Os pesquisadores desenvolvem uma nova plataforma de hidrogel amigável ao paciente para administrar produtos biológicos que salvam vidas.
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)
Partículas de hidrogel carregadas com cristais do medicamento de imunoterapia contra o câncer pembrolizumab - Créditos: Imagem cortesia dos pesquisadores.
Os produtos biológicos, uma classe de terapêutica derivada de organismos vivos, oferecem enormes vantagens aos pacientes que lutam contra doenças e distúrbios desafiadores. Tratamentos baseados em produtos biológicos podem estimular o sistema imunológico a conter ataques de infecções ou direcionar vias específicas para bloquear a formação de tumores.
“Essas drogas, que existem há apenas 20 anos, fazem mágica”, diz Amir Erfani, pós-doutorado no Departamento de Engenharia Química (ChemE) do MIT. “Eles podem salvar milhões de pessoas em todo o mundo.”
Mas a eficácia incomparável dos produtos biológicos tem um custo. Eles podem ser difíceis de administrar, muitas vezes exigindo infusões intravenosas (IV) demoradas nas clínicas. Seja para pacientes que lutam com condições que ameaçam a vida ou para toda a vida, a perspectiva de passar horas longe de casa, a cada poucas semanas, pode ser extremamente assustadora.
Agora, um novo trabalho de uma equipe do MIT em colaboração com a empresa farmacêutica Merck, que financiou a pesquisa, sugere uma solução prática para superar a dificuldade de administrar produtos biológicos. Em um artigo recente publicado na Advanced Healthcare Materials , esses pesquisadores descrevem uma plataforma de hidrogel para a entrega de anticorpos monoclonais (MABs) – um tipo de biológico – por meio de injeção subcutânea.
Erfani é o principal autor do artigo. Os coautores incluem Jeremy M. Schieferstein, um pós-doutorando em ChemE na época do estudo, agora cientista sênior da Elektrofi; Apoorv Shanker, pós-doutorado em ChemE; Paula Hammond, Professora do Instituto e chefe da ChemE; e Patrick S. Doyle, o Robert T. Haslam (1911) Professor de Engenharia Química, bem como pesquisadores da Merck.
“Este é um marco importante”, diz Doyle. “Estamos no caminho de transformar a próxima geração de tratamento com anticorpos monoclonais e outros tipos de terapias.”
Anticorpos de teste superior
Ao contrário da maioria das drogas convencionais que são formuladas quimicamente e compostas de pequenas moléculas, os biológicos são cadeias extensas e indisciplinadas de proteínas, açúcares e segmentos de DNA, geneticamente modificados a partir de fontes vivas. Essas moléculas orgânicas gigantes não se prestam ao tipo de embalagem compacta e densa normalmente encontrada em pílulas sintetizadas ou suspensões injetáveis.
Pegue o MAB no qual Erfani e Doyle se concentraram, chamado pembrolizumab, ou pembro para abreviar. Este anticorpo único se liga a um receptor associado à mediação de respostas imunes a células tumorais e é usado em uma variedade de cânceres intratáveis. Pembro é normalmente administrado em uma solução diluída por IV durante várias horas para atingir o tipo de concentração necessária para ser eficaz. (A Merck patenteou esta formulação da droga como Keytruda.)
“Quando você tenta concentrar formulações existentes, a viscosidade das moléculas cresce astronomicamente”, diz Doyle. “Em um ponto crítico, eles começam a sentir um pelo outro e interagem para se tornar uma espécie de pasta.” Forçadas juntas, as moléculas pembro tornam-se instáveis ??e mudam sua estrutura, minando suas propriedades terapêuticas.
Assim, a equipe de pesquisadores de Doyle no Soft Matter Engineering Group começou a criar uma versão do pembro que poderia ser injetado em concentrações altas o suficiente para ser eficaz, mas em volumes pequenos o suficiente para ser administrado confortavelmente e rapidamente logo abaixo da pele (a segunda preferência de maioria dos pacientes e médicos, após a ingestão de um comprimido). Com experiência em questões de fluxo, microfluídica e formulações farmacêuticas, o laboratório estava bem equipado para o desafio.
Vá com o fluxo
“Esse MAB é superpegajoso e delicado, e precisávamos encontrar uma maneira de fazer com que suas moléculas se movimentassem livremente dentro de uma seringa”, diz Erfani. “A ideia que tivemos foi usar partículas de hidrogel, feitas de biopolímeros à base de açúcar e que adoram água, que fornecem um ambiente agradável onde uma proteína ficará muito feliz”, diz Doyle. “Nós os usamos para outras aplicações e eu sabia que, se conseguíssemos torná-los pequenos o suficiente, eles poderiam passar por uma agulha sem obstruí-la.”
Os pesquisadores sabiam da literatura de toxicidade que suas cápsulas de hidrogel seriam biocompatíveis e se comportariam em uma seringa. “As partículas de hidrogel são espremidas e podem rolar umas sobre as outras e realmente fluir”, diz Erfani. Parecia fácil incorporar moléculas pembro na densidade certa para uma injeção subcutânea de um a dois milímetros. Mas, como tanto na engenharia, o diabo acabou morando nos detalhes.
“Foi complicado manter o anticorpo intacto durante o processo de fabricação e, em seguida, garantir que ele pudesse ser biologicamente eficaz à medida que se dispersasse adequadamente sob a pele”, diz Doyle. Qualquer desvio da formulação precisa do pembro integrado nas cápsulas moles de hidrogel pode tornar o MAB ineficaz ou pior.
Em uma série de experimentos que duraram quase cinco anos, o laboratório de Doyle tentou alcançar o equilíbrio certo de recursos. Seus estudos se basearam em um dispositivo caseiro que ejeta solução de biopolímero e cristais de pembro juntos primeiro no ar e depois em um banho onde eles se fundem em contas.
“Testamos muitas variáveis ??em nosso espaço de design”, diz Erfani, incluindo diferentes concentrações de pembro e a composição e pH das soluções de polímero. “O objetivo não era apenas desenvolver um medicamento em nosso laboratório, mas desenvolver um processo que pudesse ser facilmente adaptado à fabricação farmacêutica.” Com sua experiência anterior na indústria desenvolvendo tipos de MAB em estrutura cristalina estável, Erfani ajudou a empurrar a equipe para a linha de chegada. “Ele não apenas trouxe toda essa química física para o processo, mas também descobriu o design experimental e como executá-lo”, diz Doyle.
Uma ampla plataforma
Os pesquisadores agora estão testando sua formulação pembro por meio de testes in vivo, com o objetivo de aprovação da Food and Drug Administration dos EUA nos próximos anos. Mas Doyle e seu grupo têm objetivos mais amplos para a plataforma de hidrogel que inventaram. “Acreditamos que esta plataforma é independente do MAB, o que significa que podemos obter muitas moléculas diferentes formuladas na concentração e fluidez corretas”, diz ele. "Isso é um grande negócio."
Entre as possibilidades que Doyle prevê estão uma liberação lenta e sustentada das partículas de hidrogel contendo MAB - pense semanas - após a injeção. A plataforma pode acomodar outros tipos de moléculas, como citocinas, para amplificar a resposta imune ou direcionar vias específicas do câncer. Os hidrogéis também podem incorporar dois tipos de medicamentos que melhoram as propriedades um do outro.
Erfani aponta para os potenciais impactos sociais da plataforma. “Nossa tecnologia oferece a possibilidade de melhorar a acessibilidade dos tratamentos, reduzindo a dependência do paciente em hospitais”, diz ele. Substituir as sessões IV por menos injeções de injeção única liberaria tempo nas clínicas para mais pacientes, incentivaria uma maior adesão e ainda reduziria o preço do medicamento, observa ele. As pessoas podem algum dia administrar suas próprias injeções em casa.
Erfani está especialmente intrigado com a ideia de mover muito mais medicamentos para esta plataforma, incluindo alguns que morreram no início do desenvolvimento. “Existem empresas farmacêuticas que desistiram porque não podiam ser formuladas em concentrações altas o suficiente”, diz ele. “Não seria muito empolgante reaproveitar um medicamento que salva vidas e trazê-lo de volta ao mercado?”