Estudo inicial mostra que os cones na degeneração da retina, considerados dormentes, podem reter a função visual
Uma nova pesquisa da UCLA em camundongos sugere que os fotorreceptores de cone 'dormentes' na retina em degeneração não estão dormentes, mas continuam a funcionar, produzindo respostas à luz e direcionando a atividade retiniana para a visão.
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)
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Uma nova pesquisa da UCLA em camundongos sugere que os fotorreceptores de cone "dormentes" na retina em degeneração não estão dormentes, mas continuam a funcionar, produzindo respostas à luz e direcionando a atividade retiniana para a visão.
As células da retina que produzem a experiência visual são bastonetes e cones. Os bastonetes são ativos na penumbra e os cones na luz do dia. Mutações nos bastonetes que os levam à morte desencadeiam a maioria das degenerações retinianas hereditárias . Os cones podem permanecer vivos depois que quase todos os bastonetes morrem, mas eles retraem as partes principais das células e parecem "adormecidos".
Mas enquanto a literatura anterior sugeria que as células dormentes não eram funcionais, e as tentativas anteriores de registrá-las não revelaram nenhuma atividade impulsionada pela luz, o novo estudo indica pela primeira vez que as células ainda são viáveis. Além disso, os sinais downstream registrados da retina mostram que o processamento visual não está tão comprometido quanto se poderia esperar. Os autores dizem que suas descobertas demonstram que as intervenções terapêuticas para proteger essas células, ou aumentar sua sensibilidade, têm a capacidade de preservar a visão diurna quase normal.
"Embora a sensibilidade dos cones fosse cerca de 100 a 1.000 vezes menor do que o normal, ficamos surpresos ao descobrir que a queda na sensibilidade das células ganglionares que se projetam para o cérebro foi muito menor", disse o autor sênior Alapakkam Sampath, a cátedra Grace e Walter Lantz em oftalmologia no UCLA Jules Stein Eye Institute e professor na David Geffen School of Medicine na UCLA. "Parece que os mecanismos de adaptação na retina interna podem estar tentando minimizar a diferença de sensibilidade para preservar a sinalização robusta nas células ganglionares - isso é consistente com o que sabemos sobre o cérebro. Mecanismos homeostáticos que respondem a lesões e doenças normalmente encobrem o deficiência. É por isso que é difícil detectar problemas neurológicos até que a deficiência se torne muito grave."
O estudo foi publicado na revista revisada por pares da Current Biology .
Os pesquisadores examinaram as propriedades da membrana dos cones em camundongos após a degeneração dos bastonetes. O método de gravação patch clamp é uma técnica de laboratório para estudar correntes em células vivas enquanto controla o potencial de membrana da célula, ou voltagem de membrana. Essas gravações de células únicas podem estabelecer características-chave da atividade da célula, incluindo a presença de correntes de membrana específicas, se a célula tem respostas à luz e se elas podem se conectar a neurônios a jusante na retina. Além disso, os pesquisadores usaram gravações de matriz de eletrodos múltiplos que estabelecem a atividade de todas as células ganglionares da retina e que podem mostrar a capacidade da célula ganglionar de responder a estímulos visuais que variam em localização espacial ao longo do tempo.
Essas gravações revelaram que os cones restantes em uma retina onde os bastonetes se degeneraram ainda estavam funcionais. Embora faltassem as especializações anatômicas responsáveis ??por gerar a resposta à luz – ou fototransdução – e a conexão sináptica com as células a jusante, essas funções permaneceram com menos sensibilidade do que o normal. Essas células ainda exibem muitas das características dos cones normais, incluindo um potencial de membrana em repouso semelhante, uma corrente sináptica normal de Ca2+ e respostas à luz, embora não tenham mais a parte da célula que tradicionalmente se pensava ser necessária para a resposta à luz. Além disso, as células ganglionares mantêm sua capacidade de responder a estímulos visuais com sensibilidade espacial e temporal semelhantes.
"Esses resultados importantes podem sugerir um caminho futuro para pacientes com condições consideradas causadoras de cegueira retiniana irreversível, já que a viabilidade do fotorreceptor ou do cone no tecido foi previamente considerada irreparavelmente danificada", disse o Dr. Steven Schwartz, presidente da Ahmanson em oftalmologia no David Geffen School of Medicine na UCLA, e professor e chefe da Divisão de Retina no UCLA Jules Stein Eye Institute.
O próximo passo para os pesquisadores é estabelecer até que ponto a neuroproteção ou o aprimoramento dos cones adormecidos permitirá o resgate da visão em várias formas de cegueira.
Os outros autores do estudo são Dr. Erika Ellis, Antonio Paniagua, Yuekan Jiao, David Williams, Gordon Fain, todos da UCLA; e Miranda Scalabrino, Mishek Thapa, Jay Rathinavelu e Greg Field, todos da Duke University. O laboratório Field mudou-se recentemente para o UCLA Jules Stein Eye Institute.
Mais informações: Erika M. Ellis et al, Cones e caminhos de cone permanecem funcionais na degeneração retinal avançada, Current Biology (2023). DOI: 10.1016/j.cub.2023.03.007
Informações da revista: Current Biology