Câncer que se espalha para o pulmão manobra para evitar ser atacado por células T 'assassinas'
O câncer que se espalhou para áreas como os pulmões pode frear um caminho natural que deve recrutar células T assassinas diretamente para onde houve metástase, relatam os cientistas.
![](data:image/jpeg;base64,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)
(da esquerda) Primeiro autor John Klement, um graduado em 2022 do programa MD/PhD do MCG que agora é residente de medicina interna na Universidade de Stanford; Kebin Liu, PhD; e a co-primeira autora e ex-aluna de pós-graduação da AU Priscilla Redd, PhD. Crédito: Michael Holahan, Universidade Augusta
O câncer que se espalhou para áreas como os pulmões pode frear um caminho natural que deve recrutar células T assassinas diretamente para onde houve metástase, relatam os cientistas.
Essa estratégia recém-descoberta usada por tumores que se espalharam - e, consequentemente, são mais mortais - pode ajudar a explicar por que às vezes as imunoterapias promissoras projetadas para ajudar o sistema imunológico a matar o câncer não o fazem, diz Kebin Liu, Ph.D., imunologista do câncer no Departamento de Bioquímica e Biologia Molecular no Medical College of Georgia.
Também pode significar que uma manobra terapêutica adicional é necessária para parar alguns tumores, que muitas vezes são diagnosticados depois de se espalharem, diz Liu, autor correspondente do estudo na revista Cancer Cell .
As células T são impulsionadoras da resposta imune que o câncer tenta impedir, e drogas como Keytruda (pembrolizumabe) e OPDIVO (nivolumabe), também conhecidas como inibidores do ponto de controle imunológico, tentam liberar essas células T "assassinas".
O alvo mútuo do câncer e desses medicamentos é o PD-1, uma proteína e um ponto de verificação natural que permite que as células T sejam ativadas ou desativadas.
A proteína PD-L1 se liga naturalmente ao PD-1 para desligar efetivamente as células T, o que é bom, ao ajudar a evitar, por exemplo, uma resposta imune exagerada ao seu próprio tecido corporal que resulta em condições como o lúpus.
Mas o câncer usurpa essa mudança natural para se proteger em um movimento apelidado de "imunoescape".
"PD-L1 é o freio", disse Liu. "As células cancerígenas PD-L1 expressam em resposta direta ao PD-1 que as células T expressam. Uma das razões pelas quais as pessoas podem não ter o sucesso que você esperaria com a imunoterapia é a inteligência do tumor em usar PD-L1."
O câncer se liga ao PD-1 nas células T, desativando-as efetivamente. Drogas como Keytruda se ligam e bloqueiam o receptor de PD-1 nas células T para mantê-las livres para atacar.
Mas Liu e seus colegas descobriram que há mais por trás da história, principalmente quando se trata da disseminação do câncer, que é responsável por mais de 90% da mortalidade por câncer.
Células imunes chamadas células mielóides conversam com células T e também podem ativar e impedir que esses respondedores da linha de frente ataquem um invasor como câncer ou vírus. As células mieloides também expressam PD-1.
Liu e seus colegas descobriram que as células tumorais metastáticas também se envolvem diretamente com o PD-1 nessas células mielóides, onde suprimem uma via natural que produz o interferon tipo 1, que eles descobriram ser essencial para trazer as células T "assassinas" diretamente para a propagação porta do câncer.
O interferon é uma proteína natural produzida por nossas células que é conhecida por ajudar o corpo a combater invasores como um vírus ou câncer. Também é produzido sinteticamente para tratar uma variedade de condições, desde câncer de pele até hepatite.
"O tumor usa PD-L1 para se ligar ao PD-1 nas células mielóides, portanto, as células mielóides não podem produzir interferon para ajudar as células T a se infiltrarem no tumor", disse Liu sobre suas descobertas em metástases de câncer.
Eles descobriram que a via de sinalização desse interferon é essencial para o recrutamento de células T assassinas para, nesse caso, o local do câncer que se espalhou para os pulmões. Eles descobriram neste cenário que o PD-L1 das células cancerígenas interage diretamente com o PD-1 nas células mieloides para suprimir a produção de interferon.
Eles já estão trabalhando para ver se isso acontece em outros locais comuns de disseminação do câncer, como o fígado. O pulmão e o fígado são locais comuns de metástase para uma variedade de cânceres, observa Liu. O câncer de mama, por exemplo, é conhecido por se espalhar para os ossos, cérebro, fígado e pulmão, de acordo com o National Cancer Institute. O fígado e o pulmão também são os principais locais de metástase para câncer de rim, melanoma, bem como câncer de ovário, próstata e pâncreas. O câncer de pulmão primário pode se espalhar para vários locais, incluindo a glândula adrenal e o fígado, mas também para o outro lobo do pulmão.
Liu também está buscando uma abordagem mais direta para direcionar a manobra da doença metastática do câncer, trabalhando com engenheiros biomédicos da Universidade de Boston em uma molécula que forçará as próprias células tumorais a expressar interferon para que não possam escapar da invasão de células T. "Queremos colocar uma bomba dentro da casa do tumor", diz.
O interferon alfa tipo 1 foi a primeira imunoterapia aprovada pela Food and Drug Administration e há evidências emergentes de que o interferon tipo 1 permite conversas entre células imunes que estão no microambiente de suporte do tumor, eles escrevem. Eles e outros mostraram que o interferon tipo 1 induz PD-1 e PD-L1 em ??células mieloides . E o interferon tipo 1 demonstrou ser silenciado em áreas de disseminação do câncer.
Mais informações: John D. Klement et al, Tumor PD-L1 envolve o mielóide PD-1 para suprimir o interferon tipo I para prejudicar o recrutamento de linfócitos T citotóxicos, Cancer Cell (2023). DOI: 10.1016/j.ccell.2023.02.005
Informações do jornal: Cancer Cell