As variaa§aµes genanãticas nos tomates podem influenciar a maneira como uma mutaa§a£o especafica afeta a planta. Ele estãotrabalhando para ser capaz de prever os efeitos das mutaa§aµes em diferentes variedades de tomate.
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bSFlKp2PlFixXgCOhtbYiFGaeIKQ5Gt8QgyhMR7dZTXMJJbkT9YYh9Cv1hQyYX1HFnhENzXlcePmxnh+xAare2MqLCw0kLshyy9fSWT3M5vMwFqXR5l4RZfSWX05iZNLXKefN1HWlIJdpo3eSotV5j7vkADe3ogkgBvlZoDXM27df5RoWPYohg55hYB2M56Ow1DyonbFy4G71LB5jz8REad/KZagkrHnx4ghQ2kstf5oPd2JhqDQgFLgMzVVykTlVD6TLUsl8w7WTOauB53mzuEP3t08Q2qSn5bxtLTHH/YWKqbgaXsG6pr/MAYRzdd1PtHcPJEgpPZCgAg6YkorlSs2SFgW1rs5Jf1idQgdXtWnuCHSU/Ji3F2+iXZF1FwFdZg0LXHhLdWwyJxKqsjlnJ/KlxynjdEELNCA5LW2opJKAHGPMa3dYeiKgQtmmbFslxWdLVKbg00lPxtRcz4OpRMgBvzEKQGiKk24IaKNsWUQK7YBawEqHR7vMbrizYwCLB/DzM2mpp1k9PPy1inLC00ZIDbBu2Y4VcHcWpQ2iZP4JaB6xEpbcXUQ2pXXcQaW1GpiWwW5emq9rqeMO/EYR5B6+fkMq0oIQpIQmIa6I5oBvADCpc2xEQc2TzcbVGOeaZ6KeIOCO7QmUNF9dSjZRYkyiLD0hFk9ylL/Nx8my9P3l2hiJeCEs0ueLmVatNNNQ8rZMFOiP01AMqhblXVNBW/8xxwDbyzaxrErhUUhlZYGu3DMEGB6zmYBGkdfEABcx7A6h0X9YqXADUbPjZS69wt0+CEp2PBiACx7YQdx1G5wHUqRplainmY8w/a+XylXA8Bw1G7tW0xbgD9olRF3LccpzKhZmpjYxcDSb+K2OYkYBaJxUmJd3rqETVqIcxqNDO/jBsLuHuAtnUs4qlPuaFHNQTwFVzuOBSm5f8A0o0YxDsDxmFLm8XDoaPiBdzQ+hBQUx9uFZ5rmFfeV9mfkWlyFvtj8xuszFUencVWcagRaBfOpnjZr6RUDcYmzBxbz6iy0A0ISNwZpCx55pmUMqvjUB6KeeYqOyw2Yj+2enwkc9Ql3whoWVwqc/5l7CrFXUsApcvuEWSWQK4mBbOYAE2cPcQh27mO3nERran5/JUDgmJGyuJZ0t1f1mCq14gAGyouKFx4iGLmVCIKV6jRX7oCR3xmcL4hBq8XD6QKKd/HULDh+8zNVBsjEK28hctHHm3EBydytxxEUVOIRK4Zn1CIihlcwJaJikgBy1ULRtKfMIltf6fH0si/Uub1ERQrI1Gog2qGjDltMNFU9nEtQpActzAjAKLWTa7eB4jChs5ZeX2qIUidKqGLCBNezLFxhMSlw5/J8P1iMFvWfMGzVKMLSsrrlgzqxWSqmRLLhb94bmPqbom6vMFpfIwSgJQiiO4ar7/GbI8Y8S5CYn7KPLPUcvghmGzHuDBsfEqrK2EUuVcqNMopVMvayCWoUPV/GkGArHsYzLAXTzAbRXYXCbEG0dMwXHWmKmQqRZKLOVGVgN4lJuFqOeoiCcuI+4SEWwnShS+o7Ei7jl7Rr4yRc7+0RR7aiWrlfPUEtALaLn3knEqcjMOARy8GaJHdXALWtyqDNywyAe2Ii14l/ocVxGZQIlOZeQA8Ee/xiWK2r3UEzlMxXeSfBn7hD6xImMS4NmJl8PMQtrKNoK2rMKtWq1FDqDOLM1xLQY0jA73GsDCByI7b+MfJ9MQFG4EKtMqiPA5G4bGDi4OUUARxMzK0LlTsA9KA81HHYdFxw2Uwoo7jGnv8fqMev5cTKqLiuYRJaWKiEr6VKbJOgZieeeZcEt4uGaNRHbIxdKrcyQlYVq+ZoXeLmfJe1uA270ffx4+EELRqW7UJegDBeadxO2bGQy504qWBpAyNZZSBP1mQVCMog9xsieTZMLGHQllZLzCu0GjCe4ysDeVi+x71PZCo0LDVCe5j1kKL5jFFZf4NozsnAYWMpRLiBalVArQDtYxRB13DCGvLXMRLou7xqUJmRTYjJZctmDx5jWoMBpigAZS4R5yidKr7/JZbylhXEQhA3uAhQtJ1KhKBUfHSXDgiVsOLijOYjAL3mJbG3LuE4a+5iLaGYy06JZ+0fjAhUVv2hkG3D1HZl0DRCbgWenglubxChXiE2uCUzWFfMbhLjJFIGU4qFhYXbcSMbwzfFPMFq8eJiLn/AEPjdB4GAuKu64gIcncKA2p2uI7BXwXEpQAbySk4GoqpYT6bjwoV1LGCbLz9I1qYDUwGMzCmrwSBULeKYYAHgCbWIXTVN/Ebc6PUcjRjMF3j3BUbOIpxbNzKZaumWArO65i2qnI7ITUi8tkq0s5l8SlWtwGXNB74jlt38jnwcMAEc1Hvz1DUEKo1KUBMw9A8SgRLeyMK2sxSXvmK83XEDmXFxcrtmmgU9vyhG8M+aYVAWaXMTBbcdSi1UnUSPMRt2+frGqAq2XmCzOWH9oaocKzAErtZXEPK3u9vdQZrUWXxCf4NxCbS/jq7UUyi9xeFDajX2hNEXFB/VGzDQLplep0YAhgTZuoK8jmCiOeIVRBzzKWqOyuOGPIa6Fajig2t0h90k1cJcUZZxYObqXk+INJk+/iXAth14mQ/dAJgksTL2NkocsdT9bDcu3RwDUQF0sHZFXMIt0dRg3B97j+efmJJ4MGw56njO5+UVKzWnM5C4v8AmY4GTqWpqdK1Kwrl2N2+ImI32XCzPMMNoAWsav8AfvPymEU0NkFuKyMeZVLBNE5hwdG5XLLm4Fj+CLq/GvylrKU2gMWaguFbt2QHwUdVHGCcHmIFHySwlZBYfO/2nyKfy+8eCwsYq0IlPkYcUS2PUcO+MWsI3khvcw9sPcz6Gbjiop4MglxYJRABpZixNtLvuCMR1S5iSx2q0XBVwF8SDS7Q27iXYGaxN75fx2Iv/qoGKHCTMNK3ACcJFggFwjkIHgeFS9C2tEYrkNVCrr6pUW708eCKpVVeX53wtf0QYvZ3MNk+papiscCQ32wgoz3NRcDZeYpVA2VqoCI3+p4PndcjYcnklHPZg6SUoC5O5U4SvtBPaXxGiUL0r/ONYWBwsMjJCCkAwE2m60VN4YURFXKvyqC5OHplaNndzbcMzPgWyuJYF9JmjfMDzabSIU4MWwmhKcce4lNZd12hFC0F2wqB9QlwOY42kVpjy/m5nQar58/LbLlt0woPMfD6ZjMHuJqWh0xbC6yiWa5dEpFv6kLbOTt/BWRRjhdnqUYqe9T9QjGDT947gxe6nhcy7E9BMgPBg/A56W7fHrqEqe7q/rBWlRNJ+kQU3BzMujLpNebl4M6Yj1LY5JTzQoLzDE3u7iq2tr89TaOk3BWmvTqOOBiXKCOzcEucWCZiwQRzKChXldS4FlyJuOqivA69wDfNmEUhti6Kyja9fHB7mZroNH4DWN1eIpQuimftFlEZQGJ5Uct7JRjQodF/DCmlPU0xhTf3kswTl/CnUZ0YTkD6DA9p7M4x9RViLvhELSva/gg714jkDxdfaGgReRlew8ExVnluEgEQEuiBUAcmLxuFwqdguPC703Hlnv5fwttVb/4hq2fDUxtXySsK32QGoY9qqaBEOYHrCKraqvL/AOfer68REtp9kMv6QuaRez/z9Jxt4gjojy6faUKgOAqLyU+ZU5MR9Bcc0iWrT7iOdOhLJeNR5D8Ff/bS4uPr0YKxIXf+fcAX0F2S/VBz/giI0lP4KpWF4CNWGG4JI9xB4y83Ru/Xr7xtEEWAG4/L5NsQQInCfhU69IQm6fmHMEIykzSp4IjSLpPwSgXg0f8AWEmagcQxBAdyNEwj9yqJ88NCi4KEF49Rc0CPBX37ikE98sbigxSv+wFwHJs+bKOm3onfhK6+hAFALe9ygbVaqq1JcrWNF0ktwgrrf1jFoa4IAghwYGXFs0c/O4NVASqp6v4XHAwvVkuhXpf6R5Zu2eev0iM7PJ3rP5Q1EA6S/wA4BwAzRr+dy/EO8WwlbzRFUlPn8DQPkUqm8FaEHRK099QdlZ9y5eKwxu/ZLwvd1LSv5Sz1fr89UOTHZ/iPafoxiNgYYCRcNMfiClZteIJsErAZTMgly63LwRyOS6ZfQjyhymur36iMaTrcBGFnJUBJ+YHxnWJojBQl4TfuUGYi0UY6r7yjZ5xY6z/iWPY54gVAifx9JtlvnmZNB9P+w3ZP3mTqjlOY6M3M06d9/KuwCghmES699g9QrdM61AXTZyr/AJluiWLzVnmUInsWcIHHNEcTBYpfzhGqh5y/WGF06UDMFDPIm4EaqccxhSzv5jak0EtCxy8+4uLQ4ICxCfymubh8pjzFb26NiwJfxOY/WFF3kGJTYTMwQMeuTUebv0flQC8svRGSDD6V3FEoG85zH8NRVcbbIeGV9Lti+YcHtS4jRayy+yEpuxJX06g4JzSdRlSuHmFRTTAlihwt4hrVnRYaLh9otDkx4evhFGwrkY1WAtXbZjMMSrgyAS8gRTbRcwx4InEWQQdsRKK6UJqwgKVQJQb6j2nRmDFX25Khi96W2OCmXNbZSWrZavPqHYK4VYwKenx4evkCuYUzy/6gJC2xVRCmAX7I6HRhWCJLxW4b6UbVcQOU7dQwK4t6lY3gwFSu8TprDGwB6bPrLAA161AsIGaNkfFtr5UIrL1nmGCpM5lBhGFJswXXuAIMXMBotUZleMLyY5ioTUqATyphqw6GfvAys7rqYOJQ6XDLUc32+QcovAOXv9oUaNnY8MtihWwl0B+kyDZ6ixWnJ1CQBwBuCqNjr1FGpMSPmV8Q+xKOGjfLMKs1hgSlnUxxSqHklzydVCOzUXYhr4MRvIGjtgBYYgq71dfaKWNm1aMfrmVeUlwX3u4WxGWU0Eayi0L6GIDVQ0Nq4mzA3u1gvYUsOIJBpOYDQ6jAqDuMPky8xGCkafjAhitscsoADhv3DRRhR9YRWApZkHmZy3LLzDBdsw7xstlf94JQBdiy8xpAHKMXDhNuSGlmR4x+cE0FsLCKeNjpiIo7PjSmsy+iN4nWpQiX0Q9tOhf2gju8HGI1sdQLWU5qF39pLQU514gUKaaH/caKrHJLDF3P7XUy9ZTp5PcsBLUNng+ROUtkazxMDSnOYYFPQgIFK+8r7Nljw3hhLE/C1nxCauWYpsitRiGTayA0tL1AFQsKdO5ZXgUsKHzHIShdNBzCIJ+yHdZNAwqcrpuegf73pLfXbBVyVyVD9puPWm5Xy/KOIovXBMAA4TYxSQpTFy65sG4yos6hJGxLw2tAeImDyMagiQTrzAMXTgY1V5TfHuYGwX9efi8WBACgGiLZWOIWtJmtSzld+Mw+4G8Zl0oD3xALFBwR1aUMKoJdMFNGq/hFBKpGW5pSlNxBqaUXj64lDQ6DiolIgtFxhOL+MFuw/rCqF+eJfDnpxLWuvm24pZty3dkEpFh1XMdkF6jdn9UTm3xHKzCbcx4eIBFEDZVu2xdxZfK2Fv1Y8R38SAdT4lCwKAJgF+oQFoG0x/GJU4ZO64g4EmLAX7hkZNnZ+8A0R+rOazxGvPLEM6BiK0qB4ll0O/MQOcs4qNxL6AzmNoAgI1BUbyH+8UN7JWqi1QGaW2/eXEKGK3v94ccZzRZ/1KUsXiZmnmsRjIpoqF5GGHWdEEHcRHL4vjzLZaFWJa+Ep+6FVkrrwxRdNSyBlv4rXVhi7triBaWI+IVoGZTqtS1O1tRiyUpCo7hl258wP7sK/wAADKxmrThuGbMFnDcoZU8P8wKQIiVnRfxgzYFqwBHI41mF0QDuDfuRW7Ivuch1mNLyP9EG8MYxDo5Dj94bE8PEYFvPMbEulGY7b4SS9KNQi2miNe+Ljv4kM5H6TAUZYwro73MNQUdSgouS3UZGi2VKhEYxuoUBvXMSXX0jhYqXBNeYxAFNkYGUOaXUYa2q0M0U80spNXbAyxExLmuobThr+3wqExlSBRjR+0RIEbRDshDm6zK1Ot7OiAkUtuD6YatJyG5RwMiwF24g1GuZcKt3YzFVeXKs/SNFg8wfUChW3xKAmIQtK/T4jl/nMqlsH6xA8DxnmCsWOo1wS+KlJbg1Da6iDnf0Rq2XzGV9HoggBV4AvmIyg3wuommgunF+pcp3DdLKn5t38ZVXQmfvEDanOSNSdBc3yx3UuzoxAQrQq6hsYKoo1CQFkIod8bIMSFdCyUQF+XbMCqsSRN2xHq2FfFlf0mE25fz7Sgtb4Igwwsagrk1kwv8AaVPyP4TUS9xhZqXRaoxmWbC7j5HcWhW+oA3Uq4Euw2kvGI7dkDxpVFdIOL8Xi5X2vG4G6+UqXn+3P14qTbbM3OJVjpYbg+4uIrnAvzjDGOgAtuovYpeANSqW9vMXdMnEXrcEowRK3CH6x2rpGA2cS69k3cyEGuJs9/CQrl/UiEKqIgl7hjTNNw0QXBlDHHWiBTWIIZpXMVgdSwdVAaaG49YA5IK9BTTinDDhS7eruZFAHgxFWbo+PZl8Pzj6MjWIwaxqku/vPDfFs/KUub4Gtx4WEmq0lRExDpRIFg1yS7oWBR/CEAnqLML6YF4qXVyx5x8RBuNzYtKH7MxoUuLzUAQN/csXpyxrooyXuZpM1pi1+B56i6ADKXuYlXRjcdRLgCHbmZzHuWUrO4FUicMqEXaaXcorjgcwmLjcIsGGfv8A7X2YL+cxUXK6o/Qjq2PTz6guBpaXUAEDZmstgBssNQmxmOA0RgUvtiGVbGMRk4TJ3Eo1UcVV5D/E0dHkTYlW2YCWNluM1Kp5H4hQbV6OJdm3EZxREcG1w2tQThcwRqkxmFdmHcMCjVagpuh0nETqDTRSSkx0L3CgXpaeksDEXLUeA21cFwVXLPtp8YOAK/OU1uh4IFrjWESMqzRxGNY9CaOpZNDmXM/MozRYfGytQrJegZnVa28nuErgq3KpNCLP2CfG+pSI8xZgu2ykwBKQXJCrDnddQFXIbYxcVR3L0SgTBuNmYalNY++4MW7qGJh46gm5epeQAQH2gocKnRLfl7JWciJeh/lwFTj6ywI8g7itPL+0abIWSRa87mKNr1qPRbXKjmBg6AG/CWQHc2aa9vEyvUsF2QEsq8xCc1uZXyalQjZTaSi8xmWXtFCKrKdzbiiXaCKo4iajLqXNL6vvn40/nMzEsNwERKUp6l0XPTnEALqqRuqDiKoWaTCUVWXgJ0MdCkFJ1NuUe9wneheDuCyG9R+0sVz5mn0a1fREHtVfjRdsqfp/uZzhOKiGwNXxL6tdNQDGV4gGOdkQU7Lg3ajfaPmrUB4iZHEwBmIMoDF1grErAHLd1zClP5SgHKvjxlDaahDbJkx+UQUm0lViDhpXMIWuo8+YEVsDN8RC2LZu+8eKBd9PmDAof0lo7HJhDSKWGM/y5QsCy1lSGE+NSgxJinyeZdnsL0xEIK5tmJFKItG1gUTgu2Lyjf8Aca6HTfTEGbsZjvXXp2QmAPQSgoEoBzxdfpGu7B3d0QKoOh7I8by0h2XFWs2SiwhAQtA2eJTyUqpj1GaTUAK2a5zAZVTKLcAYHR8eVqGvrxBUVqGgGdvEbLjtCRPd9h9oDS6DOWVds4NZjWi8dw2rFbemI520XBXcEqlmxFLf+YoYC1zpg3dvaOX5HePDfTFsD6RUAtzGWW1upZq20XMwarcuCXF6Saj0rExbzcKhsdFOo5ahntGhZlWNVMLgAEIbAtSo6L+P6avviBzBVKL9IRuDVOczEb4lammLicutdspKETd4fpNcxVluoDSvECWELlDE+24Mlijq9RpZZ4lE7ruNOTMFiNZjFgObzOC1a9/3pFSfeGIMK5L8yzyPNxF1C3qOQQXPmLAAK0w/dl/wLam5my9VJD49Kc9QCDKbLfgai6o1nDuAqSeE31h5ViskyFmy9vkY0oNjCHQwOmK9/QhriDmFQVWc5+0GUHo7Qa56Xti5T4SmUE5EiQilqYirtfcZApiXrAVPR/n5RRsaSV7Vin3zM2wDecmmvrGm2Xm8S5DDF3L5rzHRFucyqHFELTbM7gYRlFBiMZF2sXIdEuVhnek6HRPXHxpBNkGk6HWL9xHtBVuFk2TkDBjzCMwBWTcs4a4Wh/moAMByvH23NdLTzTEoGe8y7ur5DJOFIXdwegb0Na9QKmobLz7hm6tPylylGcwGTZKBQEAs0unwXQw4TSSxWXCde4AhWkwOlnG3UcmhkRmAaw+tS1tGv+GYXNuT7GYiHjuBagGYo+1AOKA6K8RvkNvPr5rDeEdJMy63VsgJivcGqJwmNoOL6gY49QyF51FrLj9JsDTFuTQQZ4V0/wBoiIq5V+YE2h+5zHrGGXvIIM+oe8+lTUi0wnqjI4I0LY2bisOjqOOxmgw0VPULw2xiovzi+i459vlpkxy78TYNZ8/zmqGuir5X9poo82XMvPBVAzdY/KYc2qii2GAYdZgZBXMKkr7g0AWvaXPF2Lx5lJSzDzmIWpxxLQ8N2+ohSUwuJYbMr+XERG0t+EbSeThmNsBaoICnkwykqt7h2ZaaiqxHk4iDBXBLCjCNRL4KPPMeGABzLUoC6R+/4AEoNJxAg0Hu+sqrjWlz+crDRKUXB1NoDytS1tnrKDsXydTBUegfgL21WU+odGFo4/WLZgcPEyFMswFiDTWfMXjARowrEkTTVxAquIyTwDg9sY23g4PmGmyFZFNnMFqExZlckTjb6SyPpbTxcV1BpLtEGM8nEqDdscMUqr7xAUKGSuIolLctP13MtUZwZhjzQovsNqLNP5RESk5fjMPDkgAcDRphhZeMG/cOhoWI1UvA+rM5EHLPsUmpeL6c/CamjvpRBlvqiFo+38Ktv55iJw73kRsQ/Cr9ZTtPjCMOZyBmevrRZmxkKvAl8r/hPwIo2NMa6Wtf5xlg5FruckrdNwUOzYdd/evvGakdGYdJBVuS+P5zAByryp9YwqO3N+YqXXwRChu9LRCVCc3X2j2qdm2Kra2/OACDQKdEe8/eKWh5X/4i8J2OH6SlNx/CpfPUIpIcu3VfpNEfS7m+NCqX9pYlF8RmVfRmHNDwq2ecML/54U0xTeLzFLHOlzeX/wA8YwLC5rvydQEGsIV+0Pvwtvwr3KGBO6imb3R/ShS4Nod/05Upuqi9R8zcoX4VBHiCgSloHcsFoePn21MT24EJ9PcCgBFK9LIuqECWkA+7/RRxEJVsnr5ynIpWhavcriXhAsHInYm4EZd6gAXHbR/cEAVWgOYERBXpp1j+yorODY0Z+vymYlS0X3MKSXTl+lxyyKRMjBaAIybaGuv7mRaKBdBy9f2oOmbTZV/l8xaEjtHBDt3cHJXgMIKhN0gPrRObapl/po6eHg4tMOYwoyoqmK4P6MYgAmyvIWZONwvBqDQMpP0gzDu5uvyv+bj6dodJ87G7GdDl+hlugFOwv9QI14LlSb/UPtAWjWy9O9Q0GZAtPv8AP+b/AKoWdCA3E4NQrgVprAlnOGbnTSZvXzj+icUJzKCoNW2n1j+EZUXVWuMpmWpnE9mV5jsvM2cd+5QdCYNci2XVsLMFqUUxR39JT73ahv1x+Uz5dWTDKnOrjcPZ/AUsus0wrmUZsWTOrqXVUs1fXyEYzC0JdN8Q8iYM1MGcf8gBW7YP2Vr9YbEcniH9MWOg6hvLbvkxBRiHUFpaIuZldAMBsFnUC/EGNJrMtjrMhKgM7wyiyIiLgzaefPMAhsbcbC8+9x2iPPxfeAzruXHmOQChKV89wV9GFxssc7v5iShaw0l7tO4FzB7+Fm5h+cw7KpcO4e3YwWOjfh/TKs2SKX/X9DCmIBclcxBFUeyLp9kou9xQK7t9anZB0bs8RRaXvPzrZMbFiGvqP3ly8g4ByX9ggQHurs5a/L7Qk0iiXTj7n4BmbFVAUz1JVQCQ464EgWsI74YtCVKXXR9z+l0b70DqfRgWi6Ngo3UpjQGAvNPqTt1Q+NhtePrMtT4tImfNRtNCpVdLOrriOrQmyDpgrtgRttWrY13smD1YS9J9yVqxUDFrFpemEeFAGnz8jStFI5zEXOA7D9mVdCqBpgalUJVWgWsO+f6AHiK61m4/M8oos2+pS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Diferentes combinações de mutações podem afetar o tamanho dos tomates de forma imprevisível. Nesta imagem, a primeira coluna mostra um tomate não mutado (WT). A segunda e terceira colunas mostram tomates com uma única mutação em uma regia£o do promotor (R1 ou R4) para o gene de tamanho de fruta SlCV3. As mutações individuais tem pouco efeito no tamanho do fruto. Mas a combinação dessas duas mutações (R1 + R4) produz um fruto muito maior. Crédito: Xingang Wang / Lippman lab, CSHL / 2021
Tanto as pessoas quanto os tomates tem formas e tamanhos diferentes. Isso ocorre porque cada indivaduo tem um conjunto aºnico de variações genanãticas - mutações - que afetam o modo como os genes agem e funcionam. Somadas, milhões de pequenas variações genanãticas tornam difacil prever como uma determinada mutação afetara¡ qualquer indivaduo. O professor do Cold Spring Harbor Laboratory (CSHL) e o investigador do Howard Hughes Medical Institute, Zach Lippman, mostraram como as variações genanãticas nos tomates podem influenciar a maneira como uma mutação especafica afeta a planta. Ele estãotrabalhando para ser capaz de prever os efeitos das mutações em diferentes variedades de tomate.
"O verdadeiro Santo Graal em tudo isso para o melhoramento de safras éa previsibilidade. Se eu mudar essa sequaªncia, vou conseguir esse efeito. Porque existe um mar de outras variantes que a natureza acumulou perto da mutação que vocêestãoplanejando, bem como espalhados por todo o genoma, muitos dos quais podem estar influenciando a mutação especafica que vocêestãocriando. "
Neste estudo, Lippman e sua equipe usaram CRISPR, uma ferramenta de edição de genes altamente precisa e direcionada, em dois genes de tomate que controlam o tamanho da fruta, SlCV3 e SlWUS. Eles geraram mais de 60 mutantes de tomate removendo pequenos pedaço s de DNA nas regiaµes promotoras, áreas próximas aos genes que controlam sua expressão. Em alguns casos, as mutações individuais aumentaram um pouco o tamanho dos tomates . Alguns pares de mutações não mudaram o tamanho dos frutos. Algumas combinações sinanãrgicas causaram um aumento drama¡tico e imprevisível no tamanho da fruta. Lippman diz:
"O verdadeiro Santo Graal em tudo isso para o melhoramento de safras éa previsibilidade. Se eu mudar essa sequaªncia, vou conseguir esse efeito. Porque existe um mar de outras variantes que a natureza acumulou perto da mutação que vocêestãoplanejando, bem como espalhados por todo o genoma, muitos dos quais podem estar influenciando a mutação especafica que vocêestãocriando. "
Esta gama de interações para quaisquer duas mutações modela as consequaªncias de uma única mutação ocorrendo em diferentes origens genanãticas. O efeito écompara¡vel a queles encontrados em algumas doenças humanas, onde algumas pessoas podem ter certas mutações pré-existentes que as protegem de mutações causadoras de doena§as.
Lippman e sua equipe continuara£o quantificando como as mutações individuais e combinadas afetam certas caracteristicas da cultura. Atéagora, eles mediram as interações entre duas mutações individuais , mas os genomas tem milhões de variações. Lippman espera estudar interações mensura¡veis ​​suficientes para tornar a criação mais previsível e eficiente.
O estudo foi publicado na Nature Plants .