O teste de DNA pode identificar rapidamente a pneumonia em pacientes com COVID-19 grave, auxiliando no tratamento mais rápido
Os pesquisadores desenvolveram um teste de DNA para identificar rapidamente infeca§aµes secunda¡rias em pacientes com COVID-19, que tem o dobro do risco de desenvolver pneumonia durante a ventilaa§a£o do que pacientes sem COVID-19.
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)
Tenente Comandante Michael Heimes verifica um paciente conectado a um ventilador no campus Baton Rouge General Mid City - Crédito: Pa¡gina oficial da Marinha dos EUA
Usando este teste, descobrimos que os pacientes com COVID-19 tinham duas vezes mais chances de desenvolver pneumonia secunda¡ria do que outros pacientes na mesma unidade de terapia intensiva
Andrew Conway Morris
Para pacientes com as formas mais graves de COVID-19, a ventilação meca¢nica costuma ser a única maneira de mantaª-los vivos, pois os médicos usam terapias antiinflamata³rias para tratar os pulmaµes inflamados. No entanto, esses pacientes são suscetíveis a novas infecções de bactanãrias e fungos que podem adquirir durante a internação - a chamada “pneumonia associada ao ventiladorâ€.
Agora, uma equipe de cientistas e médicos da University of Cambridge e da Cambridge University Hospitals NHS Foundation Trust, liderada pelo Professor Gordon Dougan, Dr. Vilas Navapurkar e Dr. Andrew Conway Morris, desenvolveu um teste de DNA simples para identificar rapidamente essas infecções e direcionar o antibia³tico tratamento conforme necessa¡rio.
O teste, desenvolvido no hospital de Addenbrooke em colaboração com a Public Health England, fornece aos médicos as informações de que precisam para iniciar o tratamento em horas, em vez de dias, ajustando o tratamento conforme necessa¡rio e reduzindo o uso inadequado de antibia³ticos. Essa abordagem, baseada em testes de DNA de maior rendimento, estãosendo implementada nos hospitais da Universidade de Cambridge e oferece um caminho para melhores tratamentos para infecções em geral. Os resultados são relatados na revista Critical Care .
Pacientes que precisam de ventilação meca¢nica correm risco significativo de desenvolver pneumonia secunda¡ria enquanto estãoem tratamento intensivo. Essas infecções costumam ser causadas por bactanãrias resistentes a antibia³ticos e são difaceis de diagnosticar e precisam de tratamento direcionado.
“No inicio da pandemia, notamos que os pacientes com COVID-19 pareciam estar particularmente em risco de desenvolver pneumonia secunda¡ria e comea§amos a usar um teste de diagnóstico rápido que havaamos desenvolvido exatamente para essa situaçãoâ€, disse o coautor Dr. Andrew Conway Morris do Departamento de Medicina de Cambridge e um consultor de terapia intensiva. “Usando este teste, descobrimos que os pacientes com COVID-19 tinham duas vezes mais chances de desenvolver pneumonia secunda¡ria do que outros pacientes na mesma unidade de terapia intensiva.â€
Acredita-se que os pacientes com COVID-19 apresentem risco aumentado de infecção por vários motivos. Devido a quantidade de dano pulmonar, esses casos graves de COVID-19 tendem a passar mais tempo em um ventilador do que os pacientes sem COVID-19. Além disso, muitos desses pacientes também tem um sistema imunológico mal regulado, em que as células imunola³gicas danificam os órgãos, mas também tem funções antimicrobianas prejudicadas, aumentando o risco de infecção.
Normalmente, a confirmação do diagnóstico de pneumonia éum desafio, pois as amostras bacterianas dos pacientes precisam ser cultivadas e cultivadas em um laboratório, o que édemorado. O teste de Cambridge tem uma abordagem alternativa, detectando o DNA de diferentes patógenos, o que permite testes mais rápidos e precisos.
O teste utiliza reação em cadeia da polimerase maºltipla (PCR) que detecta o DNA da bactanãria e pode ser feito em cerca de quatro horas, não sendo necessa¡rio esperar o crescimento da bactanãria. “Freqa¼entemente, os pacientes já começam a receber antobia³ticos antes que a bactanãria tivesse tempo de crescer no laboratórioâ€, disse Morris. “Isso significa que os resultados das culturas costumam ser negativos, ao passo que a PCR não precisa de bactanãrias via¡veis ​​para detectar - tornando este um teste mais precisoâ€.
O teste - que foi desenvolvido com o Dr. Martin Curran, um especialista em diagnóstico de PCR do laboratório de Cambridge da Public Health England - executa várias reações de PCR em paralelo e pode detectar simultaneamente 52 patógenos diferentes, que costumam infectar os pulmaµes de pacientes em terapia intensiva. Ao mesmo tempo, também pode testar a resistência aos antibia³ticos.
“Descobrimos que, embora os pacientes com COVID-19 fossem mais propensos a desenvolver pneumonia secunda¡ria, as bactanãrias que causavam essas infecções eram semelhantes a s dos pacientes de UTI sem COVID-19â€, disse o autor principal Mailis Maes, também do Departamento de Medicina. “Isso significa que protocolos de antibia³ticos padrãopodem ser aplicados a pacientes COVID-19.â€
Esta éuma das primeiras vezes que esta tecnologia éutilizada na prática clanica de rotina e já foi aprovada pelo hospital. Os pesquisadores prevaªem que abordagens semelhantes beneficiariam os pacientes se usadas de forma mais ampla.
Este estudo foi financiado pelo National Institute for Health Research Cambridge Biomedical Research Center.