A pesquisa do intestino identifica as principaismudanças celulares associadas a doença de Crohn de inicio na infa¢ncia
Os cientistas rastrearam os esta¡gios iniciais do desenvolvimento intestinal fetal humano com detalhes incraveis e descobriram funa§aµes celulares especaficas que parecem ser reativadas no intestino de criana§as com doença de Crohn.
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)
Vilosidades intestinais emergentes com células-tronco (verdes) apoiando seu crescimentoÂ
Crédito: Kenny Roberts e Sophie Pritchard, Instituto Wellcome Sanger
Nossos resultados indicam que pode haver uma reprogramação de funções especaficas das células intestinais na doença de Crohn
Matthias Zilbauer
Os resultados são um passo importante para uma melhor gestãoe tratamento desta condição devastadora.Â
A pesquisa da University of Cambridge e do Wellcome Sanger Institute faz parte da iniciativa global Human Cell Atlas para mapear todos os tipos de células do corpo humano. As descobertas revelam mecanismos celulares intrincados de como o intestino se desenvolve.Â
A doença de Crohn éum tipo de doença inflamata³ria intestinal que afeta cerca de uma em cada 650 pessoas no Reino Unido. A incidaªncia aumentou dramaticamente nas últimas décadas, especialmente em criana§as - que podem sofrer sintomas muito agressivos, incluindo dor abdominal, diarranãia e fadiga. Essa condição para toda a vida pode ter implicações importantes para a vida; a causa não écompreendida, os tratamentos muitas vezes não funcionam e não hácura.Â
“A doença de Crohn pode ser particularmente agressiva e mais resistente ao tratamento em criana§as, então háuma necessidade real de entender a condição quando ela as afeta e talvez criar tratamentos específicos para a infa¢nciaâ€, disse o Dr. Matthias Zilbauer, do Departamento de Pediatria do Universidade de Cambridge e consultor honora¡rio em gastroenterologia pedia¡trica no Hospital Addenbrooke, Cambridge University Hospitals NHS Foundation Trust, que liderou o estudo.
Os pesquisadores usaram uma tecnologia de ponta chamada sequenciamento de RNA de uma única canãlula para observar a expressão gaªnica em células individuais do intestino humano em desenvolvimento, seis a dez semanas após a concepção. Eles se concentraram no revestimento interno do intestino, chamado de epitanãlio intestinal, e descobriram que as células ali se dividem constantemente neste esta¡gio inicial, guiadas por mensagens de outros tipos de células. Isso permite que o intestino cresa§a e forme as estruturas necessa¡rias para o bom funcionamento do intestino mais tarde na vida.Â
Os tecidos do intestino de criana§as com doença de Crohn, com idade entre quatro e doze anos, também foram analisados. O estudo revelou que algumas das vias celulares ativas no epitanãlio do intestino fetal parecem ser reativadas na doença de Crohn. Essas vias não estavam ativas em criana§as sauda¡veis ​​da mesma idade. Os resultados são publicados hoje na revista Developmental Cell .Â
“Nossos resultados indicam que pode haver uma reprogramação de funções especaficas das células intestinais na doença de Crohn. Nãosabemos se esta éa causa da doença ou uma consequaªncia dela, mas de qualquer forma éum passo estimulante para nos ajudar a entender melhor a condição â€, disse Zilbauer.
As descobertas lana§am luz sobre os mecanismos moleculares fundamentais do desenvolvimento do intestino humano. A equipe também descobriu que 'miniguts' crescidos em laboratório sofrem alterações celulares individuais semelhantes a s de um feto em desenvolvimento. Isso implica que os modelos desenvolvidos em laboratório são uma ferramenta poderosa e precisa para pesquisas futuras sobre o desenvolvimento intestinal precoce e doenças associadas.
“Este estudo faz parte do esfora§o internacional do Human Cell Atlas para criar um 'mapa do Google' de todo o corpo humano. Com o sequenciamento de RNA de uma única canãlula, podemos olhar para qualquer tecido e identificar os tipos de células individuais que o compõem, a função dessas células e atémesmo identificar novos tipos de células â€, disse a Dra. Sarah Teichmann do Instituto Wellcome Sanger, e co- Presidente do Comitaª Organizador do Atlas de Canãlulas Humanas, cuja expertise possibilitou a análise da enorme quantidade de dados gerados por essa técnica.Â
Ela acrescentou: “Um tecido complexo como o intestino contanãm diferentes tipos de células, e essas 'conversam' umas com as outras - a função de uma canãlula afeta a função de outra. Isso éparticularmente importante nos esta¡gios iniciais do desenvolvimento intestinal, e algo que podemos interrogar usando análises computacionais de dados de sequenciamento de RNA de canãlula única. â€Â
Embora o estudo tenha se concentrado especificamente na dina¢mica das células epiteliais intestinais, ele gerou informações sobre cerca de 90.000 células intestinais humanas prima¡rias de todos os tipos. Os pesquisadores disponibilizaram esses dados abertamente em www.gutcellatlas.org , criando um recurso valioso para pesquisas futuras e descoberta de medicamentos direcionados a doença de Crohn infantil.
“Pela minha própria experiência, estamos diagnosticando a doença de Crohn em criana§as cada vez mais novas, algumas atécom menos de cinco anos - éuma doença emergente. a‰ uma condição realmente desagrada¡vel para toda a vida, e quando as criana§as são diagnosticadas, toda a familia éafetada â€, disse Zilbauer.
Ele acrescentou: “Estamos determinados a aprimorar nosso conhecimento nessa área e, com sorte, melhorar a vida dessas criana§as no futuroâ€.
Esta pesquisa foi apoiada pelo Conselho de Pesquisa Manãdica, Wellcome, e pela Caridade Infantil do Great Ormond Street Hospital, Sparks. O Addenbrooke's Hospital em Cambridge éum centro especializado para a investigação e tratamento de doenças inflamata³rias intestinais em criana§as, atendendo o leste da Inglaterra.