Uma nova pesquisa da Universidade de Cambridge e do Laborata³rio Europeu de Biologia Molecular (EMBL) mostra como a cooperaça£o entre as espanãcies bacterianas permite que elas prosperem como uma comunidade.
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)
Gra£os de kefir de leite com frasco de kefir no fundo - Crédito: Svorad no Wikimedia Commons
Se vocêolhar para o mundo inteiro dos microbiomas, a cooperação éa chave para sua estrutura e função.
Kiran Patil
Os resultados são publicados hoje na revista Nature Microbiology .
O estudo usou o kefir como modelo para estudar as interações metaba³licas nas comunidades microbianas. a‰ fa¡cil de cultivar e consiste em cerca de 40 espanãcies diferentes - proporcionando uma 'zona Cachinhos Dourados' de complexidade que não émuito pequena, mas não muito difacil de estudar em detalhes. O kefir écomposto de 'gra£os' - semelhantes a pequenos pedaço s de couve-flor - que fermentaram no leite para produzir uma bebida probia³tica composta de bactanãrias e leveduras.
Os pesquisadores ficaram surpresos ao descobrir que as espanãcies dominantes de bactanãrias Lactobacillus encontradas nos gra£os de kefir não podem sobreviver por conta própria no leite. No entanto, as diferentes espanãcies trabalham juntas, alimentando-se dos metaba³litos umas das outras na cultura de kefir para apoiar umas a s outras.Â
“O gra£o de kefir atua como um 'acampamento base' para a comunidade do kefir, a partir do qual os micróbios colonizam o leite de uma forma complexa, mas organizada e cooperativa,†disse o Dr. Kiran Patil, Diretor de Pesquisa da Unidade de Toxicologia MRC da Universidade de Cambridge, lider do grupo EMBL e autor saªnior do estudo.Â
Os pesquisadores combinaram uma variedade de manãtodos de última geração, incluindo metabola´mica (estudo dos processos químicos dos metaba³litos), transcripta´mica (estudo dos transcritos de RNA produzidos pelo genoma) e modelagem matemática. Isso revelou não apenas os principais agentes de interação molecular, como aminoa¡cidos, mas também a dina¢mica das espanãcies contrastantes entre os gra£os e o leite.
Embora os cientistas saibam que os microrganismos costumam viver em comunidades e dependem de outros membros da comunidade para sobreviver, havia muito pouca compreensão de como isso funciona. Modelos de laboratório tem sido historicamente limitados a duas ou três espanãcies microbianas diferentes.Â
“As comunidades microbianas do kefir tem muitas espanãcies membros, com padraµes de crescimento individuais que se adaptam ao ambiente atual. Isso significa espanãcies de crescimento rápido e lento e algumas que alteram sua velocidade de acordo com a disponibilidade de nutrientes â€, disse Sonja Blasche, pa³s-doc no grupo Patil em EMBL e co-autora do artigo.Â
O kefir éum dos alimentos fermentados mais antigos do mundo e tem muitos benefacios para a saúde, incluindo melhorar a digestãoe reduzir a pressão arterial e os naveis de glicose no sangue.Â
Este fena´meno de cooperação microbiana não se limita ao kefir. Em outro artigo do grupo de Patil, publicado hoje na revista Nature Ecology and Evolution , os cientistas combinaram dados de milhares de comunidades microbianas em todo o mundo - do solo ao intestino humano - para entender relações cooperativas semelhantes.Â
A modelagem metaba³lica avana§ada mostrou que os grupos co-ocorrentes de bactanãrias são altamente competitivos ou altamente cooperativos. Esta polarização total não foi observada antes e lana§a luz sobre os processos evolutivos que moldam os ecossistemas microbianos. Embora predominem comunidades competitivas e cooperativas, os cooperadores parecem ter mais sucesso: eles são mais abundantes e ocupam uma gama mais diversificada de habitats. Â
“Vemos esse fena´meno no kefir, e então vemos que não estãolimitado ao kefirâ€, disse Patil. “Se vocêolhar para todo o mundo dos microbiomas, a cooperação também éa chave para sua estrutura e função.â€