Pela primeira vez, pesquisadores da Universidade de Umeå, na Suécia, podem agora mostrar como o temido poliovírus se comporta quando assume uma célula infectada e engana a célula para produzir novas partículas virais. Pensava-se que a pólio...
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fyZJ1QDo9Q5FEU8Wos6ledTwb+lRs1LqVEzIXcdeLeRWKl8kslyIizFCqqHlMwatiVWWyyh6/DHvNLfWVhabOsGurW3L5dPG5Pa3oSt+TZDdS2rFVVCBQr7nV9V+zU+y+Af4wvrtHqtGrPJhDY/UTqnq2TlzZcehpk6THoxVKLUomS4WwnZTHd18cZgrPkgRMlGPFLFXSvmLyqxqumkdtSpOIvuFaMeTRG4tjndHmf5+TBGhkLypisV8cG7i9qiythxb+ioSpe+TlcGrcXpfVuVCsk9j4FV6ddLOD7yvitOMzNbl1tyxsbqT01jtL2DWeGFkCuZeOQcZ+pUuMiPlXCoY9gusTFRLB4cQIKl5S/FS4Yfo8HOzk/c8mENV/qX2vDEJF+e/pfIdlx8go2VSbIanAryXQE7NFfVs6FYltTVN0bONfzstASq8oybt8GMrTbWuK1vuNreOJ/l8z/PyY/YN8D7wKWJwiKphX9Rc6nR/oqlrdPHlVhrYMty5FfBwdFcmozJ6BqALFV6ePxYkYj6+laVVrjrtWllup1+5LZFdePVWMrDGq8RmF2M9Ux8tFQMnE5KgX2dW3Cq6debc6DDtNlbnQW1mbvoNCQJXaDlH4n3ublZ4jucYej9Sb1yujtjVCZIPXrw9i+sVvjZOgLa7Dk19N4pIJe1GpUPWSuhTXytxFIxqeo5G/BRufFcq82v5MT/AC+Z/n5Kvhe3GmJi2utdAox2uXoyqw12HjbVYvB/PVMvvjeFblSeORUQVPhhViZwbq41auuVZ0xVkMrX39QVM5N1f8A7lF6GKK7rGxftX7CqLHSys1uttYFj82wwnM2rx4i2ArTLLbNU1qADM9ygtNxqp+7vaND7+KfOgaXOO8pTplt6pA4VWWFrDfYR7k9GtKmrN2SgspIKkHRZizJltpafTWdvYpemio1VLPcqNDLayyGmwQjXkxP8vmf5+TFPozv80C/xrctgy0ZT4fp9m689dW+dDB/JSw4t4VWaOXVyXwpPbJsR0ptNTX6vqi1MxrVK2s4lcfCKuxUIpBlacFljcA/TvrdCjTeovNjh1tWCp3c/G6q5Wlh0iEWCwKkrQfV772L5aPvJMs7yUrLzCqPN7whyOPVldbWM2J6bCtbY1vOZNLk14m0rxttwqx5dkNbK+nTRRba9nqh7CtZYYo1OMepHGTi9LxxP8vmfHv5/TXz6a+fTXz6a+Y1Vyy5GbH+mvlQsav6R2s6RsqfEuV/pr5jVX1251Dun018+mv8AMpldnFsmnqL4LMU8676+nbBaRX4YgAV7qFf6qvhZY1jKxU0XWlBkO9ldRiWKZlZPQa1+ti49urHx1smXQKXRuL4/TZSIJdUty1UcIzhWGpk1l0xNjJv3tP5RkLxs8aPvH4WHdmyJi3hTkIzD6e4z6dtIUxqbMh3UKWmnqNWYjTJsPCtiDpcil6GWbOsWvpoIo5FvSIonGaliB1ZeLJWzzGGsf81TuY93A5VWj4Yb6fNr5pKQpsXErjLjIbWVn6GkqTqWZVVdUw1DZGURUi5S8/mgpsoezp3pWyVDo0s57DLs6lsw7uBRwwd+BB3CdCy+uy3rOiVZp5MlbNkvqYbTK7+THG7x2Vu7eGExK3XLULMtjCxacmAxBsZiGCp2HX/hnNp1G1jUcz7z3Kjiofmax4/9f3y6+WRRWNJ2T84NuUWbGRR0zEbi1Lc0yE6duIgay+tTV4qSCxLHEYLcyrdWmFWjMXRzyMcpUmPqwZlhpNGULENTl1xjPpRMe449nOu8VkCM66yaCjbOpicimS8w5knt44I3dkHVHjTaUD3cllTcbLKXusrrCLbevUbJQDRtspxQJk66+PjlyIe0rTQzcjiKz2rf1QHtyljdidvT2i/HzN+p3hv3S+ful8/dL5+6Xz90vn7pfP3S+ful8/dL5+6Xz90vn7pfP3S+ful8/dL5+6X/ANKmVWgi+g1mYtvE5FYtr2yMzs/itcCQpuPXqYF3cjcIVYtiWS/HFwqpFQvSu6uqpUCKHI1La5ZSlr3pWiB2WMxaYdwmRjVtOJLBejVYeT4yaXJ+XjgfeyhvH8WCLi44Bt41hehQTl3SjK6YY8m4MAjlDVmRcdeetwnUrTUyskVgksaLYjAkPucjC6gW29lfnKz3X28z/P8AJVpW/NMjHNUHaY18y8fxRYPaahjfxvTaHVxyXpt1R7ZLMw6RrlFDMf8AioQ//H5huitgycHiPDk0xq+MyLZWNvW3Giw7fxofhahDplU9G3w2TKaunMi3qRU6dJOzMfH5S+xK66qWtNNK1TU+UVAsyskVhiWMU6NBLv1GE+pMNo1dbzlJg9q+9fmf5+Za2M6RhUr+FU8Ui1Lq+lYhlFnNcmg1NEgg8DLPjRa1b1WcgZZYFHUAHpn1CCC+toNS+ux4B2/7k2cVt+5MSnmbGlrbaodrPRR5E+eO/GWVrfXbU1T1VNaVPRtsveyVPwsvyDYPAZP8aYvcDU7CBS8ACjJzOMJLHx/TalVGRWmY5rvLM3gp0aLpV9vzP8/IoLFawvgApliR11+FVbCqZCWIa2qfRHG5L6TS6+0BhPhZ8ZRbYGvybUGNZyOudzViMKo9JqehiK97LNxXrvy4JdM6oI9NRsb7aXWaCgsyL/JnN28i/Ko9kbUdEuW/HsxvKlbOa8OKoUa8Agllq1i/LeyLUzQUT6dZ9Ok+nWMOEW6+ts6lbaek8II8AdTF743mf5+ShfSzBYuObK230a26iMIff8GuwienIretqmrs4wFL63RqWBm5ublr78Ka7NuvKtT03DdkPJWpDFKFWWruVBknIEZlTNMa0JU3LJuHGpbHh27VpwVAKlufnZ5azyVWivqBgwyMGfTXRMSwxMdUgmjOBnERrFQWZRadIuVrAgrMFU4oJ/HN1QrWYFYRXZV4GMkfHBjoyTE/y+Z/n5N8FTCLSo+mzQyMqxQ9ns3v+FXZxIdbVsq4BLOJR0vrsx3QgwtqM/go5Gm/ph7Ocsbk6M3DEt2GM5bALhrWAgsWX5ADKrXMONaPZCTY1NGgzJVLrS/nVipS0NFeK0F2oL1gsUzkJzEa5RGykEfMLTg1hrqgrAhZUjZAhtcz1GGtp0jOmROTqOs8TJgdXhr3HTYxhrH8z/PxHua+UUDg1qLDdc1vSsL2HsuOCDjLHrZPwkcqa71cXYhgZq2TLM/hvFuI6wjXgK34h5WwsQ++yIlrKasrc+oCk5S6vsM7mVYjNCyor2xEe9hWlIsvMZyf6tmc2nNpyacmnN5zabioWldUWsLHtVZ1XadNmgqgqgrnBZxWGtTDTDVqFJxKmm+MA60/a8z/AD8lNgYWWMK0QTU47nQ9epqGsmX18D+CDqU5BWMKr1tpeoq+pVkkRulcHxIrPVVFbg1mTzXwBInImL1DExiSq1UizI7eu014kaziHeM2/wAKuqV0z0oHtZoibipPSsNqCHJhyjDexnWMGQ0XJMW1WjVgwiOmpRbE+Hmf5+KqWNdAWcTAuh2mxOaiG5YclBK7w0zByT8NLIl/bo1WR8WxJyKlbjFyDOos3QQ9VDN9PVPpqoMRTExqljFEFmTyI6jyvGnJUj2bllnglLtFwiY2AZZj2V/2gblNMSsKHtCzZaKnI+msPezRiY1kLEzi2vDFxwy5FXTi2Sq+drAQVJWU96fM/wA/CtC5RAgCxnVA+XK7ibr7+Z8cesqb31X+IG1EeJeRCabgcTu1NyQdUTqGdVoptM42GU18ZySWCt4oqEa2sRrSY1gEZy3hj1bNaDc1Hr5DJxin9Y7ymrUReItt76iJuPYEjGNdCd+A7kMvS+lQjXfHHGtrgrtTV00J5LyrnaxfY1fa8z/OV1lyihR7S3J1GYsUXm19PRbwSpnlVAWMVQXWdRvxg8DQOZ1Wi3z0uSqiC8LGyZ1DORhJhcTnCxPiO5pErGoFnGa1LO5uThb/AE0VxE4i66CIm476jOqR2LmmhrYaKqAKce4PhOs6ZavHxjWbaa1P1ZDX2i0nJcpMZ+qn2WdeQp+15n+dVfUYDQ7KLry/irFWsdrWXHcxMdRAAJZaEFlhsP4YXcFUNYjVa8QxE6s6s606xnVM6065htYzZPmr72L7qfFo3vlneR/Qg5GhO19uoveIkZtS2zh4Duax0qrFGQrK9D42VymTlAEZTiW5T2J40LX0RZUpyixGNdyCfDzP88ddV/EXXdQ+KVs8ppCRiqh8qG+wwkn8QDZRdTU1NS1Pwau1lfziPDuHsGMs9VvTM6UNZnt5aEh9NdneVrH9Itt4eOP2dbAwtvCPmtymiBXS9ktpary0uJvRqyFheoNV3q8yV87dhFuuNnilLNEx1E7KLMkCO7Ofxq4IPE+ze/lCkzpPFxnMOI0XEn0axsMw49ohGvGqztVbNzvGfUyLuK1rAJqalqb8iDZpEvOqlHI1jUyL+/jUXgsIjMWNWniUAg+iZZOxWjK6Mnhj9K2u6s1P44v+XzKvGZFnNoASaqdQLLchUj2M/wCTV7CCb7bhj/OAFoMdjFxhBQJwE152RWj4amNj2LMTHZnNKs1rGpzkRrxAS7AdhNQwiWDT+FQlImXZ3oEyrOnV5FqtM+mtn09sCWVEZbCJkpbMtPVUwW10TIrsxHWUem7NTnXMbF6gswJjjjR5sqzj4AbNVfAAal2R+XW2oDNzfg76ABYpQIqamvDW502nRgqWdNZ01nTWdMTpmaPh7xlFdVR5t+qa6ngnuIIIfC75Qe9fvV8bPVdSNTPbd0VSxXGEVAsWtp0mnQM6JllG42NqdReH0x44NhWw6mYNPXkjgelYKOy5HLpYv+bzXtu2U18Z8Rffy/NVop8FDucenqq2P0YB4LUTBWonaco+Qiw5qT65IuSXn1DhvqhtblM2IUUwoR4duN+NzBGjFimbnKbhMc7aJ8q/l8a17unvc3O73iDgqVkxVVI1yrDnIJ9esXOQxLlacVaXUAzYqVHKN9YxltjN4Y9PCIwljjVP2vM36ZSzL+mUqRiIJZhI4/aqZ+1Uz9qpn7VTP2qmftVM/aqZ+1Uz9qpn7VTP2qmftVM/aqfwtzkTMQ2pLLAkscsUr3AoELAS3LVY2Y7TotYr4tg8acdApXtd6DYVuqTIsrNWWrRX3GUNCpHhk0CxcLFV5dkhIAR4bm5Y3jV86x/JknVFfyr9j70/LGr3HbiL8rZLE+RWKzHytxWDDMp3XGrFS2WGw1fczfs0c2e8sj4v+X/5NCjY2Z7yuqb1LcxFi8rghqWPXWWT+JOutkNNfJcXQNjUw5N0GQtkGOksx2Y1UIFAek1XBx7x14+FpesI6Mv6hYGt5GcpzPkp+df3MnvTrT1/E++JWbD2Vc27+jFvh9aXoarepS9X0qWU91ay17Zj1qteX97E/wAv/wAgDZqTUA5RE4xmCi7Ia57E4O20xMdSZdUUTGsUw1hQ9wRaLBYhapmsVGH01nI2WVlbm5BOsipdQzemUXixfkGXU95mB+Xnp+4nzu+z/wC6vZvlgpqrJt4KTyPnU8Ti281/Ua/ThgGCxajdjLcKqGFtTgZGcU4Yn+XzNk38/qr59VfPqr59VfPqr59VfPqr59VfPqr59VfPqr59VfPqr59VfPqr59Vf+FSuhWvKKoUO4UZOQbCDqUqbLsiouQ3RK5IdrwK7bHAqp0V0qOOmq8/UxslhZmXGXhXaA75DhnsZ5XY1bUXB1YcgY6dRLF4P5qfuKfWBzr9mpPfMXjkUjVOc+3/pwW9eQvKgMVmrCK8p1lt/8fIg1oty4444/mf5/wDwEXkwEpTirHQtbrT6adEyleEbuvFbauLI1VRthqrUfUKGBSwPT3dOT09VX/i3djq1ft4GphXKbDW9T8lsHhmVbXzV9n/9UtMlNNSZ+oL3pO6cnfX/AKcY6tf7TKFyEethbhGV4tbCzDsU4ymmqr7fmf5//ApTitK7b2GZkRB/FX669BgoO8mtUFFnpd/Qr2CXOzT+RzWL1i3PA6WSzSLsV203cZbji57sZqh1W6fhg2z3UifJbU4WeVfcGVtHHOpOz5S88fEP8X6imn/po+Tfay/v44fmuXWR6FR831Pa9zYw1j+Z/n5wpacG/HrG3EpXS5NnTrIFsqx9IG0b02tWQawo+oVKlrVbdqbNg60x4ChrnbViwobIWNbvwKpUqK9qo3I3JUE4tSQy4zslVNi2UvyWwT2mZVyXy1/IRJS0ur4Gs8lq/jtya+pV/Thpzus7V5C9TKUJQLKa2bg3QWji1dC8q/t+Z/n5lXkyroajV7jLr8Wj5VLth2FzLZZwflTl98ipy4TgpqqdaXNF2XYvRRAlB3wHcKmgCao2U6yuxnFVvqZGsZLDw0HCUhRbUTcobj3pI/kGK/C33DT3V14v5E+UEraD1ovoYjlEbkM2np2f0YNPCvIb0/8A9d2rlxk4q9/K4etgAor71+Z/n5ak5HSiIrvG5paYRuH8SgTHWXv06+I6VVZEt7W1t/8AmQu7nsCi2G1NW0NZtODrdZxC5TCJcjjqKTX/ACy49O2qzkqUiJZXtzpjquc9jdjuOaxa+Mx7OaWCD3zU1b5R7LFMqeXLyWpzCIeF6ZGK9J82JjG1j2Fh215/nx04V8g60Y2m7IHs5Sj7Hmf5+Qe4UBS22QBYQpmZWGUIVlny/DoEqGlzLf5/VFyG5WULcwpsi1xvTXU4EOOrsWqQY7FGbGVy1VIlSV1ypU4hOL5CM1prCLU3IXrxlV62LzrED6j2eoUuDS+5VpLD3U++au6vLWYex94jSp9y9eLV3CH1QWS3Dqtjfp9ojY9qzUCkzHwSZ2UM07mZNYrOLduqupVL2ARmLlVJNQ1V5n+flpYleG2ps9Oo7eizu9vv+EPfHWDsLjzyfamy2Yxbd7usS3cCgpw5sS0WutIw3KLWSy9Ryd+KdUsEt4DkbQF7i0iy/wDlqr5dS6puGJcWOW6qanFi3qN1vxC9xYO7+qryodGL4VtEYMt1OotpQhww4kTq6nVWbrM2BOpC0J5RW4uquzKiViyzfgqExQEFf2/M4PPy0vxPUFdqavUbQ5Ppce1vv+FX3ele9x4UUcS1o6cNbWjCcCcww+lGwSlSpcLBXqemyCOg3U3UF1NZRF4Sy0k1WsrUMLXyKStos9XExepAoW+zha6VhSzMwuJOPiWc6rB2X3vThb5UO1Ph8YlkWwENQrgq9JTI1BYrTSGcJxacDDXOIE2ohsjNFVmi1BYXAjPKPs+ZtbNaGGlIaUhpM6T+C0Ir2W9NLcyx2a76gWvpvw6fnR3OadY2MoLcAqdUFS6OKU5AjihnWUstnUZmFTeh4a0ARkMPGeh49LKcPpvXerJFu7dSkRslYHdzRp68nYtxywHxQErKTxs91PY5y7Tyo3Ez/ohXjFaJbNrYLMecSs5POq4nWM6pnMze5vU0zRaVEZwIWJ8aPs+YlOXNICk0kNQMKERkBmMzKb9fTgbKY68bPufh0/LDn6kf46m0lD8621LEWV2sJzcDvqlf5qyisxD2HQCt1a3bibbbCwCfTonFFdq3pc2zMTYoBNhqVVQo0sfpXFleW3rK0LC3vj1/bX2f3yByxvNXyJMU7gMK+CvFtnJWj0AxhxnpnvAtkWp5xRYbIXM34k7lH2PM3vOInCacTqkT0PFBqa9jZMSlRZmnp0/iVnTYXv8AqY9CnUoHpa1CaioBY13IA4yddHG2WZWWVKXmRS7pwtoAIdLVW2yvH0HfVlvFpUTotzCVCpupVZAtcNFbHpgpdUUiZJC8/wCDH+3V8bIO6t2byBSTh0BafosgQjupgM3NTcDRbILQZ6JtFnVENsL78nKGO2pi/wCbzfUpyF1ZmlacDNGNNERL9TSvNdN7z1xZWU/EX5YR9eavLGq487qytKI1hqZFjnHstPsdO/EVCxwE4ApSXh/kgAahS2sO1y1vEA2jka9KWQA9TghFk4FSLGQJksrWotifwVBL+TM6irHblXbAfS/zgG4qTjNSq7Uf9QKw2Fm3uBiJzHhvw1ORE5zkZ3mvDc7+HOF4mNZaaV4U+Z/nFdlKZZiZKtDp4UIhAM9aRLVsjJqMNiyvgfwh74f3bhyolbfxm0cX42045RRy5Gyo1pVeDAqkXsa1F7EW8hRj1tXF4z/21oNvQSDk0spK2KwavHX1XO8rtIY4oIpt2MjF9SqFliG2Yo4rdP8AzZ9yIsHhqGWLo+AeDw5TkJuc5vx2J2hYCGyGyVV2XtTiJWGZUFTcq/M/z8i2usqywZwDQjUZQ0S3gWTcdezpx/Dxm047rkp070Pq0hTKUVzZmOxNQsPTFXKVlljI1oerhC+lGy/ZYxPFaa60ruS1X41TizG1RKUsrlqnVeOFZuLI9ZU8rnRa2KoeQx5dP+WfcX3EEHg0s+Pk5Gc4rrOdc51TlVOVULpOYnOcjO5lGE7lFWtb8pa5be9pxP8AL5n+fmrueuV3paGXUYcotrUHa2i1IRo/g1HvS21/UaZj8ZaPSQGrspW1MU8Ye7M3SRCbWyLWR7MksiGzpLasXVi2WdFg/NbLKuHUMHU413CbseWLYXdLCnaqnGY8OabtZRGI1j/DI9t9m7sp0QYs3Nwy09vFca1ocS4T6e6fS3wYl8GDZPoHhw7hPpb4mDc0H6csXBpEVErD2qovzC095TXzajQo8z/Pz+0x8jkGHdwCqO1T76tdo2v4Ke+N8Mn7Ffu3xr+GP8U+5b9/J9sL4Zv3YPt2/co+GX96j2yPvH7dcq+6PkPd5b8V+03t/wByvaj7eRG+PgsXxMt9/DF+4vt/SYYZl/Hwr+3R9jzP8/6E+f8A5aP88T7T/Hw//8QALhEAAgIBAwQBBAIABwEAAAAAAAECEQMSITEQIDBBBBMiQFEyYRQjM0JSYnGB/9oACAEDAQE/AYKx7Cdk1XbqQnY3RrFLwwg5H+EZkxyg9+3UajUai/woDViVGTrJlPorHu+uqhST7/jxSLMsNUerkcmg0DxspmpimKXjeOS9dqdCkOQ3fST6WbCH12ILvwTtGpGXLS6NkY2fSaVkYN7mSKSHvE+yR9K+CcUnsJ0Rl4ccI443Il8hL0ZMamtUfDLnsey6101UQ0vkeldqdCzSJzcnuSYkR/R9KRBNCq9yTXoi9LsnJOI4pk8LjHUzgi+9OnZ8n0xtGLbGx8+CS9l9EOO3WhP0Vtv0xyXsuNb975MUFVmSTEpkqfAmpco+2SNvQ4VKj7EZ10iN13/WioaGfcZPkR0qMfC+DS+kMaJQ22HCuCmhbLolfPSMvRZrQnfb7FFxjYsrLt7Esdbkcgpx5N+Tfkdvcm/XSJPgXdLkxPaiW5F+CummxkZVSJRbkfRVDXocNjjce7OOqddq5LFL7WyM4LYyJ2PTWxGDe4pSWxGdrclkioFiIrxKLZJCd+D6joitMdQoKrZFwW6Ndq0SytI4NTJR/Qlp3L361fbAhRkpKhuPoTa2MkaZYpfo2kjJGUXbErFHw+yEUx/aui2fhc9qMbv7RRj7Z9TakbvreksbsXc+CBCrMlsjD9kmv9ommqkS0p0Tv1wZMtLYlJye5ihZdDSl4NO5GWk19K38OOK02yUrNrJ/0KjjpTo2Q1fHRbmhCXWXBHosn2jk5ckI0yUYt3YouRJ6RuyKI7IkiKoS3/EsjHU6MeCMUTwRkjLj0Srt4IyGrEq7HwR6L7mWmx5Hdix2rZ9XQNuTEhKiMi0ORHwfSn+hqvJ8fkT2EfLX3GiRXR9Vx3XTItGp8Gp1Q5JE8spFCQlXRF9E678GKMY65E86T2MkFNWvJGTiyGVMln0k5ObsgkkTjv2JWu+UTgUxuykJGnyoz3wN0YZf5bY3v5o17FKiVehxs0C/MjnjLaY3bFJpV+PGNmlDj+vI4foxRt7ksafBT8KXsbvyRxylwSwSXiQ5MiPwqCS/sVPZjlCyWT/iamQhRkjT8F+SEdTMaSXT5OPS7XZqRrRrRfSLKGzHg1bsfxYmTHodd0eR5djS57koJIojHUO+D6jap/iYnUiMhNHy5p7DmObNzSzSaWU0RmxP0aiLuRCqEfLS032tpGv9GqQsskLIsiohtsyUK+5Ekp7o0L8WGVxJfI/RkkUURxylwPG1yY8Vsl8dIljcSi3EjP8AYjHk2PqHyMmrbuUWaTT0U2yTfDMa21H1Pf40nbEhQ9iqOyQtnQ/+xpVbD1Ico8DgmuCcXBjRCZbNb7ZEVfY1ZHkSvdmhrYlTh+LJiI429yMXe4+bQrkf+9LPpmtj/sao4ZF2u6RHjtlyY46ha+CEXe4/xOSEdQthy33Et7QyULIjYo7jjFjix43Q9yD7pEe2Rhjast+yTlW/gw4dZP41cDTXPilwIjClRF6tmKmO4oi7RqSe4/6Y3W4v6EkVTNRkhpZwxb93HbJmJ/bpJS01RKV9/wAfFrdsefeoizyXJmj9ql4p8EB7CrkTXo/9NzYbSGk1Rekk6Zq3pmze5lVxokQ76/RqNY5GOKlLcclF/b4fjy0zMlJ0umb/AEl4p8mPkcP2RfopLgikhMrclHcim5D/AEz/AOi3FL7hko1sQe/hpGleB9i4MLWq2Tm5PxSIOj0SdbnqyHFl7WckYuya/Q940RjQ0zJaFJUZfTPfWivwrFLbxyIGz3P6GzlbDaTG9xQobvgb/R7HJJ0RtfyN7M9j56YMP7NETPi07rxOX4kuCJDglFt7C4NkSlE1WPgdLgUrFTK3s5NJ8jhIfJHkxMoz1p62jYtGxZqOSMPxGIhwQHwL+ZP+Rk4J/wATJ/ExkOD0R56Z/wCR76Yenyf49Jc9zIcGMfk//8QALBEAAgIABQQCAQQDAQEAAAAAAAECEQMQEiExICIwQRNRMgRAQmEUM3GBkf/aAAgBAgEBPwF5oSse2yKocjdjQr6L+zSnwOLXS3RrE76bLLL/AGbzQu1HCti33eTHRws6LrNxTGqzk8ous2zk0mkorLUX4766Io5Y92Xm+mWxYpZX6Y4fWUkUJZNn/RYsW6RPEUdjCnJzf0LaVDU4jeafhk7MOamxOtutbIjwLjoW7zvJqyepfiJzfInRybxJL3lpEqGJEl7R88DEcJtDuqiQjJfkTjqVGDhOEtxoU7dZJ+BK00YeFOEkRdvrnwS2iRfooTGJ752NeyyzFUv4iU9SrgTrJbbD5zfJOVbGFFckpYaI2nuhpwezO+L5G5LkjO4WP5mR3WS8D5LIqvBMjyWspzZDF33FKy0Pd5XXAxoo0C25OSaz9jlCctLQ8CJp0rchjanVGJhKQ8OfBtwzbgVLtJZIl1vkx8JtplbCfTFWyTGrReWqhE4XbIzUYWz/ACHfAn7FIsWxzlY98p8Z+ykOMvkSsnh4j3swmtItV7ksRRdDjGW5OFPtNDUk80vB7ylNR5GhdEOSfJGRNHxK7RJ656B4r1aYk4zls+D4lGW5HBjdnJpQn9l3sVt0LdGJnExG/RgycpNkVK7bJRT7kYM9URolhO+5ktUGtzWpcZJeH2Y2K4VRhx1y7+clz0Re5JXkt1l8e9mIku4c5ekLBt2zZZ1qySovOJPOJi6tLowVGO5PEpdpBS/mSTg9UCGuSswqvu5NCXIlXjoxMNTJYOr3lXSpEl7IuiSMWdSpEYV7KZhquTcrPdnHOXBqPVn8cmRylg3OxRUeDGxVpITmopUOUYG1WN2L9rGRKJF2OO4xyFIi7XTySQnR+TJfRLZZMWT7UKDS5FhR06WPFp6UTjGXOVCQ/Ha8UXew1Q90TzwzXGxdNbiWlEd3ZN9F2tjSuTSrsbElHjJIUGfGzFi+BRcJUyvBJ+jUmJ14oyKoaUhxaFE4JuTkQe3R72Eh9w2kuhrKy8kiOF9ipcG5RROClzk4p9eLiOHBhYcpt0LD0UjQ/EpFe0X9mj6JqS4RKFkW/YpUamaWzZFOXI3Q3fgUbEkisreds58EsAWyGkyx7+JOhSTNP0WzUi4lLPZEp/Q2WX1RjZ/SKrJySHJny/ZjzajsQ/USgkpGuIn0pWRjQ5kp3sLYUWx9q8TYpCka0aomqJqQ8Qcn0vq/oQ39kp2PFbl/RLXHeLtCjiSiYeE67zQjExNeyRgTco789MVSJSyUL3KSHPxMeUH0WWjUupyNYneUF7ENjlZLgj+nSY5rCVGHiucv6LROWlWKuRQqVrogrZKQo2Uojn9eSQ1lAsvOistQ5N7kd0MeUMuEIkyzUWxpPkUNDuJiq+6PowsZ4nayDcFTHjz19CdEVY3Q3fmcRqkJt5yenkVSMRqCIYuoi28nETNe9IaKIoXIz0PJIorJJEYx9GI91E/xlq56baL/AGDzq02SVxI7fga3dSQtDX0KM1vZq35IysaNNijSorKPI+RkhLoaETtOoixYyV+yLaxP+/tXkpL2Tkq2IvamPTDf0J2u0ctWzKVWfN64NCFXo4yTvOPIz0T5F0vkxJ6fQ3hfkYk1puIuP2jLolLVwRi2thyVaWJVtRCdbJE6umRj9E5prcjKar6FJDlF5Rea5EIxELpZOdKiWHH0YcIX2+CUqFPxvJz9ko6e6JJNPk0xnKyfY9zRKS2FHfuQopuiVL8jVJ7DbaFD/wCid5LJZM5HGuqaruIYWttshBRVLrk6MaehEMdN0RfiYhLUS1J6TEuL3P8AhtwdylTZochOUXZp1IitcdxwTjaE3GNoh9oZHOO6Ex7FDh9G6NQ2O62FhOcamRiN9clsY/G5hwuRBV4pD4I4n0YkV+TFPXyScpDHK4mHJpUTlGMbE3+URyb4Q9kOFR2Ii3I5xdPOvrKjQj40KJsjdlDzw8qiPD+jGi1NRkT0QQuPEyrRXdsRWrY90Yi3opJ1ZSjxwTmkkQdc+xdsrRiSbewppPcwnGTJRlZHnpjirhiedFllMrJuujDLyo+KOvW+TE/TyliprgqvFLJXHYqu4jsSel9wk5xEtiUtW1EYqC7iO/LOExQtE6/KB21Zh0s5SLIxTE6FIsvotDxESnfVrFM5OBrUNV4WIxOSM1Fbklci9SIxl/4aaIytlOXJoonaVF7VZ+CtHyPijC5vN5Rz1HyHynyGs1HJxv4FITsfaSV7+JE+TE4I/kS/1GH+KMPlkP8AYYX5sxDFFyS4yhxm8oZS64mJwLwQMTg/jl//xAAyEAACAQIEBAUDBAMBAQEAAAAAARECIRASIDEDIjJBMFFhcZETM0AjQnKBUFJiobEE/9oACAEBAAY/AjNV/WjYzU7aMz308iOou3jubloOamSGoZYsRUWwtf8Ax3C/jrq9/wAFInSxrBEHphlo3Ju8No9zrL3fmOlly1CwlDmZ8zqMvEXMWOVlznVy0MsX8Xl8HlpOeqC9zpOhH26T7dJtByVloZzUteHwv466vf8AEjFlWGYjsXMlBJYl3ZbC59SjtuZmscuG1jNScysXLE//AA81jyl/EnVFCkmu70769ofocnMiKk14HC/jrq9/w50Mbw+nQZ2ZaSYsRSpHVVZIinbGFJldMsXYTppmTmJpOYTgubEpQc+xDwzUH6iwui23iRo9CKVhY3xujlT+SMzXubpl1pipSTwrry18L+Our31W/A3MqEhvue5Y+pXsQjl7mSglzmNyexmG4lkoiodXZFlYTL4Ww+msLMirCaGRxETS8L+FOEI83hC3JeiWhosi+4vPzM1FU+hz0wTS5WmVaodNW+nhfx11e+qFhB6eFezLl6iKcMzMi2RnqMquX0NV08pZF3hCUtmavB0V3KaVByHMTuJ0T6kD0ehFR5lmRVcsW8P1ZL3IW5dl6mxZdyKh5dmXOXYhirW5MjjrRe7Od3OXtpv1dmOl9tHC/jrq99Sop3ISJRFRHjThfyHXBCd8ZpeMjgmrfCGco3UjKthKhXJZFO46Vepl01hyovSx1VvL5YZati5KuixFW5NOq2OYlnr2M1VxPhJZkbtEtko5ibnOzNwn/RfC/UyRnLuZa+rT9SjqX/ujhfx11e+hFinMego7lTqcupwhPxZMi7YZTIZscrJRN5MsXIdLtuZ1jGEkV0VIihRSdVy9PM+5sZlQpI+nB0l8YexDJpPJmSozLbwJwnt2NmTSmZu5zXOpQZVUsw6aqbndFqmS8Y4nSTTth6izuS22jOtqseF/HXV76vYpfDULuUZLsXqLxWMl4U1absmDlUDqamtif/hDJQ66mQ70iZNVPKQkSjNX+0sWOak5OkzTJDohjcvCKtsPUTwdPgfTp3qE6zYilQWZB3bJ2Ys+5y1WMtVzqUE1XOUgilF3zHM5I7FsYJ8seF/HXV76fQV4R1s6yml/tt41Q2T5jwiS2hn1I5yah1dhZWcxc3J3Loh8NP1MtCHRF2OupRjfYdNN6BcThP3RC3xyskzIh9tc4P0sLMiaSYbL8pNTscisSrVnk0Ku2GbuZazlMy3LK4vqKzORE1dQ6cVj6IpXprq99MeYrHMXg659CafFaL6JW2F9EssjL2PXCxTBPoKkoOelMz+RCZOCjpWqVh6MgzalhVXR5kOm5cik+oqzLJs8FnSMoq+Hw02QxpFmczksU/7YQZn3xzMSxWur3004c23YuO/c+nxCafFlCxhm0o8iw32RcijceS1Rc9TK9z9QmVJCsjN5FzLQZYk6WRhzE0nKi7+DoOhE04ShOCNSKmZqtxVLfDP2RBJDg5erCGRU4Q6VD9S25DRCRzKCxDEiMMqwVPlhlKddXvpbKvYlG8NYThmW3iMhkabMyqxTlct4SMnDlRfD0Ls5TITSjLJYaqUM+jR/eFlglG44HKjCcHqpXqdTFndjluNGbidyxljCVonDphn6hHDQn3R6vCxL3Gxt98JKH6a6vfT7lSws4xyvZkMa8PLw+3c/6PVH6jgtiqs1/Ib7Yy2cmxmJr2IRNRy7Y5Ku59Wi5zIdVKF5jhDrmW9E4eVRVTVumTrRT74qBIVO0EVbH1KCXSQSZZMiRDM2VwK04XuLiV7dljLJZ6aOF/HXV76aPYeMIzZr4ZaupGdeChtbvH1PckiukmmJIRlY4RuRNy7vhFBvIlR33IrSb9TPwV/RNXKea8xUcRf2SoNx1EvuchLJLPGSrybxelFNOE1jaRUmTxHBCcmWsy07ltnhy7l25FVXdkMsZszL7IhW0OHy6eF/HXV76aPYbwTS3I3q8ycFUj3HT4CFojuQ8cz3L7Cae3YtuTVcsZZsWIRKU1QOuuRSTRTI06YkipG79iTNUWZCMiJSsThTAnLyiwelYVegmKksOsiS4tiaVCwhkmZmVUjr4tVyKHI6U7l9GThrl7nSy+jhfx11e+mnFeg1Nz/l45H2J8/AQ6Bp6FxaP7xzm81HoZqd1h0siuxlXczVMvsfpVEYuSHjClnMSj9Xlp7FmSkRUiIIW0jXmPTThX7loHUyIJpUJ4ZaSXXcigdFQoUnPuc1RmauRsiSEyKnjlR64RVSZqenHhfx1v8ASr38j7NfwfZr+D7NfwfZr+CHw61/Q1lcwfZr+Doa9zPzUmXiUjS4dTXsfZr+CfpV/AnTS2z7NfwfZr+NUFz6tH96MrGsMmOaqqxy8OfU9SWSmS6SGhVNQQmJZZM9Cn0I8zmFl2YqiacYqWGV98P03zF9yw1pp9xwVPCKieGTlwnuWViyE3Yiuw8rsbl3DG5TREmZ7snW6X3HS+xY4a9Pzoe5lq2M9HS9GZbrCKu5LdiTksjNXWl6CpKVTuKTMhRQiCZEqrmVKxny3w9sIZYvjzdth9/U5injU74MzaKcHjfDlUFzKcyFGxKpcH04w3IkzVdJHYhYN6rd9yEL8+5krJXThJA0X7G8aJpJqLkMnc5WKRt7s9BZR01bjhM53BapkVbG5uXZmV6WR2w9CBkeemr20Mc3bwTZmpUUkEeWDyomq40jNVakhbFi5kp3ERokvgtbWWg6aPg6aPg6aPg6aPg6aPg6aPg6aPg6aPg6aPg6aPg6aPg6aPg6aPg6aPg6aPg6aPjwstZK6cIJR5M5qp1WMlX9YSywp7YRUTYzMglE0yWtUWZdmSszUOGZUJdxjYtH9DjRHcWY7GZGShkVXG/MmHBKIdNx119+x6EIzVbkLqJZDJ0NskU+BV7/AJeSon9uEM+pR4CrRbDNGGThuDmcmaqyIRvOChHOjNw/jHdmepeAnh6PbRnrFTQZqycMzHS9/I5fk86vMuRThC3JeEnJubF6SSFsITRT7a6vfwN/xMlRlwys9PAs7aP+6hPiVSblqsF9PiZS+GXux4ZqtkQsJ1IjsZajLURSXUtHkSZYxVPCpmozcZyyEsPTDLw7sl6HV+4ujLRsXein211e+mF+RfqIZJlqPTwEqWJR/Zm4jkVcQkbGWpInhOzFnLMklqwqu5KPQyrCEKldhUaoeEVomhvLp5UTxH/RFKjCxNVy7Iosse53O4vpV7k1VZqT61K5jpZdY8P+Our30yXM7duxVG5fcj8SHuemGWoh7aYwVVNJlrMr8yVhLSw2OYgpyMip3RbpIWP/AEZqtxvVK3L4XM3B+D7dRzKDpk2NsLl2RwlJPEcllhfDsdi1RZyRlnC6LWLnC/jrq99KQq+JVCIiIKcq9ylfuJ/Gmn4JRFRa6L6IMjRbYbNyMblzcik9CEXIWFrsjXbGxfVufpomt4XwsWNzYuWZubnNhYhlC9NdXvoWCTG8yHXRR8mfiYTVMlmy/wCHlrM3Dc4c2E0vMi+GdKxcdDcYyjmw5Vc3vhNVjLQsfNnl4e5ubm5uzqZ1PRfCyOZ6N8N9FrEPckp9tdXvqhbExfGW7aNvxL7np54XLq5yMadNsJMqpidG5aT9R4W2IoOdkU2L/h3xtZEs8i+FjsdSOrC+FiGSiGLXV76IRe7Lad0dRZk/ibkVbHkTRc5lBuXLovBZwdR1G55naxy4TxWRSsIWHkdzlqLrx7kIvhc5DmqOU3JhxjmrM1GxvBfCGStyj211e+MIhYXOVCzvlIostGZj/GthzI5KzY6WbYWoPtk1s7Fzscq0y9OalW8T1wyrHLTuZuIzkL45eKuUzUVzSQQZWN5UQhTthDKfbXV74ehFOEUEtmVETOmWen499F6CciOhHSdJtosvDqp8TKsclG/mepctZE8TmOSzJocjpagvWfUdOxZCaUGXDLWRNuxKKfbXV7noQiWQtsVUi5ex543/AB7aNjbHY2NsN9SFBfTV4UmVE4ZaTLTvjSoI2eEVbmWg8zLGjZbGWiBZcFrq98JZC20WwuciNy/5Mr8FaN8avfDfwV64ZVuzLTvjm8saGu6JOVHNparqcEo5jNTVcp9tdTe0lz0xvZG2HJc5n/g7I6cLM5mb1HLUv7Okvoiothdjjd+LJFO+hqhYSzmucxFKL7lquY5lGH02rmV6OH/HWyFthCJq3whXZd/nvC2HmbLDbDfTdHI4OmfYTY3S2jLVudZa79S/h5MFSt3p5UzpOkl0s2L2ZnWwqmImm4hVLthmr2OWqCinyWtpYQj1wij5/wADYvc8tGxd69sIMtG7MtW1PYoS8vGqfqIjywhHOzlpx3LHNQieG/6Z9PiWZmVUmXthnpIqLJTg8pw5/wBddXvhL3LkU7f4CKFJVRVR/ZGFi+i7N8OWCHSQzfS/9jNS+Yh+PVVhFO5b50bPCzwirbzHRxN+xKIgh4ZqsafbXOasnNWb1EOus66zrrOus66zrrOus66zrrOus66zrrOus66/xE3aktuXObG1yFYn6j0J7vC/9MTXWiGXtjfDNT1D+qirh8PhQ1aRZlHhIYyfIzVYRR8l3osyHg/TbBVTcllM+YoITMuY4f8AH/FZqiWWJeEK7JqqsNYSnKOUv/4NlmZuxl4iJoqZKiSOKrsmirPQWw9MJ4Z+rCqfcSpcwvCQxkEIyL+/AhkYfqSZuEeqEmWd8OF/H/EwhELC5losjLub3HyyiURUiaUclBLNpMuxa5l2OZkZvY/2R9Snlf8A9Jxhil8vhoYyfMbJfgTgqkOTKtjPTZkVjpWxH7jhfx1v9WvfzPu1/J92v5Pu1/J92v5Pu1/J92v5Pu1/J92v5Pu1/J92v5Pu1/J92v5Pu1/J92v5Pu1/J92v5/CnGSF04KSmlbdy2xlasLISSR+1liX0mbh39Dn3M1dcEKy7DpLslE4wyPBg9sH6i9jL4UDLGaHBB6snuTVd+ZQvTXV7/wCCjF0zYtUcxKM2cap3L0sTq2LwQlbCUc8mXdHNlbOX/wAxXEezwmScc68CcJXcRTWL2K58/Eh7SZUOqh2IzTUctzns2yn211e/+B9Xjkpxgyos3IoWxKUkuD0LUs6S6IqVyKN2OUR+0z8N+5m3Rke2OR4wNeHbsJCq8Rk09jKyVYsrEbHDX/Our38Cxt+OsfUSrUVenc3IRn4dcegzpwbSmlELYyLuQrjZtJOxGV1VHNTzEruZR0yVUVq6LXRmXwT5CZOGddvCzrYgdDGvEVK8iGSh0099iK9/IsLXV764LfltPtsN0w4MtQq6NhMvSjL+09aiFvBCWwneSZIiTmoHVsi+42yC9N/Msfp79yHSpG+xKHwm8Whry8GB0szLdEdzMtn4OZ7vBsgmvcVNHYnBa6vfV6YcqMjp3/IkbMz3JKo8ynzZkfY5S5lpuTdpEjfbyLk9x2k8qR5S5mexlUETZmfsco1Fl3ITgzNTV54Thm89cYyuxczU7mWtHnT5681XT/8Acah8SvYcMzPC2xR7a6vfVYU7SWLoUIdNXb8Ve2Co8jNBldkZqHAk6lCLVXIPp12M2cySkOl3pJlwRUkOEO+40im1sMrY6qd6SOIpISlnMiKbSTU7mWuw0u+M6oJJWOanCadyK0TTyv0LNMvQ8LIzcWy8iFg4FG/cyNTBMQWwgpXprq99bQlXZlhj/FWFTXmK5DpJSsTsjc8yxlk5rsjh0n0+L3MzOyMtPyXTPLD2Zmo3EluZv3GWq4oUM/6Nrizbp4teDOEPDm+S5ys5jc2RZaHZseZJIsi2ha6rd9Vymvcl0tGV7difxUQVPyRFXcinmM/cqpqGmrEpuDlfyZoM9dpJucpmqqMtXY2uQ98PNDMy2LE0UxWTxHMdjPTt3OdwjMqowcq4ni1rnD0wuWw5seWo6jsbly2Ni5bCj21s6TpO6LNG2FNFFKqfdmeCVZIpbUQRT+NUNvsZjpIpsWsixLVifIebscuxYmo5SWNPc80RCkS4KMn/AOhXOWCxU4H5lznXKzLScxbZ4qvXOEMttjzHLc7o6tdkSy2ij21vRbDmQ0rjzkISlocfispXm8IZlaP01BlReDLxLT3HS7oZYvuOlstZkNir/cyamWLqGifLCamQcpTU0QjMmSTO2L1wlOHrhbRdE0l6XhbDm1+hR7a3bGzOo5sJV0cysN/Bbv8AjMpfrhm7F9hjaFXVIyET37EzDFlM9oFWKC5zbCdNP9nL/wCjz/JmUsipEqDNCIRPYyjTRzSvIWDQ166YHFq/MdTh/wB+Dc2Ntdi+HD/jrak7FnomhkVWPUVRDPT8Z+gs+xPCqceRfYuTcSoPpvY5UcyuyabM5nI/9SpUEU0sdPEIFQj19DL3JseVR6DhySe5dD5eUuJ4NlXvqipwNUX9TNU76LF/DvjLsimnyWur3wszmNz1wuct15EVb4XPT8T+ipemHUWscrL9h5bLzHVuQ8HUtj3Ip3ZLeEohuWZmoZEwx1t+x1FXcd9i9yVKPp1CaLkdjL5PBFXv4Vy2vc31cvyXuzyKal3Wur302ZFZNOOXibeZNOHp+HThUsEn5ifDtOGWLmVliJIrsjN+0VfY9GcyORSZ+J1GWs/TvULOzkJjcbq7idRBaX7CkbdiKupFXvgir38XYutNlpmuyIpsepfY4X8ddXvrtsQ98IZDvSSsIf4aFxF/ZcseZmoUMqpysy7Es5TKZUQ+k3vhA5RlSujlsSdM1H+pFX/hdii9RNRuixmdifPBD9/D6TpPts6DoLsszpk6C6ynNWy8s5aUiWRRhfpKI2jXV7+Dlr3JwsSifL8NFXtpqwWhYIpwqKcHopGIWCw/r82j211e/grQx4//xAAqEAEAAgICAQQCAgMBAQEBAAABABEhMUFRYRAgcaGBkdHxMECxwVDw4f/aAAgBAQABPyGUIX0mKJsJhG95S+/JOvbIKpYf2wDuZMke6PmKW/pNovzLe5b3DSRNfLnF2wBgHj06iry8ktzUIv8A6IGsU+IBq/JOnvuIjT/lp6/+B9J7/tP9JwxvuiHmGLTGL4Cnc8atej42JtlS5vylgoAhWgsWPxSxqm41hjuDlH6h2W8qbAyM+AQwPmJMQFTJdw/yeREFm+mFMCFSC+yOXNDaodQE578iJ0+I7Qr/AAmWV7LYCK8Q6vaIjT/gVpvniZgB0QDB+TPD/cIg1P0Tafomh/Exm08JMp+Cz/h5/j+k9/2n+jTfqXM+IGPMeiUOYy0VWQVJ6SFbxKwzaWrAJc3HLHVs+YYlZovsicZjUKOOan6TvBqHk3MG7j2D1NOTPfMxC1xDIwHTL6h2dRym4pjf3zZCMqLImX6StCn38sxwnD0W0mvdYjFX/wCeQHgnOTyEo8kOEgHTLynU5BDmZsKYvfzoaVH2S4M8n+D6T3/af6NdNgyQiLIq25pALHE8hsan3C6RtlZC9q7iVPkhKj5qhmDufcWFcYsrdy9bpi4Hwi0mq+IPRLjY8kVVlSxEjjEzJ33DqdvEdtLsgXJemUmB8xy+Zd4E6itMHcMEwBsIiuXtG4M+smPQbpLnp7AF45QVUCKLY9WJFdqA6YHzDzviUFrkcoIL/wCqHZnNw8QKd0SHDLBvM3EVSU+76T3/AGnuVwuLLaJxl/4lKcczF2RKsmW9MRnEiK6IBCR8ITOVKuuJcU2wdwyiiZFVGgzmLAobslkMzzM0Lii5VuWEJx1FkFDBQL9ziSXGlEXhyRJQlp14huUC6MBvO/Tlw6ZUHTKfjM0JdcTCrMGIzinslMGO/ZZ6CDGKDZLjt6CQyyo5J5HzNiOss763Ho3M3D5jV+LxEoWP3FtbGFDhmk/UDTSZ9npQRnMKYXpO2fvOOYCdD2/Se/7T2r4pUQNzMoYEuZ20xav8CKyYmhzHZLnGficInbFVbtlD2MyR/PFHVARvapXDV6PSm4Gko86Qt7fzLJWHomkdGJnBG5fZt6gDX6ZUjSpTHLKEKoajkRjqcdSqlSKdplcAzFY7fYnhvpP+godYU4TZLilcMDWFMtW+ojZ/Hrelw9DDSaXrS1cqcG0j0RkiPKwlCE08tC6YnKvZEZ1AbZ1G5htjERkvwGJzmN8KHcxYfg1N+26nGvScTLcROvQVzAQBGlV7PpPf9p7AtolVD8sygJrExZfKRNd8S5LXM2P8Md/5eDeeId3LcvqQ5lVVcDSRsy3eCNwOJuimUGmZAn41gluUGpQG5YO3SxPIOMZlxTXJlG1W19ADaBRT0J9vh6DXjj1D/EruSsHn0ZE+UpgMkTYNsUxbhkL/APvqxPJA5ZjpevM3xKPJHDywJa3JzAfNgQ2wJZksJcUsODECUdQi6fE59TlMN1XHpZrIYtZ4cYiItHAiky7gn0cTApMWahKad+v0nv8AtPaFbFyrmIgGuUL8LAqYgOJ85N3+TINSh0x+6n4UQS7cF01mBSiXiLZIygMSI2YCJBT1YhzTQzE8C8ShWWCW0y1EZqPgBpqHMAi+EErY35Eo5DNQnjVzIwk/uowaBx6qh/B6nZCV6D/2ecE5KkrZn76gmMtEURdEVRrgSnf6pQid4xNhpGY9sr5m7fOJa1n0RG+Q8Qaa3EZ9j6CiJsjJX8Iyy0iKyUrA0BRyS3BKskrQwOtnz6/Se/7T2GGFG242riKgaPMbux8RKI2cFRUXmb/8YWhPx05/cIL2TGmoJD8wiSMq6TgA+YqyVN2l4oVQQbRZbDJHGEskXeEGJY0MagWHEr8RxBTdMSgaHbEFgOBEZwlRGAjfiXdWn9TLxTiAVA3UOoUeik3g9SgM4Gmo/QuYyHNkdDj3uZBBWbH+JU1C95igt6eZZy9R1r8GJcgZRASZeYgbncZEW5qfhlZwa5ti9geQqIz/AAzPgy7n+uIAWx8TopxBDpMcRLPQHzIev0nv+09q3GGPIcpOGHyTgfWAIFGlcyyf1/kxPzNieQGeSRZo2HECy5RKlFS23o7JWvEO+IoJZP4JfLU0h38Wwjym9A8QJq9ZqYSfCYByFICCwh6mWWLMuCDoYVDxEzCGAeiZtuoWwc8nqhY1qd4ToRcx7DOEqT37rcvQEt6IWTp5IZ8BF31k3U+W4oOnKm4qka9wkD/3mYZRKzWNhtIg5vxHdRoSzHFJMTyglNqirUxvh0RGKTzMSrGPmMOAgzLxDhcShnaemfZERo977T2rGt6xNhY4licdEKO1cRhLHiZxp0/4zZD56FoNsxjXrWSKDuXBw9CFrMFeD7mcj0dTa8v5yykZoo84AuZm3iM1KbzGPIjPG5ptGIFWK3BLxyzLf7ErO3os7UZr3ISZIGX8wFCQJFp+4eL3fS9BlwtmaPLYg+h8kqwH4ItuEzUsOw41mI7/AFQVWYZnxm2tzJMGpcgmp3G4GqDHbUjFpFiVM6oOfRYJwal3uhmMu3yT8u9Bt5WfT9/2ntyLRmeEAmD8J8wlzDGGGq1wSVLLeHuWOmIqnZ/i0TDuoL/NLUdPrqPMKS8s/IneZoMFhL2IMAeTL8VES0W/MSi2CEHh3KNgOmGjCZtRTlt3MgdbZliDupeNAbWHU64l5ZUqE49kqFkY7vEHC4raJQj8S+fshQbqibzBDS3JEpT263iVq5qiXgymPeVPotgrmmcMTeEJAEEgnj0JNkVHnE8YAI4N2ZZ/+JfgsYpIqDA7YPUb5IATHMIwUHpb9nAVdEABumfQixyMz+D3/ae23qlSyQx7BuW2IKQ9HA7IBu+5hfLf+KplgZQD3CaGGIy9oxTEp1ntnfOPTOBcFUhgOTPozkfLNesrZ6diWyNzl6hX4HLDd7ZvyvEqtG24kKW6IdVOyGeEvKV630dBYrUtmK0YKJb1GjYXUtq8QcWiVRTfN+2o8E8yRirFBhbPMcLC+YTxXBCuRF1NXxKm1I1zKNlfMRFHZ6q1uLdspD5kyZd4iO8IfI2Iec7n00tp3I3Gg5NHcXYlfohCeRj7/tPbXLvOfFnokrW69cl1oi4tkdXh/wAOl7lolDVe0Z1gRAldXmOxeqQiisHDETZ6CIVsg0oG5YQ8Y9ABt/MSZdrlXSxxiKsx17mCdVFoyXoAYx63WIWGWFptlQfNcqKLLqdsEaU8y9pHPHqMgCAHXWYlEZJg0kCMJQw59GnD49t67jwerglzLLZluWEp0h9LffEdMmMkSIolDAxne1uZRQq2YQ1TK7jnRwxy/NuKk/BL5y8Rwmj9Q0iv/wAGEpwbiSlKUSzumj2fSe/7T2/q8f6Js9CA2xvxbqvTI3/oSzDf+LfEsBHLbLwQ7kJ4miKDpCT6UwDZqoZC1l2wPmLREvcUFBczUL0qcxG2ALxULSxz1MbkmbBgfQtsIAvIl+fhG7rxo4J/aAwRvEaNI9xjiNU5znCFbYH33UsekoHJKFpgzDlNEdzrRZfHpWLrHsNJ2yoJd0i5uEV7viAaK2F3F4lQm3BMCaZf+GWcy4rcygr0Aqk8JhKHcGEQvM1VA3qL1HVCpmfL8xqJhHBLUxc4qCGDo79v0nv+09ubnWW916AFrS2LMEyw1vFGfTiS3B2wRVuH/BrOXOH1wCXLoOmOSpPWkp8YANrGIlFg4GzUV7EGmD9naZl8mYEAtY/8yE8+CWoy+YM8TglSCNMs+Kf3OBEO+h1LClrRG4EyGHGYCC46JgCX08yljLmZ6ZTlp5JcwW4qplFTqKrRWn2Z19ykuKD4TwQypMS2RoiM2suTHxDHffMoDlv5hM5G+4kCr4lYaYxDZOUsDkHRUayWzXBEiGX1O5QEDtmZc4zUC6Z0dnc234oioJ7PpPf9p7b/ABNQKq9MwNIxNBDCQnuy/W2TOvxDM8f8FR4T5kRdiPQaZVvEIR6kzWHZKbYNS/m2yUfdehUwPiVu8Jm0XEgs6GgjrGGWnyMqLXLg2Q1gUjYfj0Fo1NsksvOAlpgYL8mYImW1z4n6G2aapiK+CmCTENQ7IlNez7M1ljgJVh2zgQYlqJJYtoV6VMz/AMh1w28QBnrbD5hMTFWOodiSBUKvHMpt0an1DIUbtWvcqZDnEppa8EWCUFstw3K+S1ApklMDEC1/8ev0nvUpVbnP7XP7XP7XP7XLbLLLcGTLSpl/9cG2s61DCUvJW4X01yQsucJvP7XBqA5zgb5wE/tc/tfuqbTFaQz2hh6viCvwzqnj0SDTz60EHSWMn5S5oUOJYH4g1wk/bA4jO3bjxBZCbb2R2gzKC0UH9opxZeqZVVshcrDmYoumIBGYCTCUzNZIKxqCYickbtA1OS7XcW1URaZJf+c+1rDbE8gMNBmtw8zA9vZHOJm0pKYyt+Y+UIayMSVbiFA3hErXJzLaS09DBQC6i1iqfKhN1x73UWnbKCqywqyTMxFm5wHI28KozjjueDT/AL30wxeTQ67/AMPQwy0O4JH6BLXhBtthR9LiBNnEBaCrIyhV7gCXvmAJsM1DIY1Uq4s7l322RgE5+oiCxDNSAyjnM1lrWsfQ2ehcS1IYIWq4ZsmQjApwV1UWyg4tA9MqAHuuYGXUXJ7h/E+z4g3KqsVg5fVmPmZTLEAeZuizdqOol8C7ExrVOYIbsPLx6AFDICtDMWYfcrRpEhDD6El+WXTDuNMGrkEXClxQFBR6P9+pWxqDsDzE27+vRAEG9yTGmHJLpJSfnuO/S5m5cvgr5gp5TZ8ZtNGhlIx3VQlYY5IUNaIN7DjuHWNxuarAB2dylaeAXFjc8kS28EgI0x3McCpYAEZ5Vd9TkHw9Ao4M3c30aj7K8eiWc9irnBAhCl4gFrDiV2IGXEAhuA09pi31NWrf1HICBQDqAsD9wXhodR1oZZktmZPz34iDnM3Ee4pLeUOLu0NbrLPqe8QYWtP8z+5fzP7l/M/uX8z+5fzP7l/M/uX8z+5fzP7l/M/uX8z+5fzP7l/M/uX8z+5fzP7l/M/uX8z+5fz/AIf3zeoZuQ9PpkbCW7uGCUJvj1X5YBxA2IuU57ZjgQVIxGkeSHFukwtjpqTT1KkvUrRgwE41Q61VuUi8nuHQP/eMW5ErZgm3DguH0pG5G6gB8JaiNWcR2fj2OkdwlFbXsqDLqHwsmaQE0du8SoKBzGW0cR1dq42su3poBLnSplU2sU/BA4FvBPIEVZ1HLWsqDggIMPDkjbnUsPMoxB1PkVhtjiaff9p/tWb3CcbHuJ0ytMVrPS8Ww59bm2GqQJSHEDwtzD6tzDRPU+OZfaJrLljtGG2ZXcZ3KqnUwJdot0ZWJc7fMsHwRr0xVi+Z5+0RsvLglB+4CdpL7x7EP/M8ASMpXN6sE3GoG/qX772E4ATZGdc+jMDEogURRRRytQXEByi1fZM5zN739RS9r6LUgb9MVcE8QopJcafM532e4f4RXJdh5977T35Wq+Ynwm8P9LOXGulIqL8Shr9Q+xxLAGfoMTT0OPQLUAbDkhBmUmxZgrQqfqWMg64jo4TXEuyRV4OytxNlsuqenAhX6YXkVcEu+iKPm4PS7fbFI/hP1Yeo2H4e4rpx3MwXmxzp0RgO5qYc+uZ9NeCX5k4IYwiNNs3GIwqFZDs6jlbX2JEzxcvMkYYKTnL0W4lOHTFbe99p7kGf29yn4IduUfE2zX+iKNkccsqFKaY//Eygt8zkeVx20zXBmb0VuKm+PT8FVmJm4eGFc0Fdy5ecLQF7hGzsPSQUnFLlcRyGQkUw5nYXcJn5MaDEEwBtgrYy/WxQD26pfyCK6vEo8YwvPk4m/ZRFYX/EleYnlC3BvzBOxLYBFG7/AKTgKnasO+PNNLd4Sgm7UwE67OIBXrrk9EUpD59H1it9j3/ae2jyTbpjiZYNsOIfCYHRubVBSP8AR1FbGmcQnIR8oz8TAhmcXRg9+ghJNL6IYV3K8J47igwA2XUHyTzPzKdlvENezG2MUApzK94+KXcEOYKsXcWa4tRenadE+4Q1NzDUI/EqtEYqsKP8URyH4j93fkge5+IdyC+IDtcxwCftA4mWq6glH+o7iU7QFmKeY8kaOGG4h5lvgS5Wtywqw8zsuKUfzPpPf9p7acpU7ZlOZzYYHxKFsIDAFuJWHN3/AKaWczMNx2yBtTjXxOQUdfFnBg+YcW69FESp0tRxYocsqyUlBKhinJOmXwblQrT1Mk9S3nCN81THsc2VZ8QgVSrGJlddrBq+THm3vvUBZwwDbBMr1B6RJ8UR6m2SbacQj5ZlG+ItYKIVB3Er42zhAS8Nmf2MsMK+JakbZKdfSa6pOuhZSSHhng8+/wC09n3o9EgGrAl+0BNxbB4TJxd25mrB62GiVsZ8xDDHf+ltE+5ssIg8SvNiSvQEmhp9NAioU+jbunJF8pn9DcFI3UNBScjota8RugjMq3LGYzUL6LZkWkDaEM5tnhnc345IsxQn8p/i86eRPPnmz+6n93Fd/sinaxjxNYEOuBMbjgzt8EA7ZbxKfEKI8nojpzG4QXmNvb/iNev/AKlYbmB+Hv8AtPaZtzNqFzMB2kUaKYWyQcEvH0h1r/Sdzk7Jg0O8UNX1RVupg1ZFi/lMljXTGRIOI3eowUl6HkfXSMdpTXlf6JbALl1MIWqNQrsviBXnwgGXb1Eef9J3J/Ewl4IvTjlLyQlnn4ErgQfZKY4z+bEJU8f3C9M4SoRmmD3NbTGjZy5nF69/2nsr7cycl2FhlQdQrtjF6ECZD8zhn4maJgMTz/pijifEZoYqcdv4nGGYRFA6UoVR/MF0wxX85bPwGef+50L9x/D/AHOdIxwHaJTd/EtZE+YfR6lakBES3OV/My7mVqnmVlv/ABOkfJLnOdn+VFRuUcWy0QdseoozvxHi5rLmMCEpX98Hh+WbJRIslpr1zqzoGIKV5nUy4siYF+Y/P9JHjx1HY7Hv+09f28ZUP8yrLLoggcz8yvctnqcWPXMtdvrkgXxMm5x/qt8J2orllYIe4LwOJ2w7IP4yN+QPxPAfqci/iC6w8z/kUIsXrODB8TGlc2LOWtnjD0rCu9TVROIU3CxVcYfIH+MKo3OUZQ7GXwgPmMoZti+DiFHcRWr9DSMsdRsn1dMzhd16I3oFqBy6occzUN7PtE8uU/4I77T0xrHJlIoAbYFsj3LMlijyRApsX66oo7Zlqt7ZYSqj4Ndf6w1qKQTpgTcKNXKMQq//ADTKH0TCX/EsKFFuUvnKZzX9R/8A7Jy3qaTtmD4KJT8sVmkUoShyM6oHH+K5GssCxgXEZt2xFK/5HSE9xaP0j/7Eve+Eui8BxGShub5BVssth0SjC8oqp1LyI3LLqu4WZOJeBZMi7Lad/T6b3/aTcYG4YHRLWkScP/fruQILRnQEpMBM6lvPoN/X4JfMDg/1GeIXOYo1Eyy9eWgukvFup83pBHCdJnXHxHcT7jR8zCQbIKq/RzndSwH+HCyuFRSZPpLnM8t5YY2f8xVbdwIBtikK6lzqMNt54SCdYiBc8vU0r+UtQA79giWDlMVD4ld7ptqYl/JPo+/7yIGN5ijpG0H/AH7HsMdzKuXuWhAQ9WeWdT+IjaV8/wCpiIQ1D0UTDR/oqyxYPEc0kTTFxhtqxeZdxzAktA9ZiKpPbrs+ZS46isvylwRo+UeoQtvm9RbbfRZ5ZA1GF2swuEslJRDuZ/B2xLTPXtoDa4pgvKSkaPmbZrkjs9j38YD/ADG2VVEKMevOQdw+ZV5ojlC3fEsFn+uJr6KxGG4FM92zH0xtuITT+Y7t/ExwLsfpO9HhiKgj59X5alb+iBWO91OBQbTFROT0CWKFmz27VUFblb1DFtErSZc9TfrQsOWPX6ADVnTRc5s8R45kcB9pmt4Mpr7a9EAdTqKdHD49itfD3h+ZmUMfShFstmTp1Kss/QgR/i6/2jCKIhjSfY9HKKs3SBOTcF4/xcD5gDUF+CUwURSZeZXZMGb8ksFV0zryASwZp6gUG8YxNL+COGXlYkOb9kWFWyoEGYQPQvj11+iVQ6yzAvbGkFy59QvUOaQ/if8A7M//AEfStL4gmn8sTkLDNSoysM8ktMLqWt4pzKF59C6DgSjNTpmfrpPfU2l9EALWF2vbANs3yOd/7Wh6BBFwHmHLZiN/CCMAIA8w11BaCwTgQX8EBueOeGeGL6iGmJ79DhwvFy//AGPcKhrB/KVaw/8Afq6tHZFFiOLHfpFgh0+Id5bslMJKHr9KM2w9Kr0TXA/cTx9z4IckImUDFXkjLYIFsbuyNkXQqIHtxFTUrQrtJkHJFa/ETEJce1YgTmUv3ox7elarP6hVkI7q79/7tMt3LqIko64g5hvfiYlCnqJ8QOMmdEnG38zDUSQDDBuPpPK/qf8AsrHNHyQE3i+IpQb6g3oJmMk58wrfs4ZlB8ncRApPRUzHTAQwmXpWD6g18EM74mN+4CnieenECwHMMiz2zRvlTIbe4ZlmqV9MWpsgeBjvmYXTfDkTN5pynIKA8Fx9Oq4m5Q7+JRxUwNzL35A73yfxANiu0/iLSpwHhJ/an8T+1P4n9qfxP7U/if2p/E/tT+J/an8T+1P4n9qfxP7U/if2p/E/tT+J/an8f6QjTHnS0uTTDCoqc7PBHz/SA4IZlqF538Rqk8pjlkt1p/M1AtqHH5YLSJwswxIyvQocMprWgDdwTE7kdwx8R0GP3N100XPFNrUyasWXLh6FJRv1NiZn4lnBSdk+nPvQTWaMQemOjw3bPsXuWBvlAc3NEzkoFtRS2vggAS+yES6I0tUXDYYc5mUjUdq9P/lO4Ro7h6SWqsmUOxiDGL/ggTJwj+SWLXxHpxxKlBVjrWt4gv0Nw85NExaV8ZU4THYz8xwnZ5ng6G5jgOOSX5/iWHMVQNMvuFv6hOn75AM4VnpX9BVbfXTHn8Q1HaQoPE+rPvSktbXxKFAavy+8NNktp8wWRYarNwqjj0ahameLjtYScADQQZmW4EyOJ9J/8luYlQPEZQMR2qglwstX3He1u5X6KpnDTmFHXuXGYykgOQl0tecS7f4jACjxNJWmmQdzGyjuZREeoaN42l8PLmVCXccRUG+pihjOFDgYdLhg8f4NE/8AGZ36n/KCz8QUD3KKsBIdWy/4FEcQA7nipzBz6fS9p/1laKr0Gld8hPpPeYSq3/wjGMYxjGMYxjGMZmBljID8ysBGacRe9f8AUd4jJpNTmGUdxgyihlDmXE6lwqpiiCsniLBEQ1oSMh6ivhNHXglh3lTHhCdBdS9P4hoOYHlgphIFxUfv0Sh/EJXyTJXyqURhZjKVc4jCHX+JyVX8TdKm0vaoeYpqOYSKWxWTBmPGZPf9p/8ABxE1iUnbBgSsB6dx6v6ga6VH/wDXMyi+oJWpMYK8TRs6uXE08zSCOIwTgnHEu7Do6hpnzscpY7uYT+OERVOE9K+OL0AChzCIOGc8MMxDk97oYMuC50xGVSo3OJd/8Yiv8zZ8RLrwLUqtQKDyplnrtHU0gZ8JAxCxr3vtP/g5Fhna1CGdX5ZZY3V3KW1knEmNq62ssli5LxKeYSpXFalYlOiagWORPxBMI/MGVPRLyn1kxMPnuCKFwxCXpM5dviKb3D1qbPiMqvxKEXMZvvHv9DKmHgMmY2jjct6Zyl/WxKVMOH/FlO/4gryBFE/KXlp1TBYYKvEyr2Dww6lmcD3/AGn+DVIhy/165MpXXzL2tsESoshRhkQqyk2RU/8AaQgS2JtYd3EV47hd6CEAxj0XDtlBcJBY8sv2gSu4IBkEZIBzLkXC/IfEab/NSrfVK5maZewu8xoU3+YZmmcKbTufb3vSKcLGpdswOgkbrTknfnESmv8ACw1oyx2ktlWGYX3P3LrJeUJvysAxQG1whMfzBQ+Pf9p72CMEMRUL5Rfj/q7HxKA9DkWVUJI/Imk1fMZG+dcQdh3FOQ81LXymNoPARyn8ks2wywuBdouwWCIFtTGhKY9Q8wFIuWioqLNArmG4bcJZHCLkopOAS6Bb3Uor1HxNx6YqyVc8kRnlXtVBjjMWb7lCRiLNxuw3jzDJCC9gbJjD+f8AxTegcz9aoaZBMkOxuMbk2h1afSbsnXv+092QdI5KypzDphNe4JEc4ZYYKa/1Mg9zbIqdYlZ3z7lyRqAJoYRTkh36ZqZ3TmWM66i2T0gLiEMHuOJ8Ie5EzwRYH9cWDUAoEzcRLRro6dxVqxCv04IwppuBtOXNpN6izF9CmV1WyAB/czw6rMG17ZhisxWPIlMrSducp+I3L8tQEZnJLAD1PeYOjFKiYrqXoMZRdLDqac/EexY9aO6dR9D7/tPaLBCRGKPBAigYitgsoEM1dTmyt9w0/wDUshQfEfAEnNyJMBPIkzYHfUHZBxUzrUtyiM/MXR8GZ/HwylgRSMmGXmnTj0TLySdy1Uyuo1pr/kImmlzBds5cBLeG2fMoJXc/UxG1qdVOGIYtj2aHLcXzLnYyPQGlMPNe6wi1CXTk5JW7himJXYdy1V09QFGqaNL/AJCPzOk0FTi52RRsYnTL4Imf9QzHEA6jUws2NUQSSou0HIWFdxVWluphYzDUpT8yiOPe+091SeIUHd4lgaeMy9Woda5qM+ETm/0xYJYL1OAeF3Uqbl1NqpwkjdHCJ28iIoyeM6j7GmI7Zv7zLE9cqdJThxicgDKs6SMEx7nUCLdXFSxUDAWbRkgALlqUVsNTfdxNgbuCzhFWVQxOEuRHCiR3lRw17aNiWfMw+Saa6dyt9BGwGOGVbXiOfJbvF1BYBILwjyb8Th5ES2OKNRzZGqiY94csqYETCH7mp/fotWvj33i1W49wIaMNMjcvgPFlTfitoXKjWy3OD/TFCADoSk+RiTEhLU8dREsdZoFyQso1uXsrjUogOIOX3d7hXa20Mx/SEBxDtm2SeYSjfBjI+FlBwBlGHEyjyS1tGo+YhTFYmQijcq2ky00ovmC0ZTYjWYp8KSsWKdTUiqqnaWmX2mw4Y3H3Z7sdyQcNkK3wzLP0ZVKVlMw1fExlfiPgKhNtMeNA8hPE/UyZV+Ii5x6nOR1UZMTtYrhjuZZ3MbCM+k95yO4xkRP8JxocrRMuaRpgGiW2YVrCtEN5ZYQu1TzFsIttv+nTbgjt8T5WVARvhGgZalo3K8RsfyCpXFh+5jhdShubJDDKBgmhA0Ifd2yG1U9RXpMziOIBe+VzxGVCHJAHC7xEgbdwaBB3pg7L8ZqC2CkFdwWvOBhgcR9+SlHEvM8HNTECv+sYf+yGFsx7vgZfCDXgxiQTLKFNRjmYQTJeCLYAa+kEZYdzBuWX8y+zHkhv4ds5FYDXoxZU4XT3/nE7CJJZzNgGcdP+6zan5dkoNGohhay1KBmoQFWDX+psmVo5CaLdz4UqGgUHcrNADiFGViNe3UWw6HAhWQXMTTS1NG4Jb4nBmcBqJjsGFKpSx5hzcR9jiO3HOpYdY8xMDMCqalWl7gWRbAqd9kRAR3c0Au+OJb4eJVbZAl6BLlHcmKYdX78zvEg6mk6S4zLs7S0c4iHMY2zDqlgp8SxRPxL6P6lG1I7Rf4jssIBvC+YfEVz6lAtnw44vX3lfMieILHufuDLHDDNncKsYiArIzXxZZS36TDqneLbf+p+YignUI5RDKXKZnsQBLzqbmx5jbJ56l79EwHlhynA5TFO7Bw63bEKyH1AmF1mLGdYYAqxwRKC11Geh6QicK2xSiPFJ+GAxxweGapFcXTCRiK0N6+IbJTq5ZWXUVL+Yiv4IaZWCfDL2UvDAFNzZRucKJutmZRVJsZwrTF5iEzPCCPRU5mKygPhLmBGjEfVxItgSwjbEYZUEZ/UVv4e9whuYnL49NJuI8svL2A9Ope3OmU8YiwhqVmEInnPb/UVBmWeJ+4oGWyeZNtL5avMtcQldFn9QC8EyblD75Jm48kHLVmtgQ9GWbiElgkDCWLYjTyZjna1ESv5JVTnxKhwGSXWAO5aDhTiqcyk18xnwRqjfbOwc69NT4mmsY7k+89LkPqHo+IG5WK/CidSuZTxZhWWbKl8qHVMOmW4nIg4pLfMOzCieEVeI0bRpo/c/OupXr5p4zj3/AGnpcmIbAfkmhF+ZT6hnJDaEDKvInGXR3GyNQqhE/wBMYCYy8rL0YgYU6LCQorMKO8DrLXMM1edkoUw9y7OYLIcJWTDAo11GJZ0b4nM7i1hksI1Uaiv4/ChgDHknLSuEWV1M1w5nIvCcNGNPiWfVMyH83zM3salciotuGCaErDPt/SqoZVxgTNmn0FJgrSIdpdZ1BfME8S5zNs1KvUKYwR5JfYnLTz1MuJSMDlQInzstagIGsWe/7T29a9MLrr5iK38RVknyncfZLUANhMiyyXLMr/TtH4mtKl1dkoF6iZCspp43CZrucyWmW1dhWZUwxLo/t6D22AsO4286R/rEC0fwx7u6Ryigv4YfwvcwA3azLZ8xLZp8S5yQ0QF8S/pNlxADmW0IF2JasDgjO24uNWV6A0PR+3hv095lKPQbfj2gcwXIfR3j+pZsPUOXRgvgIpzATArAg+Plg8gECq76EzBXSfSe/wC097mV9Ga0+UV2ag2CZq8D1C9S5WJwxv8ASij4ZgK8RkHrEG61XzBbwQ5GaYPOew5jqkrxFwbbuC6ieJawheYLHG/M7iRoDDWISjA8RlupjRvULSnifpiEpgtUfHMs2LohoH5S2Q9R11MEbn9yJ7Oal9IiFhbh7uHMP5FxUI1g7fa9AuiuUIypTXv1BWgmrZ8zuvwwd/8AGebFdPlnSPxGj/xjWPmJ5sQxDtZU2vBHbfysqnxBEaBLrEdxVWtspHHlCBqFe/7T/AKrGmf/AKIyujUZDLAtbO4nw0oeX+k3fHt3L/0m75n3vW230OZ9L0/oz/rmn033Jp+PYt4z70+p650z6M0PZNibej7Vp9Q976mnsNE+p9/2n+H7MZ1Zun2PYf/aAAwDAQACAAMAAAAQwCh/9CAWeCNPpfdA1/8A/wD/AHW5/wD/APzDHbnz/wD/AP8A+gAAD/8A/wD/AP8A/wD1iWn/AITjx9WhCYf27I7/AP5KOO0/xtgKvnjPV3//AKAAAP8A/wA71/8A/wA2n1lK+dZuy8upOf1oa7S/brJzc7qw7Cdnr5ff+gAAD/2GITX/AP8A/wD8h7ZKkrKfFJ9zmV/rhD337bQqNmTT0oPEKX+gAAD+lBHB3/8A/wD66qCMtKQ2dsY+xkO72qP/AP8AY8v1prZAbgqDa4hAAA//AFsofP8A/wD/AL+XqJd6TeMnkn5xO+Y42P8A8LKohY4Au1H6O28MAAD/APB2h0//AP8A+lJzLWbW5LKXyT7CifV73/8AIdqrKp8DP5nu9soAAA//ACLdH9//AP8AquqtfknCxs4TQQuqDtMV/sERx5neAssHOx//AKAAAP8A9i1t07//AP8AKrxPxz/B/wCXa3mrmJt+7+kNEq8OXE1pB183igAAAABNFILED/8A/uSYYcl1q6Skp4spgWtS/qW//wAi/wCNHKAJvz2kAAAAAAAAAAD/AP8A/wCzpgzu/bKAhd7kFYOCD/7P35l4HsdTyfIVIkAAD/8A/wCPP/8A/wD/AP8A/wDqSsxZq35vOFPSwHSO/wDGbdjen1BvvrZ8TKAAAP8A8K7jz/8A/wD/AP8A/v8AC494Op3HjBhIiJff/wAuOJWZUi+udHxsugAAD+gkO7rX/wD/AP8A/wD/APyIkkst7LSYTn2ff/8A/wDs88apXFN4ApV1qAAA/wD/AAlA1H//AP8A/wD/AP8A/wD9BAAhDXr8VZQx3/8A/wD/AP4j8v49WpurEIAAD3dnM7wf/wD/AP8A/wD/AP8A/Wu+XMdWW7+y7anX/wD/AOa801T+YVrZK6gABOzP+PyHf/8A/wD/AP8A/wD7jW1//wCesONLRFymxdf7K+RLs0suPv8AygABkzRX7/8A/wD/AP8A/wD/AP8A/wCqCG+54op3zLYd/QhsOz6z9gvmuYrWYKwADfMT/wD/AP8A/wD/AP8A/wD/AP8A/wDtf7+03rFvgWBaDcketGHYRhzvfu9nOMABDBLDDDDDD/8A/wD/AP8A/wD+Z77OwhG3Pt0m33/3bRzWZP8A/wDalxHuoAAEAAAAAAAA/wD/AP8A/wD/AP8A/hqS/KbwScNcYR8//v8A3avv/wD/APARqAJAAA//AP8A/wD/AP8A/wD/AP8A/wD/AP8AxKEh+KbkhUu7mUBT/wDvpZEx/wD/AP8AKXlTqAAA/wD/AOFD3/8A/wD/AP8A/wD/AP4kyT2QW1ur3bGyHXf+2euV/T//AMtkYJqAAA//AKmo/v8A/wD/AP8A/wD/AP7waK9SpIc9CjKlFk+P/wCQOu8ajQEVRiuoAAf/AP6lWi//AP8A/wD/AP8A/wDSjeaG+crlVUz5HSzO/wD7i4jUbc8gk6SigAAP5Y2sZP8A/wD/AP8A/wD/AP3Qm25QmSTHbHmAf4qNf+FL9NAR17UZgigAPUSEZb3f/wD/AP8A/wD/AP8A+uG10UfqxsBNW40vmlJVCzbgSkwiNC1CQAAP/L5hRff/AP8A/wD/AP8A/wDr9GxyZLdz6vb3bY8l47uP8E2aZcAfCYwAAP8A/wDqFLJ//wD/AP8A/wD/AOF7z2OIAJyD5x8Bx4F0F1z8APwJ54D+MMAAD/8A/wD4H3//AP/EACIRAQEBAAICAwEBAQEBAAAAAAEAESExEEEgMFFhQHGhgf/aAAgBAwEBPxDVLF1m1afFDth4EPaVvEKc3fP0K4Wpw2KPwXJFixAgP+LpZI4uLvwvRYQ7HsSeTwGuQ+F0HyzYSUORMMmOPgDq5XFr9lQTbGw78IP1ArhBa/IAYS2b4wJMLQZf8ReUkMYdl/Y4P7aOvzPk7lId5ddZ1wkeE6yN/EF9McHeoRRJ5fT+yMWydLX6Dm94rpuF+1Pp5LbDLHqBy1haJapkTIDwJdrIbI78VWkK0UyMt+LjyOJTgeIduxzn8cbrFxpif7aohVtr88j8T3PqQRdPXq5r5HjKcmSZyZYc+/G5wwnkJAwczlPax7mGd5RcN+a28zicEz/lgx8kFnIR1jqBhgyDV1e/2XvHY8QGsOny9y95/IfZvUP2w7z8y30kOcjXjq7iw/pMos5Irra7sI1Rw42ESd+IOng8hrsaf/kn1Lz4WPDMcMAmdHU6hPZx42QxCLOh8lBHmEw4+R4eG+OY4kLoZYgJGBHYeYtYRosACfURjds01stvMcx55a/tv2wJDJQBafHFxPaF/ETgthqjffqdcsfdhy9ybHy3Vh93IBYclk+DHglMJf0kN2L7Ibh1PA9yq3bN16geZi1HY3fVhsPswYZHh6hrFvPdkxhgsxo3PHUYO4k94EcRDgtE/afSGMt3ZcpzPN1PifDoJOTq3QsQyIre7FITx6gJpOMIHbP5HN6jx2eDz262SrvAt+C61NiYuLjFDra5WrXok8ICx3Pml1P0jIgdzO9fSjBt0gyFDie6jJZ5tRev5KahAIEquSyub9JgxvfhYo+AAe5DlPy9EoUT46JU6zvfCDAtDiTtBpnv/DvjWZNg8A/ppkUhdmbes22HXEGYwjJhyxHg6iXjiocEsGaEjORHy2MG3D5d6IjIlpPfzENIixPsAqJxDO4kFxcHE4cYyAckI9wZ3PdXfg8PXiK7sDDxBYXYXC+obfnBNkd3I4t2dT8gP/pY4aX7+kxz6c8bouN2IZvNqUlNieE8W3PqXBgww+aLOCT2v7WnRH6guLbYc6stT5DXIcH0dRY2510dRKfs66t/YJ5ZOueoB5bFMwAzx188LCwuDxtlnnjwfMY7D3MiyQPH+DLn4hdpkyz5+TfhkEvtDJ1XDChxPyYJA4cEi1tu/q61B7m2WWNzZZZ4O7pIlprcF+gLhBs144wBvZc0513u06vDBmdfFg8aDLuz6skhOQjF+p8EO2/rC+4D0xwwsjdsCEfpKOJt3hnysDb8O4ZztX7lhtszcmOXqcA+DBbd2fYYrGFi2QAwHUq1WlvwMNOQD+pZxZG3oSVnH28e58dpL9L+VxtuTzJ4/DB/JKac2YCT35fHf38I3p4RvC6w2B0c3QPCQ5uorRbqHSQ8PEK2bqcObYJE3Z8F7lw2TeWYfln9n8snP4xJvZY9IBL1ZzZLrvwyz/B1FjyyJrqCHMkajFjxPY5F+HSTyLIPD9sQ9WfJbmMF039Zd8kuMtG+j4ZpJqI8Mqx0wwHGf5cjIZyx3GcPSP8ARI8e5cRUGdWlx6sGq7YmRWdB6kfjAePSGD48FYe4EaTB4uz/AI1yVVq/5HHMYAZO+tIeRtGrHQTbDucwPFuZ3IB7m9I42zcfg3d0GXGfHuyguAgVnKL6FevUg2u59RT9WROV65h1xJJ6g4uLjouNpwahvMBzAR/ZA9cSaemSHgfgWemxWwj5XDfAyMcRgRHr8y9ITCHC3u8aX39SyDkkndizjMJx1yJ6P5GxQsYDwIlE3H0xiDwvSZF66uYM+M+Jzfxlk0dyC1sk8LQRd5j4PnE1wZRFc4uAP1cgRgLy4/JgDzZdnADuwbnuBBQndyRyAn/vABzMIIHCXIxti7LHy398bLer+MAdFzdW/JzbMdELshO1+o83ch47cEe53UXUQ9AheLw2n7gc11PkWXHueGJY9JqD8gL+hbnlr8n4N+G/Js87zIDPv6+ssZH1wfkqpwy266jIY6ThnrmTDssMGieRnT4AKJ7QcXRFY+jxHUHc9GX8/wCMs+OXXcnqOvjlnnr6hsUcbaqvjzIoHdzP0gIXiQTCPAhcU0ufB1Pr7se2WUOzINhlLLTfCh3ae7f1f2t/VgkWr4tH+yY/PPJ9PS63bdy6/wDt13ddF1XXdnxe12xdcwvSers8hPl8rtdvoYvfj//EACcRAQEBAAICAgICAgMBAQAAAAEAESExEEEgUTBhcYFAkaGxweHw/9oACAECAQE/EFkGyZLZFlqAOcvqykIrpgTu31ZnVxME8ydh8QmYxx8OrPjmzaf4Ycl3xBowwCGjDL0QHBZ925zdtG12hO7+LoOGTt5ZstHnHqN8DMLhatSEQX8eX4psnhzz1XQ+oW2C6xsjiLF6bLmeMhHV9tynEGPd4YeG74TosM3pEqW083syLZHcro6QBnv6jU1Mur7/AMKrCRBOtfPv3DU8mu8W3G2NJEbrnwclGt6zbABki4sDtvZ1AmJNkQCeFpbYnJYcpzHDH0hdw20dSPtafxApItvmmmX2DNCd/wD7mTZ72Ovid3UXAIGOC04vsWvGf1HPNg4YF08Rtw6sdZah6Q9L9pFpCJ+mClRxHlbHWfc90dfcpzm2s8TDnifuzW9p1W7/AMSkTmHCdN7JieO8uG/MpotnbEtbv4nc45slbHaG42wOY3AbIvpkHaEOGQQWHUpYIbyW/MN6tSXnSQw/Vlj8AHRnu7KwNRudSa4JLz6+7exzGOE3w8zzgi7ZDiOvk4BXC9VzZ8eAgDLru45Z44u4oYu2/WCpC6OE2EdbToxxyzwtRyxDHFzkPMn1EZujuAf9FnY83M9PVvHc8N7sQj9ae5ddiy5fwLO5IFm2XJLT4zZlw2LsAUSMNZnM32pYplCkBerAdWhxOcR1xfRZ7ZWUOSfIy4Dw3aCfS9TYK4X1awJdt2WjyRG4HqUXSi3IIu/wpCfskx4a2z1PMfDCZdPC4mTHI1vOB7LOe2wX/qEDJ1IwkDTuTHGBSui/duNzI6b9eHrxMBXLG4Dktm1WdtJJT3Jp6Pv/AMsi8lg4BBZsKfgSuwAPq4G9Oo0OZ078fU3pWi904sm3ZU2A88yAFrPLi5NwNoOEibCjJgk6Nl7xCFcOnwsPLl3UFxg5O2AGo/X3ChiRQsyJZeP8H0NhyQDGI1ksNmWUueO4Vve3vcs2DGMu8SLYDgL1N1fA0n45ovLHlYvq4AiEduuc2sTCGc3fUGyfg/dDv4RGpXpA2gnEnhIbew8y04kjXiRJlcItGGjtnPDbjK+xaOjmWDOSAtjPcCyPV6x4dYfd9jbR6k35quIRgzLPxehjtOo27yRgBCeMD3P2jV4gbD3L+yM5bl468CXXfgckOde7CV6L2X0FynFqFyjhnq6Hv5MYe7PQ4kC9xnInD+FjhucHrEML7LBx3INGTQa0ax6e/AGcJO3xyywmWF0PLcuWU8G/bb9NhaRM5J7+IbO45sQglNS4d3Hn4l6XAsomHZOHMJ6v0xY+2AObXjwNR9vkj/UQATrcISOWAfW5FxuQDerZBcW0nv4IsID+4i0bcWGMPGIwPxCQspHu80H7g9SpV78PcBcI6+Aa5BhiAGwHMT+F3bP1s9hZnG33BuEM6uYzT3H18J7+B6e7fg8btHhj6lV1/CsJq+NDPhg8wI+EtsseCHZN8zkQHfqZw1FsHqGv1dMgzl0zYrh7j2snvyXJbuE3WDeMq9/jGngxhnMk6l2rY2rViQiWzcVYYWvDdyInfdoyCddeLq8HpPqy78zaH+7LXEzI4R15yMryA5OufzAz6TW+rN8CNeWbR23G2jAif39SHSXqs+GdYNuTxz5jouPEcRdsytmfq3XFmf3EdPE6H3dGBhnwOIMp7/wHrBALi3IHi5MdC5s9oV6suazU5jULXt9Ng2+iy86iCY8dMOF0lbO/DQu3MlK6f6to6Rbef8U79wXlCXtcHpjwmb4GFcoyGElyN3UtDOkmsumyeei5m3fgDD48Jx01KwSwvM1C/wCGy2QteotHrOV7+ondbnqYoeo7CvL+rh/m51CqZkIm9TybYPnqvpLHGfufr4948pqywUm92ID+57+YTTuHevxdIhNhMDuKHaAXwk3blctA1ysyzjIM9OpbniLB0XFuwVxJjLTfCx2GOmk8NtunUO+VyXWNGufU/wD8XekM9/LNljOasKRbOH4nxDTmJImyIHiALjuvGDD2322k4nrLnO2xHH3aY3WP7ROObO4WXDZX7vV9p8Z5UeyGtJCbfxp9xNVseDWIBCGQHBPfkN87TmMcfdwy/stmfjZHInHn7kLwT/cFzyZBDfUfFznu1LUsiNLR6n17krayyCrj6sHIdMgSx+Gbf9T7QR4fFTu/VCdWxsALs+ezIeyW7IE5XLT/AOxFhkQH47wLv9LAv19xgSQOzIDwSneSvRTLrOzeJxGHr+p/yxsE+uoRX7uKLp86Tl6PHn1IPdo6tey16LTuCeMGs9+Vi+G7PsXSN8IopY/i6RyJIvZ+5AeW/UB4vL1JsNlD6u3vTwRlf9oge0RZzR2uyTZxis7DuFZOrAOO57jq+i1Nc2bL6YuGEffjiSiS8I+Ap1CO4nq4nMMfuRY/hGk5aQ4gB/vCmn7hIpxHzO0rWczZZyQ1Nb/1bPfP3co6/cPAxsC3IQjjMVUTmeo+Dz40I+jCC/hKZX3N1U4dQ6b81O4hPR9RjH4Xq9rpu27v48X/ABvC7/78DqXb+rpuv+Z9XTe/HvF28dvizdLouh+DrdUeH//EACoQAQACAgIBAgYCAwEBAAAAAAEAESExQVFhcYEQIJGhsfBAwTDR8eFQ/9oACAEBAAE/EJXiDb32x6kuO50TDhv1hCbTrcAHScv4ePjtjUdLbikEXg6ioWlweC1ysDJMa5joIdn+otQL6J92RS7a+s8z6x63vDBatPJcqgQ2CEbdwHd/WXLi9lMqHh4GWMZp37kojpCmmGWsvyip9IWyPr6DhEAImx/y+Z9IibK/n/u+vmdT9l2/wW4xc+kpwto+CUimIVdRJ3iHC6hg4KFTzN/Bmohh2SQydxNaWtd+ITWoEGouimiBL15swobdAzKf1gqMqp3UKzVxYU+kO2lr1O53JVdw0A8higYVxiGXQbN1L0h4RdwwSNXZ956vadxEpZMDFDPS6YSuxq/9zhyi6WFJBWAf3GFKzlki96O/8IQDbBF2ErZMwGkMtcQ47iIETh/wAUx5FfVKLphthUe7WVf7n+4hY3qrDq+hz8KKTMXvKS6fUF94JgvQfvEq8s4fXX+P9318zqfsu3+DgOooDOmhPFzqGHAm5zg+sxJzC6cahCOx+xBBY5eiKsMoL6h6zSO/MxgBPFUBhoTLK1KTMrEarSZRqG6EESrwXiAULENvaO2qwLzACS32maLW3Aq1JkZnZnpKexejjzCjBMF0kBATvMH3DluX0kwVSzuMJlzVA9IDFF+sXgaYsTyiJ4cPz5hGXUItzFdM7YJiFe1dfNdycvB7wAgOc7JQ8B1LQCvlir/ZHjEUpu9ZzL7zoX6wdyhOKMxR6kFqh5izMclfbUEXNF1SeCFUf4P3fXzOp+y7f4NhdOIoKvBGa4viFQ4ZfMxEEzKSAPLGFN9HjiUxNtqAsYKCMhD0eIqOg2GKHDwrmJMab1DdNxowh1BU0yCuYEGwx3BwvMKkUqGqjJnGvC6hUeDXTC5BwGh2xmAp1CjFmymWnBwXbK4j0SiUqarmpXSdiGCtkw/aBAeyO5fHxTgFFNkUQZgqr9YguGh5PrL8QsqIcSbIMCX1IlNPyGyPcCmNRYKj7gt5hCZaYjXKvkqE3luUgTD48+WIxlRYK/LuZnI8zcs0BfUjJXqlUVLqqgqZdIaQ6glexMCsPyIkoQAvDCGXNasYrSACjaZPR4hCxZdD07jlwNIlJ837vr5nU/ZdvzVBV4lkfCsX4OyIjSJ6/wCAURNkulF6dSuCWavUO5SXFsEtkKIzSnKMIBobYCJhVuVmYDeX8wE4WlQXDJRBcoFAEHgWCVcxwhQXlu36ymIobAdVM0aKecp225Q1CSxqpAqlVHLsjHWVSSsfZjtLWUpUcSoDbBS4gAAbKlKiGrl4eVDcxExs5IkaUQmjAtdV8BQqfJEbKxbpjw0Ng0y5BThOUZJ4MdCFNcRm2/rlmfLgNPxGkeoSE95hqIRCiS1W46TqI5tX8LQyYhjV1jiaXlVo0QTUPXq6OD4uYaC1C9iL5S8KnBxKvOyFZEZIuVfcV9tLM3ElGbWxBUsaCiCO3nJLCKbqKDe1iAIfdC7AzAY9UbGmvD5Pl/d9fM6n7Lt+WkGBthAIdvUyRubuLGD4hGG/YIqWuHv/AAA3pIB8IGmUkMdiMdaAOG5ci9Jljl1S1hEayEcrOFrmKFLLFzrJgXiHklKnBBNsYLQakMYJvYbuNCF1kVB8othiNImoLLXmLgS5GDAQMrpFuyMwQLabPMJm+AaJnJRVmo6ww2DVI8ShhkvHHBGSNWI8oj8gQ84/qcgnCbfAdSV9G4Mez5igTsdxdG0tXMTpKy/6Rw0/CpGGwc/AkoK8RlV9fgCtG44HBNbPEClLFL14lzAaf2R7Yz+ERLkyaJVdSqWtlSpiXIcxVOrvKjqUUMloI6RXQ2xRWLIxtBr5DtixVhro9pXCxywihmKwIAMHyW/EyNTop9YoWZJtMwbuEQLEAAVDh/1LiCI9Pk/d9fM6n7Lt+RjC1aJW4g9x5hVJVP7RdTpdZWN9V1hRAWFqNMZ1+JW5dZkKQ8f4da+NQVgzHAhMfpGts2LzMpGAYg0skxsxAmbVVwpB3HYUnNQQwLs5icE6Yatiqqg4mSVos2opFZquoBNRscShb0RX1nBlw6Be7iKvmTMAGyERAoq0erIfA/aTHbOgr5jmw7D4L7gLtauXHnriIGYGoFGxp7InNThOvWKEOYhIvBRkg1JXE8IDOyWpLzjQ/wBxEafhhVanb90FgE7uA5ZdpFvL8BoG1g9eYQFb74mDr64ZeMhbcl6jEhy6U/3GoIqRXDFKlysdTKuu4BxxqsrLDSaN0EUO6lpjvDd7b95gU8aFV8GUaUC6ICaHG5bwQQXzLIhNFS8McLThvqFQNk2HMCalSNkiTKCBp16xEBBhHj4/u+vmdT9l2/JTNi2ompQjwsE55amH4LTnxC1tFetSmdU9hu145gHsiUw9/wCTPgWzcBV3V9o5UZpMddBDp0FfUY3DaoGrnABFCXUuHChdMR22sRdQcFEpcvRKGRAIivENg2KLDVwoDmFx1CFO4UQbggODiPRClZcLu51UsS5HsC1mLRAeTgDr0gGYrkGU1S6YeoImTaqqj6ymIhG8xUw1h+filZsEGADTDHUROOI1UR1EOQud+sT3EynHzsbyxaQ1hEDAFXol2/0F37xpUL1amCQ2VY8xw6mNWxGV30CGXlthefeLdwU0TiMKgcvf/kGrl2hAhay4j7W9vwduksZg2NvbzFvsBfbCb0kplVVScSqImaaLgGFA0Muag4Ru4i1JKsvwkMlgU/W/j+76+Z1P2Xb8iQRpG4KWmzJ5lPeUX1nmYBsYENsa9DCvxKbPhgcnSO08/wCOpOWoMNrIuJXVsUTByhX2GZcmAoEYqxIwJRu0rRcOEZIBh1KjEF4NyxFxc1XMywpYLVlEKThw+kxXnq+YIsmOI2C8wOCOwyA1B7oW8mOU7EVmZLViqghiyLuq4ISr7HVrEnwNQdC24nSjSIZ3YwlSZHgQGJRr+QB+0bzMluH4N8U0jGDi1hi2RR5dnUzgCgeIW5DuMeHs+ZUa1RAs0QwcuhxyhTANHmLlI91iCpcZxmUmFg4EwWMsDU0yLDD66g8QPrpZQYOApXjEg+7F3FIWHyelSkdhbR9JTVRowTG3us9h3A6G6jogJZwgHjGEpGF0UeiQJsiyZVQo3fNyQ1RlQ+9f38f2fXzOp+y7fldzLF+LixdcC6uWrK8ECP35XFtgo8ooDgwP8is9CK/IZQxuohGsJjxiZRxdHpBwU9GNGCYC6joJcVuOi1sM7Io0oOC8RlK2iAbgNsZ2ejQRyi9Xy8wayGjI/qFbtGY5EgzaoIoFS3MJKgXSJgN7LISvoRBBAKBAUBHcJLDVDccIUNh81NhmAAsxMeVM3ghCymDVvMaIBFspcM2nHxXZwzeTqEwYGZahoDpiEDmH4i1tA+YaBlbJU9kD9chmgjY6mWXK9lvBj/LciqVaW6M17QgPoFIDUa66Abg1jwnEueURPMGoWoHoMrWxaATEBYqLgC8BCUqFe7iGA0HCQqAtBX3iNIK9yENw52hcnoTJaOxt7PFxApCmWoyTo36Szdi+/wAHYcmfL1AOoQHzOp+y7fldCAhXx5lCoJScY5ZWq124mvG+xJk6eUPr3BYbvxh4z1Gn/H99BEy2icbZXguBDyAD6fG6Whl4WFZBrzxH88rEGPxAdwBKbVDlwRe/QZpGEXW1KlJ6HJq4F74CllRVUOAuZy3Et8MBWIz3IE7JrNfcLjFLHiFpFBGT3ikLwh2EYawYaR73GkoS4R7YBcvKREaRHz8rQBLEhHlodMDuhmWviV4EUAyI+3zHMb/2iq7jEBKhKLxLCamjGK7NkTOs6KIO2rFxXiLmktWQh9kO1Qy6DYkeGHk29saANCjEfBvcKoecfmWsSikl2osPEFKjOGDFhq3UMPDSRYUrg51v4MopodRRCLg8Q3BY+IUKr49Jgjh1+AQbSz7H8zqfsu35RKLtfsQ1SrBmWBzR5b9dxyrZZNeZkWus49ScJik4QMsWa6jk6Sk/xZepERtmBYZIarNUv0+OJwMjUQe6I0xMRjlKMyxUtMUOY4KcA5fWCO+lyvEwus8i+sWMKVwsKe7lyj8FcnIyksBR6f8A2CFV2pVxyFrwZjq77rEyhoN1mDn0Shkhs1BcBfRliasNR1wihGJZDsicKnxcWCM9n3l4jNvBBQK5C/vLGV8q3ClzvNMt2PVY+8xkgNNG2WLEwEHj8TRXtGU2NfLn+pmLXmd8uIWE5UeIHrbclf8AnwciC18+ktdnMHc5JF34mNoTnmZs0BbPSCjZiXEtrHmBSp4czCR0oaR8Q+BtStEc2xpFj6M8HdCH3jq+YyBtwH0GzRGbNrfRABAoJzmEq7czghk6oIdq004Xj4IMgUeI7RyfmdT9l2/KSxkB73/qOG0iizUYPmB2xcFnzEpR4iu0tx9JYr1TwMad9/4kEcZjcrzNAUw9JcSxvjzBj1p7O/lAo6XAtRjfxHaoLneMV8K0uFvrEyjmVQjiHwqoJyYPeMGes5Q9fg1Qaf8AuIMqosBbKBKLdvcGFyx8PmVeeqXXmFmnzFVLWMYHLGCppGyEpRgQQMmXO5UQPMZuWklRQRE5TcbHIum2OWUVFVF2AkiElYK7lhm8xGeUPf5WTxk+scVcf2GYNwcTCVeDo7jjULobcBKECMcyyagWoDiYcMMBHCKB33FH0uo8wKwcmE1SUnxZGkAQtZVwRGhjFjMDWKSLqp6lg4Y7gCAvd0VL0W7q8TyzWleAIzLeVwkSGzbgiQWxfB86rfpKsza+3zOp+y7flPnR7NRS2ldfBcYKbbPiFf2S4GXiiiGjlj/CdrtQrmjLK6v2LxKWz7iIxH0zqAuq6Fy85h2E2Aep8KKBHkHceAoj0vULHauV6+BlCyhSoEmguzAQ70TRqVGE40f/ADBOWgCMFDHOghbwpSr8/EjdDyvcVXjGOR7I2TKoCEi3QMTLUAg5YZxdK6iHUENLRgURRKYm2DtmWCpQ4CwMOSF1WwvzMeQDyS4JzmM693AFNpv5T5AWwSmW2vqj457tsOKhAI2C8wP0XLcvq+vUhWiw/FDaN7jEoMQoXDN7qXvADIieJRw0EMEgocPMEbgex3W5wcOe0HE6I4egH8I8yWX/ACjlLZHSBsuDSAuIHpn/AHfJ+z6+Z1P2Xb8uX7+9AEXl+JTBq2vg2FEMGr7jAsMHD6wUbMJGe2O3fZFwhk0f4SIvD+Zy0g6uJRFVtWFVxeYmUJheYjpuq4HmMcDYaSxhsvcoRUMYsQYwZdAS89iiqz1FKhOGNykSLCpZ4EPyzCYTl7v/ACC17kt0HJmIVSEbVmI0D6Jpw0LhIwb2HyS+AOkZgmxSw9evUr42FYPrLNpMtGLaoL3LLFtF4IIo1LxMjaADuHmBSrmuZ4OXBTM0qoFptC2F0+sNqBaxbsh8uJo4eUzFYqe3yeFwlEaCIM4dHlYCgC14lelGOsAQgplhLR7OJiedg69Zljcl7Ib4JslXaT+RBsGUHT18NAIHKISvlFDAmSLlogKoiM9g6RCKCmkPEuTt76LqCVZcHEWmZFLlsrAtWL2Ewfd8v7vr5nU/Zdvyo4IP2hLqrH3+ARFWgt+Ih6DG29HiKxVQPf8A2LapEccsOzkmdVej6zqaj04/wOs/D+YOBmtfEwrXExFK23cuNOk+B4gwF2hcEAgl8Lh5Cq+XmHpWDwmNBu8kvs2h4qCTj+iJmrrVyRUCKA5jiu2qKYZml/gjuKtXF3rPMxOyY+SJtcLNJjbHIyUDt0OpSldwsHuVMK43UtKW1zZE9OllsfYACORzO15L5lyDA1F66NwXgKyOT1jWVW1LAOt33LnQMsDlX5CgFqcRAik3HVqo+l/3Me3mpleS2KDiACOavSBwFgOuoMSHjCLOcsqVE0Iq2GIgulWZZaIK6Y8SHCTaSWTA1VXXiCwpyrlNAm5iTWRtp0SnPgaSuIKpm2Jtm5bwDctDqPHt5PH0jNK8iyWQnSV8n7vr5nU/Zdvy0Zdv05/uOF8ItdQyh2wK+F9kOItV7GYktB1fxyiNh5Qx+z2/wXO9pQpHV4YedPSfBASM02tw2jjTr4DSJxKIRbWFw0LdHMvGsC/o6XZzKbqs9QvgmVoVKcUgt0x5evN4gMtvseYesAzcvMA0PJ7QhsBuUcMvsrMIDTfIxAh27Pg1bLwwCRjoWWjbGbjSlvhg7vbs5tah4I8S6phYbMU53PBFAAOuIzIrBxRL1QRT01C0KsBjKsI0/IbLxiCvmARrD6AQXw3xRVCDR7Zw3VouNlA9x38BVrZXQ7lgyIUwrxH2x7OY8itgxnUCXCxCuqdRCsNA4GiDnaqxOhl3b9YAq2xldS2ADlgQMBX4fVgGcLg+DC0sHZxBx+x0S4BniObMVdZjaAcjuzj4/u+vmdRRNIJkzP2L+p+xf1P2L+p+xf1ATQLA8MqiYC1WAB0P7Yh4dUipiykYDMOo5eWioe8qNSWQT9i/qIN+EgR5O5etM/Yv6n7F/XzHYYdRiBjITiBuNjTh+GdfqTO8Ioil87fj4H+a3l8UV6IXlFp2ML8EXc0ubLxMYF6ieDsYBA0bMoUxoEuETbbtIaSKKK1hjDUN3dFTPQeh8xAwA2uoYKVsppIw+yBZJgrnU8y9WFqdyg1qFxgWwLHhmXgHASvYMC2WFZcDiH3eJgSAAbXKA3CJDH35lONH5Dr0UzXosqXZywxHB3UEGYAnFworK7s+0JrndkzAE2U4mDeMuVLVTpTiUd96I7nZ5S0A4VcTHjFfaDG7LM0u4LFyryM30BXn6SyB1vEHC1noOCFsdwDqOINFdQQDtHKzI3MuSK8SxIJ+xCF7Tl7ThCcvRFYbTX7f5a+FSvlr/CZGoe5EGTAXMqGVDl8EgmyWi1W/eYWxfqfAAsWXTOdbBdEcpdeU+kYhS6F+kTNVBlYwNCy6IpArztiBLvWFiytykoMR402O7edQIAIG+cqDcHgVdjSRwQPqMK9ZomM9wFtgJmyyr/fwJaI2dQkMeRuHJW0XAK3LBaC2ERZqMnuX9fWVKurb9IidEFYLz6y3Drn6Q+8qsmW91ez8jyg8OFsPTlT6/G5sABZ+Jwtgq4wotYuHWktLrraUxsKmqaq5j5R4tI8INtKKlgmWQCjY0xMId01Cw6KbzEB4uL5/6hYDXRFDUbl6cUXKg1r0y5EpgcxNHDqYnhgnwMx8Fo8f9hqSGWGDoD+cYbJRp3O5g45RtiJhU2J9nwZyqZh4nJxHGo0G1ThQy7RBdKVDTLumr7+CmrVrtgpAeSLUHmEMoFXFxhIXu7aMRoylTziMH3wgSEZ1VsoaLMgMu7gP9PipyUQPMBejBFXmNNg/6kTAuJjY51bl3T3Hm4LpVBVgOKblMslZagDqQGfQwJm422xfwZlq0V8ECwbXL4mh8XB55D9PkBjZJ9YiilQV8hoAw2kLLAoU1DUT6Et73MbzYA4QpSDKcwG2jQPcrVHGosIC7oECAI7LJQpMoUahZqbbM+JBqQ1YUehK+5iAnMeZYPQVDpGGcC4gcdkLVJgho5gLJTLS4Im8Vavnj7QVWXj0nK+YyhycXxP8k4cOHDhw4cOHDhw4cOHHCuGpi8Csx+d3BmvD8GLCXEFETocRhcFNTDFGhcfAFaNxiX11CcAg1AkXz44iFSpfl2TAVQzFULVIeEXIlRcAq0MzcvnqAByB2oiMVVu2We12MHcRKKHEQDE7XjmH9Vso9MJxHFXR8y6D8Mt/fLA1kqMiCUwujTKrdJEIyz9ZskLRNOCLhgcf3+QVv0ZiuL18QtDuBkEq65gT34dTWndVELQ2MRV7Yz7Es2zaMpNizXuwwscjEx9b2PMKWpoG7jm7XivWCqaOCAlhwEVK39I8EaMBgOPLGNLtY6a6VBtqS9DwUxOCGCV6EBvTDIdF8DqIVFxw+vmdT9l2/wAkw2S4Cocw5RKqNhr6EUdxDozic8xMYpxOvjUbGAA6g8zBiComBxNBzAuoPpLUtOyE6qFJ95iA5EFI+zg8RdLa1rSweQcph9nBM4yCr4JYuSswk5iswolBynBEgN9cIBwBalV9IikSk3Bpsn2AWjO9Ytoksq3wEr/Bl7RAgul4w+TincOzmCLpwvSHKj2eOvi2leAQDSsEMrq9QxM0LbN6iv0+F07cOJgwyc2VKDnQS2C7aNekVb/aY29eBDb5W1ibC8A/UxeK7V+APgg4botHcoa+E0gMl8E3ByVagdgtP1iGQ7cRFZv0Yu1AvzOp+y7fnDoD3AmFZ1V2a/g6bJQSpNyi1oHiZpwyuyKdqdrzMJUNrlz1+Hp6+FJfSaJmhuEGprDD4Zc4ZBqL1GyKg2R+U6hm4dq1LKwgEIsmgfSLFHZj1XVzTGHbzKiJ3kfVBgADLW4K1BpU4y3R3ADk37p8DboF8soMRlGHhIJ9k7COEAiqLtb+TBOmIW5WnjxGh5chtdkdKJo0OyZogtVUW0xVGF+scWkTMsO+ZWIJtd+PgYS5fUZpV+pHZjLW58sGmPgJkivWL3fjOWYoAIdpCjJDBXWr8atqXgmWnRjBAKBc1HRx2kvMctPDj4CveJbHFseIB2kPzOp+y7flEha/aECPOiplJZxty8wjgFTzv9v4JpKSCsCS0CDyQSXDo3HApkD/AHLqmxhYgNW9eVfYlFQwrL3ERZYCXaDTZLqw+hDsHrayX8u0Vl8RkW+qJJBe+ITUraP6Vs0RaVXYLjFxgR5kostLoNwiK3ssPSD4QoHUwaypdtQeiFlhCCmuZdpxniGFab68ylWcv1gttJ9j5de6tqHy5WYASeDKz108j2MwlBcT4MVSra7fi5b2sHP+6o+sOFh7ce7B5B0Q5uXfdmAhpKMl6PaJAhxcQZeFNwlardwZkmfqz/oH+oDnOHNSvHuAw1tjIqAIwe0b5ppv1CCXWLxEyk4FfBa3jqKjtP2+Z1P2Xb8twzLw+IVZj0bnZ7tYeepVGDADJUGgoqCczSvTzPBDX8EVWNMApB+sHiJ7xZeDWOPeHG3qxZmDC7GVtV/GkQWbQizDCW2UeG8/BaJ6WBI4Hk2cMu1xdfCR3hVDDzVpMeCrdiZlL3Z0jiIhVI5XMgPBEoqSXwS0uvrKlQI2y8C/UoJEEKamhtMDHAA4hAU/NcQfFyyyvVtg+UURNkYTFQhoSmEM34x1U2RzGTKbVP4YzT7Focef7MKVXm/7TheklD/XAOPvmVuHeo6QnbH1q0vAiC/8MBK8XkyiVFfWBl9KZIPeJQ7Je6CGIRP0lY4s3/VRTaqXBUtD9AuX63p2SxsLwNM/d9fM6n7Lt+QLQOZWrVARUhQJlH9QqVAClXwqA6CyDmVZhEHD3DicFyjV5fwjDZD4U/KUMGNNm5hLV7x5GKKuWVzKlnDPEcRmumwijUhwKhW8xCl/WLbbOYCExpiguANiIVB0LQ+CFLjJ2SjJjSEFqDIb0qWfaaWoUhASqwLUaC2KncbIqcEriK2leQhqkNX+WOWCdLPtGQHJtmKjBc189l/U7ggfhYjVhGNvqDhb2isLXrCrR7wWHaWMCJgrQV7xJadOIZVLdNSkDCWBZlh0haJ4CZ+w7FjdSHgsiclvWBxb3mNoj4bJhheBgcUU4YMQr3WIHbg8wpQSpdPDniW03Wv2+Z1P2Xb8lG7VJcku+YRkct5ojBYBuKgoW4V9UpGqLLPpGHbeIFnYUAPtHv25SMy/gdP8IAiK5h4KeNopIVvSMTWyMEKrpjk8+k2Qx/OCJ2hwnwQItAlBac8zhyx9zP5YlnM1meGA0w57hgpvBJngGDDnQ6hl0m3wSud+AzB6o5R3CeDjYxFHwx1DNWX2MHpPWRnOY9wOLirS28t/4eYFr6kA0UU39eKb+rA9F7pV/swSk+qmyXqw80naKvuVS9wp3EZQHBEbFPbU4FLq8THEFov1sNbPQQGX3S/H5wTGUNMoQbnEiHplmU4pyjaoHHEOqwQK2z5p1P2Xb8g02Q6qOE6Yz7gNh4lAxDbxKG5c6mcxYp/MxRUoIOgb4lg5byGn+EYpaiwPjsJdSEESJxo94UyXCQY9VSv9cGo+bMvp95RRTzhTbluqhRtTkeYg0CkbfiJVXXiMWx9YKBR3UHlDsvL7xqoOV3HvAtsVL83v1ZmITLeiUmxiL1qatllneDQaP4IK0FrFTOdRmDRxELihu4iQPTL6Shm1l7YlUAkab7ixxifWDeincVdCLJSvgf8AybB95/Uq7T7hKsF7MwuqzqM2B2VEb06xUsQ62TiI29ncp1K/M6n7Lt+QEtO3g9ZVN+EiBo8SXXpG4EBcIc0HpimUerLON5ESwnouY1Js6g+hClfw70qlCFi7cMQ5RFzFlmusAYYonwbmOk4RGMl7wtyyAEqkRkSeaJXvZCMiCtEEt19BFcW/RKa89EpVV5pmJyLaGImDgE2gUGdl+xBlxWRyj0caMzDhe+JZdp5hUtKvcBBc07PtAkwdtUlm/RXfeWSj3lr/AChzVS0LZ2pqBiFl4TTSXxunEgRTB9CPGJkt3EKI5mW3oxpJDYw6vE3NiVT7/GzFeCY7YfJsXW+XpDpZ33UC5Lo4YGmPOKBxw9wrOUnbxLV5X2+Z1P2Xb8aW4Nmgg+0u+SwMmUipysqor3gRttBDilTGDzcGFFo+r8AVoLXqHMao8fMK8yKHr/Fwy3CCW+kNWJ0zwMkZjZTLYh2Xx0MtkU6bkPQJsYCYiRU+KXCqfdJiMkiui4gjIH0hz5FGBmNotBSFHkIXE7QPLHG30EtgfCfBivhpo7gKkQ2pFABRABSMaYOtytvsTryf4xJ2tEqjZsZpWysW+FIBaW9yx1fb1PX41xG4k44i3U7BEiE9/A11C0y9elArrpl22i6MELZjoik3IauWrLYJHxeTqo5lhUWJJs0ePDOIVJZ7iVKNV+Z1P2Xb8OLliDKHLyy0ZcUEFhej/cceUuI2gK28RjhqIV8VRV+CUbhGAwNs2oaXfn+MitUwihZ3HrzynDTphQNRxcc5JFAJTdIwJp1BOMm6RGOHxHbq9o8SvaIFWEulehcp0equAU0OjHx8JhCGiGBlMKGQjIsb0uM4dAAiShCrA8Ov8V220eCc+/JEJfCn4imxxdS7N0beoTaBQfrMZW38cy22OBomtuyXLppaKUX6Qu5tpX0TDcWEpJhCeAPcuVbFVEFkJkYt8wyy+r3KJ/Rdzj9Vg2kvFxa76jYc6WD70qej5gyxQ3Z+L5nU/ZdsdBOW/wCoeMNBEICi1YqTqxv4q2b7L5g5WtDLBcebYwJDmDs1ibouDbLeU6dH8SrDHcNSVSjYviFKo6dxK3BpsxNJY8wJn6kA390q0z3i/H1Rbh9Z/sqP9xuC0Pop9+h+fAqPvl14mo6RiDcK6H1gppA6wUfb/Co8DLK5Yo1EoJq16lnWXUUfLlh3XDHR/wCxpkNv63GSqtrBDVKAiTm4O4oWuk5h4r6Ay7oDTzBqcTyeB5jcRhvcLv5EmEWS7xmNs9ySiv50qUal3UCBGq/M6n6LuEeC1wIRRasaoi4PkChxctQ7a7UTEHKwy/SAjTdbwKnnPSv+JVcJrq4SdQCXcpNkK1RN+f4I6EMPPtlzDDSuSo6sl9RlmR4Cbc1EC3ZN8hCvT6Tgn2RwoTh+Uu45hJKqlSXNldxkV6EtWCvpf7jviGz/AKiIirlX4AS1fTzAl3w3MnSbagrsyvTG4QaI0ovsogQNNFfKHSdOe0taiWGIxAKbQ3WEC4f/AGeUV9vmdSkGgO1sZkAysU45wcvr8aG5uzL7SgWzvKCyAbVignY/Vy1TocH8e8HzPNMzMDlK0sJLlP8AD832jiD8j1SWhD4zNsPRUOv0hP7gmk94YnjehaEK0uSYmCuBT8BRE2TBGWxGvrHaJFFy2Wk6qtxncyw0n+44W92CcQauvhrT/wB3yUTWBJcRCBVZUQ1YK11Hg4YgQ7xx/wBxVKtrt+NHGFjWCJw5XjEZrbHAl3uXXpAWA+khEMWpaPTgcEwIUxoWerwufgcHVVyfIwLNr7vkM1t/H8zqH8M1++47+keX4GFJoIIg4+H+0KW4xPoHqy9J0OA/kkr7x0giQwPEuwE2xCp8B1o6lc8yrNQjb+2TVE7bvvMCp8GCav8ApL+fYhzfZOdmK1iJwH1JY0+0P+7ydYCyEabXZlDuDC0driqwrZl8ZlIXZhHsjWh1GWIEv9KWffghkaJZpLoF0y4RmAqHJ8cn1e8yC8RGTD/RBQ9BFJpqs4IlFWu34oqCvRKiZp7T9Iiff0EAhhuiz7QTpOFhapcdvDKFtyOGGpd5KiYwGQckMsFyKY80eA4qDdh21yfCgCh5nzDQ1OG/vFUCQTmj5mXCp11wX8EwIoCCgD/gJgTcRV+H/SJSpV2v8qyv2gpYkoiuFjXcWNvBGIiNr1FZByDEqXXAiRt+ZYyQRuvx8qgF5jN/oKnLH1ZT8WmiJ6MMc/rOdvJmCLjfUOS5TwXzAhMFm+yypsyA4W4NA2QDjL4+kGUrMhCg1x8Azrg+NlBHUCKmY0LdI9DEI78ygdD9XP8Ar4GVt1A0ROuH2mrUy7Qe6fiLmx7s2AvwMuwL5uAPhPT9SWvvgH2YhQKkTfdxZIC8BY/6hYuGHajJBEc67HETiKN6Y0te6ygXzAVCuo3YcwJvXI3dfM6lyH9F/CtwnB0/3C9gotWInBh0/wCP5go2RsFplOlmJFrUBFltMDzMStZZGnXUs36YhdXQ6IK0K8EzjD0bgVoXeUE6ATriMkVblUR9FGhye6EWj4zQxXLtsh4a4yuWaOSwkNyEtGi46fScyjLIIUBkOaWyRM5D/SNgRSPHw91lQTcBzK0DEK7lA04rLK81o+GiiZY4g8sFWhb3Kr63LxxkzrBT0GCOKtVEKZXc8ywfqILhaZW4maajqI+CHP8AQmFv2kFthM8J2NxSHVJsoRWEWcVCL4QBWWLuZC1bTMBQG3ErXp06Eo7eyHSFMQg0j5mGrLaFEHVuhQi2CPlP9S1x7CX9v54oUKFChQoUKFChQp/JMQ/RLAqRZSjzUEcgoYogxXCBghgzTFUAiNAHKyoB0u69YKtLVmB12LocfaBqM55RFI7MRjG1qOVgttKUoTUKXmw6s4j4hsI0+kuhSlMkJBrhFqFsA9MtoL7IjQfsIl4yoDAGyvtYu0ENwr18xE4WQ2DoqZs9QaU7ga38Glbmesvt8cumL8RdTCgfedwIyq7sf4n3D8y1IwL9+Iq2ds8sWUlDLeCYMA57ekRJXt+Q6g94ljXkw2gBBpXP+4RBG1qOFAdCwksldhNHD+SENYbBywdye0j0qJasRpaqvt/8qllv6yMg1wJj95GepLM2QDuL8wq9D3iYBcDQx5b5oAzGmdu1RiaHOChFvtoVURrfte6mb3YeQjVYPL13BFFMHB944loergF8SwbEek81HlAVZOl7MaM2L2H9z3pVshSwhQtfaY51Ejwsv6xKg4FVFu7gMHMzvWIDtuB8R4WoiS1+LwSr0k/cRcILQ597/E+4fmUgpp4SAYoCglj3ocHXzoSUmmAGK4Yd4XWIhFDR68kWNKM5lFzb2tbrhgeB13SQR96Rz3F0C2ndxyoWa8z931/8keFqDwCX5ZRvHL1NFzyw4gLViJ+cvD5JVgblSaQUdMLJFw0+GV1J8sTWOUN4YisqwUpMbjhOnlioeCmlB/uJjylq1K6ox6rzAhZFl6GIuRxXL/eO1VFdKX1XmFCOIcPeConl3/g+YWWtHpPWBGBxwyzIS0x8pMJXu/wfazFviBidH7yx9ZGA2v8AEY5SMfrMLsDPibGJgI1he1/wOXlTK2HmCl/0qiwmeE3LEIG8aLlkZLWseqO6cNOx83EysF35iF0pwmQ/1P3fXzOoUgAAeC5/1s/62f8AWz/rZ/1s/wCtn/Wz/rZ/1s/62f8AWz/rZ/1s/wCtn/Wz/rf4Q4VknNXldEK0iCSARUINYxF+q33MutrWUemVXUHYWzqZkRM9nMUwXStbm0UFgyhaWqC8RWOIoTymBGy8EJpBprbCopoG6itBKRpUOccuocQ75H1iiuKybJTCUKBqAMbngwnWGTqK09ETNhvMu8Kqu5rWMj4+f7WCJ5EaWyiUfmo5encANFJ9/wD2EGqiIWIsn+JnfDAbLt1Fc67Jc9ouqMMwQsJWNZXBGKxcy1FRY5MTIF5j2+Z1P2Xb/wDBQ6YMsqqQkOi2OlQKmtlV2IjazoYtTVVg3Mkjig6+sJguaNHozEtMA4XqLRjZtUbIcEy+kTsDZmQOqDQ1QwjY77zBtjm5r2hWYWiaB4lZyii6PMQfBpUb8ekRJBS3bekYgopHhiq2tvmAQEDLPwfBwuGXzhuCNedxtdw+4LXJ86gcRfoQqNDLksK+8usbww9tKn0qv7lTcj8SorWKr64/xOk8JlNRyXG+kuKKqlGZAS6NHrBK8ZwlK0/o0mA7Bs0Sp2wSvmdT9l2//BSi/oJRKxkyl+qJZm/Fx4nL2RbXmBLY/MGUpWTqbi11CEyOUIIV7mCAppgmrZQQTSdh7y7rGV4higcEWuh4R/uXbCbLbgI3cBpJflePk1LaMlvCGUJo3XcNLssOe5XhLYwxY4FFOz43vnyBjbUZImVGkVCswCqC3o+a+nUVW6plXeiM2w6VG/O0juRWvtLt2YfHjZ5Nf4hZW8V9YKulbZhB9JjLZJaK6lYSZhD7WxMRqBgVq46FJgP3Y20Bfp8zqfsu3/A43tbeCXN4usxKad/xhd0ZYLY9CPWZyYac8f2se0BlaQUNBcv2jYAHJ1Fn2Lq/QRGy6XuMmxttsxtBcu0vTxEYcbxzM8GlqVAl0e8YO5zzaO4ihWcAMPGzDGsLzAcw7JZKMVLG6ArZcaWuTEMpbviwNmJUFXwWap3sZogLp+zMJyhNlQRWo78OJpzI98HMOHTK48ePZ8xunYwNeZ95TV7MMvBvEEXBgOLiL0JhQYBeIdYWLXSRERSNP+ELGOBLdRQBNi4iOhoV2nIDBwyvX1/LnP2gAAYb8stQlOVqPghFcE+Z1P2Xb845E7eiamQviNXVdiWzsc/xR5xQ+sU7IZYaPEAJpzp7maonFk9o1aHAlBiZsyuYwW2MuI51DIA/WKGMC+OGJTagfMIupOdKI2Y0UMQIBGlEKKgyJcOaJQFNsdAC6oYIhxS1R/qOLdQcJYdwQ+8H6SgozVaS4QvbD36zTEXAW16qOJNsbDCuWrRUv8BzfxBFHiWuQ1KGMMPuTYMnyq8l0DjMoHDKWIlGVFUy2oNnwIqoZCMOEJwx3dbb0f4RVaZUeDiZHMqWCHX8IgWdvnqPTDq9ATGsmxxFqXCl6JrQVBTWJT5nU/ZdvzLpk+rAax2rKCOSjQku8ByBj1B2DhI4KsYrrY1/EzzszAnOop1Ij1cTMsLkcqmTTMi5lIwjDq5Zw2wvruO3oyNEioITZahkrxcI/sJYu0ijERvNQQQIzFowwGt4hetHTHCAGR2Sn0cXYxMMoOgq4XJ4L1XiJZ5AuEnWMa+pjRTBRCqeOY2xpkGY4YLkGFpcgFW+JkOChzDQJg1wwj70OnmUVGGVq0qS/DFb6nyuljseMS4HJiIjPrKguIRmbgbhzClUCUSo8nPhgnLFJsY+YXAa9T52Crs8uvSLBSiqIhlwFYycZDDXBHXLzFO4CXKJ2jbkKxWHuLiqlvg7e4QE1/R8zqfsu35QQaFpepV1QSz3EX2LzFrSMGiDyDSkB1G45BTUqSOJ0Vhl67/iODXL8yhVVQwtGUXFs0m5vi4tGPIuUDmKbTAasgMAYCpDmLh3RTcq9G1+Y6oShdxCeiMuW4JdHW3QwRxVfCUIA4LaYRmpllr1lhKtZxbqNYhkDULaQDx3cKCEsBCQ7mEABXKMUYEtigGRg3w1XR9ZW98ZHpFurJHJF6CtM3cFKlIKDOI1cHFxPIDJNwFj7fNYrcotxuYf94hAmFywW9QRVLE0xGqNLlOJaSZBsKtyomrT1HqS5eFZRly03BZ9olQnyQm3aLJg82/7nUKSBQYBGNcSYUgu8aO0syNoukbeEjRBFATqXxvh3DQ45HBC0QD7fM6n7Lt+ZQtroYhNcAOeog8Vq1acx2BDlg2L7NRzd/0QHkGv4fmRjo6cH1m74lzrHF8GIlYFAhDcBBvwxthZSLOJTk6gY6HKOaizXIW4QuMbJFH9QSpvYClYZfuIixIG91TDG3HdiesypBVe/wD7HYS+lz9I2Gm6tM79Ftd+8swytOVlKdNl2yuEa6NkFaNDVZApMUEx5aOXxH+Iyq4h4lC6RpV+WErilDJ6QqRKMaUcQ8LeImU3ceksUSCzo18vSl5h+KLpDC/WL3ph0xStmAbeMyy0L4NkIX9DXvChWxubvb3cTOFOdkxqkzCnyGGZ5cKlKlqBZNcsrDXNZhxOu8dTSlRCD7Kbalo2NRW5zD1j3aJ3R2vcIrSX5nU8kqtW35sGfL0wwhoBjw0C0Sd5lEmyfwwiELk8xFcK2sQVNt2/w/VCE7V05xCfSXPW9zedBS6e0sNoorQ1LgAaR4hlib7DLkotOEfPShasw38gpTcSKBgMVhGaYrBaq/LMbdRwqWN23yRcgrVuRltRK1iqsMWcwgh6Bk8wnNmUTFy3tpQ+kHKhAOdQiwYYvvFywAKx3AY04FMPLZVC2UOHMjXrEI5CLL9YhvfZlzudEMHkhVeImz/6x3GVjsfmI10MTHkTsjThe8g5C17HhiVz94YMGqY0fRFkW4nbTEcr3dkC0zyNzi0G34HZPInVf9wvKn67lnLwGJhWp1D7K/BKwSWi6vMsSi5YlNe9cQGsqJ7xFaPP4vmdRNY2/MsTfNRaxHqSK/8AVDZ8K4Y7yB0jGhEenEIwAWvm7wSzBFCRunOBfWNprSztERwrLURkVeX+GbHsEv8A6JVP+hmGCXlWZTagKublhgFqCKDQWgoRtThzcbWhgmG42gStyB5IB7NuxMry+/4gQc2V6v0jp3mWFS7snDEtChVyyiarBTdM6v2ro8xyUlPZ9YWq61Am57rJR2SxXTIEuCLdeAJ7DAB8ExCtRvjqFEgFIZE4l3iAIrjeiXXeKGE8wsCygYI0XqBWuGkE7JZ8PzJZywkcTKMKjnx4YyMTpidr0ckpFXKW4SjPSRCjb9o3MviAbfWMQk8SnDUyORmskN3kRAsXg+0YHea9TBv2JhVxLNxDlwRC2mL6fM6hrkUWF8xcwEpWPW4LxSG2VxLAEV4mHFemGFtUngdF8kA7InPfUSEigOYeoKJFLywMiARw1/E3KvAfWNaO6xCZqx9iFdsQ+SFZC5OYHBIbgT1iE4KdnmGgK0HMEFI23KnMocFw6dMd4PxgsddQvXsVtgRNPJjPrAAByN3DXB1ChjFDwMX5jlhgxPJNEHai7sjOuQV6wPCRa9GJX/pwBqcyw9zQmKz6xXfOrUIbVgDSM20WQMDqUQrk4wbAize5QwCqt13Kt7JRX1/E24QD2+dmfJdFtTAtq5OoItDQ9zHbEFa+ncKYKjJpMYjAdr5SPdkIvXZzZJ/2UVUp6MOBxw2JWBejMNM7eTKtEuYm1RttlrLkBLGWj7xi2mD6fM6lDGrceZQZkHID9JksHpGMh0hK0chsMb5xBDgpqI7A0HXmJGkFX6pnEikdRlXL/Exvh+YaMcMyB9yGwsLuKxGQ9IjqVQPMvIFqVovEpMWV6ozhG3L0gFJeGXrnNfiEVtUcB5jFsnnLkGHYi8Qg05txLIKKJhI6xRYYt4JZoGlwSmrxjHvD9rtyYgoD2EU5R4DnxNHjigww5GswmS8xW89sdJXFGoxZb3HUYwACFEYVnfvFtwRtx6p6iP4l6+bhVOCCJoH0fkNZvaBRCqyTB0I7Dx7QPdZQDFKCdWEjGcgcQJh7koRxMMuyNynbUfIApLHJMsBHCB8QqrmVnBGN3L+IjuI7WLg29sxZTwSxPPEXbyv2+ZlrY2ZK5maPqCb1d8O5lWw6YLRgo2T1bW5/qOIuvgfRio18WmF+arrQyvTllObnKRofxPWKesm/f/2E9MivtLkrKaallE1sY8Q4QyqwekpVThXUCNsDW7D7e2tVDY7sbq24pDLQOX1mUQUI54CMUfsdQxZGKvMTO3YOVSpsAHEseJm6qo2CalJkjFBHE0PRXomcZUVyp5IFu4DlcrFOCxtjY7EMMcNRw2ECUAmuEH5FwWxI5GOXRAvwHQKzMGJQ+IqD3w4hhOEENW7gM3p+CBCdn5vgtZrlnWerBAKJTgqpVWgwvUPNHCMH+49x7ZKCJ28MSPuaYbR5cQF030gf2EK8ER2lso1KeD7z/rTsPrMttFzXFukwRAz2+sEOA7wjCLf6FEB2D3VAKbLXuj5nU/Zds1LdzkvDBQL3IsekYM0tfYZUkIpOj3GbZ8uT0YdqPAIiZFyR9cHZLoWtw9fw1Y6YnwKr6kYHZvtERTkm8jGS491QwsXLoJ2ou4kZRi6KZQViA3FaalKqIGtVhnVuZBbJ2cy5YXMwHEs+DRwOYthvWIXQrK4jIeCrrcPKmCVbqXjBLLWLFAs0UYYb/IysBKVlkwx6DZ1YqAFmxeBmH6GCiRmzuyhshZLpOLP9xEPTyaQIewoEupNErCyn1aVt1RPvv6iOhZP3PbDLRKdtwRA4gBKPSU2Q6X+p+GtZhHca8fCxCpagmlB9GJBdpUxc9ZjS48wFYD3nIJ6MH/0wuyH3gpq94Ngr0ShbI6Ny5JV7ZVJDwCdoT/qjXuBGssgfHzOp+y7flbLEeQgYCfY+8qbb5OY+EKg1pR0MJCi6CGH18wm2DNcRqL3ZHu+E9eP4eWs5UonhBDV9Icwib3MSWqQ8zP0iIxHabjtYTRqu5gbyNExBBUJhqrjCiWlQwoBsBzcViAjFMqFdMTqXmu3XiLd0DUvlEo1VMu2K216HvEKwULH3iKkPbXvCyN2GiNZ2cBusVtnJIQRwgsMxHyFAouHD6IxhQabQkqFm05fXqKqIs43ONiaqzuJclUYqeCfu9I/eJ+57ZXXozKlVBhCJsxEjJiUpCHi5y+QU01H8fXmWvtUXpH0h1YS/gTwn1Y9f5hMWu1Zwj7RfC8k3dPQqVplwFxDt9q0f1BIlgIxB4ckZr24Op+76+Z1P2Xb84K0JCmD42j3ItJphVgJqErz6nhM/8Zqe9CdPcWBSfwrJumglyNgZcArgOOGbVjANRJTjNEWxvgWz0gI2rSi1iwt0eoo5mSg8BMcl6qNHGF59Ebxa1OXiKxWEOTLXLbEb8RaFkxBe6nAIiEi5F3BYHAFGfWXjs9VgjpLbVHhCK5cxUDCeb9JUohdLa+SOBxwGIQ4tN5MHvlqRq2DudfZGOgKO8ytlZFqloZlvrmFbcfaXvgLfYhi6R95QvDDocwUF+sDUS7mWZYSFzh8QSldBDbI7xmRw+BlIJv8AtkV2HYRwJLotOYHz/wC5X6HCE/7ZC3ZbT9CENrsAQVTeKD7SuCIEBA3cFXC5cm1YSWh5bhjUEPHzOp+y7f8AAZcGRHUEGOiwux2hsjZLwsq4BN37y8SwDiXx/DT7In3n4er0m31/ifveJ+74m32n4U+8fzPwTh7T7T+Jr9vgn2f4T7OfcfAtsffP5+Dv9X4jfcvxPwIffPxPsCfY/wAT7mflx2w+A3Q+DSafk+qM2hqc/A5nPw0+DWbpq9ZzDc/In7zr5nU/Zdv+H7b+Zq9J9lPvZ92/qfm/H//Z)
A imagem à esquerda mostra como as partículas de poliovírus recém-formadas (rosa) são carregadas com o genoma do vírus e se transformam em vírus infecciosos (vermelho). À direita: se a proteína VPS34 da célula for inibida, a montagem do vírus para na metade. Partículas de vírus semifeitas são mostradas em vermelho. Uma partícula de vírus tem 30 nanômetros (um nanômetro é um milionésimo de milímetro). Crédito: Selma Dahmane, Universidade de Umeå, Suécia
Pela primeira vez, pesquisadores da Universidade de Umeå, na Suécia, podem agora mostrar como o temido poliovírus se comporta quando assume uma célula infectada e engana a célula para produzir novas partículas virais. Pensava-se que a pólio estava quase erradicada, mas a infecção foi redescoberta em Londres e Nova York.
“Agora temos uma compreensão completamente diferente de como o vírus age e, portanto, melhores oportunidades de pesquisa para talvez encontrar novas maneiras de conter o progresso do vírus no futuro”, diz Lars-Anders Carlson, do Departamento de Química Médica e Biofísica de Umeå. Universidade.
O temido poliovírus pertence à mesma grande família, enterovírus, como vários resfriados comuns. Já se sabe há algum tempo que os enterovírus reorganizam drasticamente o interior dos infectados, mas não se sabe exatamente como, simplesmente porque a tecnologia não nos permitiu ver tão profundamente as células. Graças ao microscópio crioeletrônico avançado em Umeå, os pesquisadores conseguiram pela primeira vez obter imagens tridimensionais de como o poliovírus se forma e assume as células humanas .
"Ficamos surpresos ao ver como o vírus transforma processos na célula que são usados ??para destruir vírus para produzir novos vírus", diz Lars-Anders Carlson.
Os pesquisadores conseguiram identificar o local na célula onde o poliovírus forma novas partículas de vírus, vendo locais com vírus semimontados. Surpreendentemente, essa "fábrica de vírus" na célula acabou sendo superfícies na célula que se assemelhavam a um processo normal na célula, a autofagia. A autofagia é um processo descoberto relativamente recentemente em células que foi objeto do Prêmio Nobel de 2016. Normalmente, a autofagia serve para quebrar partículas das quais a célula deseja se livrar, como partículas de vírus. Mas o poliovírus consegue reprogramar esse mecanismo de defesa contra vírus para produzir mais vírus.
Os pesquisadores descobriram que certas proteínas são particularmente importantes. A proteína VSP34 é usada pelo vírus para construir novas partículas virais. Quando os pesquisadores inibiram o VSP34, eles puderam ver que o vírus mal conseguia montar vírus inteiros, mas principalmente apenas metade das partículas de vírus. Outra proteína importante é chamada ULK1, que retarda a produção de vírus. Os pesquisadores puderam ver que a quantidade de vírus explodiu quando essa proteína foi inibida. Isso confirma a teoria de que o poliovírus quebra esse "freio".
Uma vez que o vírus se multiplicou na célula, as partículas devem ser liberadas para infectar novas células. Isso é feito liberando as partículas em pequenos pacotes, chamados vesículas. Aqui, os pesquisadores também fizeram uma descoberta surpreendente; ocorre uma triagem cuidadosa do que está empacotado nas vesículas. Apenas os vírus que estão corretamente formados e carregam o material genético do vírus são colocados nas vesículas, enquanto as partículas vazias do vírus não são permitidas. Dessa forma, o vírus pode se espalhar de forma mais eficiente.
"O novo conhecimento que estamos contribuindo sobre o papel da autofagia na formação do vírus pode fornecer novos insights para o desenvolvimento de futuros antivirais que possam complementar as vacinas. Temos boas razões para acreditar que nossas descobertas são válidas para o grande grupo de vírus aos quais o poliovírus pertence, os enterovírus. Não há vacina contra a maioria dos enterovírus, mas um antiviral que atue no sistema de autofagia pode ser eficaz contra muitos deles. No entanto, ainda há um longo caminho a percorrer", afirma Lars-Anders Carlson.
A pólio é, com razão, uma doença temida que pode causar paralisia e morte. O poliovírus começa nos intestinos, mas pode atacar a medula espinhal. Ainda não há cura para a doença, mas a única forma de prevenção é vacinando-se. Em grande parte do mundo, as campanhas de vacinação têm tido tanto sucesso que a doença é considerada praticamente eliminada. No entanto, a poliomielite persistiu em alguns países da Ásia, África e Oriente Médio. O poliovírus é transmitido principalmente pelas fezes. Em 2022, o vírus foi novamente detectado em esgotos em Nova York e Londres. Além disso, Nova York teve o primeiro novo caso em dez anos de uma pessoa paralisada devido à infecção da poliomielite.
Quando novas partículas de vírus são preparadas para liberação em pequenos pacotes
(chamados de vesículas), o vírus garante que apenas as partículas de vírus que foram
carregadas com o genoma do vírus e, portanto, se tornam infecciosas, sejam
empacotadas. Vários exemplos desse processo são mostrados
(partículas infecciosas em vermelho, vesículas em azul). Crédito: Selma
Dahmane, Universidade de Umeå, Suécia
O reaparecimento da poliomielite nos países desenvolvidos pode ser em parte devido ao declínio nas taxas de vacinação, já que a doença foi considerada quase erradicada, e também devido ao aumento da resistência à vacinação.
O estudo foi uma colaboração com pesquisadores do National Institutes of Health, nos EUA, e da Monash University, na Austrália. É publicado na revista científica Nature