Os pesquisadores pedem uma maior consciência das consequaªncias não intencionais da edição do gene CRISPR
A edia§a£o do genoma CRISPR-Cas9 pode levar a mutaa§aµes indesejadas na sea§a£o alvo do DNA em embriaµes humanos iniciais, revelaram os pesquisadores.
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)
DNA - Crédito: Arek Socha no Pixabay
"Na³s e outros estamos tentando desenvolver e refinar as ferramentas para avaliar essas mutações complexas".
Kathy Niakan
A edição do genoma CRISPR-Cas9 éuma ferramenta de pesquisa amplamente utilizada que permite aos cientistas remover e substituir seções de DNA em células, permitindo-lhes, por exemplo, estudar a função de um determinado gene ou reparar mutações. No ano passado, os pesquisadores que desenvolveram o CRISPR-Cas9 receberam o Praªmio Nobel de Química.
No estudo publicado na revista PNAS , os cientistas analisaram retrospectivamente dados de pesquisas anteriores nas quais haviam estudado o papel da proteana OCT4 em embriaµes humanos durante os primeiros dias de desenvolvimento.
A equipe descobriu que, embora a maioria das mutações induzidas por CRISPR-Cas9 fossem pequenas inserções ou deleções, em aproximadamente 16% das amostras havia grandes mutações não intencionais que teriam sido perdidas por manãtodos convencionais para avaliar as alterações de DNA.Â
A pesquisa estãoem andamento para entender a natureza exata dasmudanças nos locais-alvo, mas isso pode incluir exclusaµes de seções de DNA ou rearranjos gena´micos mais complexos.Â
A descoberta destaca a necessidade de os pesquisadores que usam a edição de genoma mediada por CRISPR-Cas9 para editar células humanas, sejam soma¡ticas ou germinativas, estar cientes e testar essas possaveis consequaªncias não intencionais. Isso éainda mais essencial se eles esperam que seu trabalho seja usado clinicamente, já quemudanças genanãticas não intencionais como essa podem levar a doenças como o ca¢ncer. Â
“Outras equipes de pesquisa relataram esses tipos de mutações indesejadas em células-tronco humanas, células cancerosas e outros contextos celulares, e agora as detectamos em embriaµes humanosâ€, disse a professora Kathy Niakan, lider do grupo do Laborata³rio de Embriaµes Humanos e Canãlulas-Tronco no Instituto Francis Crick e Professor de Fisiologia Reprodutiva da Universidade de Cambridge, e autor saªnior do estudo.
“Este trabalho ressalta a importa¢ncia de testar essas mutações não intencionais para entender exatamente quaismudanças aconteceram em qualquer tipo de canãlula humana.â€Â
Os pesquisadores desenvolveram um pipeline computacional de ca³digo aberto para identificar se CRISPR-Cas9 causou mutações não intencionais no alvo com base em diferentes tipos de dados de sequenciamento de próxima geração.Â
“Na³s e outros estamos tentando desenvolver e refinar as ferramentas para avaliar essas mutações complexasâ€, acrescentou Niakan.Â
“a‰ importante entender esses eventos, como eles surgem e sua frequência, para que possamos avaliar as limitações atuais da tecnologia e informar estratanãgias para melhora¡-la no futuro para minimizar essas mutações.â€Â
Gregorio Alanis-Lobato, autor principal e ex-bolsista de treinamento de pa³s-doutorado no Laborata³rio de Embriaµes Humanos e Canãlulas-Tronco em Crick, disse: “Os testes convencionais usados ​​para verificar a precisão do CRISPR-Cas9 podem perder os tipos de mutações indesejadas no alvo que identificamos neste estudo. Ainda hámuito para aprendermos sobre os efeitos da tecnologia CRISPR-Cas9 e, embora esta valiosa ferramenta seja refinada, precisamos examinar minuciosamente todas asmudanças â€. Â
Existem importantes debates em andamento sobre a segurança e a anãtica do uso da edição do genoma CRISPR-Cas9 em embriaµes humanos para fins reprodutivos. E em 2019, houve condenação internacional ao trabalho de um pesquisador na China que editava embriaµes que levaram ao nascimento de gaªmeos. No Reino Unido, seu uso em embriaµes humanos éestritamente regulamentado e são épermitido para fins de pesquisa. A pesquisa érestrita aos primeiros 14 dias de desenvolvimento e os embriaµes não podem ser implantados no aºtero.Â
Os dados para este trabalho referem-se a embriaµes previamente estudados pelo Laborata³rio de Embriaµes Humanos e Canãlulas-Tronco de Crick. Os embriaµes estavam no esta¡gio de blastocisto de desenvolvimento inicial, consistindo em cerca de 200 células. Eles haviam sido doados para pesquisas por pessoas em fertilização in vitro (FIV) e não foram necessa¡rios durante o curso de seu tratamento.Â
A pesquisa foi conduzida por cientistas do Instituto Francis Crick, em colaboração com o professor Dagan Wells da Universidade de Oxford. Kathy Niakan édiretora do Centro de Pesquisa de Trofoblasto da Universidade de Cambridge e presidente da Cambridge Strategic Research Initiative in Reproduction.