Estudo: um spray nasal protege contra a infecção por coronavírus, incluindo variantes imunes evasivas recentes
Pesquisadores desenvolveram uma molécula que, quando administrada por via nasal, é extremamente eficaz na prevenção da doença causada por todas as variantes conhecidas do vírus SARS-CoV-2. A molécula pode ser uma ferramenta fundamental...
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)
Domínio público
Pesquisadores desenvolveram uma molécula que, quando administrada por via nasal, é extremamente eficaz na prevenção da doença causada por todas as variantes conhecidas do vírus SARS-CoV-2. A molécula pode ser uma ferramenta fundamental na preparação para futuras pandemias, pois visa prevenir tanto a transmissão quanto a propagação do vírus.
Em estudos com animais de laboratório, uma molécula conhecida como TriSb92, desenvolvida por pesquisadores da Universidade de Helsinque, foi confirmada como uma proteção eficaz contra a infecção por coronavírus . A molécula identifica uma região na proteína spike do coronavírus comum a todas as variantes atuais do vírus e inibe seu funcionamento.
"Quando administrada por via nasal, a molécula TriSb92 é extremamente eficaz na prevenção de infecções, e experimentos realizados em culturas de células indicam que ela também abrange as variantes mais recentes, incluindo XBB, BF7 e BQ.1.1", explica a pesquisadora de pós-doutorado Anna R. Mäkelä da Grupo de pesquisa do professor Kalle Saksela.
Modelos animais também demonstraram que, ao contrário das máscaras faciais , a molécula pode, quando borrifada no nariz, prevenir a infecção mesmo após algumas horas de exposição.
Segundo os pesquisadores, a molécula permanece totalmente funcional em temperatura ambiente por pelo menos 18 meses, tornando-a adequada para uso como spray nasal.
Os resultados foram publicados na Nature Communications .
Antecipação de futuras variantes virais
Embora o pior estágio da pandemia de coronavírus tenha passado, pelo menos por enquanto, a proteção administrada por via nasal pode ser uma ajuda crucial na prevenção da propagação do vírus no futuro.
“As variantes mais recentes evitam efetivamente a proteção imunológica fornecida pelas vacinas e pela doença COVID-19, e as vacinas atuais não são eficazes na prevenção da transmissão”, diz Mäkelä.
Além disso, o spray nasal pode proteger as pessoas de doenças graves que não obtêm imunidade suficiente com as vacinas, como indivíduos imunocomprometidos e idosos.
Segundo os pesquisadores, a molécula também pode funcionar contra futuros parentes próximos do SARS-CoV-2 de origem animal, que devem ser a causa de pandemias de coronavírus inteiramente novas.
"Como a região da proteína spike do coronavírus afetada pela molécula TriSb92 permaneceu quase inalterada em todas as variantes virais até agora surgidas, pode-se supor que seja eficaz também contra futuras variantes do SARS-CoV-2", confirma Mäkelä.
"O TriSb92 produzido de forma fácil e barata pode ser uma primeira linha de defesa muito importante para conter uma nova pandemia, enquanto se aguarda o desenvolvimento, produção e distribuição de vacinas", acrescenta ela.
Uma abordagem copiável
De acordo com os pesquisadores, a tecnologia sherpabody usada também é aplicável à prevenção de muitas outras doenças virais, particularmente influenza e outros vírus respiratórios.
"Toda a abordagem decorre de uma solução técnica baseada em uma plataforma de proteína aglutinante desenvolvida na Finlândia, que não foi originalmente planejada para o desenvolvimento de uma droga antiviral. Ela oferece uma oportunidade para muitas outras novas iniciativas baseadas na identificação precisa de células doentes ou patógenos em pacientes", diz Mäkelä.
Na próxima etapa, a molécula deve ser testada em ensaios clínicos , após o que poderá ser disponibilizada comercialmente.
Mais informações: Anna R. Mäkelä et al, Intranasal trimeric sherpabody inibe SARS-CoV-2 incluindo recentes subvariantes imunoevasivas Omicron, Nature Communications (2023). DOI: 10.1038/s41467-023-37290-6
Informações do jornal: Nature Communications