Decodificar nossa resposta imunola³gica nada mais édo que um desligamento genanãtico
Pesquisadores do Instituto de Biologia Química de Yale começam a desvendar os complexos caminhos usados ​​pelos RNAs e os processos biola³gicos que eles regulam.
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)
Reprodução
Como os genes são 'ligados' fascina os cientistas hádécadas, mas questões igualmente importantes sobre como eles são 'desligados' tem sido amplamente esquecidas.
Como mensageiros que carregam instruções do DNA para a criação de proteanas, a formação e decadaªncia de RNAs celulares écratica para manter a estabilidade e a regulação celular - e tem influaªncia direta sobre como nosso sistema imunológico responde a s doena§as.
Pesquisadores do Instituto de Biologia Química de Yale começam a desvendar os complexos caminhos usados ​​pelos RNAs e os processos biola³gicos que eles regulam.
Publicado hoje na revista Cell Chemical Biology , os cientistas revelam uma nova ferramenta biológica para ajudar a identificar numerosos caminhos específicos de "depleção" de RNA e complexos de proteanas associados.
Mascarado por vias alternativas de decaimento, destacar os efeitos do decaimento do RNA de uma única enzima apresentou um desafio aos estudos tradicionais da função do gene.
Para complementar as abordagens anteriores, Vicky Luo, a primeira autora do estudo e ex-estudante de pós-graduação, aplicou um novo inibidor quamico de uma importante enzima de decaimento de RNA humano, DCP2, para expandir a lista de seus genes alvo regulados, incluindo mensageiros de RNA específicos envolvidos em a transcrição de proteanas importantes.
Essas ferramentas químicas estãofornecendo novos insights sobre as vias regulata³rias em células humanas e doenças anteriormente intrata¡veis ​​protegidas de possaveis tratamentos.
A autora saªnior do estudo éSarah Slavoff, Professora Assistente de Química e de Biofasica Molecular e Bioquímica.