Em produtos químicos usados ??na agricultura, bem como em produtos farmacêuticos e em uma variedade de materiais, as piridinas são frequentemente encontradas como as chamadas unidades funcionais que determinam decisivamente as propriedades...
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)
Prof. Armido Studer com Dr. Hui Cao e Dr. Qiang Cheng (da esquerda). O flipchart mostra a transformação química da loratadina, um importante antagonista do receptor H1 da histamina modificado por meio de um grupo trifluorometil. Crédito: Grupo de trabalho da Universidade de Münster / Studer
Em produtos químicos usados ??na agricultura, bem como em produtos farmacêuticos e em uma variedade de materiais, as piridinas são frequentemente encontradas como as chamadas unidades funcionais que determinam decisivamente as propriedades químicas das substâncias. As piridinas pertencem ao grupo de compostos de carbono-hidrogênio (CH) em forma de anel ("heterociclos") e contêm um átomo de nitrogênio (N). Para os químicos, a funcionalização direta das ligações carbono-hidrogênio (ligações CH) das piridinas é uma abordagem direta para projetar e modificar moléculas complexas, inclusive no estágio final da sequência de síntese.
Este último significa que os ingredientes ativos podem ser modificados quimicamente sem ter que construí-los novamente. A funcionalização da piridina em uma determinada posição em relação ao átomo de nitrogênio — na "metaposição" de difícil acesso — é extremamente desafiadora e rara. Uma equipe de pesquisadores chefiada pelo Prof. Armido Studer, do Instituto de Química Orgânica da Universidade de Münster, desenvolveu uma nova estratégia para colocar vários grupos funcionais na metaposição das piridinas. Seu estudo foi agora publicado na Science .
Os químicos usam uma desaromatização temporária da piridina; suas propriedades eletrônicas são invertidas, produzindo um produto intermediário estável - uma dienamina. Por meio da química radical e polar, os pesquisadores conseguem, com alto grau de seletividade, colocar na metaposição um grande número de alcanos fluorados, bem como uma série de "substituintes pobres em elétrons" (eletrófilos). . Essas transformações também incluem funcionalidades médicas e agroquímicas relevantes, como grupos trifluorometil e halogênio.
"O importante", diz o Dr. Hui Cao, um pós-doutorando no grupo de trabalho Studer, "é que os produtos intermediários de dienamina funcionalizada são facilmente rearomatizados em piridinas metafuncionalizadas sob condições ácidas ."
Seu colega, Dr. Qiang Cheng, acrescenta: "O alto grau de eficiência, a ampla gama de aplicações e a meta-seletividade de nossa abordagem permitem que doze tipos diferentes de medicamentos sejam funcionalizados".
Além disso, a equipe desenvolveu processos nos quais os medicamentos podem ser transformados diretamente em derivados trifluorometilados e substituídos por cloro, nas chamadas reações one-pot, que envolvem pouco esforço e ocorrem em um único recipiente de reação. Para isso, os químicos usam reagentes baratos e disponíveis comercialmente.
"Nosso estudo fornece uma resposta para o problema não resolvido da funcionalização da piridina na metaposição", diz Armido Studer. "Acreditamos que esta publicação dará um impulso significativo ao desenvolvimento de medicamentos contendo piridinas e de materiais funcionais orgânicos".
Mais informações: Hui Cao et al, Radical and ionic meta -C–H funcionalization of pyridines, quinolines, and isoquinolines, Science (2022). DOI: 10.1126/science.ade6029
Informações da revista: Science