Preocupações crescentes sobre o recém-emergente 'Pirola' BA.2.86, uma subvariante do SARS-CoV-2
Cientistas de todo o mundo estão cada vez mais preocupados com uma subvariante emergente do vírus SARS-CoV-2 – chamada BA.2.86 e referida genericamente como “Pirola” – de acordo com Mun-Keat Loo, editor internacional...
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Cientistas de todo o mundo estão cada vez mais preocupados com uma subvariante emergente do vírus SARS-CoV-2 – chamada BA.2.86 e referida genericamente como “Pirola” – de acordo com Mun-Keat Loo, editor internacional da revista médica BMJ .
Em seu artigo publicado no site, Loo afirma que as pesquisas realizadas até agora sobre a variante sugerem que ela possui um número tão elevado de mutações que poderia neutralizar o sistema imunológico de pessoas que foram infectadas com outras variantes anteriores do vírus.
No seu artigo, Loo também observa que alguns profissionais da área, como François Balloux, do Instituto de Genética da University College London, consideram a nova estirpe a subvariante mais impressionante do SARS-CoV-2 a desenvolver-se desde o omicron.
Os meios de comunicação informaram que o sequenciamento genético da nova cepa foi realizado em amostras de sangue de pessoas infectadas nos EUA, Reino Unido, Israel e Dinamarca. E as circunstâncias que rodearam essas infecções sugerem que não estavam relacionadas, o que significa que a variante se estabeleceu nesses países e provavelmente em muitos outros.
Loo observa que Balloux também destacou que a diversidade genética encontrada na nova variante sugere que ela já circula há vários meses. Ele observa também que todas as suas mais de 30 mutações foram encontradas na proteína spike, que é a parte usada para entrar e infectar outras células. Tais mutações, acrescenta ele, poderiam permitir anticorpos neutralizantes.
A investigação até agora mostrou que BA.2.86 surgiu da variante omicron e que tem 34 mutações a mais do que o seu parente mais próximo. Loo também conversou com Kristian Andersen, do Scripps Research Institute, que lhe disse que ela e sua equipe descobriram que a nova variante tem a maioria, senão todas as características que sugerem que ela poderia se tornar uma cepa dominante do vírus SARS-CoV-2. .
Notavelmente, a variante ainda é tão nova que ninguém sabe realmente o quão virulenta ela é, pois continua a sofrer mutações. Ninguém sabe ainda se os seus sintomas serão piores do que as variantes anteriores – ou quão eficazes as vacinas atuais podem ser contra ela. De qualquer forma, Loo sugere que os governos de todo o mundo comecem a prestar mais atenção à nova variante e talvez, pelo menos, a começar a monitorizar novamente os números de infeções, hospitalizações e mortes.
Mais informações: Mun-Keat Looi, Covid-19: Cientistas soam alarme sobre a nova variante BA.2.86 "Pirola", BMJ (2023). DOI: 10.1136/bmj.p1964
Informações do periódico: British Medical Journal (BMJ)