Ativador de células T oferece proteção contra coronavírus em pacientes com câncer imunocomprometidos
Boas notícias para pacientes com imunodeficiência adquirida ou congênita: os resultados de um estudo clínico de fase II no Hospital Universitário de Tübingen liderado pela Profa. Juliane Walz e pelo Prof. Helmut Salih mostram uma ativação eficaz de..
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O ativador de células T CoVac-1 oferece ao grupo particularmente vulnerável de indivíduos imunocomprometidos proteção sustentada contra o coronavírus. Crédito: Beate Armbruster, Hospital Universitário de Tuebingen
Boas notícias para pacientes com imunodeficiência adquirida ou congênita: os resultados de um estudo clínico de fase II no Hospital Universitário de Tübingen liderado pela Profa. Juliane Walz e pelo Prof. Helmut Salih mostram uma ativação eficaz de células T contra o coronavírus. Depois de apresentar resultados positivos em voluntários saudáveis ??na fase I anterior, o ativador de células T CoVac-1 reproduziu pela primeira vez esses efeitos em pacientes com câncer. Os resultados foram publicados na revista Nature Communications .
Mesmo após o fim da pandemia de COVID-19, as infeções virais como o SARS-CoV-2 representam uma séria ameaça para os pacientes com sistemas imunitários enfraquecidos. Este grupo inclui, em particular, os doentes oncológicos que, devido à própria doença ou à terapia tumoral, não conseguem desenvolver uma resposta imunitária adequada após uma infecção natural ou com vacinas convencionais. Estes pacientes muitas vezes não desenvolvem anticorpos contra a doença viral.
Por esta razão, a equipa de Tübingen desenvolveu uma vacina com o objetivo de proteger melhor os pacientes imunocomprometidos contra doenças infecciosas. Esta vacina ativa especificamente as células T, que são outro componente importante do nosso sistema imunitário e desempenham um papel decisivo na defesa contra doenças infecciosas.
Para tanto, foi utilizado o novo ativador de células T CoVac-1, que por si só está sendo desenvolvido para imunoterapia contra o câncer, um dos principais focos de pesquisa dos imunologistas de Tübingen. Já em 2022, o CoVac-1 foi testado com sucesso em voluntários saudáveis ??e mostrou boa tolerabilidade com estimulação imunológica muito boa, ou seja, ativação muito forte de células T.
Resultados do estudo de Fase II
Um total de 54 pacientes foram vacinados uma vez como parte do estudo. A maioria dos participantes do estudo sofria de câncer no sangue e apresentava um sistema imunológico significativamente enfraquecido devido à própria doença ou à terapia do tumor. Houve poucos ou nenhum efeito colateral. Apenas algumas queixas leves, como dores de cabeça e fadiga, foram relatadas. Endurecimento local desenvolvido no local da vacinação em todos os indivíduos.
“Esta reação local é esperada e desejada para o nosso ativador de células T. É uma expressão da formação de um depósito no local da vacinação, que evita a rápida degradação da resposta das células T e, assim, permite uma resposta imune duradoura, " explica o Dr. Jonas Heitmann, um dos primeiros autores do estudo.
O efeito duradouro é particularmente notável. Assim, mesmo quatro semanas após a vacinação, foi detectada a ampla e forte resposta imunitária das células T. Em estudos iniciais de acompanhamento, essas respostas imunológicas permaneceram inalteradas em força. Mesmo em pacientes gravemente imunocomprometidos, as respostas das células T ativadas pelo CoVac-1 são significativamente mais pronunciadas do que em indivíduos recuperados após infecção natural e também mais potentes do que a imunidade das células T gerada por mRNA licenciado ou vacinas vetoriais.
Desenvolvimento, fabricação e testes internos de vacinas
O CoVac-1 é produzido no laboratório de peptídeos de medicamentos e na chamada unidade GMP do Hospital Universitário e Faculdade de Medicina de Tübingen. Também aqui se aproveita a longa experiência e conhecimentos especializados na produção de vacinas para pacientes com cancro . A avaliação clínica do ativador de células T é realizada na Imunologia Translacional KKE, uma instalação única na Alemanha no Departamento de Medicina Interna do Hospital Universitário.
A instalação foi criada para testar conceitos inovadores de imunoterapia o mais rápido possível em ensaios clínicos iniciais, para que os pacientes possam se beneficiar de novas descobertas de pesquisas o mais rápido possível. O estudo também foi realizado sob a direção do Hospital Universitário de Tübingen em hospitais de Frankfurt am Main e do Charité em Berlim.
Com base nestes resultados encorajadores, a equipa já está a trabalhar no desenvolvimento de vacinas utilizando activadores de células T contra inúmeras outras doenças infecciosas que representam uma ameaça para pacientes imunocomprometidos com tumores. Além disso, este estudo também oferece uma importante contribuição para o desenvolvimento de vacinas terapêuticas para indivíduos afetados, que atualmente já estão sendo investigadas em pacientes com diversos tumores sólidos e cânceres do sangue.
Mais informações: Jonas S. Heitmann et al, ensaio de Fase I/II de um ativador de células T COVID-19 baseado em peptídeo em pacientes com deficiência de células B, Nature Communications (2023). DOI: 10.1038/s41467-023-40758-0
Informações do periódico: Nature Communications