Um grande estudo do Reino Unido descobriu que os padrões de sono perturbados em pacientes hospitalizados com COVID-19 provavelmente eram um fator de falta de ar.
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)
O estudo de pacientes em 38 instituições em todo o Reino Unido foi conduzido pela Universidade de Manchester e Leicester, apresentado no Congresso Europeu de Microbiologia Clínica e Doenças Infecciosas (Copenhague, 15 a 18 de abril) e publicado no The Lancet Respiratory Medicine .
A equipe descobriu que 62% dos participantes que foram internados no hospital por COVID-19 apresentavam distúrbios do sono , que provavelmente persistiriam por pelo menos 12 meses, e destacaram pela primeira vez a associação entre dois sintomas pós-COVID: falta de ar e perturbação do sono.
Em média, os participantes hospitalizados com COVID-19 dormiram mais de uma hora, mas seus padrões de sono foram menos regulares (redução de 19% na escala de regularidade do sono) do que os participantes pareados que foram hospitalizados por qualquer causa.
Os pesquisadores do estudo também descobriram que os participantes com distúrbios do sono eram mais propensos a ter ansiedade e fraqueza muscular , sintomas comuns da condição pós-COVID-19.
A análise estatística identificou que a interrupção do sono provavelmente causava falta de ar diretamente, mas que a redução da função muscular e o aumento da ansiedade, ambas causas reconhecidas de falta de ar, poderiam mediar parcialmente a associação entre perturbação do sono e falta de ar.
Os autores do estudo especulam que direcionar a interrupção do sono, reduzindo a ansiedade e melhorando a força muscular nesses pacientes, poderia aliviar a falta de ar, mas mais investigações são necessárias.
O estudo usou dados extensos dos hospitais que participaram do estudo PHOSP-COVID entre março de 2020 e outubro de 2021. O PHOSP-COVID é um consórcio de todo o Reino Unido que pesquisa resultados de saúde de longo prazo para pacientes hospitalizados com COVID-19.
A qualidade do sono foi avaliada por meio de medidas subjetivas auto-relatadas por 638 pacientes aos pesquisadores. Também foi medido objetivamente em outros 729 pacientes, que usavam dispositivos semelhantes a relógios inteligentes que mediam os níveis de atividade noturna.
Ambas as medidas revelaram consistentemente uma maior prevalência de distúrbios do sono em pessoas que foram hospitalizadas com COVID-19 em comparação com controles correspondentes do UK Biobank que foram hospitalizados por qualquer causa. O impacto no sono da hospitalização devido ao COVID-19 foi independente da internação em terapia intensiva.
Um dos autores, Dr. John Blaikley, cientista clínico da Universidade de Manchester e médico respiratório, disse: "Este estudo descobriu que os distúrbios do sono podem ser um fator importante da falta de ar pós-COVID-19 - ou dispneia - por causa de suas associações com redução da função muscular e ansiedade."
“Se for esse o caso, as intervenções voltadas para a má qualidade do sono podem ser usadas para controlar os sintomas e a convalescença após a hospitalização por COVID-19, melhorando potencialmente os resultados dos pacientes”.
O primeiro autor e matemático, Sr. Callum Jackson, da Universidade de Manchester, disse: "Entender as causas da falta de ar é complexo, pois pode surgir de condições que afetam os sistemas respiratório, neurológico, cardiovascular e de saúde mental".
“Esses mesmos sistemas também são afetados por distúrbios do sono, outro sintoma frequentemente relatado após o COVID-19”.
“Nossas descobertas sugerem que o distúrbio do sono é um problema comum após a hospitalização por COVID-19 e está associado à falta de ar”.
"Também mostramos que é provável que isso persista por pelo menos 12 meses, pois a qualidade subjetiva do sono não mudou entre as visitas de acompanhamento de 5 e 12 meses".
O professor Chris Brightling, da Universidade de Leicester, disse: "Os pontos fortes de nosso estudo incluem seu tamanho, natureza multicêntrica e o uso de diferentes medidas de avaliação complementar para avaliar distúrbios do sono. Associações clínicas consistentes também foram observadas em cada método de avaliação".
“Pesquisas futuras devem agora avaliar se as intervenções direcionadas aos distúrbios do sono podem melhorar não apenas a qualidade do sono , mas também a falta de ar, reduzindo a ansiedade e melhorando a força muscular ”.