O professor Bernd Rehm e o Dr. Shuxiong Chen do Griffith Institute for Drug Discovery (GRIDD) e do Griffith's Center for Cell Factories and Biopolymers conseguiram desenvolver uma nova modalidade de vacina que é uma vacina particulada estável.
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)
Domínio público
O professor Bernd Rehm e o Dr. Shuxiong Chen do Griffith Institute for Drug Discovery (GRIDD) e do Griffith's Center for Cell Factories and Biopolymers conseguiram desenvolver uma nova modalidade de vacina que é uma vacina particulada estável.
A nova modalidade de vacina está em fase de prova de conceito e em desenvolvimento inicial . O artigo "Vacina baseada em epítopo polimérico induz imunidade protetora contra estreptococos do grupo A" foi publicado na npj Vaccines .
Para demonstrar esta abordagem vacinal, ela foi testada com uma vacina Griffith mais estabelecida contra Strep A, que atualmente apresenta forte desempenho em ensaios clínicos em humanos no Canadá.
O professor Rehm disse que os testes que realizamos até agora mostram que esta tecnologia facilita o desenvolvimento de vacinas que são seguras e induzem fortes respostas imunológicas contra o Strep A.
“É uma vacina sintética baseada na nossa tecnologia inovadora que utiliza células seguras reprogramadas de Escherichia coli para montar partículas de vacina com alto rendimento ”, disse ele.
“Para desenvolver a vacina, reprogramamos fábricas de células bacterianas para montar partículas de biopolímero revestidas com antígenos Griffith Strep A e descobrimos que as partículas eram seguras e protegidas contra infecções.
“Desenvolvemos um processo de fabrico económico e as vacinas resultantes são estáveis à temperatura ambiente, facilitando fortemente o armazenamento e a disseminação nos países em desenvolvimento, onde a refrigeração nem sempre está disponível”.
Dr. Chen disse que este avanço tem o potencial de ser um avanço médico para o desenvolvimento de muitas vacinas.
“Os próximos passos são produzir vacinas de alta qualidade e avaliar o seu desempenho em ensaios clínicos ”, disse o Dr. Chen.
O Estreptococo do Grupo A é um patógeno humano global que causa uma ampla gama de infecções, desde doenças como faringite leve e impetigo até doenças invasivas, como síndrome do choque tóxico , fasceíte necrosante e celulite.
A mortalidade por Strep A é indiretamente causada pelo desenvolvimento de resistência antimicrobiana resultante do consumo massivo de antibióticos.
Globalmente, o Strep A causa 700 milhões de infecções humanas todos os anos e há mais de 500.000 mortes.
O professor Bernd Rehm e sua equipe colaboraram com o professor Michael Good, do Griffith's Institute for Glycomics, cuja equipe forneceu conhecimentos para testar a tecnologia em um modelo de infecção por Strep A.
A equipe do professor Good desenvolveu uma vacina contra Strep A que está atualmente sendo testada em um ensaio clínico em humanos no Canadá.
Mais informações: Shuxiong Chen et al, Vacina baseada em epítopo polimérico induz imunidade protetora contra estreptococos do grupo A, npj Vaccines (2023). DOI: 10.1038/s41541-023-00695-x
Informações do jornal: Vacinas npj