O estudo poderia ajudar a explicar por que certos tumores cerebrais não respondem bem à imunoterapia
Um estudo liderado por pesquisadores do Jonsson Comprehensive Cancer Center da UCLA lança nova luz sobre por que os tumores que se espalharam para o cérebro a partir de outras partes do corpo respondem à imunoterapia, enquanto o glioblastoma...
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)
Domínio público
Um estudo liderado por pesquisadores do Jonsson Comprehensive Cancer Center da UCLA lança nova luz sobre por que os tumores que se espalharam para o cérebro a partir de outras partes do corpo respondem à imunoterapia, enquanto o glioblastoma, um câncer agressivo que se origina no cérebro, não o faz.
Em pessoas com tumores originados em outras partes do corpo, mas que se espalharam para o cérebro , o tratamento com um tipo de imunoterapia chamado bloqueio do ponto de controle imunológico parece provocar um aumento significativo nas células T ativas e esgotadas – sinais de que as células T foram acionadas. para combater o câncer. A razão pela qual a mesma coisa não ocorre em pessoas com glioblastoma é que as respostas imunes antitumorais são melhor iniciadas na drenagem dos gânglios linfáticos fora do cérebro, e esse processo não ocorre de forma muito eficaz nos casos de glioblastoma.
Até à data, a imunoterapia não tem sido eficaz no tratamento do glioblastoma, mas demonstrou retardar ou mesmo erradicar outros tipos de cancro, como o melanoma, que frequentemente metastiza para o cérebro.
A investigação, publicada no Journal of Clinical Investigation , poderá ajudar a melhorar a eficácia da imunoterapia para pessoas com tumores cerebrais e poderá sugerir novos caminhos no esforço para ajudar a desenvolver terapias mais eficazes.
“Se vamos tentar desenvolver novas terapias para tumores sólidos , como o glioblastoma, que normalmente não respondem, precisamos entender os tipos de tumores que respondem e aprender os mecanismos pelos quais isso acontece”, disse o diretor sênior do estudo. autor, Robert Prins, professor de farmacologia molecular e médica e de neurocirurgia na Escola de Medicina David Geffen da UCLA.
Os pesquisadores estudaram as células imunológicas obtidas de nove pessoas com tumores cerebrais metastáticos que foram tratadas com bloqueio de pontos de controle imunológico – que funciona aproveitando o sistema imunológico do corpo para destruir células cancerígenas – e compararam suas observações com células imunológicas retiradas de 19 pacientes com metástases cerebrais. que não foram tratados com imunoterapia.
Eles usaram uma técnica chamada sequenciamento de RNA unicelular para examinar o material genético em ambos os conjuntos de amostras e, em seguida, compararam os dados com análises publicadas anteriormente de 25 tumores de glioblastoma recorrentes para entender melhor o efeito que a imunoterapia teve nas células T.
“Estávamos realmente tentando descobrir quais células do sistema imunológico estão mudando nos tumores mais responsivos, a fim de explicar melhor a maior taxa de resposta ao tratamento”, disse o coautor do estudo, Lu Sun, cientista do projeto na Escola Geffen. do Departamento de Neurocirurgia da Medicina. “Nenhum estudo examinou exaustivamente o efeito diferencial do tratamento do bloqueio do ponto de controle imunológico nesses dois tipos de tumores cerebrais antes”.
Nos tumores que se espalharam para o cérebro, os investigadores observaram que as células T tinham características específicas associadas ao combate aos tumores que entram no cérebro, provavelmente devido a um passo de preparação mais eficaz que ocorre fora do cérebro.
Antes de viajar para o cérebro, as células T são primeiro ativadas nos gânglios linfáticos . Durante esse processo, um tipo de células imunológicas chamadas células dendríticas compartilham informações sobre o tumor com as células T para que possam atacar melhor o tumor . Esse processo de preparação, entretanto, não funciona de maneira muito eficaz quando os médicos tentam usar o bloqueio do ponto de controle imunológico para tratar o glioblastoma.
Os investigadores também descobriram que um subgrupo específico dessas células T esgotadas estava associado a uma maior sobrevivência global em pessoas cujo cancro tinha metástase para o cérebro.
“Encontramos uma diferença bastante significativa entre os dois tipos de tumores cerebrais e como eles respondem às imunoterapias”, disse o autor do estudo, Dr. Won Kim, diretor cirúrgico do programa de metástase cerebral da UCLA Health e membro do Jonsson Cancer Center.
“Houve um número enorme de linfócitos de células T encontrados em metástases cerebrais após imunoterapia e, embora o número de linfócitos de células T também tenha aumentado em pacientes com glioblastoma, não chegou nem perto da mesma extensão”.
Prins, que também é pesquisador do Jonsson Cancer Center, disse que a descoberta “sugere que o aumento da ativação e apresentação das células T pelas células dendríticas pode ser uma estratégia potencial de tratamento”.
Em estudos futuros, os investigadores planeiam analisar dados de um grupo maior e mais uniforme de pessoas que foram diagnosticadas com melanoma que se espalhou para o cérebro.
A outra coautora do estudo é Jenny Kienzler, que era bolsista de neurocirurgia da UCLA quando a pesquisa foi conduzida.
Mais informações: Lu Sun et al, O bloqueio do ponto de verificação imunológico induz alterações distintas nos microambientes de tumores cerebrais primários e metastáticos, Journal of Clinical Investigation (2023). DOI: 10.1172/JCI169314
Informações do periódico: Journal of Clinical Investigation