGIMxFiJl4Q3FZeDL3dRlBEKiuDF9pqK1mZVsgw9RW4lzDkLsbhNTcLqO9VGbaLg5+ZUZuoPCuTHXa1DQ4FC3cyYthr4e7EZapRCvvKmFSBQjYiWsTyzQEKbmNHgxsdNBvPUvjmOpZeIoO6rmMCuI1ffRUbJc2kAzGm1hUdBNjBrmdhuEcFogpflQY6toviXuocxTllhzYzzMmNTykO5RC1xuFuB4DfqY1zMo43TERkbdOzMo5BmfdViYLu7irbbow2tcyuf8AyYbrkzGlcmfTHyC4GJEAqM20TcinjVl3dxfmAJj5C9V9ocrMKJlTE7J7hH8R9wIKJ3RluKvPwMlihFTb1qyE8CLj26nEIqAa+UsCgda0P2QylEKxRMOD/VGJ+mY62NYhIi9TGDuh/CmD0Es5mLBt5Mz5R9Ky5uUYaI5mwaMyeWB94G4qcbJsat34MqwPM/jUzApJueIehtgBPUCKi7m7mTMz9+gGJhx5F3COy4xMpDOSPwN1HyFzZnR1HJjFMKUIzFjZmHIEu4eTfpTGz9TGKShxPE1t57hP4Ly7r+Y6bTWgM8PgBXeZm3F7MRLPMY8xUZhY9PhlVRuE8wFqEdayc9TxOBQNyfgkdrBEN7vdN0xNfEwlum6mZhkzBY97CFjYXXsRMjLYGr4mTuYvC71szwqOh5E2jH9MO7Im08VMrBsF/skx75lwtj9JLXQhq+PgMxJuNDuNhVSTkMfFu66hxJiWl+8fIQNggwkjzItVuA7mXKycDuYcflpzCtk1P6b9PcO54ej9UL+WLM35XyUTUCjGsfIMzV0IoVMdfsUXcag3s+0dTHhr64fDPy321Y1MeFnFxPD1zkMPwGxyIviXalnlttmWhW6bsailM3q/tBi7urhPM84bYmUvyvcTKXB4gShzMvigOuZ5CuN9zxL/AKYEfytnHcs/sca7mqYKBKXGHMz5q9o1x7L90xFOlnjOTFFD4txE88u1NzMaFzQigcn7zPl3VUXJ7hRqOBc3orTyg53K0rIeGPEzYgr7Vi5HxcTJmbJ3owA69JMbLtNak1M+YhAVnh8xyDn1CYGp7qNmReGMbk+gZfKa4mXexJ+QnjbEyFTMeajZmQhuVHEOPdBksbW6l1xA9dR/FFhxCzE2fhMyC3rUixMg/RP+Z4P6j61yFeox3Gz6SobuBQOvkqbYNLNUNdsoxcjKu34Wm0XfozJ+jtE8Mm1P+oP/xAA3EAACAgEDAgUCBQMEAgIDAAAAAQIRIRASMSJBAyAyUWETMEBCUHGBI2CRUmKhsXCAM8Fy4fH/2gAIAQEABj8C/wDK+f7ex/d2f7lpl/apK2Uospo6l5cHFfyO48G1LJ2KbX8edU7v4E+bLf2OuUYX7l+HOMh8YFu5fb7GUWl+gX+Arz0j/ceGn4fUx+M/U+EdKfNEqVm6bfwZafk3SgrHNc8iUo1KS7FwlVLJ1Ma29ER1hdvJSJKXPbJcI/uy/qPcbZkpeI07Jq+jt5FGPLF4cq3Sy37D3R7HThxXBuk0Tl+ZG6fHb481PM2b5+GrodeHtv2GorHJz5cFvJDbP1DjtbaLrHnusfeov8BfmvbY3Th7Wbpu0ULZx8CsddnRscMe44+2lz9McjxFxSLzjsyd8UfNelDUuBpdzbBfxRfvok8H9GV4NknUoCUVwJKv3FGS5zZS5Ot2/ZG9R2p6ubVsU2+SSeUTnVpie3I65F4az7mOHrcuDHS3wR8Wr97G92UPqslCfqkP0r58nShbmkPxU7pcH/yFzeCUr2w/L5rnnuJPwU4S7G7xFh9hLv8Acr8Bfnm5flyVvuN4FKEr90RkL2KfB0SkvcUVPc4sk9JdOH3PU93sbZNPA4TW2X5Ze5v8VLcKHhQ6PdlxVnTaa/KRfzpbjaRvk6b7G2MXzyQuNpnSzbv3v4NxudDUHBtji+xQ8V7nvGrKK3VixSi86NpW37jfjdNcVpUSKafJF137jiiXh7ueT6dUOXI92Eb4TT+FpUVZFRS4NqXVeBJilBEfk/pxUl3N0Y0ynpSVmfDzBnQ3FrlHhq+GKuxGT6qfBuf5v0J+JN/wSpdz5GnFEp33403oW1+r2FSq9IrDXdMx7Hf9zB9J3W6j5GrP6hFttX76bvDf8EXKLW32E7k75sz2GkKXdmxex/VOYq+B7+Wb0xwd5zbE0X4fqNvEvzJi8OCt+yMabbVL3LSpMm9opJZ+CpadVZIyaX8DcTrmVGOXgaaoc5x6WKVSwJtaPujKH3kYkr9jr5em3a4v3E/8kpQefkW5qz5F9W3I6vEx+CtDM/dyrQlFG2urcU3TPRuTHuXcvsPuSe2jpXpEiNW5PubFhrsP30lCr+S9HURT8R5GhbW4zQ5+I8L2MJ4GhuTw1SEuXo0u3diqO+SI3Fpo+rD1ex1bF8PRMbzuEc4Msc27E7bM9Klx8igpdS5OdHKLszpbdoezw6+S5V1ewtqzRmK0WaJ0klH/AJ06eRz8REK/yRzWS1LexZyuaP3G9vBV5L3UW5ZfY3Jc8/YX2mX92pRwzdFbUJSq/cq8vRyum/Yzn4Lqi4K75Nu3kl7RNniRTio3/JKezD9jnTxNc48NFQSwVtps4/ci/Dltt9RlVpD99Ex7cfwfT2SnfwLxKrPB4d3TXJe+mkdPibrE3RKc0i171peKOn+B74Xn1EPDfV3GvDTTXNd9PCguO+jcMOyL91p0T6fYhA2TVRXc/pypLTdTx3R1YaGr7jdWVTivk2J8XkalV9mKb8RjV1XdCizb4axxyN7aZ1DVX8m7/T/19hfar7yXiJ12Y4b91m14SsXizeX2HCb44JSbR9TxGupC2ekeLMwiicXnNiaqryVHEu9Etik2uT6kbkhy8PwrbE5YsVG2KwYieGvTWSuRNSVXdM63x3LSs/8AxF037ih3Ol0jFIvxJJ+x4aisV3Q1KMfbA49nwheH4SwsISlJ3yzf4Tdrt7n05rqLSdnpVfJd/wCDw3NRwOfeWn1ZduDHJteUxRXbR4VnhN3uJRnLHKK27U1fJa4OrgdPk25o2w5P6mIjhHuTe65f6RuTpf6WdMrKZXUkh+3yU5UP6cW/kcc7mqr7C81eReRv7SUauJtneO6Pqfm4Zuj+Xk34r2Gqil/0Sr0o3ZLSs3RmNSvI8Pb2JOqm0NybuRKMFnucLncJ/wDB4demWmIpIU2rSPqJc8DV37Hhw7v2FHxXcvYnHalRujFV8H1/Du7yjDpn9VkY9i/Q44VFNytdyVW8H1JrqfBsUypcL3I+N4dV3Wl+HX7GxYchOT4NsU9YqPNiw+rTtZcoL90R242luea5N0mv3OSmo7B0+SpcoajydKHvvpyNlxz7xZ9SL2m6D6i96f7M+IknJqioyljuJQdte5b/AAK+8uql3N0eq3knF9JJc2jdKVPukcVZO0+rgdnS7+GbMJ96FL2Z9TiND9jgfTXsbKyxbuF3LKg+5nOn0nhpCeWyHjV6T3kKVtS4oSTo8OnmzpG5pUOQ/wBuD6niPHwIxKqfY3emSEm6VmDdFn5f4HLt2Kfc6FtRk+TcubyOcu5ukjcsou/4Y5PubVVj6/3MK7FKrS5HasS4ZteGNKfUjbeEJrsbo8Lk+pxGuDq4Iyh3JTZu3vPZG6L2p82N/oP059uCXiP0HTiLJOWSMar5F/8ARGr/AJHONZLeiheGYuXuWdy4v5OrRtTpFvS0bsU0OC4M38MbrhlTf+De/wCDdCRsX86Jm2K2pDj/AKe+jf8A2xd18o6DKFCFZ512v1keqn8lvDHPfdkYzlaZh4G91UfC0uJGDSXuPc/T6UL6vDxZLbfwQ+pHuRrjkah6u71wVLxNqotT344IqNrq7my8n1IyUZo2f5/Q1DxfSUsHVwj6kXcbNvHyV4mK7n+1ceR+F+d9z1brxpGbquMaPsbd1peTHDIrwn/+j6b5o8VK17HhzvpR05JeHH/+eS4spdMu5f5EboKyKvqNyniPKH9Lv7lvW0KHiLh+oezxFaE/FcaK/LyTfpf5UbX/AD8+VOUe1DWxfBu4IOErkYW39vNhvTn8ZX2kn1JDUeWPwhRpWu5cn5kpK679z8yFXCE5pyl2JJPbF9vNh0XJP/JthDbZVWil0+fpePY2Yr9jpdGX9jn/ANS7PSz0s4Zwz0s9LOGcM414Z6WelnpZwzhnpZW1/wDmCkjKLODPk4els6MmfJwX20yvNx/ZVsjSdn06VLuJlJOmS+ONbfYXsKC4Qk/Syaoc+613P+CSa5HSxFUSrk2e5T1cnhG7w+lrvptR8eTpi2R38y4KKf8AYPXH/kxhjnB3WH8G6XTFclp4N0d2fcdaKqo2brY5xd+9dj2ot1+5lxafsNFEdytDpj3ZslHsXux7lpZWi3aLbyRbIuMeRwrJT0Upc+w17fAvZCa5fwX+Za1FWb0oyf8A0U1gbw/2/Wor50TofiLlix0+xGHGkZ+4sXR8fsKb/kfi+Hcb5G/Eba9iKX+DdgjgbuNsiqpkpc0J+G690Pw4epcn7HvGhpEa7L2NtIUX3GmL4RurZfc3J2dXpQrlu+KG1hDkLDtFOO6RuqtH0rd2JzjK5M3zF/ofOD6nh4+P1nd7FpZEvgz7nUiLXZitEo91klJmXgUTbLnlj2emXF9tMD6ckZ92KTeTbH3J7bWC/wDcdTPqRyLb3HudFuii7xpcrfwSSio4JWsWLckXo/3NsUSvsZdUPdK/Ycu8+Rc8kZZr/oSavHclH9C4/DX76LH8kmdXJ7uJvlfwiV4xwfu9IPsOXics2ozzXI5E1zgh+2keDhtSxZj1ex1I5PD+BbUUTr0xjRXueJGf+st9h2iuS43eiGcozklKu9Di49LKisI5EmrLSVv2Ivu1+LzpycaSi0VDk6uTFUZX8mEVRW4ddjP30rHSweJ4aukOpVkfU7LzbZu+CWOCl7lbv8kfCj35OTdKeGfSl6ZcM4olSzIg37HB9P8AJEUPDh8G/wAP1xIzlalWS07RCIlf8aN92NlruOxvd2Fz8kZw8TD7stZMl1gl9S2+w9jwkS2q88G9JNEWulM90L/goivZfjsI6tMHqOTPBSFGGJaVJYfcr79PuYSXwOcOZDxx2JSR/V/wbIvJtR+4pXx2F4q5apGWURr9yVn049j6fsLsj+msvuJ1l8nqotcjluHMU63UJypFMp8HpcUhNPHY2+53z7HVtp/8H046LI5eHNe7s2OnJ90dXA/E8L0P3NtNJG2LIeHDjgcrVxL/AA+TnAk3pko+TBdj90WdeBLka8MyZd6JenaXp1Itfd56jaO+5hG6T/kc7wW9LvK5K9LXBtng5PqT9TG+Wy2bokfEjlld+xlD3ywOL9Bsj/OmOGNPm8CU7tIxk+X2LbwbnooTSG4y/cSm+THYfGY8FvSo8Dc5LPI0ulFZv3RtcsfhraOC9M8a8m4uSZTwVHW4rGlGM+VWY+7uRug9rLjxQ4iUnjuY41tCa9Qm1xyNWjqaxwjOuCngvfkvcmdGF5McHWqMXtKjEy/JiRbZ6jP42vLktZLNzlruY9hJSdsytLXc/c3djbWew8cFSVM3Cj6aMOy192lIvuZfmrd+q/HlyLvkvTqxpQkmbU1ZKd8ji9HNrAizArRbRnj+zOnkzzrh41w9N0+EPay3rupaTqtunwKXbS1ol/ZuCzKLRnuWJ+49KUdUvnS2zpNvhw6u7KlyYEm8vTjBuQjJnSmyy/7G48zV2JHWKfhvntpUR/UyLa3em2+kqR0jnJUVyhcprTOlcmOxTZzSFJHP9j2f7teGWOUkVEuTJX/GnUsss3P0nStL7m6fPmT9jPcwZEuwk+xgv+xMHUhRjosaZ0svTJjhHUtPgycGedbkdL0uKKkxLStKRXiIdHz+j4Rlo9RuRjXK/DN9ypIxpk2RWRNm3shSbMVgpFvl6OFacGdaHnHsOWm0t6YL0tDfsPJ1PH6L0oVx0ytZFFopo3NG3wkW1+BwjikUuEdMNKKRcuBdSL7FSytM4MC+TJtSsWufLb1p4ONVDwvbJ1NmH0/cuWEVtLiUdbOktO/wNrgqh/6WVrtiZQ37mXpdGDcyh1+Asf7aPYWxJMvTOjxd63yUW4HVz5K8mdcsvyWVt+5FMwOyuxCWls2RLXqM/ewJUdJxZb1vRp83pgo+CkdJxZmP36kYdrSkbe5ZXdmS+xkxokes6ZCUmY47CNtFfZ6fUXrenV9re+WKcdLRnRGBvTHf71vllxM+XJSL76Z1yYWrX3rNta2N5oj7ibEktHcSpFwSMswUKhJYEX56vOqjHOilWK0bZ/t+zRQytaXJtKG0WX7D2I6l9z2KgdXBzgxqxLTjXJVlRkrODLHJ/e/cXuZ06O4/ezOlHq0wzaUja1g3R0i41a5F764LEoGRqDzpjVNvcUURaHTyZL+1WjczchMZg2619za9OlujnB7aXHS0K9Llx7GDJg/+zLG7x99e+lvTqN0bvTA8HUdXJjh6Y1ol/u8nUXY9nJVl6XIsVaLYcG0T+w5tfsU9b06SjGt+SVfbsxI2DkU8IxwbkYLF8aWzHBd6yccHU/v5PdEWiitMx0s2lsWb0z5uTbpR7suii32OkXtql2NzTiixXxpXlUTbBG6v386KXlpCa5+3bMIxyUZWSkVJ4ekoovSlpjk9RybtMFP769tKowznRosdvOibLRRxpjSyzOvq0oq8mNLkjftwPaZ5+zJPy9bow7R6tNm5X5MaPeV9m5Zej8qkx2NlxyjCrSpRPTosHbTIq5+/ngxpa06jdFqii+2udMHUY1ybavVJHK0t6r9tNvkb8rwfUjhlPyfsdLHvXBUelG99heXLJV7/AGFZgrsYZWtyXSfGj24H7aYLifJT03G6m2bpM6Y/hMWbbo26Z8m5GVnXOjv+Bbb+dE3MpaUy4SM8eSr0rzfuytKRTemBtInfPB05EnpuLbo94mTkx3+wvEWDIqjdlvj2OK1j5H5cGeSvbSmzpGvwVmSjbZRbMvJT0oswZMaXWlocvYybi/JdvRyQ/O1o9JPyXH83kaEU9Lsb86RnTBUuT5KMydij7asfkvyVEtmS/wAFWmRPtq4yKs+m4qmWsx0tMcXytOrCOngyP4LfctFMW30+XP2W9JL20XkiLyLSWjXnQqMmGWzsJyaMeR7uDo8mTBnTC0tvA1+CqQ9qzrjg4wNmLVHSTSzZl59h/SatG6RemGVZS0yY0pvyfH2WdBbfOkdbIi8n86Svh6Pzp1ZVGcHOvJ0nBh4NxtKRvbMyODq8mTCPUVL8HTOpYMcGKOrBS5LY/bR7eC1opcpnOto5GpC0uT1t6Uvsbo6blpWmNE17lHJhjS5FH20SWj86L8rikdTMFGxGdKkqN0GZLiRUsaZ1wO/wlSLRjzWYOrgUEzksyYM+atKX2ef4Ma28GDpdM2yXUdXJ8GOEcGySovTHJTdFedSQuxwXIxo3RjTcWlZnguxe3byb9NqOTJfcb/D8lROfLVmedNqemNc/fbsub03H0/yoVaOtMFXpuPpyydRxY9qH9ja/PZRY+pZ7GNpVcea9cfoOC/sUvuWY4M6fWuikyojzzpa0pleHn3Pq+Jj2FRZtSr7VPnWvJyWkZ5PUv8G6Xcsx5K0tl/pOPvUWzLHHzbrzpbEkI6xtfatFmWdOloouJ1IvgtZKbo5wUY0yWWX+sWLqEikPy1qhIxlv7mOC15LRaPYcXzpZ1nSrOK0ycnT2/XMMqRlWy9amXF4OkuZa+9jTJRaMlRiNyJQMM2yRfBh6Xts2xx/YnP4LZJm+TLXk3bhTjyJIs6joZlmOf7Yp5QknRtjyV3eltlR7I30dKxo98+CvDeDP9s4L9RmBKrT7G1LTLKjR6qLf/p5//8QALBABAAICAgIBAwUAAgMBAQAAAQARITFBURBhcSAwgUBgkaGxUMHR4fBwgP/aAAgBAQABPyHySpUqVKleW0vLS/hUqVKlSpUf2eb+obGcR+YE8CZ0w3EQ4lfVt+zzf0Bc4WEbihOuL68NXhHJh8Q0RT6dv2eb8i2bjDKRHEA2YsKQAwkOnwaWb/JDMwnJEX0bfs834C5cFnsHjSO4BAzWYnjMik6otluIG4ir9pDfmmvEa9wCVLpgRYTSOEHiaeZC4pLHjb6qTZCqk4I9uiWViRgKFL+mgBX1LFX0cv4gSxbJLY3pNMa7XUKKvt9XcV3Vy7gOWENBT+UAkZ4iKnDKfqUCBpaIqB8kTrdsaOZZI/oRE2fUJUFxKlFLihKG6/XG/ADei1kpLYYQJWYaI5rmEyjJKiQRqLdM63Lrxt9BLey7VUNUMDBQnUGAE8HEGohkjVn+8xQDWl3UbHKfQCIJHLomCl+fMFmTIdfM73BPMyaYYaKbHlmMEd63EVJT50TDb1CoFKs7TifyP+TKA2pmrWtPIynS1uHwR223DadPk4LSiUSIIiXhCHUqIzRMRKXPQ3AjZozub/MSjlR39ArDUdYpgvBGlRacykynLh+IpZB+BCLFvpUUwFrCrIOjcAZabpNTviIidytz9fLvavubeBqBM4gohB4upvBj46Rhh8ukcEgpj9FghHolxhOdBcL0xqh6mCQriELEPDcQal1m4CaZIA5Z0lZN2q/Gm3Iigfzj8XAokapagEgHwZYcj2P7idE/GGHRDfDIA0Y/14BBRaXqBEsUW3cAMRdnJKLJYc/7NuAwrTOnaaUxWWjqFQ6hXL5uybQEtzgVT/kVF5GY4bY8zAF2l82dzf6tuWl8vmgSm0e4KLeccw7EBbL+5Wj1GMSjGqsQXrtnCKMwlPlikYGuarBucGE6EtTprqZ4fYywSVxOLiU19AtRtmA7BhMK1V7MIazZjxBdea++o/Z2m5n5NKn6VgOYMYaQx5JEmDwz+lLmP0MWfdL+0WH+xR45I3K7iJBXIiZsoesLyHUZsqPr3FRAV48HhifjMqczrEBQB8kvWBTg+cJvO9xQAtnFfxAVvKO2w7T/AALwZOz/AM8QCovhnMeXWC5dE304ijVnppJYzvwZsKLwVcQW/NgWMovibmFUYdgykoywMOoloGAviUKgrqY9WXXoh9IHNQiCdmE/ChKZRa2XAvV4iWO9OQTAPGITcaDiOfhPc4fP8zCL7eYa/wCph4v4XqMWmwtSgoZMrxCEGqqUhXXUHaLVMOifN2e7JGMzpPA93aolyq4dsW6A4IuNC4JlToxOmgR8l3x9nTDl8I0PAXArwouYTTFl3K25rDE48JE8LLxXT1KH9JEaBXWWLdtFGB7z1QE+HIhYXQRseeYyFNMoWCBrxZi6XBsPeEtBgl3fJcNUVPcpBoSfRDZZlNhRplZdgxW5sKNK68a4LvtLPVgqmOqiKJd9IjtBP6ZjI8ks5jGP4d6lI+MxGPs7igjDmuCVYYHtwtMQqfjT9y1qghNO10wAVZMblqLbPOBSxYrmPTtRt1GgHNFGPcRRu4Ob3L6Omo2URysb0eO9pbgdRuYA7h0J0YmI9MFBaqOmvUoHJ3KLpIsVo6bho7nhDdjN+Yd3PHcfVbftHFocYmVRVeJQFI3XUy2i1hDabp+xpmMbpoQlICy4aRVomxMzYyshKEAy7+ggy+gwtdsj3IxSTM0CmeZnicnUJyO1LhRVAYQbek4GFRSf/HLPXylicsxVVq3/ANuH06sYEsRuXQBzzE8aGhAaIJN4ZzT7IIi/DGWOepkCV5JnGDVqpQzWpWMvGUif7W2Pl9nEaZOYNBVbogMEMMagBmypmCrfch9BYZAO6zUzFkmYuRmd3uAm/ggmAhKC9uCMURr0Shg0EQJjdAi1mcUqIzqnuVVV0wlbzB4I0dTXAHdh3jUSKTQAzzCTobZgIAtVre4KYwFiyFW3MvUnDY5gdFp/SEBo5T/YMcmCYcCYG2/9zQK23UeAvQYEWC83zDlwMJmLZWjj7QMVMRMSXsK29eBklzCLvDCiLmYU5mDMXlOvi285CXS+ZTGTzxGryLefEAB1MFZZ1czB3DSHlSgp2gu22PUTS8hg6yNMaJm1ssPTBIUFu0hrphupQZwTbbojj1CnVT5OH3MZZ7EprAnzM5yQ7RBAxrxMjabRlSvEPJ6kWd5IwEAop3lEi544QScL0jDaCh3AG2iABdc7dy0NjNE0DAz7cVCSau+JcANERkVOFhrAXi0x+BgJkStBwEsuN4CvDtAf6lLU5mRMOZ6pGJz1A2tVjlMYldOpTkYVOI6LA/EVKiX3BmLx8EsziPmWUtw9EyCpwRDePhA5kS9SwjBknIk8alaLB7IXoHnqEAREDUmiGkyA6apqWvxuuftAuHL0ih4hk7fFw3Nq9pQRjNJ455SzCTU7Tbzi4bYRfc9HExTmim2aw0wQvDNmdOaB3D3Vxa2ksBCE0w6h6MMD4klmNOb1LQtbi8S4HBfFM90Il8AMoQZDDz1Eg6f09R4Fz3iak22k42iP8xa1yWYOHWjmCzGhNfiXsO0ZBBmfpLbGZUI2gjaWc8x6HdVFeV2y1Z1fAlQysDF8xnK37YPls+CPQXp79wtOmwdsNYgyosNQmHubaPJMIKHMtOg/pFeQGHrESA5FvwUMwCnuGrVpGgxHfKNTiYE/Bj2BK0aqUKOo9S88kXsQC9rUHiFt99S+H26iFycFgwRWcwOaF73HI6YZW34S5ZUfxTDB3zMDqugIhWznuN9jPZgJZuvcCLawDI/lrxAjTs+yMVCwhsumpmP5IOa8OHm64qIgnfEwuXMaJdiGhHG3m1fMvcDbSKA59TOah9DMhl4NkHQXsW/qG/ZD06igQekNk6kdM0ccyxuHI8QnFsVBxRO5UTVtaIWzKkYzAbZcEKujcWG/iWbxXwSVkIgh/sULWflatzhG801SDJT2lJi+32g+Oxx6gfxSY2QUqoGrQFNkurMaYyxL/wBjOtmXRpJAHt7uUKwrK5YiVsYeCDFacGCWqJgymS8kgZeIt5htEFgYDRxFGb9Ny4Df8ErLdzAk17ohBmODXECWFIWrgt+MORHOBCB+GcTOawcbHxUJljS9ytcRw1E2lpMmR5gCXNWtwqpxKXi43AV0dy2PQ+JLu11jUAQGueZmPU4s/iVN42Yq2XEAUBslhMvnSpWuduGfYtv16/JRQTKkpm6hzUQ4lmZNMhfgHbjiPgSuHJBUudvORixXBN49Q1Va6hzIKL2XCaodiyLSi11mE3I8ION3xBhNNycwEZhg66GBr8LuEwLvbLzW0MEQdt2xnNGrnEqBh/KUxBeGMeSQWquB8YJUqQhzu8csIRXah9yghdAYO2HUwCHXMrVgovcAHc/iUhiXe47HOoqbGrC5ZTge2f4UySaALuNgLeRNxENThuZCX5ZVVKw3Nyl3yIv4Qh52sag/6zuNlW+YBCwWrlclUgubR2oCYy81iGAwR7reSbmVcUpUdkbiDUgF/b3KOqCWJRXgl/UnHuZn21BXzgyylnRT7ZsCUxeMAeYX4O7zPXfTibUDQepTuuViXP5G4Vd0GcQiIYKK+xpmcZLmcbxOXgEKorglJlm4cQglIJVTUlXibfRVn2QFTIr5gmtHHtldKzw5haSzhK3gRANoEATdxoYxiMlr4HSjcwOVuTp+IwBXcSCm71qVrgr8pejuDqB3L2NutS3uDB4FSBQX/AghYFeoxhXQX/MwABb5mVvhsrKwqDWNOrxxKBT7HirOG4ApbMKrnT2g5h2azcLTqm+SXJxzFQgheeYbEJ18K1mybF4FcwUt/UVEQa1/csWzw9wfaNdQC1HIRzNQfxM1ej34sJL2q7czKkOXBPesxphDcpj3ArjupM7BfL/qLGLaYttvhq5DseYglxs/9QYMFPaaIlkGozFnxVwnbfH/AKhtY7d/Z0QXGCZKgzBEREd4ibzBBTCC3iyOHgogZ5g/Ft9NsMMnzKnRbXqAVCYreZYc3HUrIB3hG5SV5LSsC8R+jMFYBP8AcFI3LhKueZbHLaCtRrXuAYh78c1f0WA+wZewexqFVvciysgqrZ1CJibvK9SnTDNlO/oY3mWzLsHmPSceXuNx47SNC/ICNgz8zDuvjnp8REiry+TSonMHJWAcQxoFjdwMe6XGVYhDYKemW8NwFty5lH0BhhrOH4IhKzof3EEljVQ6QDmyYkBt7fUfQjq46XmY6v8Az9vT4CY3oIh4HiLM6GeyIZS0ig14VTEJUTfNk2+qsPSviY77b4m/1tjBBIOVt/SNagnRrwQKFvsmZbZiHTpSviZ8jdPqXtvhGJoOCLoHI853DQCy8xXWFvG4qtv1HhhN9IuJuKixKvU3u/L9dswpanf6/XHU3oU2kw3AeYVS7UuymFxiBEOYnucCLZhDQz+Bm6b/ALP0SyeeK1BzKYTBXi5+NPBYYMNJeMz/ABkOc3/Z+rwG/BCEJKtlEdN+JBpBAieAkRum2b/s+iUHysNmws3ix8RSpcy8DyqB+iQMXIlJwoKdyBI7f/149sxILb6j3APcBaEKFP0YF5uiGgge5l4Jz1zZzEoFJ9CW3KnCCVHA1dQS0rv6QXRMgXzqIqSn9kjd6DUobRSx3BbIriUJiV4G4OJigBUOHwLx9IGwCzknu9Ti4IHiq4cFa4jinZ78uo8bEYWaXBXIoCZal2E59OeIo4vOME17laHlOZsl8PEbS4ti4m/oAqAdEz69KJwn5Y6Ck+mmv+bC2iCoWqKCjK4HoZQAcHtNh2G4gxvMxXMrQpwg1NG4FtSt3BfEB0DmjiAekas2gZbvFvEoh6Rp6ktiUdq8RK6HOYxEXgYgrL16jYllljOFxxoK/hCFjl8UHs67jATH9R22L5lXlqWAqUpAV34SgCeCStskWC0cNGJbzkqtTIlcuzMwB/b5vSUa9RcxbDuKCaZj5L/zRRuYAFVXuOitnRKSuU79MqWOFI5jYABj3HdVLz4U+o2A2UwSoomiKWIvLmNFYwudfG8DOK4z0laAs6vMzUYHM5SFZ3KUua6YgBYWHcuHFfBAsFGRPXCthCX2NQb5V4gDPde0YrBkxK6AsssGVwxHIrogoDoMpFsxAyXkasPmNctRgCDkpxGGnrNxNE013KsacPEZ0AukG6gKAys44+kPn7DimBQ21iYXjgQBSlXf/mTTpdIuqtv1FprIqyA/0gGgaxUv0kWMowblaIMQtFELl/8AtEbExGqx8EFkDwWZ+GEVW3ZM52XPyjS9GNHUAsjW5v2RddRgLgF5jqg1mXmw/g/E9SrVx7snouK9wormIVwG7B1BOyXKDxBVl6G2LplmFUr27lKaSFECLioMIA275upRdssSnoshhLV6QUhS5SwaIsJdyq4OXcRgintErKzZ8fr6epiusQaozEjaUx1RFqSU/ogN3nlJmZwckQ4WN0xBt7xDwDbEvspwH47jecfyyyqZqEOVI32MJmWWZpf9TCTkuAKLNjHi6ntDbwvcsFQnCGKYuB4McxdlN3zcwaarHHL/ADCsYDCu5c2hrVcyqtoPEwt0ZkDV0pqFQXiFIrYShXI1CRbFvqXpCjlqINAYXirKpGUTO87xCV3Uw1YS4S5b1f8A4j4fhCI/fJNzaNTJ9A6jAFMoLHUHPLLaLggfdr9ULQnUoRgwlg/7DOoCBpZ56lVWezFoAaZjdvk5mErCLDdNMVsFiX1LkZco7Qr79sWdUxLxPLK+Dl4mWQcMQtmNp0wW4dK47TrhLIyG5YbDOuI/gsU3Fyx3BnM7AmXtgR/V8w4N/noQ6Kv5mEiDLVlMw2yntltXTmAiEHlVQ6qurmNc7FXUeYnZKcbWa9xNBXaNvxNIi8y5Er3KATGUsnV4McxymkAba8UjVF8hHmwbjtL4mlAKuEit4GJWvmEGqRaM9lcVdSzEDbUwlAdwCyruvYl0Rs6zM8X+oFzXEMNwLNQykFqGvcRoIXbGN3gk0N2zkVPuaPH4mMwzKRl0gqWI5UTLjiBeeZZg9SIy2wzjUr7p2mIAFZhEIJgL9wAivmmA9FZ5gRUdNIwUluuoK3LbMIxyDtCVZga9TJb1IWZgm+RmjwxY400eo4atpRtzmHqIPk0cy8omdpMQZqS7mTgiutIzUtq4GyXozdjAnu4e44qzcZYzvHEHY7KS9Knt1F83x3LtAudyuuxhXaOIFhjANaNxuWVl/EVDaASm4TrNSHEut74U4jpANKI1KXD7i9L2vEKNDlnmWvti6jouf01SuKr1KKqjqIu01GhqILlEMYp24lrsTqYpbEGh8sW4CzHGMgOD7LqPgfuoMkickc9F7gEpzVruWcZJaaQYC6+vuG46sV3fMy0yF7m8KyxE9EI8TaBdZYjLewabI2Grw8XspARLjhGBkwEFVY3fYw8mSYa3ZBow59fiMmy6TqHEAYJbjfFG5eZjjwdWeYlsCwxmG8oYmQ/kjZLrgHEssHr5jna+DRKDS8sCl3FzJbuUyNuTmXuJKu0UfxdeCsD0YYxNZqWY6JhSkZ7oaUnj9KkC4iUsfgSnIhGKgJWOSD6xDMIINOrmUmXUc1ZAS/pK2b5gUlm6lj3JgMA5ixblqzT1A7EygsCMYOt5giiicL7gPaQvdEnJkNR1x8wMd7p6715t7BRro6iGUFKXikdXA4IoJel8evLpe9kHyriMWLPe5g0BwTFeg8xbbfOKXwj7zHmXtFXmIuv7ZV3Nav6BaYOoNepqGmldREqtf1lieOJlxnipW5z7gWJVnNLM4CwN4IKgn/gwHKECprMbBog61iKYNXFTAmyWt1B2PmT4aEap6ysjx+TFuj25maHslCjd6i2YDM4ZHDfcGtS1Ccw+02g/SKNjAKnTAGxjn6lXb/xYtiDEQdPtKoaLh0Jl1NkS5jBSAbTVaJupuO8FrcMW0mDqV8Lt3KmF5iq4BiZmtNdT5KLlIYAji5akZiuU2sEhED37jpCKS4F6QGYiqEkj+h/YxbUvQj1i7Zmj0txtQZncGBXtxxKSZDg6iC+5SvWaUTwgUc3K+2HoJ7qVc9R42AubgNGIGhg5YQWpFvdTBjaRzpJw78Jq6yRFT+xQHtBgWVbzGx2qM8QamH9++YwUHKWeX6nUxLgGAY1hMywQYdW8ytk1pyuXvcCsaXvY8QtFI6fQlqQ5le7PT3GxlRg+0DTBgXDmIw7YctSDEz7lfQs0EHB+xNoDuNpWW8RxcnZFb7ghSY6TViZ5MQCqEGARcxrTKvSZRJnGywmC3gndXZl27zE1r0iFgvUsxCdSugYKqv8AwjYvITFAJh4F0dQyCh/Uf4sYFPiZTQ5ZSzb5lDskFsSwH9h1mNy4LiOWjjO4Og0NxkBNVxBZL6IGOQ93iELV7m4DUOaXd2gcBmZpj1R0nTHlWecw8eOe4dcFrk4gVukxGleWMKjRQCvlN0F5S4xqEuZRNRzpRQMoOS3mUX7/AGEbiUqs6l/g4geiTUM9zoB5hKVMbwvwRr0i3ZpVbl92Z3qZhpD8zhAEQVZrUCxi3KIK/smRFuqhXsCtofUYEEYnpRi5WVgIleoNhdHjBX5kAwLclzjWtVCHGxl0/wCHzuDthZgEJc/1l0jRwyjVxF9DNrHxN6fpKS9TFN1AeMNhCwNgFygjVAeQjcCJpY0bX904FOWXA6mIsDctyTYMvQLZnF+D5cjDlwviZY3LjdCyMlaCM61UDDMHEHAbWVlMMZTN6XL9MsmJIRCvaKOPxHN5dytq1/wdSzyVELFc0KIVDJy5xiYDpg5lD41NzZYfy5cuBNIf6FGc91Aa3yLLqg5O5ebN3AdtVimbD+ZkyLAWRntisleoyWmql5Gmj14BbQiNs0IMoQrFkuKXqIYuJjuVAWoRQlS5Ai9pF4vgjJDJbUIHIItEV+KKqlbxwZpjdU1HstH8w04+2aTTcD8ziv1BBXLLc/iIrFxiS8OP0NRowEe5VuTEEsZ8MtiOIJfKsc5yubsIOTNRBTN5CNxvuEJNf0BI4NL8HHFdxd22UMBYhe+4bVKi2IBQ3FQEDtxGFDHAfhcQf4kx0VdRoCihwnJLuIiuIFJauG5HdEsbjXWpU8xpgGC21wxouYrlXWo5fVSsqLa3KJNCj7IXqGZwZYtslFFuglccDmKoQF+CXm1/qZE0/uBVCn7yKgr6gMRRSMD2qYMxBOuvBENQ7txB0lRSGpSUeb+EC4qd7NAr2wz/AJQG2D79lqiEOlmKMqwT0IhBBcN3GJUjFtE6XBdi+FVijZOkJjlJ8wI8cPZqNsJnVCbnU/vJAKJnF8XapkoAYljLaTJZWCh+9wRZ6hkLGYBK0ll4Ri4yDUtE+ziAQ/iGj/NQA9zN2sbVBlXDFVcV7yh3IxuiBdwferghZZinPPg8BTK5QUYUSsN1lh7+WPMq4JZdS0NjuetX718ZnCO5QQb2MCHn3FXOGpRuvLEoILDiVTrzH0lbI6YUCyBhzOIma6YSwbi2HFTXNMBYD/Z7JLNkzE3WX1JjeWzlqXnj0lZFp7mZEmfUxMrr2Jr1NwFwcC03BVUtj665a5gw41Uqbko+DLxmO1csFai/5TPuPARujODEaKJXKvuAc2Cpmo+5lX7TuHvNwvwOjEAS4WIAmLlIURBlqUBIJtV4AlYHEEawIKsOVD72KzYxAa0tuOhy0zidwQtL7SpyYF7rU5EqCZNwgQa5hOSK2MDuCKFTC2x5YDlJXAlFZiFljOIoDqIBzyYyeRNaGVfEAtr/AGXFw2x8w6g4QRBjLQHzKrDUyxX+pifPDM7IXkjfLIA+Rsm4gHD6gqjbAGzPMpWD749Y3L2rdTMxDYck7KJwNSpxeOMCk3G28wF5cQKDs+38wdy2CcCJEuXFRhF9yyc4fJMIiZVV4tfGWk9BFh6S6jjgVPc4AsDiHsj1oh396j0JdVemXdJrUzfEA7JxUZKXLG4IQ2tJcDKE5ziLxB7wN3dGmpaW8wVh3ECAS9QABbOJTua0RtCQtw0ASLj0XKRvO8TScMtW8s0zfEvk1x3GAauVpVzMNaKm5eaEYH4gRClPqzEGMWhMMJ40/MdShQ3De8UFZRe4uY4QzLhACiNIyxtb+3goGInbvEaNVf7DS5DUQVF21qAJrxffhKzKoK86zKLCHsvE+NjdIgLLLqZbcplLIOUxKv38V4lA3DUC4qjtlU2IAFbiUXXyRNMybNsQUCU6sQvCpwzIkfqME3VG0abjrNwwF1C8Jl0/MDk4gqXDH+cnxHoUXJNkjm5g4O6nFXAFxoYjgDtRmA+oe5dQ1iWINIEDBp9Pvpg++kMa3SU/lYKy1OxzLGpalDwEcwYs0CZrxywIcGvtgAHMobBeWHumGoXrGY6Uz3A9MEzef4SMial6stAdyyPERTTK4mAtFrVniObnecsQaxC1oygNP3lXqOQveBq8EzOHMwrDECpiYJD4d+FCFxmZtDkmlVHkjbaEHSRlYwBWYgV1Lml0zNg+GtxoBVAujLKKCx2QRHsuWxGZkQxWhzTGQN+OoiYX/UM4xZBG0yyn03T0R8huaCkgDHmk3HE4YnJKxvjUJXaso1d4hrwwBpdwMG5ReRxLno/YBWjmHT/6InpUFnyKlRFXNZccx/iMLFpxOhnMs8g6hMJEprcoIJW9u5RlCobErI4dSqpp/wBmTqmNr/0+/r5xRtURO4tEvGou4zcKe4bFQT6nJEKhpOIqFlQJmdbgaLlrr6YqiJl4bVHBrI+2iWlYjks5mpUuiWEDcuysgPLCCYxxZ6qUHSHwxDP1aOhY7lcyEcE8LjCzeszrPUfZTeJZfgIMRy3Lkm5jmD0hQxLjVGJ0fsOomZqco7wUQBAxm1TevB4x0qDQMCMkG4h3LpF9JeVCgGWeZkfxjcwQCL3xLeFWOXgdZSlsxz+gtOZbBNEobLWYchmIqHEBJNm6jrRi6lzgZbVwWCZk5Y9RyLC6liWcYgUpSElbcCb1YVBDBmVvKzTLBNxC7Lo8MzAemUJ1AiPEp1UK8QWUX1EZMwNGPqyCC87mpk4ZbcFjhlG454Zc/PTqUcNp+ZmaIK9IZwtxLfT2SlQqcnInG4L+xcC2yLS1PJNx+GDUSvQcCK3A4Z2hXLj1NNqosNmZW4EVX9yrnwhZtHGm+YWp7TLo0p2GJqOMpok9QP6FUGXm5riFVGRvhgTT7gy2fcUdkBWp8I9B4ZtQkKxUapKXYUWl+VlI8I7zFYTUQqx7TBpxCWlykCK4tR4YM+w9zeDMZeIxHP1kbc3ZL5XC7FRT+JrxF7EysgP0mUWjmRn5jy7GqgFQLhxAZVnVPH10ryy1fCHE3N+jbBHFb4RXDbBQbmEIDYKuXZG2iCN3z+IWIMoekdTLmZFN+CS7DDZeJY9n9EMJx78G7ApELmr7gcDdf3MgKYFjdGo3FjZHXyvUSsZntb3OYMDMnEAuRmosL3CzCbi9qglrw14kYJslG651LYN2FUTmrcVMZFWMY4+txcEL4my5gy5mJHcNwYEwWHb5fIMmQ2StO4YKFRuGGoIOvrO7xnwAVfSIVAAtynE/+LPcxEq4RU5lBcPWF0sRFSsLInMVsRLBVy4hrZ1Cj1FN2TcTBR0mSbr9E8d8TrR3CgZpTFs53UXyeEvO3kgt9l7gDUvGZaYsqjQ3cuksthQsWZ33CVs17jaVqQOomuqgwK1Y6ERdg+UC2iqjKPrzxTQJLl99dE7o9xld5EKZ/Yhu3UVEoGES04n49KkZL4KxvaaxCzyYi6sRjT9bjdFSwDDqD3kgrGMDBCVZ0CKFC/mX90JuiCBs7l/AXLqwVhrGsGUtZT0b6g6uHuMMKuprBhh2zLK/iX4tef0SWENpCkSrMi7GYafM3wHqI7EWH/BEQ1jjx7hSnPUe7jmZE9ziBrm9TSHiIJQNSeJEZTUdwsMUxiZlFuEAOiXkw2RoSz7BaNrHzGRKKQsJzmswjmE2Qxk1M1BrbiILQEv4mKCWMR1tjMwUbcTjWlUck5Led/WLleW5zWYTFxNwaYlpCMY/iPUksY7hT0yKh6iBlO5lIKIBu3qAVgzhBKMVtDbcsd0aIguH6NFZLii41RNdJWVZBQtzOxK0zy49RqpmINxhZod5cN0QTpNS7hTlmGCr9zHncQwTcpeJVNwFammalhGYPsjrSvcNQ7yuANSr+Y87TmWHxgZ1BzHjTnC13TcoPwo6Yn8SrCi7TAozEkL+o9Qazdl/XtIIzODFvEGQHRTUFnJ5iZOV1hSOo1xBHBxe/TNGP5l6hVoES4IuZIPZki2yzWo2ye2UYL8I6PP6XQZ7YtGkpLH58So2+IV5PEWJgMhY1UrJEW474lAcsMIVPSWQggitolK2dgmsx9pyPw8FB1BLgCIniNRxNz+BLZwMxKjOtoDrxseyAS45lgqVienJ2ZMtSy/Dgx9in1ag5Nkwdy/XCtJqMoxKGpBGohOiJQo2U5Sn5lQKuBBByMqxY/KlJggUQsO57WA0zP8A5fpyiXsYjAYO1/RaWUvAgKw8Iw5gTcwiJYQ3GtWoDmEHJFtt+24GR4nRe0pbRNvRHlnauYQW67jVbXUrp8nhuYiX3uPnNYl2sdCYZs4DHsMMeEXLB3t9ka1LxYSm3cre/AWTMzjYI5pNoltpKO8vUPbsgHLEyjFtyypvUYoUqqL/AOCW65/XZEhBSHjfbwX4O2ARsIW3P3bb2MTEu4kCVnEdS7PUBwzDtY315HpOIzTdstm6AGK02EvjYJoS+0MfMa416nZkre09xKolreX+aCXTKpmO5dupHC2lCspASrV0jC1bHjKBpUWpa4P19awbSKktLZ7sJYT0meYno++o8eYmAolqLl5MR5hrIz9A4GoctnPH+ZctC0EXlMD7iWWW4qCTlQBuaxEiW8mIuykAQw5lp3N5plhcqUiK4YoAtYU7Q9spRdP+BM/UFgnXhZ4U7huMscz+htmxwZEHGP5mb+LljG/FpZL5mwsFZrETH/iOGAJv7ou0WyCA8SuJTwgvsaCrS+IA35n/AFrBDKitWLGyI4y4SB1KcZbf+D0jB7nxi+ovU2z+p15xVb9FoyuJxpmwstsXcaJ+Vi8n4l/CtnqDayYo2Rwypmiasl5S2gi23+1hrUNEgCLtcAMrjWG5UadMqPhXLKDChWEJFYbfU5+cFltR2iK1b+2UVpJc5l3HIS40BTgrPrbLDdtzZL8s1Keyf9cRElr/APx5/9oADAMBAAIAAwAAABDywwwgxzywQwhTzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzwBDRxwTABTzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzQDDRzCTTyxTzDjTzziOfnzw4/bziIJ7zzz3TzzjDzzzzzzzzzxyiRyRSRzzDyhqs2XgL0Hdu+y6DC+ZhBy4WMryK7H3zgFHzzzygxCCgCyByyjSgWbliBwoqQx8aPuN5WCGOvP4QgOj2HvQMnDzzygDioAiQiRQRSrvHRf8xykc0HDX3BNGw4PHvrTji2rhHm4RBTzzjiQxQySW5BxTzBcHLqwTDEmyL+POAoif07Alhxmg4Fa0X5fzzzjwTQBwRADDhSkDv5iAFFnTokfA3jW0rVqHMBqxodRJ7pmHzzzyxAQSizAyRihzwlS/vw5oIjzxLt1yyDWhyiRAVzxKs7yzo7zzzzyCSCiASRByDzzwxzzzyxxzzzzzzzzzzzzzzzzzzzzzzzzzzzzyhixSTixBDBBzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzjf7jjDfTD3jzjfDzzTzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzw3ph9KvXZWvft6T9VA+vx4fzzzzzzzzzzzzzzzzTjjzzzzzzzzhhHX8rhNsyZwLGFryUFiUNF7zzzzzzzzzzzzj1c6FjnzzzzzzyjGS34skAZpauEzRJP0lgjDpbzzzzzzzzzinMmsh224J5FXzzzzyQt5JhO4957/qY2oA1CY247zzzzzzzzyBRJlA19aT1KpbJzzzzx8926/8Ap9flc8f/AHnH/HPDPPPPPPPPPJbvtBNIQ0VE5DKngNPPPPPPPPLPPPPPPPPPPPPPPPPPPPPPPPPD8bLbxdBDlWESUH4OPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPLGZhNFRqijAIIMGB6vtPPPPPPPPPPPPPPPPPPOMNMNPPPPPPPPPSEeKt4OnfsKRbe6709vPPPNNPONPPPPPPPJGOBNDPOPPPPPPPKeckyOrK/CyKFLAeh7kPPPKNKGCHPPPPPPINOJECNPOMPPPPPPLtMPQ8S/PnLPptwAlM7PPONIAIHDCNPPPPGDt7YILT5WPPPPPPPoaZJSc/EttceOS6fRAPPDMJPMBPNPPPPPFx88SCEg7Q9PPPPPLF8zxOrm51d9ZLcPFt2PPIEAOOHMINPPPPC3SeCIL4/SFPPPPPPPPZiJ1gyonMdAwSftBPPDPSo+GisUPPPBNrUO/OCTjJrPPPPPPPPCl/uDFX7gZoxtCEPPPMFtN6MPs/PPPCLK7VKDMAZ7CPPPPPPPPLAfaS1SuqxNXQNNPPPECXbANxXwPPPIGOLFLGJBOGOPPPPPPPPPPAKNPNC7sBCHLPPPPMPCCMJAFCPPPKLONOGIPOCAFPPPPPPPPPPPPPPBIEALPPPPPPPOMJMPOOAPPPPPKMANAAILBDPPPPPPPPPPPPPPPPLKJFPPPPPPPPPDLAHADPPPPPPAGMHNNKBHPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPLKJAGPJHPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP/EACsRAQACAgIBAwMDBAMAAAAAAAEAESExEEFRIDBhQFBxkaHwgbHB4WBwgP/aAAgBAwEBPxD/AJqN80uooZYAWcjepoH0pbYAs9Fn1jLOSILD5v8A1MQCqlhY40GLeVlSqFfwQdIlBYFtEtZ7enU25PxKlcPgtnnRzBUMCrZ6eaXvK85lQDSoCPBO2KR/IhffIm1Fqvogh0PLF6LxuDIK4ca1jcGgssRq8wUTuBVw11iOP6+aiV1wwLqIGKFO/iaSzrhVuFaj+YBancKeLh1FY8wzlqIOAFbZamtwuswEmHj5lGmJZUw+gaokXgjzOufkYzJjuOAu4ioh0ux5lQuuseL/AJmOaLamAdXLLqVfuviLpaagMn6SijuHFlzqYg7MQKjhqVEdyyBHygViDtd3/ri6bcQ2tXhwy6qXCMAxE1iZXdTUlld/4n8CfrCADUbA17bb03QswRu4So10vyzBRCBRLTO0Rktxwahfrc0QLTuAgNf3TbcTLTwyi25lTx+JgU/MVuZYrFAoxG0B3PgnngBq44zgx4gYOVd/2iqOoCBl4g24iU0iApEW71A64/iGwy/QJeGOAcH83CimUbB+dc2Bl1BpcIoeAFVW+pZcyquovmV5bilBof2mxbELxMFmoi2iQwXEdnDorjyalMCFNRtG0KAYhth2ZiI6+iSyKu58woUw3HlckoX6M/N3C+4g75D5hdwShfNVqA5v0BCiNmx9Dn/oBW0x3XIVhBrTkbRBLTkTqJX2RhZ1FlfUI/MZkQG0yMthlDcAgCobC11MBCcstDKpfcSsSmrlAKbjvgLuKC/rSnMF14qkBSiByblcu4kphxKFwC2Ibnb5IbNxBZlT88JoBDLtu4ukLEYKr69823jRozAnMUqYhtPZS2imMENwENQS9NpVKgJmKFdQTQS/CZmbLlhqDIMVAbo3NCMwqVzBSu4RLi1uAkNI9sruNdTJibEpDzHD1QBhgYpCPJMPYh3Kj5iXvVQ2gBY9RDJBhtmSptDcIEFREqIbqUlpe1BK4h4ypZVEdsvF8RCErzEVUFIZYmL7YApELiDU7i4LXUL8su2E4jZIMu1ZDasrK3G3fqGsyhhmGEkRWwabJR0zAhgzFVtiKyZGSLUcIrItibcCmoI90FaICWZY7bOTduoZB1BRA8xFSoICNleSPhC/sj6QaXni8RoDMQbiPySjO8PITFWE4t5iHxmMncs+xEtcT4gC3JD0h1hsy1EIIbs8g7jmXkixiYFP2FjwgCmcB+MqCoEcVFtjE1CASQmngai3LxFCWVpuDLpLRVTEfYCJdOovVHhcerEJniUlyE+SSxpih6XAYlwnbLGn7CFaIldrDCu4APiTGtQJTcuXMsapO60FN75A6lyohydRoVRDLGbgaPoqCYQLYN8rRPCbzDLy9itbaijkJo/P6RgHN4hAFDuZD+idTcy0yjJEpINGYCXRtF4hLFXHDRDjMH0MWiOBWSnodRBt457EYwayhE1sPYeW4dPiKmP8pRKcS7u3UGhqII6lkqzBQSlDUy+kNriYQxu4mxiNQg5GLbf0K0QW19zBmC3m9ZmVLI3mo6Kbr2bauGTSCFSkX7zAMN3A1iPkzLLaWUA2iChdQfTMWxgOZqeDJb6a3sgC3ZBss4Jl1A6Sr1kK5H9oBCcw1ylk1CUg7g/M79phZjpdHUpGTyRIpgFXcQeUv6XN/hYZpgZtwAx7JbSu+wgUVxf+UKImnrHaJXXp0mF0fcdDTCs4jZFvcYsImtVK3cofMFs5gyEGvYYPlDQGnIsqE0jt+wfvin29I/8ACv8A/8QALBEBAAICAQIEBgICAwAAAAAAAQARITFBEFEgMGFxQFCBkaGxYOHB8IDR8f/aAAgBAgEBPxD+cWXUC/BZll1ErqJ1AXUr5Bs4IHJuLeyKVdBSXzGrvISMELrM0kxCP0ibyy9RKiJjsxAbvEoHPQLaIZr1n9TFmFVOeiKiBQYrakIOOtLDGoXN/BMi7NXFlPunIlEdh0JUNRSrzMhtGUM9DFPPQMW+IgWQKIjglG9RqugoJBV4uFdenTadx1lHm5gBoimMRl4cXEYPRD7+NQ34AFvhsOLiYe8QbD7Yj3OYYRQEZOzTcBxVWpho4hCnEBfaVNHrME1E0KxAQZxcBef1FUS9hmCuBeoMKwKxBV46IyMvVLKsrPvAUdINlO4BRcPIjEh8YQuCX4EjotcfeGvBYcPXtCUZD+5S69u2u0U9c/5iq2xU3AWFCj/vMP2CfToDF4gZjMZy4YFK3BOZeBmf9zEwu+gpC9kV/wBdNlV0GiyUrp/uO29e8ARxERpmDZbTqIyHMJcy58DVdOdxVtcu3a+qFl6m0VABhu5yQIysohasRqvpEqrAbllVXd6Su8vFMpSiAmGAMFyzE9Y06Q+xEMK8Nwj3i3Mo1Is5lBoH4Iph1FOEWnpKzfRU3LvVBsvwKUFRq8eBG8R7IMKOtIDyQVYo64qJRXxFtvqFQ4irv+fiOolz1ST1eoC1gzXVQ+S5FXDSYZvpAUW46I6ktTL2ZrUsKi5QXMU7gWNwWEvo3pM20ynnfS5fxp/aiMOZbSaoJx4ENBm39zC4PFfm4ZLbKK3qGLdyjLO/pCL3faPgyR7SpjtAGXdQKX2ghBI4InY5l0HLDTsiAJ5ztCUiyEiWEC2oJ+5xFBO/JSGmvMQbu5RvHeM2zeoAhoN1uGnce5KUu3EDpfcaB7YpHuc8YZVol6Q1UZFUXKMWssWXeOFgjJgdkog01GAfNIkb7EbQCPEGKR3OJpw+5mY0z6ahot1uX9ypBtYtZJQvxNLE5kQVzKbOCIBiN3ELermXqjiNMKKZU2N0yNjFBUwAZlYTMqYm8cS52uGYw1Y1LOXy2HQRQlSAeiZ9CWq+Jf5jkm33U0z6TjxjLxoJTF4aHMKiCUwizEO1O5VRBKYp3iC10QSmKNwnDog7inHnJbDqfDcU+sHfPjtKV3BFUscVDFMEaksOO8otymr+SLibdRzDltsNWZPsSlZfrMmoJIP2ijfRAD3xB90sUvN6nBY7/IyQdwo6lRiXVxKUbdxWhcM3nH+yA113KG4LwQsuDtMgJ8hyDV9J4FnQgwTepI43S+bcRqLw2ibqJQYcRI/S9otFFV+YN/IRMMWd9R1HwhcWbNh2l0dLEAVHeM2W46DW/DdZVw+kyhcFEOdQXgDfyFxEZmtEzuXM1bg49xlWc8QYOsQVIutekatKgeglPQLxCR5xkevSMNTBVZehv6wqGyvPaYSr4JFRggIufbwvI4lVPIaQrmuHpLwCmINniuGaF5f9Ru1hKOyHENFChCQ7X4gonLljOON/SJQmlxINKOXn/wAmB79oXAtGSvqvLC6aOYqTZ++3wK1pYaUyHN49IJv9B1pYmGKajOme0IND5FjlI4j9yBHIEo02D+J30cblrCXtEkdAjumIh7IJUI4e00ZTEMcK3C6YH8RqzvnmME53EhVOUUKX4FSLUBwtTaZQ+/1KocMML6haq4/MXZflIrGDI4d5y9IZy01EqGD9ysaCZfWECxt732itQvtHAJ6IY54+nHclQaEQKpjRe8fnw1YlEiDZfQBbOYFjA2PEqbmSWuUNJ4iFTwOksRu9QK8plZqe/MsQ0y1yjuK4AmxWCP8Ad3JAKmYytQmbJmWKt7xVbfI3lP7IFFdLgjWcU/zL/Q8d3Dc94dchNeYQtxDuAMEGpWkq4CSiZMA1HA58kZhoc9UsqOrgblcpl+QVA/4Qf//EAC0QAQACAgICAQIFBQEBAQEAAAEAESExQVFhcYEQkSAwobHBQGDR4fBQ8XCA/9oACAEBAAE/EPqLanvPee8957z3lu4J5g3JPIfaJckS5izme8957z3nvPee8FP9qQXGME5t9pSETaVPARegivCX/wDCWdoij+2SRail2qH2ZthcEx+2XUDcMEZlOB+kMBGe5eA31L9RIzk/tclICWAWvUCtBjSNEygsxFH7RRdQdDc2ihMev0jt2KjwLwSrUF4Yejmo6sf7VK5UQRj1H5jwlwzXRM4H7TYn6Slg/SU4fpBKuYFMfpAeP0jHB9oiqK+JcSypwse5zJ8EdiO/rt/aFVscMYiO81RFs98Spe8IqoVZiTKlk0IJZaZklUzGRRHbDEyfbZg2Mo/iKlRqWF5LJqTAGYwNuEqvvFW/wkcsQMjh/CKesALWXaLpH8hEK3UgazXE+w4X7xAoGTRPCKXfFiSvwrDQbkKnmiZquoCy9OZgF2qKF9jqXtmhbWIzQ2JTMA006fwgrQSkUHLb7DXzL0opK+QUz8RRrISKp4JUBK0OR5lJYWWWbPxFFJ4C4PqQCZTubEWBdSvx1Klf0swBKmmpaLF4gkBcIFBLfpZSWLCSdCfoJmzAlu4iKSosEHbglgAq/wAQIwvRbR8se6EBAemsxF1SqUqu+8wBQCmna/MtrVow+fUMgCZIHAX/ALBFFHIaauvqCoG2D0ouT1R5YZBbVVDns+0b9mAU3/CW7FSNNHg5hozqLwnGID1iiUh56ijWkfZ0v3zELg2PH1CIZT6Erl6EPYOyWA0XQNLx5RyIgC7NVTuCYA6OvAhzRURkDqJlLGmmnHZnUMdsQGqv61EcDzMhBA4JSA/piGcBJckTN8NRB8JoZ4+0E4GxOn3XqKpUIyM/9ywIqrQPJ8MFI6+pB4stWF5ggKKwKNZrklCtgg+EtksBG4+6JdbtnkuDAil3VV4/CQEKQ0BKJk4MCnIpi3yzWuoa2Nucr1UEEJQjC/iJYhWa4Pv+aLquG4pYhhfMMj6LpS7gqU3ImWWxia4aysgiVuElGZSFrNQaLZcuSb/UhL6wlalTVN2KAdJzmGIVwgfyt4hmxFgN+YQY4iBS+e3zNS76L5iIZAXuuZU8FjqoAaXA5+l8AGwBRKG+JVnJdV6rf9carpyNfFlVjiHsoOVE2DwagxdUKUb0o+ZgGDDgniZ/4vvMQ6YhYOe5QxHLd+X0q9r0S5ZcvtTXXT6gPO73YX9oBNRBVaN2+cxbyLYLDuPC2mbslbljAXC6rmWAnwu4egRsHdfVrZuOTzcMRoDT5sam/wC24AoMFfvLs5EjDrrEt2TAXV8JL2lYdMTAJARpcxyBtJ19bCOo7VeXgxL+JuUk65r/ADMQQcTPl1cOO5IwC4b4cpENkgHfyvcKDMldgXi/EVuhiLQ9iRkHZj6+8ErH3lB+BLVbbhLlo8lbzAWuVsVmweipFBfykLMaWcqZal1Yaas5/AoBaUEcmYMcFbHuK0DT3Rj4xFZNolNtV6hKtRGUF4e6gppKT8nMyoU1HEdoXpxwgIy/00iDFIGoF7hBR9BYyhlsBRMM5YqBykVGb/UgwDTxMZ+Y9K1AZXI2PPjUBC14l1s6l0gETD/vEr3Zk2R1FFNNTSCOGHkYg1y0qqOf9JaCGishL2m4HnsdRHuq3ORmg6a8zG/FWwwj3BKNq2WaF/EwmBt8B2vOIMoU/TDrzBJo5FhCpJLFL355gIVBFK7yP+Ppml4Axh/IhtLLO3VNVE1sXNI+eIbHKMzWK50W55vJPHMSvEcCvYOyAAV6JVQg4IhA0xQEFgFtLLIjAGjjXDjmoP44CljgdWftEoolAMB1CYWKDSP8zZzqMMVVuUmlpYZbEbUNKctZlwDYO4Hw+/RGfsQ1U+B3uJKuG4K1I9nrxDSRdQYIAhbeIIfM2Hi6tCLV0bPKBIbbV0tzCihTFweJUHdUC6lfwsyV3isw6+smhX/1iMSjouswSy8vLivuxIqZUsO4NI3II+DiHllg1XB5bQN/T9PGBHhC2WhX9cRnSstt3ZHh0AVvco/qoHkUNTKaiMykujC6/JFhDbtMg6WH4BOJehiXEYLg1nwM61RvEX7iJYdmXhN/XcJS+Ut3/wAzLtNvqZlqoK1Jc1rxCWMCtjOvsY+JcA6CChIjQ1YdHzBexHa2sKBYyPMcIHUUGU51QoQvN/rEohbHcIbxaeimbDzc1EOCaMYldgbLYWh7Ylfiu1+YXgEbl1X81BIoNDWiGHCtv2lmB2NA86lmBaMApzzmOJVDewGVY3xBUTaRXkv3FlZQpjFinxEfAAHWe5aqKU6DUpxmewdTLa25fPiYx3UVky/8NQ3AEWWAoGrPtGMKC4roTd6cTOaQLNMa+Km6HhVIVqNkwRFXQSz7XFxOoHlDdQ1oMKj2svSHMRNt1W+IsEujOw4Y/AOwoRtgTVH7zHv/ABNzUNgGvUw511jhiVTLoV5kstr9oBtHxOB4e4DAnvg7hIHpAXxL7DIrJReWtbjcWM26mMsiAqLrjjNzK0+1pYyRq2xDNpZHgxVyy9wCLj/iX8KNgdMrCyoXggkbSMvwYYRRyuBaBCRkaNW4q+IiYWFO3WB6lpDt9j/lS6KumzxcrpTVEX0DYcKEtVjRBDQIWc/kGx8w4Jmr2xHxQylmozRGMo5lx7XxG5CvMCijpYAgViLAQbGKUygxMWUflFkeP5laTb6oPXeSn3XEEsAtceglbRCdt/2sIYJaRysZIZahYBR0viLe2gteSYsJZa+Jqo6Hk0wGyWyzA5ZYxWu+0N1AeUALcNfpF9++If7LPZ5lVgwpi3ghcVg0OOZSJJKVLlXPWJXHLm3NMro0YxNbBir9WCiJZqrqpU4R4w56m11RZYhfisyoVAWmM5lDl2E1qFzDAuiLfcbNV0ylNWq2voZrKqYNJ1FCFwGDDs8dFgwHdtsy+oB0QlBf/qMUrhX1zBWRAwUXNYBadMXMmq1Tp/iJXZUyfUbaMmaYinLUV87d3wMhC6YsJUGI0H00vv8AzEMczar38Q06RVNV+0BWxfUrrCyygb/aJRblPjqJbqFMs/DkMReb6AVNOyHRgDSjH8QtUaC0cFy6DT2MaAYOCWA2YYCdY7uIVLlybf8AcbWcjjweJX0CMZjo17bXR36Nyuq5jnhQsJ8gt6Iqt4DFa81RBhWAF2NFwL60t8qVjVRg+XrMJIlWxUIAxXk+BGRuAAYLwg0D6+I/j/UTSeI7nlgvqlNsekYpwi2Ku5QbioCLwMw1IxDqmtGmOBZL3zmMNlrPMwcG34ClWrLk0RtUBbxTnmsyo73JVVWioCwFgJQK7zCgDJlQzmK2iuvR+blnTsVBtlgi6AaLjMUiPI/SLsvYMEz4zQ1lUuoGA4X9T5SEa1o2Viq+36zBogt4WY8gHA4ZSStZArX/ANjEstqAeKZJzMJWglZ8P2ljntuK8dQE5BmxNZldExAbIdTuqXLrDMkGeHPf2IcbTVqEJ5oA4bgOfAh5GHmEYrZnb3gl9JFAqkvC8Frp1+kvpEY4ysU+MMTVWxBQ5vJnUe3Q3YUOwoqZE4Cyr6zDq4RBk0nxb8TBrwju2/UuOrIwI92Wr8R1UfYaL7TqUkRWTWOP0iSAVw4yeYKtOVJzdt9faJC/EyUAIObIftFWArBUvWaIvf8AxG036qQLYlG7OIxAzoFucRoiicwXN5ajtxqoogpzzxmDiK2Kq83EeAyCmZQW0B5c/wARUV+wKrNreo6pxOGzR+8YSkuu19Rshy3IUw+E3NFa1nNREYuh9VFhFNzwDFUcRMoJyHphK8QuhdxDlktLNY3N2oF57qU4pWU3KMs1yXwgzF5Ch567j+P9dHY9S3sMFo6jG49oYHeVhlhSiEw9SyGoKmsxVgneO0ab/aIzEwuGRC5O5kO/8xfghLfDIVdZ/SNnVsk0cDN2SGhVss6f2lVZ1SsQrdynkBXVg4L5lva3Oq4jVu8IsNVXBAIkDqxmpaCIY1MAgFouQlV44crwPcSCEnGpVH6TfzAHBrPTySvQjQvRT/iNTdg5rkPXJEEjQtbwMeIOajgttX6psmZhY9jELoF/tJeClSVdObijt2m6z8WyhSqIcHGPO4IRtPRXNNnc16FFy64gHmcVwdvUbMNRYrO4fXeir7wY9Twaye5jkcjZg6KOO2HJB5bHwdw/FCoL5GagbFZRAa547id4s2cra+P2mQkBrhy/eIzYlun4OIfB7cQc+/8AEHnCbUKT3Acm0ut/EW9/i39oBE8AoOcW01mK2HPfczWihpm8fMIkJxDJqnMpMNb0fMEcSnOmWZAm22iWGWgjiGtI0tjEqLYUzXzEA4uDTcCOC1UtM8Hsg0AZBxMYGJFtf8/SE1rouSWRM0AVWdOf1gHYV4QIdoFvsmwQgHj1C0BE8BaB+2YjUF0LTkt1ClQYWS+4PfSkuInrFcKsJdcLmGSoLfLozBfX3sDcAFDKxbFRfkS64AbxzEYolI8P4/1EViNcdsFJ6iBIi9Zda1sO5vo1W5mlyk8czqm2WFaZi260PpMmkY0VEIO58Yln4I1pQxUdm+ou9IJd8in5g4Ajpw7riiNotrTgbqv1lwfKIdmV1HJobqPIJX/O1WZH1B20qEjEi6qOvMtsW1NMBt7Czfm94mbrLaRcfvUFDjMKOaO+o/1SoKSw83MawQtEdHfuMQ2kNw0TjzcMbQFdFAx7lF8eNdH1LYm6L5ljuTaix2MrUeAX7p5uXCUaUKeWUeNxeHXuNUlnaqcHyxqFS7rRwmLsUpH/ABj9ZguslB9y8far8p2RHDIU2tw1gcRVCgfN41KDOQ3GOLW4CylhBvz44hN80FSv0nn0gP8AMxSluP1juW55XNnwxIUTzYyIpAHsCpL44MCsGQThKH+bgQoUlL/wl4MEttDf/PmFUFF5b/8AkDyIV7Ox7F5lg0bbMbtlatVK8IYPCzFAFjZjxHUwgeKtwzEgCK+0oF1VCxLw3Az6IpT7RK0JlWeRcrQ5FTXD1Fj7hbw6m9Plij4YNT2A6jKqawaD+YZIM5nK8fEG58pjw9Rt62g6TfJz1HQCsQgz37liWsmTdXgZjNoiwJFp3kiE50MtX8RCHyWJP3hPNohSlfrHmtydr+Q8hDo+WP6UNylsl5lzIRYzN/CVNEwpsLuDQEaaCp4DMNSpBuF5Yil/ulZ6li/BZ4PQ2PsgRXVrKumH7Z4gmM0nPNZvR5heO85Z/llXEKCheGcOkcmvGNPiENbemqB6hMUTRybgEeGVdDKDNAwx1LKoYOwbqGsBTDbm64iQlgVV4l3oM06e/cM8K2fIWDESaUAbd1F0B9B/ZKTkJVruAACKla5gIRSslt4i5nOExhP8xhmilKPFdyoMaXTQt9VDVDW5rK5tmRaAS3XP8cwiQpWTXuuGUUmHKp1EIo1p29wraXBa4GHGhgHgilJc+LCaFEBYFfzGYSFUXKnDLlt4BNMqhgGIz78zLmE9zmvmITJZbJqt0VivUFRaCkoHqPZcqTghRlQBpf8Av3jkr8Fn2ZWYmKHbBZ6DMaaiBwEb+0cwIlLvqM3kNstu4qjEo2eZkZDGRFQG4lgpVC4b8xTh5F1bweIUBI8lKtHIaaeYIcMMsBCEf3I5USjhiFN+yBpfYoSMlRHbQbvuM3VwYKMPlsc5gHfsjbyupQk9EbD5TMi1enwe9TNCULsqHiUJKR2BjUNdRmffmKz+2onr8mjBKCu5UK6goRAlwqKblyx/K7txwFiFB6irLMsVaNRItlanDMj4iy/BEulq6DsvVfMDwUA9pZ++obElcTMWw69RWNiy0dFRnxP+1xb5/aAJ5rsHmcfDk5LjwlWrz9ED6tjGap4VJwdKKiBENB4YCGsAFjyxntGlNjV6gZpXCmagtXYWBFY0v96PruBL137+iIlmx0nTFxfWjrzL22YDI8SnBuuJwD+YMBdOeX7QX0u6Wr1GA/iB2+Ylu4NrgdI0674JcelKVEsxDWDrwW9hL5tYuypfi5dy2AGpCq+CDgGabjzcUBVtjieoS2eI8Abis8Y1Lii1JYzLdRtlIKzyy1mdAhLKdJdag4cO4p7YqHggOAMz18Q9YpBwFM2cSl2M7bd/ShIXYlidQS5cgJFXBOCjh8wLCiaXkePvECozFirDE9N8iy1/3UQ2AtS7OXXz1BH0r/J7jIirlXn6UwjrWhrpDXkOos6wI2AOPMfpoVClN/vOEKlQ3EaSrZL69pSsHPM/4PytgpmISi+HuHh9FQxLFIW0B1PtMWELwxlFzAqARawmY6uNx0TZ+GGmyP4DbNNuamzsLLVOzzFqDtsfcWXVY6vwmc1E2Bj31SIABxGmpYe0Cvl+owiQDUgfLk6hO1Sqgp1yw9gMBqIUrCs7zf6QI2UX0RmrGd6SaF2UKHL3+BE5xGsl76paKm7/AMRtAEOm+mZ7hRIq1t+5sxDmOLRGq2RFx5joxjRuzsGL9bGK6fJLj0FAb5pjkBRFEWqlkMarDGNuAiFAKFsDF+vMKjjsD/aHJIIjd6I3g2S1+rNWsDkjOqj5HcUGsyxatEgAWodAMdW7gH7d5sRAeNMS+4EhNrrcKATKNrz/AIj9XQ9MwDPF3a9kzRJrhLu/2YhekngrUzrEAYKbsieR8Cl1VrFv8BDXXJBFDbXcVCUCg4Rfys4m5UagaeC4LbzKzcbG5XtNpZVZAMq0ylAJGIgMrRx3BFrGFIQKGoAp6iuGr1+G4YAAEU+jAWydM3XxHYItDorUZwOhuzyRjq7S8Hol/gRCkTSTHOQTC7rzUVH2/wDabPoUUZxEBuAQNKTjUtYsy6x3uLf4br7m1XAmIDUGKHAb28mnuC2wZtfuW08t3cXECKu1/E20yjKfJHnHuqIPUwb6rVT9xMl/guWwAoUIu1xALutS2X+K5f0v8i/zBcWRCWo0ZiREuLYcQTKBsiLvZMwlKs8UIdR0tjgyQDSWXCPipUngkFEsVgw0ev7PNxuIy07lNdznRb2ktTLGJDaxBMoi8EyZhjgjFKx1tIw3cTWVYJcmChFUP2f7P/fyl4fyQthBGvqNckQrEx6GEYCArqCmiBUwwOYDBDKYuoIft/2eJiwlY9YkpQftI29XdkAt+sQI/lIn/KTP/OQTBfJB8B7SJAa35jV0+Lg5f3CLf5SB/wCUmL+UmiL5IA/mJaF/kiMJSspEFk7SBYdf/rtXqKKvW2iX4yovfFw81sFsrXURINcDljt4bH6hECoaZGCKQ5KF9X3FEbetsRdPEahMxFI8fUFaNwRQgW4h+8F2vHc5bYMF6lEK9dPwoUi9BLchxw3EqgwjH+xyNAooPL3HksUA4bwvxC7AKYb8RxUUrJVytc9uDS244eFluh1AoOxr6UesMO2LWsVuP4ZiKrTKCz96ltZL4OPEYl0pxWIRUyIMj6Eafx7D5hiE8jjSQhmwPv8AzHDKlVQtaP8AMIDCzkruGTnR4Tv6BLutI4YGBku58oFMxot2b1KPSzkyX/MJNhj19QmwDLoiFUrpw8Mv/QusnqIiVSP4AVoiQUQeZX/tMAKrQEv4gPcHuErIaM488w47wnIdkGoyWNA/2TGkx2seIY4uthLlzX04vmoxja1LuXOQw35jVEWS/KvEPhwRUSsxZgVooDeTzA6uLSsebgKsztLxUpYFzQxUOKKU6USiRg0g8Yi3ljbh15jZ/JfC9x1ViNNguP4lPTWXDr3FQ27HJ9BantO7iUJbUZsfJiV+XBuu8ym8vEXuN889q1ENsdq+0ZrNllWd/TC4dTAee5bU20ij3B52Q04dEtLV6AeT4jOj7QL++JT9F5QLjxF9sFV+iWvMJxgzUEqkTU9VETH/ALIB2h+8YJWdwznKibo2wG81r+YcymTmVA0yvdaPUUqK5rCAEb1nIviMotIFdj+Y4BbMrGF2uB0XxjUNbEVLNjX3qP8AO/OG29fxBHhC35lcRVhWCbx1cGoBCQAvcJQYIhsNYggaGRYHPoYsGIZWbub27GrdQbKRfd+s/ETRsIsc4L78S6tQWC6DeIIq+QK3zXMFoHZuuI7YNwLO1vzHY9ZH7QGNVOArJFhDau1CLhXRsIh6W+14ruCQUJ2B/EduyE0cYcQt5bfYmPOrVbee7ik1rwMOCFMTpQFMvAa9Z4WTKaFaL3DTUUByxQGOA5zy3tlKkNSno4gSbznZbglOJtSX48wQKFYmv8/+ziBbr2w0BhtD2XSPMTKEgHVIjXBYXWXMrZdVCr+IOxCg+ZZq1BrVRHGknvcEdCTHyiIA6XY9wLPgAtcse8RnAco0cKwbrOQJhG7QWPvqWoAlJwXBIsSxYWOowZGqixVc3uVMb1xZS/xEDqFa7FyneBqW0hKjS7R4iMgi+UhWmK9JRjioOGhd5s4IwyLT9SVCrWv5gUqAXA0fzH4INNMCtiuqn4jiRKS/ZEeWx0dfzCjUbfJwhWvERq30UriV/ZzRzEpNcVXBf6xghzaQJ3cSOdxtOPMACCsYETctCAANU8NwXJFm1rZ+0shFQMhDgBUYDBS/XHiAytUD7YiqAGBq2T+uqDaTDMI0uFMplsaoMpWoHQPLFK6vD3ENif0SajJsBo/aA7orNY/4jjgawqDw9xcrFKWGaFx4ZagkNQW1HCBe5Jv66gHgOBOJcizBnxFVFNK/aMVGSozhIRFIB5nwEATNNy7ZTGgVmuueyDVpQ6HmWCAsmhlFLaW2IWIjotjBGghWiNn2zCvAXS8n7g+02O5i8XCksfA2+QtiAXACVZCKNYrqAwp7A8/EC1i1WxJoSOrqw93LcFi9LhVLp2VIj94ViirB6uWF/tVuDBSGZczfKIKAf6lV5RQU1zK0q4LEQ4C/mJKDIZpoo/VcuWKFNADuCcpwsoDKDtwNHNZ9Rm2BR2b/ANxE5QTGeY/SgFBXf6x8b5Mq8rLC3k1zZ/8Af6pqmXxFOGW11OYKuxzUrJZ+yHBwuiJCGWOItFa1ZuaTBR3Aix4WzLTAWBiJWXV2mCo8A8cpHJrKINtX7pYAvP57AAWs1ZX+ZTWLA0PiVd7YkquLgJ6KD5PmE7U3Nxd8wVWJkTevERu2btSc4+8tJWXYoxGRIl5A8kRLUMF0AZXvRVQHjxKKlRZbwbriNNqrFgEHmJCbEGE/kjgXEEN7y+zH3mFoUXyu5roEG7xFNUu0bPFS/wABrHQ5flWoQ8lGgeP8zJcuRdOL76YV8o2hSZOdTAELY2faFlyV8kGlVxXCd+JcwFjDcYBzhG2ICSphWH1qZQCo9kYqw5F0xiY2WzaVmpfIWA2nb/MFVcsKHYGuGVAkZaE7nA4rU6iLWZcuMR6JItCV3xUVUMyrZ5jD3VYsHN5gaCKIC9yCfur1K6C4lIAVCeAraZ0YeOIZea1ZZ8MzZWS+L4/pwXiAFSLYRY3btm1lchDbz+EEkrLmXCkc0XNFB4So5TG+tP0zihO/hqUJUqi+WK1GMolyh1W4QwFldvMW112uXTpQOUXdNijJF1LhQ0n5p0xqEwstOyyzrZCAuK9ar9IKUlockA0JVpVtsL0667NlxDK/VpUwbYRz7g39AotxcalwHS8/vMcfkh2+8kCJUC8sP28DqIhtyF1GzrcCq7F0gCt9t5Yy9fhbgsWtVP2Rhi7VrrFQu1IOXs8RasZKQTk4xo5SB7glBwfEthv3B1KSWqxjyWLyReWA4SBvOaWO/JFtC0GgkNKzSrAxBjToE3ja1IarPUo97LALbG43RrWlLr7SgQu44XkjIAJAmFepU2KXO3lohgwuwnmMRQVJXKD6g2NPlM2fhlzSBzqUBoVFvCzpZSJbrRHLFmELAN8B65joEIimvA9kQZVXlv8AprXVZmJVzTLEAOoCsRRQ42dyuJFPib6uh4gwBiBCnAIXFkunLKxScr4ZWRuuziPanxWGXqtPIcw775AvUay7gf3TFsKMEaqgq1cvDqD8mdO7C6dICkC3zHgI5FIUALhx+YkCNJzKQ1+DTuCPKQtdwDWLV0rpJVEKcHfcsBgVSsbIVJomW6vUfa3t6IgJSNkvDEnEs+IoReMHkNh1HYjWefJAUK+LGqmFC1XxLDaUXy8xFrW2VnP1iB5YuzXCRoNq3YRW8xCHsIV+lEMXuzz8RRWtKQdJ36jviFVKv6VwtEX+jDJlAOKxvxLQcnKsZi2CCg2ccRDQ4LNAbW4l3PZXaNB3uLp/AdQURGkjv9ClcfqHAOymLXZLtxkvl4jeW5TGzxKg4Eym276lBAuhodH0v5fuuwfEuHLCDnAX8ahwKlpNv/dwOxxo3+qN2SxVv+lQohZe2LlAuwwG4uheoZZkORYIaIdKhSBliBeC6iDi9FdRzcGEKjw34Y79xLmZK2yyIRBosZa4pYcRYvsNQyaCieZf4Pa6kYhj0al2HS7hRRLLcoo7nUw5CytMAqLPERGkr8oi/wCTXCRMWikr9upf0VExSdyhSnCXLTJEJQMBVVo8/wCobFjmFL5fqDYcJwkOrRV2WIfQqlKUbuB2oKD7sGphsm/5+8Ssel6dfXDSFJpIAIGi8+4vHibI1K1MrWy+Igk3bMPmIiKuVfruWkV5JTkRrmiIrCQbLywmRShskHA+hXX1GZr9dHETwt24gQrg0iVEWrtfwX/ThcNZOUOecCnWGG45EC0m0VK8jEqmDQcsdAjDfvFDUOjqOzEF5nqA5My+sGnhmHAL9weSImdnmLZYwsv+oWo+m7j4QDxHVonovublKqbdRhruVv4l5QJ4eT7wrueeB6zQpXQqWS8ZTZ3KE/sYjMMG6gg0k2H5iIUickehiVd5il+ZeWbiKoPbf4SaBNJEBOyuZemPYxKVbX8NpqbAa7f/AC68cDzCrv3Esv54/dhWY45LhlFc9/QgYWuuC4t4AnBeJwv4Nr6ioBawBzFV0sw4hAbnFrqWP7KR6U4guJoQWKW1AYa1Iih1c0FTC3mE11Atjuohb7aYxVHZslAyOz3DUgVltDzYYS6jNYHE6hqzKblMQttgdLI4x1f2M1+ksEtNs5NAJkrFhdxmHXUUZCIq9KQzmNpl1QNTMBqIY7cZbVMtVLFGUO2O4yrtJd4UcEP5bYrdxW3LVwXtFGUQsGLMHsVYx+m7gI91eiX0qlkdwh1W2mEdNXsLmsLpXmbiYl0cCAMaMB2J9o/ESM6T+xCXRypY6ribNTDqYAeAI1myotLfigvwgAqnAz8xHjUKOYKyg2nzLqWNVHQQhvPMOYgzxCMK6RFg6lyiE9nqZ4m+4DAJS7iSZVyhlCjRyR4neHcLrnAxLH3sn2R1K1Lgpb6MttazXEqRk5l14bPEFXYcsr+FyKcXyFRFRsllVL3/AGJXYxBoaobmUysgalsQMdxFA1kSkAIslHHJGUkM8cQbHhV+eJhI9HZjUyJK18kowgT5y84ELGxwEfNWEweZcQbShQTMbq3mPmk2yGixl0wVDGV3FJkNc+oAtDYIZRciYHPiEHwVcGLoPE+OM8wbe0vCIyzqbxBKHYrF0LDU5iVRLB5II1EpXcHjJ0xiWR/sILaj2MsZuUQVcDsd6kFRZo3csbSJFhFbKt1RVCjsIgNAXutQrlS2l3COpUuqxGTBqKsx0LfHtjDlRZYqX1abLmHmsmlEsxGL0RGVa8QEC9NqqKA5Lq8EqIalpAnQYxDLUFx4SWVVRB2hROoqx5+8ylgGM8wAuwtgvmZbMZ4Jt85ww8FhwW6l+T+wlQ3q4++lX0gEkrpbcJx23VB4jBDlTa7lUyLNtR1DMa4YCXVmLiMhCl+4w3aPUVRK9MblQ+SlnA1pRManVLjdAe+giPV4FxXnuGYpDEStDS6JeRQWxiUgWAXiEUxDqUbLQEyWVuX0stDcK0yq+IFgHhUZdlFy18wtu/B9FESSwBzEwSdravMGHbiHUoN5IlNf+MfhPwExfMEuALHsIWuxbBcgNllMovTErKPlmWlIOax/SeaOWNOTczbQk6zC+0C+p32GOZVDRHG5iI88DgTfiSSmoBA8ITxyDk4lbugMkeLitEu5bwKmvaCe0TMQgbMFy+HPjqBrTR8RFqLS3FCqIjCx9oqfWtzQQqAigN4il3E64mHAo5jQBvqG9W3JLq2Fy7Km7I3B4It43Fq6rQsS10BL4TY7th/8MToWZxnZi3mq+YW8QNATS97IjUWoQdglQ5PjhgkICKjpIXAHDiXB08NqXwpkg4GKE02jdf0JDI8EHARYtEerFhbcsOI2F2nmWrLNwECoslnBiBsHBxFR6urhgU4XZ3GbLEOlQem/6SVG0Vj7Cq13CrKkxUZlUm/pY3jSvSWGhDZ8fTAQExgMTEplIM3APBFAYKffLy9sUuLqUA7aOYGKHEJCnlIyPCwmodN8QYbfyY3EzJlJge48oC7eUG3T8oLlzbFhWWXl5eTGkcm2SQlKCJtjiVMl7d3FqgtRWIlP9AIEXpWUmhMkyysTaoaYGOVwnMww64jZUAS5gy8V6IchEICIaAuBxBpVdszIlPETSBwBKAbyrCMKaruLZvZ4/oKFLNDi2VrZWvUEKrUY9Ayg3Dq1nbxFLOU5iuY0WIFFUvUpCg14+nQcnDnWEEoVUbrcABAVbCWxFy9UUEehmZjItFyoCrCLhS0peioq9cwrRmPLiFVXfcrK7agKNiNKFsHcHmPaVc4riW11KSfcSk8hctJpeEKjBWgKmCgA8H5KKgr4hxFqHxCAaNEyxKZotwPwKMH0LdMMr0ooPis4TJ0VwpYDSPH5xfooWxCsUFSTPgTSAalqFdDKzcelFuY6C9sZcJSAsu91K1s+paG73M8VZuOwwdxhGKmo60W2kz52yqnkulfno2FY9RgUwLSQKwzuXFGW4rGdxUWOGmtSlGgArdQ+RFwco2+SApXRBq9Bw+oNdEzLk5zWJUUN0CUM0BZu+YXHAU3KMVqoVcIlQG79Tz3TLr6JHQ9wxxxDKQgBiVqFuSUsqiI+zbcxGbZVFSpY1hvDEUC0jEbtyYqMko3EJnFcJHXpgq3BBZMxKa/I3SQWXSKCgNEVDQShcFiDglyhd2yhOBF0sdzmULYwu1bV6gJfESvVBL7/ADSVPue60QCKP2hVwumLjOfEzPExEj3wwW1gZWBSUcwElbkgqmSBby+GbKZRUprAaYKs2woQagBQY741gs2fnN8dESCpLyq3sMQVuOsMvYAUruDgA1vi9XHXVwdHuHlUu0oMcAcROue4BCSNOy4stNdHuDUGqrUPFdC9QHall1B7jIEamzI+omLByOIZmwMHyqPGzFwOIxZC4iz1LqW0Tn1LjIauIgUmUdQHFXSGN7sj0NDfSVFcgxMJSpQRwE1N4ISCyolNQtn48uK5gmJUhCuu6YzL00MoF6RaRZysqdZbXEUEVi4PYaMG6lIlNzlhkF1XAAFNmahJqdPD+WS7ashOiAWA2mNWGq3UKtutWzMePpLcviFICmyORsglQnMpDJFBT6lnIwFNjGoAcsQs8LrEGK1pckemNjMnmtdxQcrB0fnOeLMHErVK2XmF3ZqaiSwFrl94LDS6hGAZmuGEjnIdQx9nTAijAnnzL17JHv1AaALzALg6BMpK9nMXIy/SCAY5ErDrQJf/AELijp0+7OGVwC/JCRrEsKhY1tEAFoKwNY7Hai2VcsGGT2e0C0ciW3EwDtdEE12su2ODkRZ0Y0ZvFjG4G5l+FZPMX0RrruNdcfQcQynDGDv/ABCTtKCViXLXmUhxEJWkP4DL9z7CIlzk0OgjZSWmuYImKorZWiZUNbCUgJyZU+qVA4cwbwwt1pgh0lJ+WBrouhPGAtWCtTQ1mElN7Rdy8GAU7QgBs9x0wbrgluQ2ZIoXF34gBi26jN8hg7ht4GDopgXEvV6vEV6hQOJcR5HJmuAxTuPTcUOpQQZLx+cdoa+ItNnBnUGrYFWYwUpFRxYDouoQK9MCFjFmyVwoRlJ1RdQulDOGCNeGHWzioAEioujxG2VeY9wOwxT8qIlisPP3NaSQaQjhSqeYwEV1UyVuI6L0MY86I2QbA3HBjqFOUUGkcxozcUjK8HMQ2wx0jak52ftmcuXXJKFuE1xbusEQMlrSeYa2y15Jl5FsX3MRxASbz+JRgW/XcBqW6GXhNQrMp6au4roxzynmotNbefcLcllwm8wAh0zDG22GlVSpoRyy4wzJ/fn8ttUGQu4ZxBhwgBawbNLqVDFyuGupjq4OjuGveEik9wd2Jk6ZYFR1MIKUEOgA1uO2qaIdaDnMrhuj5jFG+ktoEJzlVGaCMPUAA5wv5+wTx6lfhaPmF9FQcRChZhuiUihNKOpbHDEPJq6I5uicQWAMkZ019WsTCApw5JRFLGUg3bmplDnhgkNZY90xxEB5AkNZ1BS6gUKHllK2PBeZxCGrbjM00lPkkRcRIqGGY5B4ZuAUU3UORS6GImRC0SCBittGbmZDMu165epakytlGigIbfIg4CUvxC3ml1LXWKgHs/CohZk9cyiVC64loekD9YTBsTE0dxVJjolCQ7YlcGbHmZUG25QB4JySjBMEzsDHZgW5D4CWOfyiBTGQVxDdN6afioYKQsBzBs7FEtsD5MB6gk9BZccj5QLkmVJ5EgkChkOIvYtGI9D3YpoBuoCouToN8RmsZU19pZiPBiKJreiGFKcsVGgx5idocP5wrNrZMjBGnDCgQOV4hIWVq4wAOVMvBgM3DmulsqpjqJlD26jZnOuGC8RL1KBBSpq+Yfdj1DAtcsRlUsyqKjiAMgp0nAhXcW87IWcja1xLiuSBF1iUvToGKQdjKu4aTVQJfZt6ljIGI09iXdkrx63MEsKBRmR4hR2FI8otoGtjxKaMVoil7qO9tfhtWqprywbQHM5qHDc8yqDMSscRqVbUvKOfnMSGyN7wmhbq2OoJgbzEvSLfuDF6gEgdKcEXVBGWDZFOevMZoRQz+QbK1UQWC5zqLooU54gQbsNwKFMW93E1e5voksLASxn6xxGBUEM5WtJYEwfKXNNF2B43L6g2cxNi4p1AALus3CX+Zh+GH/SVAwbxsQNWE0uYUAb1j89Yq8cprMXRCowmIMaSltTBiXqdiGV1GOR3eWGjamYNVOzcEEQqBYtb1LOOOI3I8I4tjkOIO6ccEB5QzmO4FwMpdQYUbnxASlRdYbILKG8HB4joLFoLdFxQLEp9S1+ACkzgranEvVATB2GULaftM2QYuo6hjlBamHQXJLVBRHSbtx+FAqhfRht0V2QazY5gpu7mkwZ58w7I0pDbyfaMQmaW4bQTtn7xwouVtZhilIGlQKVSAGFLClQWwFYL3F6tCPz+QaKgo8sb0K5qHSIaWtzEhZt3LwUDNRvinqIrlYW7gQqFBFVZCGrDQ1iD1Eu2LhWAJsUuHgoVZyxB1EaDiJArYSqGRl0w/iwVnPcvuRo4uLapuDLe4dpNH9AaiIttYRS7YF+NkVdfs3Bkg2meK5urzAh20JtDmKKwncFWOly9NBUUxpuEN3ZcxXJ8i5Qq+rlzkJGuHU0LG4kIrp3AB4AuFx2bNrdS6keBVxkdwUoZS3mI6IUy0B3oqiUYdg3M/wDQLY4Qi6RNCEzbMwRjqY+zhbi22/hFb2LNAAGCXKke6UNpzLGgLz1FgFrdMZCL6eZVzWQjqYnSVT7pltkUYgaAua9wAg0RH5Bo5YcXCwbJklWgt/chBpNxFQmo7mHDAjh/IwwmHshQ4BZZFXld7szr6A59wEJAKIBa4qN5Q5u1QC+4aUpfcKsM8F6iwzVZjIC6EAAM8xurHUphuUEFfEtxCo0xcf0dtJYkkZTDFA1TbFheHBElC4YB2mD+h8QMxMTowEe1C8sHkN5DiHMszTmEhtLtblkxZzUo7XkgSoa3nsIq6XW2tTGFwVo71PKqWwCB2S6l/LYLMtZHuAQhPNQtw6dw2VzI6EaIEtV9w4YOITnmk6frAXJXEwMaAw+0Xsx22jXhGgBd3FtX8TToaTyVB1EkVYHcfKtBB3mKKL58xCdDqPN5lHNY3T3KxuajOJZHd0RFtqUfWWFkSFQthETUSZUk1EkjMpcRNtNen40plmFyjRgAS+qjqK2iHmDkU4ZWujwiVPQEfxywFHzMKAC2wd3JxHLAFFzUsA5RFkmF7ga7ZYgtGXqAwMwk3q2j3AC0+FSsua4hOxO4MUBgeZg6rmv6El6Vi3wh3C3EZFY4nGhi5bVGYOxiqSq8aXUY5GUkvmXZOopwio3XLMPznP7GZFrIUDVMF4WH4IMmWYxgcYNEWxIofUqTpheIKEXY7isorZViqvPEarJwxvY9FRcHbxMAbm5blYhRiwlrBuMVwvxmLaQfMCYPYg2rp3Gq/COrFKWFRUFIaJa1u4JvOOPAupmuFyOG5jd3KxULs+ZYGsOIcJAsBLBCsNO5a3Skv8ZCLyHsiAbTLUAgbQ2B8LHNihlUdo0WFnAyMVq/cXrTBCyOoizYMDgsZubhDlJhiXhZQEY8ShYRGiZuKaQ4HcA1F2CcyoDQOJWVfb1AUJ9pcEGhOWRv+iPqKbdRBmqryZcnDslaYNxoKUIe5RR8lZuIqa3ySkKGkVBja/sS7g/ml6yMkUiilXr15iiApSbeYgJBSjUwnOhHqb2R9rgjmBGhohWAAtWCpsHVQMJV6TCXBG9i77l/alqsxGnAj1QWGjX4yCuEGo61FemOSAzd9xiMNIG1bKVayZYXFQe0zDDI93ASjaFiBUdJ5mCwnODTbbVsF0NxzLnLmYb2jH12FD7/ABumS4PMs5XtEuKOdwW18IInIQCvUYbRW1DXkGUWaeGpX4XEGKjtYxeF2SKDIuLjBgsW6jolOpeCj3UsAhywhlbRpXmFyOZ6aFRzFOkuW1XMYlyA+NY0DmZb/oiTUkxNWauo+4gTTEfFFkS2Bw5SwwDDlHjIFCu2KxhVCbifJCvI8xMnHMNdsauaiLsCJe4HpTIRYDtFXtD1sD6RKllVmJ6LhuJtjG276gFrtPeJkqAlkOty5RDswVm5pKBcRUy9ywIR4iU1QTLb2/kHCG4eEUla5IakRwh9IWMUVRiQ57g4I8XkjULTFrOgfUAagEP9pLAhRdpxCrFFuZS81Kdx4RvpXERWily4UqhQrd77Z/GgQHDuKHLaIiU/AjUFuRl1JzmHBUoKkN6PMKrq4MO2h4hVNG4NpAXBhArkmEbtco2MCmH1BakOy4EXPJOB3flGOKkDSTf0lFCS2YjxNPLiK6/oCMxeIf0YFaSURx5nLF22QCxXuojFgrDiNQEGWPUYuAbalCVpM2icQumZWsbW4K6G5vxNYQoSN0T5httG3iIRYtNyupKtEzrFxUxzdQMrs8yzbU9ZLMbJlXjzGoXREbWXdRbc/kUbB8nmAXbckySWyXpZ6Qq0GU9R4zhoXmZ6wGyJ6cqGOwNAP1luv7jM/I2ByxK0A/WUKFhuxKARBxKtdV56lcVemtRyiSrGVgBY3N/jQHLfuFHVsBvEGFL7lCgV3KtJ9Mui6BwwQ4WRzLBiu4Oawc3N4DCi9wgJZkxXjAGoaucU6O4aS2bGBlm5RgS4RlzniZsLDEPiWIsJJkQziInQ1zuKCq7z/SoR9agUVSWBibHJHBKuUz3abZpqAmpnmZTl09QwAWszNQVrRlbattXiXplqvswQJzLD6A8TPSOoQDaE6MfSnu+UHY4lwYIqtrb+SqoQp7SsH3VwsfHNQHBvJMu6pO2WTBpJzFCwHYx6ehY8S7V35lNrpcbICucTIVYQcC7+UGOVLdlTCpXLqNUfJmGL4Fh3xhZ6/IUVzteupcaUfeMIqdEA3oumDELhsz0RoXfEqPeqMxhOYgvApzN73h5hnAc55zFGKox7hCH7GEsN8wNLGDgFzS/MHapbmUbEPqLrcIG90eH9MKNm4CmHzKleXMG07YaoHp+C8DBHbVGFd9xlgO65hrV7ri4UZjPK4GECG5CWQEbJqzLNy07RUtrEREtfyyQQU2qLbntQxoq5WOywUS0CTGCVRgG0UgGA9oCseXmXcGJQ0wKi24Rk1GymOsr2GO6OJj5YTIHbXMZaWzRuOUDhTki2/kIhVJzMzn6pHbUozQ5cREi8z5EBqagCjhKhhRHiE9DZRuVFIdlkRGpoC2bh8qVRGqMNQRDbMjD3CpcbZbYHLohhNJX9rFtsbfndf12QwjzURw3EumYm5zsPlFuLl7Lgje0bqhUWcZ3EsSr+bZoFX8wgfBKyF6I6jZXB1oya4gvVzCATG/D6jrImFARLgOFj3GXdzK1ACocN6ksMWxqCzTwYq/yqQQ/WDRkaQwWjfCJ5u5hqB5wYNdkajAr4QLZqAUykdIxvCy4zCiq1EU2G7WKLOcWSirQpNwVdSysTi5RAMmWBFj7sqRLuwH9e4uuYMT6AuYIZK0QwgDmUeSJrDEBUqJsvh+eMl4A5IgaGG5oTbRwSkrkKWHwmjliUociIjSV9VNHO68x/ZRLuZxvELNg1aiq7lDMWDjy/mV/IYTMnZe4VEZgeeI5Sg4muQsVoxLoh9ikvbBi9I3L65CwGABwmJaqjk5lYK5aigpI8ivmHaLsPpiPXU04v/wAEbm1sg9EYbhE1qLOSKVhh8sU5Qt7x1/QmgU+YgAPZdjKWlZu+JdYLqu4s3jW0o4oXB0QFAFrEpphQDxaqUr67RjMRvVJuC4LRRAZ0cXzFUrz+ahXCgjC1AazUxmTpgWxvdQ3e6LIlqNRlwOFhYBpyixFpT1C0xDgha1sZlqAc2QEKXmLEzkYLkEYqOxuKrbv/AMJm2IJVGGGVEOJ4gE3rFvf9QKhFE5Ittv0DoM6uCjYo9xVbW388ablpotJ5I6k9F6lIAJucYNCG1xUQF0spBbodBlNj12wIOC0ZVGbJclQ1mK1R4mIBoysZREmxcZFtb/tZEKpNMrPiWO6lec0VJAgCVZASshmSey4SsvZiFkSjTzcEB4s7AcpBY1BoZXRspyCM+aO/qJ2I2r/bNkJ2NRlSbDyRso3qFG0SG5QtUC1I+IUsuw5g9F9IyyavZkqfwNjg1Wrz/wDx5//Z)
O claustro do cérebro é ativado quando uma pessoa realiza uma tarefa complicada. Crédito: Brian Mathur, UMSOM
Escondida sob o córtex externo e enrugado do cérebro está uma área profundamente misteriosa, conhecida como claustrum. Essa região é conhecida há muito tempo por trocar sinais com grande parte do córtex, responsável pelo raciocínio superior e pensamento complexo. Por causa das extensas conexões do claustrum, o lendário cientista Francis Crick, Ph.D., famoso pela descoberta do DNA, postulou pela primeira vez em 2005 que o claustrum é a sede da consciência; em outras palavras, a região do cérebro que permite a percepção do mundo e de nós mesmos.
Pesquisadores da Faculdade de Medicina da Universidade de Maryland, no entanto, agora postulam que Crick pode estar incorreto: eles desenvolveram uma nova teoria - baseada em dados - de que o claustrum se comporta mais como um roteador de internet de alta velocidade, recebendo comandos executivos de " chefe" áreas do córtex cerebral que formam pensamentos complexos para gerar "redes" no córtex. Agindo como um roteador, o claustrum coordena essas redes para trabalharem juntas para realizar as muitas tarefas cognitivamente exigentes que realizamos a cada momento na vida cotidiana. As novas descobertas e hipóteses foram publicadas em 30 de setembro de 2022, na Trends In Cognitive Sciences .
Compreender como o cérebro forma e coordena essas redes no córtex através do claustro é importante, uma vez que redes desorganizadas são uma característica típica em muitos distúrbios, como vício, doença de Alzheimer e esquizofrenia. Esse insight pode ajudar a levar a melhores terapias para tratar a disfunção cognitiva nesses distúrbios.
"O cérebro é o sistema mais complexo do universo conhecido. São esses avanços teóricos baseados em dados que impulsionam nosso conhecimento para aproveitar essa complexidade para melhorar a vida humana", disse Brian Mathur, Ph.D., Professor Associado de Farmacologia da UMSOM. "Como a estrutura mais conectada no cérebro, o claustrum é uma janela para o enigma do cérebro, a mente."
Em um esforço para identificar o papel preciso do claustrum, o Dr. Mathur e seus colegas conduziram uma série de experimentos em animais e pessoas. Um experimento usou abordagens modernas da neurociência para desligar o claustro em camundongos conscientes. Os ratos não perderam a consciência e continuaram correndo normalmente. Este foi um golpe contra a teoria de Crick.
Em seguida, os pesquisadores deram aos ratos uma tarefa cognitivamente simples ou difícil e compararam como eles responderam quando o claustrum foi desligado. Normalmente, um mouse pode executar tarefas simples e difíceis. No entanto, quando os pesquisadores desligaram o claustro, os camundongos não conseguiram mais realizar a difícil tarefa.
Imaginando se essa descoberta tinha alguma relevância para os seres humanos, o Dr. Mathur colaborou com seus colegas David Seminowicz, Ph.D., Professor de Ciências Neurais e da Dor na Faculdade de Odontologia da UM, e Fred Barrett, Ph.D., Professor Associado de Psiquiatria e Ciências Comportamentais da Escola de Medicina da Universidade Johns Hopkins. Os três organizaram um estudo de pesquisa onde conduziram exames cerebrais de ressonância magnética funcional em voluntários saudáveis ??que estavam envolvidos em tarefas mentais simples ou complicadas. Os pesquisadores observaram que seu claustrum apenas "acendeu" ao realizar a versão difícil da tarefa. Este evento coincidiu com a ativação de uma rede no córtex envolvida no desempenho cognitivo ideal: Golpeie dois contra a teoria da consciência de Crick .
Dr. Mathur disse que o terceiro ataque será quando experimentos adicionais apoiarem sua teoria da função do claustro. Ao fazer isso, o Dr. Mathur e seus colegas agora procuram entender como o claustrum aprende e se adapta para orquestrar redes no córtex para ajudar a apoiar a cognição.
"Compreender como o cérebro forma e coordena de forma flexível essas redes - através do claustrum - é essencial para tratar o declínio cognitivo, que ocorre no vício, na doença de Alzheimer e na esquizofrenia", disse Mark T. Gladwin, MD, vice-presidente de Assuntos Médicos da Universidade de Maryland, Baltimore e John Z. e Akiko K. Bowers Distinguished Professor e Dean da UMSOM.
Dr. Mathur acrescentou: "Nossa hipótese nos fornece uma estrutura conceitual muito necessária para conceber novas estratégias terapêuticas".