Remdesivir provavelmente éum antiviral altamente eficaz contra SARS-CoV-2 para alguns pacientes
O remdesivir éprovavelmente um antiviral altamente eficaz contra a SARS-CoV-2, de acordo com um novo estudo realizado por uma equipe de cientistas do Reino Unido.
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)
Renderização criativa departículas do varus SARS-COV-2 - Crédito: NIH Image Gallery
O remdesivir éprovavelmente um antiviral altamente eficaz contra a SARS-CoV-2, de acordo com um novo estudo realizado por uma equipe de cientistas do Reino Unido. Escrevendo na Nature Communications, os pesquisadores descrevem a administração do medicamento a um paciente com COVID-19 e uma rara doença imunola³gica, observando uma melhora drama¡tica em seus sintomas e o desaparecimento do varus.
A condição incomum do nosso paciente nos deu uma visão rara sobre a eficácia do remdesivir como tratamento para a infecção por coronavarus
Nicholas Matheson
A resposta a pandemia de COVID-19 tem sido dificultada pela falta de medicamentos antivirais eficazes contra o SARS-CoV-2, o coronavarus que causa a doena§a. Os cientistas depositaram esperanças no remdesivir, medicamento originalmente desenvolvido para tratar a hepatite C e posteriormente testado contra o ebola. No entanto, os resultados de grandes ensaios clínicos foram inconclusivos e, no inicio de outubro, a Organização Mundial da Saúde (OMS) anunciou que o medicamento não reduzia significativamente as taxas de mortalidade. A questãoémais complicada, entretanto, e uma equipe clanica agora usou uma abordagem diferente para determinar os efeitos da droga no COVID-19 em um paciente monitorado de perto.
O Dr. James Thaventhiran da Unidade de Toxicologia MRC da Universidade de Cambridge disse: “Houve diferentes estudos apoiando ou questionando a eficácia do remdesivir, mas alguns dos conduzidos durante a primeira onda de infecção podem não ser ideais para avaliar suas propriedades antivirais.
“A mortalidade se deve a uma combinação de fatores, provavelmente incluindo replicação viral não verificada e, mais importante, a resposta do sistema imunológico. Um ensaio clanico que analise apenas o impacto do remdesivir na mortalidade tera¡ dificuldade em distinguir entre esses dois fatores. Isso limita nossa capacidade de fazer uma pergunta simples: quanto bom éo remdesivir como antiviral? â€
Para responder a esta pergunta, uma equipe liderada por cientistas da Universidade de Cambridge e Barts Health NHS Trust examinou o caso de um homem de 31 anos com XLA, uma rara doença genanãtica que afeta a capacidade do corpo de produzir anticorpos e, portanto, combater infecções.
A doença do paciente começou com febre, tosse, na¡useas e va´mitos, e no dia 19 ele testou positivo para SARS-CoV-2. Seus sintomas persistiram e no dia 30 ele foi internado no hospital, onde recebeu oxigaªnio suplementar devido a dificuldades respirata³rias.
Excepcionalmente, sua febre e inflamação dos pulmaµes persistiram por mais de 30 dias, mas sem causar problemas respirata³rios graves ou se espalhar para outros órgãos. Os pesquisadores dizem que isso pode ser devido a sua incapacidade de produzir anticorpos - embora os anticorpos combatam as infecções, eles também podem causar danos ao corpo e atémesmo levar a doenças graves.
A princapio, o paciente foi tratado com hidroxicloroquina e azitromicina, que tiveram pouco efeito, e os tratamentos foram interrompidos no dia 34. O paciente então iniciou um curso de remdesivir de dez dias. Em 36 horas, sua febre e falta de ar melhoraram e suas na¡useas e va´mitos cessaram. O aumento da saturação de oxigaªnio permitiu que ele fosse retirado do oxigaªnio suplementar.
Esta resposta clanica drama¡tica foi acompanhada por uma diminuição progressiva nos naveis de proteana C reativa (CRP), uma substância produzida pelo fígado em resposta a inflamação. Ao mesmo tempo, os médicos notaram um aumento no número de células do sistema imunológico, conhecidas como linfa³citos, e exames de ta³rax mostraram que a inflamação pulmonar estava desaparecendo. O paciente recebeu alta no 43º dia.
Uma semana após a alta, a paciente apresentou febre, falta de ar e na¡useas. Ele foi readmitido no hospital no dia 54 e recebeu oxigaªnio suplementar. Ele novamente testou positivo para SARS-CoV-2, descobriu-se que tinha inflamação pulmonar e seus naveis de PCR aumentaram e sua contagem de linfa³citos caiu.
No 61º dia, o paciente iniciou o tratamento com remdesivir por mais dez dias. Mais uma vez, seus sintomas melhoraram rapidamente, sua febre caiu e ele foi retirado do oxigaªnio suplementar. Sua PCR e contagem de linfa³citos normalizaram. Apa³s tratamento adicional com plasma convalescente nos dias 69 e 70, ele teve alta três dias depois e não émais sintoma¡tico.
A equipe descobriu que os naveis de varus do paciente caaram progressivamente durante seu primeiro curso de remdesivir, correspondendo a melhora em seus sintomas. Seus naveis de varus aumentaram novamente, assim como seus sintomas, quando o primeiro ciclo de tratamento cessou, mas o efeito do segundo ciclo de remdesivir foi ainda mais rápido e completo. No dia 64, ele não estava mais testando positivo para o coronavarus.
A incapacidade do paciente de curar sua infecção sem medicação antiviral provavelmente se deve a falta de anticorpos, dizem os pesquisadores. No entanto, existem outras células imunola³gicas que contribuem para combater a infecção, incluindo aquelas conhecidas como células T CD8 +. A equipe observou que o paciente foi capaz de produzir células T CD8 + que responderam a 'proteana spike' nasuperfÍcie do varus - as proteanas spike da£o ao varus seu perfil caracterastico de coroa (daa o nome coronavarus). Embora insuficiente para eliminar a infecção espontaneamente, isso provavelmente contribuiu para a eliminação do varus durante o segundo curso de remdesivir.
O Dr. Nicholas Matheson do Instituto de Imunologia Terapaªutica e Doena§as Infecciosas de Cambridge (CITIID) da Universidade de Cambridge acrescentou: “A condição incomum de nosso paciente nos deu uma visão rara da eficácia do remdesivir como tratamento para a infecção por coronavarus. A resposta drama¡tica ao medicamento - em repetidos desafios - sugere que pode ser um tratamento altamente eficaz, pelo menos para alguns pacientes. â€
A equipe ainda suspeita que o remdesivir éprovavelmente mais benanãfico quando administrado no inicio da infecção, antes que o varus seja capaz de desencadear uma resposta imunola³gica potencialmente catastra³fica. Eles dizem que o curso da doença de seus pacientes também ressalta o importante - mas frequentemente conflitante - papel que os anticorpos desempenham na proteção contra infecções.
“O fato de nosso paciente não ter sido capaz de combater a doença sem tratamento sugere que os anticorpos contribuem para o controle da SARS-CoV-2â€, explicou o Dr. Matthew Buckland do Departamento de Imunologia Clanica, Barts Health, Londres. “Mas essa falta de anticorpos também pode ter evitado que seu COVID-19 se tornasse uma ameaça a vida, porque ele não tinha anticorpos para desencadear uma resposta imunola³gica prejudicial.
“Tudo isso sugere que os tratamentos precisara£o ser adaptados para pacientes individuais, dependendo de sua condição subjacente - por exemplo, se éo varus que estãocausando os sintomas ou a resposta imunola³gica. O monitoramento viral estendido em nosso estudo foi clinicamente necessa¡rio porque em abril de 2020 não sabaamos se esse medicamento seria eficaz. A adoção desta abordagem de forma mais ampla poderia esclarecer ainda mais a melhor forma de usar o remdesivir para benefacio clanico â€.
A pesquisa foi apoiada pelo Conselho de Pesquisa Manãdica, o NIHR Bioresource, NHS Blood and Transplant, Wellcome e o programa Horizonte 2020 da Unia£o Europeia.