A descoberta abre caminho para um tratamento mais eficiente da sandrome do intestino irrita¡vel e outras intolera¢ncias alimentares. O estudo, realizado em ratos e humanos, foi publicado na Nature.
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)
Cerca de 20% das pessoas sofrem de IBS. Crédito: Polina Zimmerman
Os pesquisadores da KU Leuven identificaram o mecanismo biola³gico que explica por que algumas pessoas sentem dor abdominal quando comem certos alimentos. A descoberta abre caminho para um tratamento mais eficiente da sandrome do intestino irrita¡vel e outras intolera¢ncias alimentares. O estudo, realizado em ratos e humanos, foi publicado na Nature.
Até20% da população mundial sofre da sandrome do intestino irrita¡vel (SII), que causa dor de esta´mago ou desconforto severo após comer. Isso afeta sua qualidade de vida. Dietas sem glaºten e outras dietas podem proporcionar algum alavio, mas por que isso funciona éum mistanãrio, já que os pacientes não são alanãrgicos aos alimentos em questão, nem tem condições conhecidas, como a doença celaaca.
“Muitas vezes, esses pacientes não são levados a sanãrio pelos médicos, e a falta de uma resposta alanãrgica éusada como um argumento de que tudo estãona mente e que eles não tem problemas com a fisiologia intestinalâ€, diz o professor. Guy Boeckxstaens, gastroenterologista da KU Leuven e principal autor da nova pesquisa. "Com essas novas percepções, fornecemos mais evidaªncias de que estamos lidando com uma doença real."
Histamina
Os estudos laboratoriais e clínicos de sua equipe revelam um mecanismo que conecta certos alimentos com a ativação das células que liberam histamina (chamadas de masta³citos ), e subsequente dor e desconforto. Trabalhos anteriores do professor Boeckxstaens e seus colegas mostraram que o bloqueio da histamina, um componente importante do sistema imunológico, melhora a condição das pessoas com SII.
Em um intestino sauda¡vel, o sistema imunológico não reage aos alimentos, então o primeiro passo foi descobrir o que pode causar o colapso dessa tolera¢ncia. Como as pessoas com SII freqa¼entemente relatam que seus sintomas começam após uma infecção gastrointestinal , como intoxicação alimentar , os pesquisadores começam com a ideia de que uma infecção enquanto um determinado alimento estãopresente no intestino pode sensibilizar o sistema imunológico a esse alimento.
Eles infectaram camundongos com um inseto estomacal e, ao mesmo tempo, os alimentaram com ovalbumina, uma proteana encontrada na clara do ovo que écomumente usada em experimentos como um antageno alimentar modelo. Um antageno équalquer molanãcula que provoca uma resposta imunola³gica. Assim que a infecção foi curada, os ratos receberam ovalbumina novamente, para ver se seu sistema imunológico havia se tornadosensívela ela. Os resultados foram afirmativos: a ovalbumina por si são provocou ativação de masta³citos, liberação de histamina e intolera¢ncia digestiva com aumento da dor abdominal. Este não foi o caso em ratos que não haviam sido infectados com o inseto e receberam ovalbumina.
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Um espectro de doenças imunola³gicas relacionadas a alimentos
Os pesquisadores foram então capazes de desvendar a sanãrie de eventos na resposta imune que conectava a ingestãode ovalbumina a ativação dos masta³citos. Significativamente, essa resposta imune ocorreu apenas na parte do intestino infectada pela bactanãria disruptiva. Nãoproduziu sintomas mais gerais de alergia alimentar.
O professor Boeckxstaens especula que isso aponta para um espectro de doenças imunola³gicas relacionadas aos alimentos. "Em uma extremidade do espectro, a resposta imunola³gica a um antageno alimentar émuito local, como no IBS. Na outra extremidade do espectro estãoa alergia alimentar, que compreende uma condição generalizada de ativação severa dos masta³citos, com impacto na respiração, pressão arterial e assim por diante. "
Os pesquisadores então verificaram se as pessoas com SII reagiam da mesma maneira. Quando os antagenos alimentares associados ao IBS (glaºten, trigo, soja e leite de vaca) foram injetados na parede do intestino de 12 pacientes com IBS, eles produziram reações imunola³gicas localizadas semelhantes a s observadas nos camundongos. Nenhuma reação foi observada em voluntários sauda¡veis.
O número relativamente pequeno de pessoas envolvidas significa que este achado precisa de confirmação adicional, mas parece significativo quando considerado em conjunto com o ensaio clanico anterior mostrando melhora durante o tratamento de pacientes com SII com anti-histamanicos. "Esta émais uma prova de que o mecanismo que desvendamos tem releva¢ncia clanica", disse o professor Boeckxstaens.
Um ensaio clanico maior do tratamento anti-histamanico estãoem andamento. "Mas conhecer o mecanismo que leva a ativação dos masta³citos écrucial e levara¡ a novas terapias para esses pacientes", continua ele. "Os masta³citos liberam muito mais compostos e mediadores do que apenas histamina, então, se vocêpuder bloquear a ativação dessas células , acredito que tera¡ uma terapia muito mais eficiente."