O revestimento ajusta¡vel permite que nanopartaculas de carona passem do sistema imunológico para seu alvo
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)
Imagem das nanopartaculas no gla³bulo vermelho. Imagens cortesia de Eden Tanner / Harvard SEAS
As nanopartaculas são ferramentas promissoras de entrega de drogas, oferecendo a capacidade de administrar drogas diretamente a uma parte especafica do corpo e evitar os terraveis efeitos colaterais frequentemente vistos com quimiotera¡picos.
Mas háum problema. As nanopartaculas lutam para passar pela primeira linha de defesa do sistema imunológico: proteanas no soro do sangue que marcam invasores em potencial. Por causa disso, apenas cerca de 1 por cento das nanopartaculas atingem o alvo pretendido.
“Ninguanãm escapa da ira das proteanas sanãricasâ€, disse Eden Tanner, ex-pa³s-doutorado em bioengenharia da Escola de Engenharia e Ciências Aplicadas (SEAS) de Harvard John A. Paulson.
Agora, Tanner e uma equipe de pesquisadores liderados por Samir Mitragotri, o Professor Hiller de Bioengenharia e Professor Hansjorg Wyss de Engenharia Biologicamente Inspirada no SEAS, desenvolveram um campo de força ia´nico que impede que as proteanas se liguem e marcem as nanopartículas
Em experimentos com camundongos, as nanopartaculas revestidas com o laquido ia´nico sobreviveram significativamente mais no corpo do que aspartículas não revestidas e, surpreendentemente, 50 por cento das nanopartaculas chegaram aos pulmaµes. a‰ a primeira vez que laquidos ia´nicos são usados ​​para proteger nanopartaculas na corrente sanguínea.
“O fato de que este revestimento permite que as nanopartaculas deslizem pelas proteanas sanãricas e pegem uma carona nas células vermelhas do sangue érealmente incravel porque, uma vez que vocêécapaz de lutar contra o sistema imunológico de forma eficaz, muitas oportunidades se abremâ€, disse Mitragotri, também membro do corpo docente do Instituto Wyss de Engenharia Inspirada na Biologia de Harvard.
A pesquisa foi publicada na Science Advances.
Revestimento ia´nico em uma nanopartacula.
Imagem de microscopia eletra´nica de transmissão do laquido ia´nico revestindo
a nanopartacula.
Laquidos ia´nicos, essencialmente sais laquidos, são materiais altamente sintoniza¡veis ​​que podem conter uma carga.
“Sabaamos que as proteanas sanãricas eliminam as nanopartaculas da corrente sanguínea ao se ligarem a superfÍcie da partacula e sabaamos que certos laquidos ia´nicos podem estabilizar ou desestabilizar proteanasâ€, disse Tanner, que agora éprofessor assistente de química e bioquímica no University of Mississippi. “A questãoera: poderaamos alavancar as propriedades dos laquidos ia´nicos para permitir que as nanopartaculas deslizem pelas proteanas invisaveis.â€
“A grande vantagem dos laquidos ia´nicos éque cada pequena mudança que vocêfaz em sua química resulta em uma grande mudança em suas propriedadesâ€, disse Christine Hamadani, ex-estudante de pós-graduação da SEAS e primeira autora do artigo. “Ao alterar uma ligação de carbono, vocêpode alterar se ela atrai ou repele proteanasâ€.
Hamadani éatualmente um estudante de graduação no laboratório de Tanner na Universidade do Mississippi.
Os pesquisadores revestiram suas nanopartaculas com hexenoato de colina laquido ia´nico, que tem aversão a s proteanas sanãricas. Uma vez no corpo, essas nanopartaculas revestidas com laquido ia´nico pareceram se ligar espontaneamente a superfÍcie das células vermelhas do sangue e circular atéatingirem o denso sistema capilar dos pulmaµes, onde aspartículas se separaram no tecido pulmonar.
“Esse fena´meno da carona foi uma descoberta realmente inesperadaâ€, disse Mitragotri. “Os manãtodos anteriores de pegar carona exigiam um tratamento especial para que as nanopartaculas se ligassem aos gla³bulos vermelhos e, mesmo assim, são permaneciam no local desejado por cerca de seis horas. Aqui, mostramos 50 por cento da dose injetada ainda nos pulmaµes após 24 horas. â€
A equipe de pesquisa ainda precisa entender o mecanismo exato que explica por que essaspartículas viajam tão bem para o tecido pulmonar, mas a pesquisa demonstra o quanto preciso o sistema pode ser.
“Esta éuma tecnologia modularâ€, disse Tanner, que planeja continuar a pesquisa em seu laboratório na Universidade do Mississippi. “Qualquer nanopartacula com uma alteração desuperfÍcie pode ser revestida com laquidos ia´nicos e existem milhões de laquidos ia´nicos que podem ser ajustados para ter propriedades diferentes. Vocaª poderia ajustar a nanopartacula e o laquido para atingir locais específicos no corpo. â€
“Na³s, como campo, precisamos de tantas ferramentas quanto pudermos para lutar contra o sistema imunológico e levar os medicamentos aonde eles precisamâ€, disse Mitragotri. “Os laquidos ia´nicos são a ferramenta mais recente nessa frente.â€
A pesquisa foi coautora de Morgan J. Goetz.