Pesquisadores do Instituto Max Planck (MPI) de Química Biofasica em Ga¶ttingen e da Universidade de Wa¼rzburg agora elucidaram como o remdesivir interfere na polimerase viral durante a ca³pia e por que não a inibe completamente.
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)
O remdesivir da droga Covid-19 (roxo) éincorporado a nova cadeia de RNA durante o processo de ca³pia e suprime a duplicação do genoma do coronavarus. Crédito: Hauke ​​Hillen, Goran Kokic e Patrick Cramer / Max Planck Institute for Biophysical Chemistry
Remdesivir éo primeiro medicamento contra COVID-19 a ser aprovado condicionalmente na Europa e nos Estados Unidos. A droga éprojetada para suprimir a rápida replicação do varus SARS-CoV-2 em células humanas, bloqueando a ma¡quina de ca³pia viral, chamada RNA polimerase. Pesquisadores do Instituto Max Planck (MPI) de Química Biofasica em Ga¶ttingen e da Universidade de Wa¼rzburg agora elucidaram como o remdesivir interfere na polimerase viral durante a ca³pia e por que não a inibe completamente.
"Apa³s estudos complicados, chegamos a uma conclusão simples", diz Patrick Cramer, diretor do Max Planck. “Remdesivir interfere com a polimerase enquanto faz seu trabalho, mas somente depois de algum atraso. E a droga não interrompe totalmente a enzimaâ€.
No inicio da pandemia, a equipe de Cramer no MPI for Biophysical Chemistry elucidou como o coronavarus duplica seu genoma de RNA. Para o pata³geno, esta éuma tarefa colossal, pois seu genoma compreende cerca de 30.000 blocos de construção de RNA, tornando-o particularmente longo. Para elucidar o mecanismo de ação do remdesivir, a equipe de Cramer colaborou com o grupo de Claudia Ha¶bartner. Este último produziu moléculas de RNA especiais para os estudos estruturais e funcionais. "A estrutura do Remdesivir lembra a dos blocos de construção do RNA", explica Ha¶bartner, professor de química da Universidade de Wa¼rzburg. A polimerase éassim enganada e integra a substância na crescente cadeia de RNA.
Pausando em vez de bloquear
Depois que o remdesivir foi incorporado ao genoma viral , os pesquisadores examinaram os complexos polimerase-RNA usando manãtodos bioquímicos e microscopia crioeletra´nica. Eles descobriram que o processo de ca³pia para precisamente quando mais três blocos de construçãoforam adicionados após o remdesivir ter sido incorporado a cadeia de RNA. "A polimerase não permite a instalação de um quarto. Essa pausa écausada por apenas dois a¡tomos na estrutura do remdesivir que ficam presos em um local especafico da polimerase. No entanto, o remdesivir não bloqueia totalmente a produção de RNA. Muitas vezes, o a polimerase continua seu trabalho após corrigir o erro ", explica Goran Kokic, um pesquisador associado no laboratório de Cramer, que junto com Hauke ​​Hillen, Dimitry Tegunov, Christian Dienemann e Florian Seitz, conduziram os experimentos cruciais. Todos são os primeiros autores da publicação sobre este trabalho publicada recentemente na revista cientafica Nature Communications .
Compreender como o remdesivir funciona abre novas oportunidades para os cientistas combaterem o varus. "Agora que sabemos como o remdesivir inibe a corona polimerase, podemos trabalhar para melhorar a substância e seu efeito. Além disso, queremos pesquisar novos compostos que interrompam a ma¡quina de ca³pia viral", diz Max Planck, Diretor Cramer. "As vacinações em andamento são essenciais para trazer a pandemia sob controle. Mas também precisamos desenvolver drogas eficazes que mitiguem a progressão da doença COVID-19 em caso de infecção."