Pesquisadores das Universidades de York e Leeds, em colaboraça£o com o Laborata³rio Hilvert do ETH Za¼rich, estudaram a estrutura, montagem e evolua§a£o de um
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)
Em um experimento de evolução direcionada, uma casca de proteana que ocorre naturalmente nas bactanãrias evoluiu para um recipiente de proteana que pode encapsular o RNA, imitando um mecanismo de empacotamento do genoma que a equipe descobriu anteriormente nos varus. Crédito: ETH Za¼rich / Stephan Tette
Uma equipe internacional de pesquisadores lançou uma nova luz sobre os esta¡gios iniciais da evolução viral.
A equipe afirma que suas descobertas tem implicações para o tratamento de varus no futuro.
Pesquisadores das Universidades de York e Leeds, em colaboração com o Laborata³rio Hilvert do ETH Za¼rich, estudaram a estrutura, montagem e evolução de um "recipiente" composto por uma enzima bacteriana.
O estudo - publicado na revista Science - detalha a transformação estrutural dessaspartículas semelhantes a varus em "recipientes" maiores de proteanas.
Tambanãm revela que o acondicionamento da carga genanãtica nesses contaªineres se torna mais eficiente durante os esta¡gios posteriores de evolução. Eles mostram que isso ocorre porque o genoma interno desenvolve caracteristicas de um mecanismo amplamente utilizado por varus naturais, incluindo o COVID-19, para regular sua montagem. Esse mecanismo foi uma descoberta conjunta da equipe de York e Leeds. O professor Reidun Twarock, dos Departamentos de Matema¡tica e Biologia da University of York e do York Cross-disciplinary Center for Systems Analysis, disse: "Usando uma nova técnica interdisciplinar desenvolvida em nossa equipe financiada pelo Wellcome Trust em Leeds e York, fomos capazes de demonstrar que esse sistema artificial desenvolveu as marcas moleculares de um 'mecanismo de montagem de varus', permitindo o empacotamento eficiente de sua carga genanãtica. "
Em sua evolução, a partacula semelhante a um varus artificial empacota e protege várias ca³pias de seu pra³prio RNA mensageiro codificador.
O professor Peter Stockley, do Astbury Center for Structural Molecular Biology da University of Leeds, disse: "O que énota¡vel éque essa partacula semelhante a um varus artificial evolui para ser mais eficiente no empacotamento de RNA. Nossa colaboração mostra que, após as etapas evolutivas, os RNAs mensageiros encapsidados incorporam mais sinais de empacotamento do que os RNAs iniciais. Em outras palavras, o fena´meno que temos trabalhado em varus naturais "evolui" em uma partacula artificial, e os resultados neste artigo, portanto, descrevem um processo que pode ter ocorrido na evolução inicial dos varus . Esse entendimento nos permite explorar esses recipientes como veaculos de entrega para fins terapaªuticos de genes. "