Nova pesquisa acrescenta evidências dos benefícios dos suplementos de gengibre no tratamento de doenças autoimunes
Uma nova pesquisa revelou um papel potencialmente importante que os suplementos de gengibre podem desempenhar no controle da inflamação em pessoas que vivem com doenças autoimunes.
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)
Domínio público
Uma nova pesquisa revelou um papel potencialmente importante que os suplementos de gengibre podem desempenhar no controle da inflamação em pessoas que vivem com doenças autoimunes.
A pesquisa publicada na JCI Insight concentrou-se no estudo do impacto da suplementação de gengibre em um tipo de glóbulo branco chamado neutrófilo. O estudo estava especialmente interessado na formação de armadilhas extracelulares de neutrófilos (NET), também conhecida como NETose, e no que isso pode significar para o controle da inflamação.
O estudo descobriu que o consumo de gengibre por indivíduos saudáveis torna os seus neutrófilos mais resistentes à NETose. Isto é importante porque os NETs são estruturas microscópicas semelhantes a teias de aranha que impulsionam a inflamação e a coagulação, o que contribui para muitas doenças autoimunes, incluindo lúpus, síndrome antifosfolípide e artrite reumatóide .
“Existem muitas doenças em que os neutrófilos são anormalmente hiperativos. Descobrimos que o gengibre pode ajudar a conter a NETose, e isso é importante porque é um suplemento natural que pode ser útil no tratamento de inflamações e sintomas em pessoas com diversas doenças autoimunes diferentes ", disse a coautora sênior Kristen Demoruelle, MD, Ph.D., professora associada de medicina na Escola de Medicina da Universidade do Colorado, no Campus Médico Anschutz da Universidade do Colorado.
Num ensaio clínico, os investigadores descobriram que a ingestão diária de um suplemento de gengibre durante sete dias (20 mg de gingeróis/dia) por voluntários saudáveis aumentou uma substância química dentro do neutrófilo chamada AMPc. Estes níveis elevados de AMPc inibiram então a NETose em resposta a vários estímulos relevantes para a doença.
“Nossa pesquisa, pela primeira vez, fornece evidências do mecanismo biológico subjacente às aparentes propriedades antiinflamatórias do gengibre nas pessoas”, disse o coautor sênior Jason Knight, MD, Ph.D., professor associado da Divisão de Reumatologia da a Universidade de Michigan.
Os pesquisadores dizem que muitas pessoas com doenças inflamatórias provavelmente perguntam aos seus prestadores de cuidados de saúde se os suplementos naturais podem ser úteis para elas ou se já tomam suplementos, como o gengibre, para ajudar a controlar os sintomas. Infelizmente, o impacto preciso nas doenças é muitas vezes desconhecido.
Os investigadores esperam que fornecer mais evidências sobre os benefícios do gengibre, incluindo o mecanismo direto pelo qual o gengibre afeta os neutrófilos, irá encorajar os prestadores de cuidados de saúde e os pacientes a discutirem de forma mais estratégica se tomar suplementos de gengibre como parte do seu plano de tratamento pode ser benéfico.
“Não existem muitos suplementos naturais, ou medicamentos prescritos nesse sentido, que sejam conhecidos por combater os neutrófilos hiperativos. Portanto, acreditamos que o gengibre pode ter uma capacidade real de complementar os programas de tratamento que já estão em andamento. mais estratégico e personalizado em termos de ajudar a aliviar os sintomas das pessoas”, acrescenta Knight.
Como próximo passo, os investigadores esperam realizar ensaios clínicos com gengibre em pacientes com doenças autoimunes e inflamatórias onde os neutrófilos são hiperactivos, como lúpus, artrite reumatóide, síndrome antifosfolípide e até COVID-19.
Mais informações: A ingestão de gengibre suprime a formação de armadilhas extracelulares de neutrófilos em camundongos autoimunes e humanos saudáveis, JCI Insight (2023).
Informações do periódico: JCI Insight