Neurocientistas testam com sucesso a teoria de que esquecer é na verdade uma forma de aprendizado
Os neurocientistas hoje relatam os primeiros resultados de testes experimentais projetados para explorar a ideia de que 'esquecer' pode não ser uma coisa ruim e que pode representar uma forma de aprendizado - e delinear resultados...
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)
O esquecimento pode ser uma característica funcional do cérebro, permitindo que ele interaja dinamicamente com um ambiente dinâmico. Crédito: Dra. Nora Raschle.
Os neurocientistas hoje relatam os primeiros resultados de testes experimentais projetados para explorar a ideia de que "esquecer" pode não ser uma coisa ruim e que pode representar uma forma de aprendizado - e delinear resultados que apoiam sua ideia central.
No ano passado, os neurocientistas por trás da nova teoria sugeriram que as mudanças em nossa capacidade de acessar memórias específicas são baseadas no feedback ambiental e na previsibilidade. E que, em vez de ser um bug, o esquecimento pode ser uma característica funcional do cérebro, permitindo que ele interaja dinamicamente com um ambiente dinâmico.
Em um mundo em mudança como aquele em que nós e muitos outros organismos vivemos, esquecer algumas memórias seria benéfico, eles argumentaram, pois isso pode levar a um comportamento mais flexível e a uma melhor tomada de decisão. Se as memórias foram adquiridas em circunstâncias que não são totalmente relevantes para o ambiente atual, esquecê-las pode ser uma mudança positiva que melhora nosso bem-estar.
Em Cell Reports, eles apresentam o primeiro de uma série de novos estudos experimentais em que o efeito do esquecimento natural, "todos os dias", foi investigado em relação a como os processos normais de esquecimento afetam memórias específicas no cérebro.
A equipe estudou uma forma de esquecimento chamada interferência retroativa, em que diferentes experiências ocorrendo próximas no tempo podem causar o esquecimento de memórias recém-formadas. Em seu estudo, os ratos foram solicitados a associar um objeto específico a um determinado contexto ou sala e, em seguida, reconhecer que um objeto foi deslocado de seu contexto original. No entanto, os camundongos esquecem essas associações quando experiências concorrentes podem "interferir" na primeira memória.
Para estudar o resultado dessa forma de esquecimento na própria memória, os neurocientistas rotularam geneticamente um "engrama" contextual (um grupo de células cerebrais que armazenam uma memória específica) no cérebro desses camundongos e acompanharam a ativação e o funcionamento dessas células depois que o esquecimento aconteceu.
Crucialmente, usando uma técnica chamada optogenética, eles descobriram que a estimulação das células do engrama com luz recuperou as memórias aparentemente perdidas em mais de uma situação comportamental. Além disso, quando os camundongos receberam novas experiências relacionadas às memórias esquecidas, os engramas 'perdidos' puderam ser naturalmente rejuvenescidos.
O Dr. Tomás Ryan, Professor Associado na Escola de Bioquímica e Imunologia e no Trinity College Institute of Neuroscience no Trinity College Dublin, é o principal autor do artigo recém-publicado. Dr. Ryan, cuja equipe de pesquisa é baseada no Trinity Biomedical Sciences Institute (TBSI), disse: "As memórias são armazenadas em conjuntos de neurônios chamados 'células de engrama' e a recuperação bem-sucedida dessas memórias envolve a reativação desses conjuntos".
“Por extensão lógica, o esquecimento ocorre quando as células do engrama não podem ser reativadas. armazenado em um cofre, mas você não consegue lembrar o código para desbloqueá-lo."
A Dra. Livia Autore, bolsista de pós-graduação do Irish Research Council (IRC), que liderou este trabalho no Ryan Lab em Trinity, acrescentou: "Nossas descobertas aqui apoiam a ideia de que a competição entre engramas afeta a recordação e que o traço de memória esquecido pode ser reativado por pistas naturais e artificiais, bem como atualizadas com novas informações. O fluxo contínuo de mudanças ambientais leva à codificação de múltiplos engramas que competem por sua consolidação e expressão."
"Portanto, enquanto alguns podem persistir imperturbáveis, alguns estarão sujeitos à interferência de novas informações recebidas e predominantes. No entanto, as memórias interferidas ainda podem ser reativadas por pistas circundantes que levam à expressão da memória ou por experiências enganosas ou novas que terminam em um resultado comportamental atualizado ."
Como agora sabemos que o "esquecimento natural" é reversível em certas circunstâncias, este trabalho tem implicações significativas para estados de doença - como em pessoas que vivem com a doença de Alzheimer, por exemplo, onde esses processos diários de esquecimento podem ser ativados erroneamente por doenças cerebrais.
Mais informações: Livia Autore et al, Expressão adaptativa de engramas por interferência retroativa, Cell Reports (2023). DOI: 10.1016/j.celrep.2023.112999
Informações do jornal: Cell Reports