Estudo descobre que 'produtos químicos eternos' interrompem os principais processos biológicos
Uma equipe de pesquisadores da Keck School of Medicine da USC descobriu que a exposição a uma mistura de produtos químicos sintéticos amplamente encontrados no ambiente altera vários processos biológicos críticos, incluindo o metabolismo...
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)
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Uma equipe de pesquisadores da Keck School of Medicine da USC descobriu que a exposição a uma mistura de produtos químicos sintéticos amplamente encontrados no ambiente altera vários processos biológicos críticos, incluindo o metabolismo de gorduras e aminoácidos, tanto em crianças quanto em adultos jovens. A interrupção desses processos biológicos está ligada a um risco aumentado de uma ampla gama de doenças, incluindo distúrbios do desenvolvimento, doenças cardiovasculares, doenças metabólicas e muitos tipos de câncer.
Conhecidos como substâncias per e polifluoroalquil, ou PFAS, esses produtos químicos sintéticos são usados em uma ampla gama de produtos de consumo e industriais. Os PFAS às vezes são chamados de "produtos químicos eternos" porque se decompõem muito lentamente e se acumulam no ambiente e nos tecidos humanos .
Embora PFAS individuais sejam conhecidos por aumentar o risco de vários tipos de doença, este estudo, publicado em 22 de fevereiro na Environmental Health Perspectives , é o primeiro a avaliar quais processos biológicos são alterados pela exposição a uma combinação de múltiplos PFAS, o que é importante porque a maioria as pessoas carregam uma mistura de produtos químicos em seu sangue.
"Nossas descobertas foram surpreendentes e têm amplas implicações para os formuladores de políticas que tentam mitigar os riscos", disse Jesse A. Goodrich, Ph.D., professor assistente de ciências populacionais e de saúde pública e principal autor do estudo. “Descobrimos que a exposição a uma combinação de PFAS não apenas interrompeu o metabolismo de lipídios e aminoácidos, mas também alterou a função do hormônio tireoidiano”.
Um projeto de pesquisa inédito
Para entender os efeitos que a mistura de PFAs tem no corpo, a equipe usou amostras de sangue coletadas de 312 adolescentes que participaram do Estudo de Adolescentes Latinos em Risco e de 137 crianças do Estudo de Saúde Infantil do Sul da Califórnia. Eles descobriram que todas as crianças e adolescentes tinham uma mistura de vários PFAS comuns em seu sangue, incluindo PFOS, PFHxS, PFHpS, PFOA e PFNA. Mais de 98% dos participantes também tinham PFDA no sangue.
Os pesquisadores também mediram milhares de substâncias químicas de ocorrência natural no sangue e, usando um método bioestatístico que desenvolveram, identificaram como a exposição a vários PFAS diferentes afetava cada uma dessas substâncias químicas de ocorrência natural. Esta informação ajudou os pesquisadores a determinar que a exposição ao PFAS alterou a forma como o corpo metaboliza lipídios e aminoácidos , bem como os níveis de hormônio tireoidiano, um importante determinante das taxas metabólicas.
Os pesquisadores se concentraram em crianças e adultos jovens porque estão passando por estágios críticos de desenvolvimento que podem torná-los mais suscetíveis aos efeitos negativos à saúde da exposição ao PFAS. É também uma época em que muitas doenças graves que se manifestam em adultos começam a criar raízes. Os pesquisadores acrescentaram que esses resultados são consistentes com estudos anteriores que mostraram que a exposição individual a PFAS na infância estava associada ao metabolismo desregulado de lipídios e ácidos graxos, o que pode aumentar o risco de distúrbios metabólicos e doenças cardiovasculares mais tarde na vida .
Uma descoberta que se destacou, de acordo com Goodrich, foi o fato de que a exposição ao PFAS teve um efeito na função do hormônio tireoidiano, que tem um papel crítico no crescimento e no metabolismo. Por causa disso, as alterações nos hormônios tireoidianos desempenham um papel importante no desenvolvimento infantil durante a puberdade, o que pode ter efeitos importantes sobre uma série de doenças mais tarde na vida, incluindo diabetes, doenças cardiovasculares e câncer.
Importante consideração de saúde pública
Outra descoberta importante foi o fato de que a exposição a uma mistura de PFAS, em vez de um único produto químico desse tipo, provocou a interrupção desses processos biológicos. Essa descoberta foi consistente nas duas coortes, embora tivessem diferentes níveis de exposição ao PFAS.
Quase todas as pessoas nos EUA têm níveis detectáveis de vários PFAS, que estão em uma ampla variedade de produtos, incluindo roupas impermeáveis e embalagens de alimentos, em seu sangue. Estima-se que 200 milhões de pessoas nos EUA tenham água potável com níveis de PFAS consideravelmente mais altos do que os níveis recomendados pela Agência de Proteção Ambiental dos EUA em 2022.
Alguns fabricantes eliminaram gradualmente o uso de PFAS individuais, mas os autores deste estudo concluem que esta pesquisa mostra por que pode ser mais importante regulamentar o PFAS como uma classe de produtos químicos.
"Estamos realmente apenas começando a entender a gama de efeitos que esses produtos químicos têm sobre a saúde humana", disse Leda Chatzi, MD, Ph.D., professora de ciências da população e saúde pública e outra das autoras do estudo. “Embora as intervenções atuais tenham se concentrado na eliminação gradual do uso de PFAS individuais, como PFOS e PFOA, esta pesquisa mostra por que o foco deve ser a redução da exposição a todos os produtos químicos PFAS”.
Autores adicionais do estudo incluem Jingxuan He, Brittney O. Baumert, Zhanghua Chen, Sarah Rock, Hongxu Wang, Frank D. Gilliland, David V. Conti e Michael Goran da Keck School of Medicine da USC; Douglas I. Walker, Dean P. Jones e Xin Hu da Emory University; Xiangping Lin, Damaskini Valvi e Zoe Coates Fuentes da Escola de Medicina Icahn no Monte Sinai; Tanya L. Alderete da Universidade do Colorado Boulder; Kiros Berhane da Universidade de Columbia
Mais informações: Assinaturas metabólicas da exposição de jovens a misturas de substâncias per e polifluoroalquil 2: um estudo multicoorte, Perspectivas de saúde ambiental (2023). DOI: 10.1289/EHP11372
Informações do periódico: Perspectivas de saúde ambiental