Estudo identifica o gatilho para o desenvolvimento do eixo 'cabea§a a cauda' no embria£o humano
As descobertas fornecem a primeira evidência de que um grupo de células fora do embria£o, conhecido como hipoblasto, envia uma mensagem ao embria£o que inicia o desenvolvimento do eixo do corpo cabea§a-cauda.
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adePMsqxGXH+xD3tB8kzxmwpxhXF8ahro1RvSvjaxqWIPHxAmIj6SgK1/8A0NBAuwI1P59ROE8f3Gwam059FqZquJYK4LDl7A6PWR6GKMzj8ZrS9YrLvmCVrkLlTe2FsGWmxETkayx9qNoMSyvWdzjnVldXX6evGqIuBZLOHTB/z6TG/wCZD/zrc/Q6RPYa6VJ5L6hre67JUBYL1w5fEV+8bS2qEY/2AwMc8fi7R7lQG7o2zIMUFKkOlSAkX4FZnwclW5i+3YibbhhiYggGYqYnFUTFVo5FYZCIYCcIsTsY1h1sjcaufTDNfGqVaXAPMqw+nQQlqk8TVHZuXZliIVPpicavHDfUMBLR7AqwahTd7kt63yuSkfyGUPgG5lUcg613sz8hhtw265PbMrZrBnEactRhx3UrFs+MOQ4srGRSxniaEY/1cOnU2Wds+STD1OLX5LWXvTtNs8nEMM/C4tpdRmjwVUkqx8eIFUROP5JbT4hRyVIVclgFd9GHjSKaVG1bN5QJmN2RnamliK6/YqhI/ujEZLqrFiYjFUt7ijMAiUgleNWkazyRuMZ4yssyYepUA85IYNxn920z0HEBnZKwJrWRs3EEvsXY9Hb2126sX8ikYKMgmAYKztegEDYhYEWJ2f8ARx6vI9phyf0cKnWvuD4lyMTZgej/AA/sqHpjqbT/AJrq1HMZRx0Yq6ZxYCSJaAp2mxzkgq5JWJ4gG5KKjcqwynmsrvgLb0czMcEccOZnASsvEULOSgaUUk+j5A3EsZXIsCrYRyKFo7NoE4/icWoUetTF1LWBVRrsjMowiWH3s2TCZx7F2sqrtjnRizRXYROS89lksrCx+63+f8/CHj4ruDD2v5zKVLOoCrBDAX2s46k+Dv8AZDclUsrYFGgmsZcQOyM1jOeNUbG6n/nRStteIyTWfir7rGGP/wAcZLjEX7rjiZBLfP5Z1elVALM0peD5VthXYa2e0b2PvDMkQdxGwTmWdwFgc+Sj3T7UrYxvacrFP7Vgn5CgLbX6caweK3kI7lQwJxNwJS4mAy3/AGFW/wA4lFgFB9ymWfInGT9wz5mRDLuQEjclo/JeFzKbsS7j+VXUqVUmYOGERF1qqNjnWnj0tkp3D0z2e1zDFBM+0JU1z6/TiEzjUBrOcf3A2DYn7eew/Ztlb5Nepj1dER8MDGY5DQxQJkSyxZgGOgEDiBlBZtpxSqteyFwCYuUDJsqV+5rBPM2UrW+cnWmk/NFmp8fmlnHuQ0o8d/GrtvK69pdxQFIx/lEVxqPtPUxmK4A4ujjPbNgD4vs0rstJg7gXMsAzqRKeQwFibCbHVqjgUTK11F8xD3WOycGxCT45gAZx6VWmprrvMftNbVziMPNyMs/xA6nj/nG0eppVWTETE267aVDDXIa2Ze1U+ne3j9n53MBJHySYDBmEd1PrLHVq6m1pe3sYICFjV+wtrEsfkmV2EGuxyjWssYljmUHERNpcmG/x4gg+dsgKXaziJ9NXxiTTUK269eefZE+74nzG+BOP+7U3HqQNXx1nkJU9TuFTF6PCZnNtLLASsaz0rqzCgyEnUwCcdcTKk9jX0IlQOfJ7RYoNv9ZWdhqNs8oZcpMTsxFhcxvmVkknokd4iDvxEzRRM1RDSTyaGDA4i3MsLlo3c+TgRV7pMsXaswjug4X6nDO24/wgZirga5mJiAkNvONyDaL6Skor1EY4KMDP+gu01xF+ZmNPicN2n/RPa5MDehmAZXxixHj462Xgq5WMmIqGBouA/sMurVm8QEanqmnWALm1RCko46GMiVwrmePEqt0jGoxQMu10rSwzx6nSmWWIsZmmejNZR+3GYEr8qDl7AkNzzuCASm8BbqFwy95mYvogiZi2lZyB0D2xIVQWbxDxPXiH+cCD0UYJmIy4KLmVKgmczMyALF3lUuqFg5A1ZfnExBGlDYs5qhgQFGZs0pqttlVCVG5SC7Rmi4ihShbUA9Bps07xhsBW1ycqgxYyzYxbej2WVhLPJCTE7i5R67Da7ZVWBaZ6PGM+jtMPEZZ4kEL1rDaSdgIhBjMK45zO5mBgJXlppYDxlOLdIaVIHDZgaypwJmJXtKl3mCkZeyrGVBFH5ZdhYmD/ADKuPRQWJGCfT7glK4et8qxEDAwiVn2qoHpyOMlwsoepgZmbCZnCr3tZVaW8ZLK/o7JVw6q41qIGvgtNjPsIdYuhmvtFZMFTQUhYqKI5CzzViG/JchYbd4R0YMSvMb+tyRHPtV+vbautiMLThLl2t0y1zBPIYzEyxJj06MqH7vK7b4J9MRWKmh1trubUH4e3LV8m0Q2+QdRU2nJwlFFZY8n+uZiECA7H7Y4zGGD/ACJ92sxK/vf3MfQfO2UqKYKpGpZSocAaiLckvLa0swu5pOj5yYFiKuOLTopfEflBXrvV4VBj0liaSIiYLMpVkbK0vFr1gsQw+SyNXaCxedxKyQWVITtC0JOjDo5iWkKOS6r5FshykGpCEBCxnhJC+IMbkWWWjIcGOpA8omEaOnfjaVo0apbKSp3MEXuY74qsE5balnZoIp1itKvdGTWFi0oPjsvdXcj3aDOBmuGP8MP5axlh3AMxExHC51ntWZEFZMVAIuC0M5HUTMNvsDSyzIIUleM7T6KzHH4Z35F2Ja7Mp90UHJLKa+TtGyypUzDwNCgqUXoJbZtNiIGMJaccBmFCmWkCMDD0OOqtHTvdUAWsstXsuGCOolhm9cwhWobWFWZRxK5zADKq/JYeKEVmMIgwD9R2eYZVyixqsAPIrIYzHovy1niqOXbAmkZYqYAHZYlBhI1jFh8H7oEcwArM9yyH+Sv7yMTisBZyFTQxsomGZq6RFImgM079LfG8Zkjmfg/ACiVER2bfjWeSq3+0H2eOUVDHIrCMqbNW0awIgubexw06MDawlGK1qQaOtRTVZyCzAnJBK2DtG1IJshqXHyeGrkXVqzni4jUr48HNWMV6KyFjOQ2tRY5W51n1D42jTE61xKhKO5cht47fMq47OONT7uUMwLgfMpCmFFmsOxnawE5+YzYFZ2GhLbrRSe4T7W6jDpx/Io7PxS4Q22m2V/HJfLKTt5MRXWKcjYZscib7qyAArtXMnGZXUbHsr0jD3cNtDfSHIGti9tq211ZIH7cQ7Mys0XIJwYVYwVmLTmHKSlGaczkFhmI0F7Kg96upBTM8ex43DE5F60xnLtscBmEFgwGXCY2RGReR7uOfnb0x1Ne9MwqBB8ccyqwrPpjZZ9NRTG5dag8wktcl4xiW5itieSKSJ+Piaqw+CykxDh69PC7bOJ8eh+HXo/xp8jv0U4m3aqS4oJlvTbGce7L2HCrYubvayMTCMhiUi+4gVBgMy+5g5JJ3KyjmWVmxkeukqZnAe1GliggXKkNvXmmchGxPJieYRVVo+NOQnuMTtmnFIlooEtA3D2Ara1PHZi7Zg+dovcQZiDErca3WblwQYD3n0URvtz35DK7Chp95tv8AGjOzT8QfFTeQOvXwV+QJiINwK7Ea5cMoLSygIc4XQh8KBYGxn2nqP2D/ABr85zCcBXmm0ACKOQjC1suqs0oqZLrnGHPoDgi6Fk1NsrbSxuYqpdZ5HzDFXM4BzKK1jKzLaNWvyzxVlXH2jqRPEAu4yXGaDk//AKchGE1yRgQyoYhQa3IRKBtbzTmw+hPcXuUJrCyiNYDUqEnkoYRMRYO4I65jnsShCzKy62e6kDMYYB79Kzgg7Tx99QzqVkl7tg2MwRrWi91Vts4zHclR3DLj7f4xEMsifNXw52iEqy8fylDXTWnK8j2ncv8AMJwVY5U5BHZVjNetfRVi4VeB3yvZLLFrAeuyNW1sFVW2vHEJqRLbjqXOsy2KfldTOSjPVjBTjAV6ANutUuYu2crSmLnzDG9QZXnWz5oG4JIsrfeuxMNj0B7BmZYuHX5q6Bs9yOMlClhh6msUYKe9mBJZNh4zBx9ig1Nh3ZEIjqjW2UlLdSgs/bsS/B5Oi1hpviXHJ/kX0rTLE4mZ8zhNrdazOwJB8zbWYn/lhFEX5cZAJEMMA72Oe8VL9NTZbs2xsNWqIrh7GPuBhcz5gHZm0VjKrfddcorFashsNyvcu7tk11sZbWtapbqwFdrcihqyfVEin32vmbFYMsy/BQWVMhjLBBNo6ZlVMuM3iP7mbyVegwZ+eOuX5HtNHI9istgZLDDWTSf2Kzym2sLb1ldRnDnyVuvfuMFcIwLPn+RASV47Gcfi6PyqwJjJxgcX+19d9SWYdqNkaGCGIYUxGBn5HbYEoGJc+xZsykKqWvmO/un5x6GE+lZ1meh2DnRx7WX3Y1IfKWHePlJRZpYbMq9WT4zFr7bCjMz0vymJkZ0cDZpupI0M09zUOJqdXt1jMTMxBk1EYYbQ5WZ6+6cFcV8pgWrMp+drJlovIKTxUciLxWRyuylmABICt2EL2XVlAe5YP5azhqtn49asq8kjQHsRAFB6NV2pssE8wWEC6H5z6L8h/afmyhsKjSrhWtGpCJ7mgVaxuC1rksOznvOC3zHaZ9BKKPKpGjO4VUfFvIQeH5AzK1Ob0BSpBswzYF0ieJpciIW9MStYwCxn78jCVslgs45n08qTUPyMoxj6mYmJXMERciDV4eG08HjWq5tD7ilSwDpckrUGlles+DxryW5FJ1xqcwDYcY4V7kZWPZ+G/jAzKeGXnG460iXJ3dZUqbdKWlaVMLCqh2JmYGIJHmSCD5+JtKbNJXYpGHJaoCW8gCdmB8TG0FRh6g+bGySYfRYvco/aqQ73X8krNsyh/JxlWARExLjhakyTxybLgGl3sAczuw+Dt9Ko1xm5mdj4XI8dgK2sC1DGHZWRswiN1F7mO6q+1CkkIkyolTbNyLRmuwYTj9GkRQdsBY9xlb+WXLo1f332gV7AwpBkE4b0b2gxvn+KsASgrr5Rnqcl/bpmY1fIg1aWJqWmPSl9LORWA4XE+IO4EMTjlx9OVDWd2MPCe2HwZxq0M3rxfqWzPmGGAZldUqVUayV/t0udmzKbCrrUrgccTxAKaRmqoJPxfurBleLxqRGdUZiSChJ8cXxyuylS1jMBfg/XCLyFaOA88WsOAGVWBTQ1qsa0A7wuYH3rZzKm2H2txeRrHHtClJ5AUORK2ZSc2Guha5ciOtdIz7QGpDVZ1mZ90fr+OqnMrq3CI1bisx7CpuLbM5zMdZO9qro6widytRLhmvuAQOgJtaLbYw4rMwtNIc+5WrxK1i07TCVwvhNjtnM/E1gET2we4fL/APQfC+ifNbheP9SFh5gMXuZOFnKwVUDa55WYKy6PpWjfPpUZriFcxvaaripb92gntKxpjZT1ViAYhxEzmmmq2PWlK3aNKU2Z0vVMkw9SoWTjDE0WqW2vY1dhZKOxYk31FgBmOz7VaH+GlN3sOBXfoV5kHLlrZrpqZlenaeIqTgynKtvs+pMZZ4wJnsPhuRaCS5MBimVhrZy7PGsWwrN+zdPM5m+0z7T6L8YUjSHoFzOEN08eBym2tgmMTYfSZzERmapDNcjAnLYM1uFH3Tj1VVLe+Ki4LuDNZiVD3vBGrLH7JxeQa25NGJ5GVq8OeQfZmZ9B2B8m3yKAhA9r/UKJ0WIM49mjXZVPIbDyVBNfScfEBybKto9etajBs7Ngjfw8ZAtf3nwzQCL8K2JUf2mwrP7oAxN3siN76Pc1oAdmiQmHs4ycReytorpd958DP6UMsqMWssXTSJNPb9OzR6irUjxSq8WTlcfvSCFUKpUWGKKoOaFlPKWyXW+NfISSNV/td9VrrDWHlcgBC6sa8xprFXt19yrs1jBWIzEX3LysNeqqKMA8lfZ6L8dQVM0as6e3DqVrodRSv21KHgr/AHDdtLfuxYWKarT8kATHtsXMNQ25BDWNH+f1qMl8JBE7DsdkzB2HucTyQsJuc8ob14nG/qu+WMWMMA9Qen4yf1Yn5T7lp9vhGbeM2gXWbmNyQFDG61jB1Ay3Q0qX5fHrWulSW860S2wPZmAkRHN1RPijFmlVfiqVme0r4abXLNEOCxyFsilduVWRFxXTiAAR2hMVi6bENa29Hr+eEBnlrrZ3lbdy2Qa31QWgM1mFNx3F3aWHNuTXVloOyBgECWqfG1Dx1RJZ/BXje33TEr+BXlvagSynNtaW1dz5mJx3Ci2rB4o//nuU5wSRV4w/Z8RKlOsQ9egmP1L88XkNgEYZgymmzZlYRameV1BFYEkmF9VrsIdrorAJaxJgM41YtleVawEwYSeZCi10rOVaWfppiYgHsNfVCnylRrbVXYllHiBGIxhlPUb7qPfS41YT8Vffay7PYxg+KRiP2TMTOQy9Ad8VNhadK+Ie4rBofn88ktq9BWWLD+v8p+5QVwKgNbDorEn0SwpNq2IVIoUwxX1ldysHVXmlVMttLenlIQscoe7Pn1xPz6YlXGseJxrZ4xqcpYtxjY3PU2gfsjJb5iqTKgZZ8+lBIKw1+w1+3xts92gddpjHoDKB5Jx0LRaFVm90GdOSCVfAgUtDVoHbv5HCODyV1slY2OgrjsM/JCHFi+OisbTss/GKItQ8Qy5SgkoyVpg2RT4mQ7BepnAD7QHJtKvLBLBg/pb5nAtxbYmpQy77fQwzM4Z/ecd46+Ct8d8NcqkQ9zERY4/R+XxmYla4HmafUEy233eYrByXZgcoRmYhwBVjyc1PeKSZWvaVVFeRX7/GZiUr1QuZZlZUJyWCPn3bzGw16HzQSlm2DbZiJdqdy8B8iuiZL4jgtMdUdstmlt9QuRaG3Xj1UVje97aq6TW6Bw6lb7d34rjH9bcjlIVu5TWQWFY1jNA2DxOUQ3hUxV0jdTMswoucwDqxu7Tk/pb5MBwWY3UK+Ap8sZCk/OIwmk4Ve3Is2DOJWu07DMhMcahx1AIT7UGRpNcTBgGSiJq47QYlbnN/HVYyETBMxiJ2wGtRsi5IZdZUAz3uzQNM9qxE/sDAiabNpotA1jDWES/1URfnRSaadFsv91hZ4qdb4iOQLadpoxni6sEoOLLv7OK58JKXNfRcwqDVhiWldWxvtGMd0CWoWpsP6aT7/NmI2/pr33Y3jw1xwJYe/wBJ+Yy4nCtCWXpo+CGciyv85jfP4qc0V02+Q1AZvvrpI5qvLGMDsxtWKuxuBSZ6yPDtg+SZzB66z21o3JLDozxHVhicdMywxfuTpUCmqwIQxYWA5JaLZKDs3iW9EoRWu1Q7ewv+5VZm64i622pgQsVWIr4rR0StWtKo3ZUTcBcyh22EusFcZ4dcVr77fc3EH7NpPkq5Vssqckp7jZWEY59BlZRa7TkcRoVYeplXTqFFVfwJY2qLjW5/HPlmj/P6T6H0qP1FBqbNOBL0w59OFxe70/dp6N9vhrZizTiPlmyrV6uzr4H5FhtdEzZb8n0Hyv7izWE6glmIQmJX2X6xmCpaabBlh1GfC+YkG0ksxI+JkYDJKD0G0Ty4a2zK/wD5MOsheD+fM8WycZ2wqbS5Ts4h+bW7DSpN5XqkOihlW1rK9Z+aPlOMStIVaGGTx6PBXXznMbm9Dk1vBxltltLIdBr1SptKuLkaXcOsyytUjCcSk2WsR5KyWdPjkf1DkOp8hdgJafaf4de+I2tgft2ENnVQqtjiioNazTYa8YZPJuzf6VNq9lpMoZhZy8i1gSKv7XXJZDCpmJxSVOik3IqBmJIAg1gBgps044/evJ2+TrrOR36ZimOmJjM0AHFUAWD2pnZ86cZt0KDS8Y4eYqlimiz6jWJyrCSNlfBretoKWc18FNVrSqWXCuNYSWM8haYEVFq419i61sQiiWWMUp45Yck0rQvtN3IQ18e5xKzXYLANBWHWuoCc2wzUuE4jvDYlSeNUSh0CHJh7R+jmK3V7d/rzFOScynAstf35xD8KTnMByACZxv63OWz1F+TKem+6MntRfdj3LVPokZG4QgGsdNqQPLXapV1igFq09yneN92yMbDWoLEhmz6YHorgqB24Ai9RmYzOFdNqeG2G5NkrbfhrXA9das4YBTmpGU5IqrrzGrGLrPGGvfHkJmVaMCIczOIrS9z4y2wVgEzKWHld1r48zDEnFYo9hDx7mUJcWNhrY0Olc5HIaxlUg8xi7cVipSzo5nI/sWfAY5P6j6CZyFOC3fpiL0MT4Pk9vEVdeTx/FaVxFyDjMWvaLSY5IPlOOOC7hdG1zKiJ4WY6eML/AFjFdnKVCRmL0Q+kTkYnkJYvmZMOYfTMMEBme1Pe3WeuO6xjpY/zQFo4r2bFSJ1lcicVMwnYsxWvyKJyc7BpiCbmAhppFUGcvBgi4gQaZ1YXp4Sex3DOOoNltS1V0MngxuhwJSmzPYmeP4sXsAbijELKsGOcGzt0EsbA/W3p90HU+TWNg9esNft/IPtrQ2E1KgpVStvxbUpZeKZVxw5qoWqdjkX1q9ZrbPFyFpcRDo6poZe3uD5Fm27IzrplNSXekywawmLG6G4In5xCIBG6GcwHEHwDB91/T0vlrmmZ3FWcapC35OqC+0LXvGfZdopEfHqvcor1lxLnXxV7ytumjf1iDr04aV45Ks7PisKcFqjCoo4xabnNNy2S9UL14lWwsOCNPfkAO27frEIg9K6yzJWwlYOjmezI8M802i2e2p8ggPK0AXqBfT6xNm5oyvJKsulwaoyp9p+CpaCvAetLJ4zSTWryrjJLm1Zwckdg4ljZgMUZmMHEwSVHVk+CDmZg9LpV0zfK5mnWABV2W5GIeQbGsbLZgMYY9CfSvLSjisZZbLG1FljN6VA5bpgfZAhM+nMoUEFAYT2sa79vmvnifE9pMsUGIKRC+G+qjuhpscsf4c+laAmqqBxW1fuW3j5joVOsA7P3K/aGDMFhFdIJnk7yDLal28SgfBq8ht+prEBqsgh6j2Yj7SoC+updHGfLYc3MVIIjHHrVCO9TEOhsxs8+Ipg9Nu7/AIQZjJ31XNy0yIhwjv3WcM3z6MfbPmV1bTyrXG5VrhV0V22MAlK+yz7l+3PdYRxZUVCsUJsKpf8ABYhtsr/0PtI9usB9vf0xBC2XCfMpQstqFH/jonFTCFPcAdF+OQOwJrg2T81fH2J5q/FV41BdVjsNbK2YJ3GWbCqpmJKuyTiXeapltD2Hd7bB4qsaXkZ4jtvd3YwMUb12jBxMSge510Ieb4i+5bhPxFMZiZV826xOpaqtWw7+PQtpUZ/4aZg79NTNdR20CFila1C73H041OY79kz5H4qbBuLOidzDql7dWDqvtuYvvJxPgjtnJIvfrXuKunF5Hz/GhwauuP8AAz2Pm0e2sfuXKDCuZ4ZTSRLmLMucKuIzDx8ZvezAQE+RxmvmDWtF2a6vxPw7CrLeTYbEc3YZyCa2IQLbrPqBPMpldojKHeynQazj1y2zdu2ncqOCwmIwgEqo8kPC6tQw5BovwL0DNrNlUu23oTAYVggXM+IRmL2UUVyywObhiamcfjM7ck+IZPpXPHkgFZs84yq85F+GufaVOcVEPZzQND8CUp7sFQ42bBlFez8h8Cw5b+NPu+FNi5jKYyboK9QzFHqNbw4QvaVqHviqnjd8o0Pyqvg9Soq85LlrZ2549WGJxYib3eFNnpVpzK2qJOT6ZIi2EROVmVeFm9ks49ixc5Ffa1V4tqBGJjMFMquWqfVpo77y/wC4fKZSOtViOMMJiH0SNiKfb1he2HsY3ZJY5QNbERKqjy9Iz+Rqq62a+lqihxAesnPYKOtdbsdtVsmhSLnJHkTxsCKel9qMcT4hzninWvlP2fn+NPuLSwSttYG9qfbawj1lyRrPIRNtye1oRtq/GSy/vU8cEW4SphFqLVN2ZQutALFmPvd2rHHua21mxObyFx+fSsqreiMQaWS5eRyEVVYGEgToxsibIV8rZ83tN2Y+TOKeuQPdiLdCw1fGcTXrWBYRMxWhn5b7Vggs1Q22Yg+X47LXRYGF1JrsOYnvVAHj+2dRGw11mQj90ZJusO/k6B6JyzYCLljyPZTe38o+T2uDE7NeY+dYFl/HNjtxmmusqGtjuS6sIACC1gDuzT2moXLWrcdbif8AmOFOtNIMC7PZWuKqkpS7kM9hOf1KCxtqahv+cQbuUNHzifmjLIqbTaovZxSjeEg6ID7WYKldli+UumIEycQoAAAVuXUxGzLAMGKcHqMMNvgbehbELQT8vazLXna/GNUgrTWpStlwBjKRF+969ZgA8Zva4mMM2cquZ/6przZedntOW/l4nKNZXVgAAw1Q/JJVA3KMTlwEOvLVYgMa0qECWV1kAZytrx4ZkCBmZUUksvfGqbbkdm+wjin9B9HFfiBwWdnPBJF/Kp8z3cZ6oiM7jj60k+MMQW47eMM20NeS/thzKMktnZV8UssDQzjo2OS+9k+1dpiays5mpLshJ4XHR47e5vRF7CbRamMrpHHX3WMayYK21WyuONqdSVqpyxpVlesiUqaq/mWdQDJHsbXcVKFS27r+em96pVdY1SeTyWNomSxLCMZx7MNdV5QVKR6silDgH3q2p6c2jJNcdDsimAMIlEGBCv73OTHEx6D9fDxTVVaTYGRhyORVSzXs7aEimk+QhFBrEufES3vVHVAELDoMWH05mlKhnM1LRK5cvYWfEMo+9dfLbw1ZrOPobFG+IFgrOKU0K6st6F7HU0wOQ4YszWVArr41VTLV0htJb7pf7Kg/bntRiDNhp/aN3J2Vj/gEUKKOKO7yTbjA7zax2SIf29Mg1rNfZ4lVVDPP66lrVXJ46FfA0FdcCKJsQ2rb2Z2tOzcinxN6Aw+h9BGb2IQoa0mGVD3r9tfIVGfZzuyxmLkNg13EPdgxLIw1Z7Moli7AV3WeCqsPQJY+DnPqnzxO3a/aaiwvRx9w3HYvxtGAxKK9o9lW/wBSJa+wmdIB+5V8dCZnJCV21t7+Q59AsX3FKwBfkluof8NHK0XgWhzeMWMdgNjNZTXs9960huVY5a1i1HJtWUckWzlt4kawsDmDMrJlOdD8YitrLPsDYs5NGylSD1LKzX+lYTNcqRiZnFCiu29rJmC1psHXSEdopJqGqa9+NrIoNbWjE4zqK72bdOQ6vfTuMYP4iCPqtHhtMqRqn5TeQ1hlO9dkGnmus3jnAC9AzozXJHpnaF9UutFzL0W7gXvsxBiWPC4cWDt/n/DwbvDd7bF+nOxos2XjzC1ryrN7EVWUV4nwK7RW3N7rqQPHpJrEB1ai47SzABVWj/ZZXgpyK66WNVkPHQx6SCVI9BFrJiKqQdu7YJOYBLjpR6pnbULGVQ9ThA1ptfb2p7arGSyXcfMWrWV1h5crZpcyzpj6K2JxwXPI5R1RmM4wAsvbZuKDuniHION7KyYBlde/G0UlYHDTqeVRFstLP94PtXuYAjW9odpbkFWINg6f/Hx+VZQU/wCgpFfKRxkMrs68WJiEYhM/9928KkdWhwexDKiwZTlXf9zJFa2EU2ORaT6bFYtmT463Vqaww8FauST3KV7t+Yvy43oxMT88arL2nIx256i/bUuK7D4UoJeMxDU+RRc4dEEtCg7ie0wIDKyKksIMrOALAJW6bIdbD/YrKtT2GJ3HwsPI9vnnmM8jzabdGtbEWptinil1+3pS2Q67TRslcC3/ACL3KLMTj+4czpGUZ36dyV+YwnA743IVZW+VNXfiQShaxCMqKQYAu3JzUjts22YYfQNNNlaqYgir1Ye/Sg9NUZXQzFeH2cVI7mJlhjvEbOKb/wBu87xLCjW+80krxzVtMfTxuz6bYm5xifAMrMq6oUxkOD8gMJyB7RPzMma7RF6YncEeDlXeSwyqg2D+s0tkEYlnzd8/41lK98ZgFv7jsMqvpifIpBq4hZmGmJU5VrbCzJcylLPY5NQ8xau7DcR+vTbs+gnGoR+OVNbePMShnKv4S3bTEr6b+pLOWlYs51jQ8l2m+04nZ5K6zBgAxqQzTYNBjxeRxBczI57z+j8TJxBKQPpZS4I8WXNBnMISATExBiKOgvSAeTmXatZ7p+a7tQ/uKsRN/a5Eb/LxcNKzq9ieVWp0h6MPQSsuXxXWogqzDTYYVIldc2bWsXTsSl5dxcQoENdItvv44rdatiePiV2eOtBmYAA6e49kdia9VrLr/azZPrx2KvzO6snPZhGI8+JXaSzjtG8bXrofQQLkhBDXGTE1laZiqKOLiKuD3s3IaWqbYeoO53nXEUGY6XCtyX3trbExgQfCiDILsf8ANRaa2zsqMVFqbr4iGbikqOHYZXUKULWM52z8BCwi3xfG66Wh0u6uuDOOyWbRaiZ4d5odt1Q75mZWcjHWvThc2L2oigwEVozZ9Mz4gMpbDhhbU9ejuHE8mZnpxE+WaI3bBrU9R1NjEcgkg+nECiXWWMy9kA7ETxHZV0DVeQ6NsM51XRXwfJhXuYw+itDO4egX6J/z8W4A9FUciCwH1utYWgBzqMk4nc9ph2qei8WR8ILPuSA4C29auY22zHEUwVljnww8pga7UYWlFj9lAM7pOV2BjViNPUdSm7C8i+sxL6zHrGxjQJmKmW8U7QugPrif+jFBnjMr9sfV4q1xnCSshoAMW2KYGIO5hPexhsxGfP6cwPNjM/6aOU9ZrvquCp7i3SnBI8jGvxL1DyRBZ7gZWVdLAwsqYcmmxCHrr6I6iErDrfGpcD4NT4F6bzUmces72glvz8zaHsYwcYh9a1LM1D1oVJir7loRqrECONRBq0QYIYS1ZSBtdSIK1yyjVlIirO4ljAfIJGK62K3oopBM1ythUM92SXm8Lf8AxAZxuS1UrvSyMwybq1nmYi9rGiUErVx1WuvRQ+qRLlIBWu7kr7zyAsDbx+Oq1L3GETlapaCWIJIsKMllF02RGsJYhCYsKRhD8/Ib5DHBr0nnwr3O8yZmCxojB544qlC4YxNhOyPas8oKZwKGxLlGwgE0zK/bHatVe4ypjfxfEq1tacu/u/8AkAyi/V2Ow1lIIR6rQzs08x132inJbj2OauPh+QZk7eE1xbxHYMeihnGbMyCxT3hBMDKKGZK1aDjqJYMQ9wpksuoXjO8dfErMWgP6RKWDjTMSvaoqfK2EFrSo+63AnkgOYa2xo2MwmWEu+k4+2OZdYr7lgf8A5dF5QhxctdvjPnQi9qdvp9zVxhLr6eMF5gtrp5DJc4TkIeE0HEuM+mUTx6xAhDrq1K5mTtZ1A2T0GYDVeQK5XzVML12k0NlKtZcaq41zRzmAZ/XxDk91yrJQLozMd9SW/wDdsYCKcGpxYtwbcAiXEiU9jQoFNypec2D5P/yx88P7j94/ts/s4v8AU323yv7jON/bZ/ZZH+yr7W+bPv48/N3yss+av6W+4RPmr7b/ALrPu/Jgi/pM4n9t32cP45Pwfu/P/u+WfdXKfmz+z/3fP/SSv7eR8/lv9f8A/8QAJhEAAgICAgICAgMBAQAAAAAAAAECERAgEjADITFAE0EiMlEEUP/aAAgBAwEBPwHWyy+1ZQ8XYl0L61C6me81pWq1v6TzX0lrRf8A5i2RZZZy1T+jZIQ9rovEiy9bzeK1/WWUWyM3+/oPHyJayFITGP5FYvekvgjNl5vD9HLFa0SQu1F4WL1Y0WXjjYvWvArFCVYfUl67mixMe8kJf6XhM5F7Vo0V032PDvEV66ZKyihRFErF9k5Ujxyk377npPyUQ/kjjiz1vyOXU/gQnlZkkxF5vq/eZCgn8iUYlllnztRRxK3WHhbPNllZvsrNdyzZyOXJda+uixbMbExPMl6PlHjX8aHpWvEooXY9VoxbskRQiEORxKIxPhlcmfikfikNfVrrbrq8cq+Rx92iUkcsI/K6oh5mTgvIvQ01mtl1PDF0yWLL6FL0SfsWWM8XkcWf9FNcl9WtHszmUxbpHmlXwQ9+8IhVksxdwore/oMorF6SIsvKHhD8kfGSjyYlWEIoePF8klT6LxZeyWb3YiyMrKK0sTsoijzON+xCFCxRQppKqKU16JrF+yUfV4va1ixbWX01hxsSrDFpCNnD2cUonqU7xAirkfjTR5aX8YkOSQ3hibcaJZWv6Et5fPe9Kog3Ec7Jzagzwx/ZFDdC9nNR/iSkOY3j9l+qxfStmitE70sXS81aOIi0JnwS+csSIpJ+ySGLLHhdjFo4iKH8CezynlHM5jzxsZ448iYxZfXIWfnF6J2sMS2eYQ5Hxv4/G5H41GBx9kp0uKytK6nq4lYvpdjE2UI8EqkeX+ws2TIEfLwR+b/T8l9LF0MrFi9DeLLOW14brHosQsTmc29Iqnoh5T72IWGLFFbvFFFZfiFFLrmxMoXa0UJVpfS3b2bOW8mWX/osSVkY6r6TFsl7y2J3msSsWkvZE8n9jxv3syxdyyxC0kyxYbEvRXY4pi8a3ruS6LwymhDEtmOdEZXmtV9diWtC63GyMGtL+zdMsroRRW9FaMS+z5PnV4WVqxavRfR//8QAJxEAAgIBBAICAgMBAQAAAAAAAAECERADEiExIEETMCJABDJRQmH/2gAIAQIBAT8B8bKZyu/NbaolSzZY5WIUGyUaeEj4+BxoQl7JlZorwSH9zI8KyhM6fio2LTZOFYrw02huyTQlZJNCm6zpyGrXjbLwhP72JiYyrFpo+JE40RRFF0SdiiSXjbxowSRreCdDnwPxa8X9rwsWfIiLRqWWb2WzeQY8pFZhIm9zKKIRVcmpGsbixPO23Q9P0RjyRGkP9F4gPk2+FkGSFRUaJd4rEUUPghJLsnOxFCVsf8cUP9NqZDiRLgvkS9jJWKT9/bpQTNfT2vgQ8ac67JSVl2PLjZbibrGxtn8f+OpK2ShslREYhMcPZtVmwca6zpy3xJaXuyjdQ54vMkhfZFL0a/8AUvCIxtmw6LxFWyOnSNaOFyfGQnKBObm+cWQHVEpNcERMlPMXwcM4oa8EhIrkcKZNU/rTroct2GI0V+RKkamU6PlGnPoem49iFZTZ0N5t4Q5DeUyy7H4QHIT/ACJ0hof1tNEXnSdSJcs1K68I9ifBPlEK6HRuJdFZiiSxWUhrCGuBuhyT6zeITt8kmPzeY9jkOsKA4m9lneUQnRucuBaNHS5HqF2KJJYiyXIyLTfJPbhMbwhvgrd2bF6OsKNj08by/o2PEESVFiITSRPUsfOErGqKKKOjcW5Gy1hMkLHZOFdkI2PQ4HGsWUWU2dYaIrnFjwtB0SVeUY2OHA1jcRjYlwThRWdtKxjpdYs7NpCW0epiMqJOxEYolFR5NTU3Gl2OTRPT3KxiJJUURqiaQn6KGzsliPZu/wAJvny0eyXeJo+KhKmUPookaao1v8RKG3vwQh9iFBNkoRuj2QEat0IbNOd9kmT7EehkJ0OSH2NvEZcUSeVLzTocmaUbiSf5DlceDYxMZPC1EkQ2y5NZqXRQxKysqLaNFcWalRx8m0WqXZNkNPcTi48i1YtEpqyPIjbY9PGkrfJKiSKKH5vwV7eRmi+SrJ8FnZWNPokOeIjHISF+I5UOQyrFZtkbSMqRJtm2ho0nt7HXrFolyK0KfBV9i7Px3E+/qToc7GR4Ia9Lk1J3iJKWIvgkxrChKrHiGHyVEYuyM0ietfQiKEkShZW0e2cTTj+VD0+CSoXeEz1iWqqof00SViQ/G83lSFrLbRLko6Lw4srErZBeyMTobaYpWSjZB8jSjI+RJE5X4WbCSrNeXsssi6GVjTSs1KZtxpaSnElGnmlZL8SxFDVEMMlIjA2iJMnKxOiMrJRp2jVnaL8GWKZLkWEJLaSzWG1WaxppMYoko0UaX4msoi0+LJRR0digIS5Hpbh6ThybxyJSiQQ0bj+w4OyUdppsn0RSZdOhFCiSzTKxFE5pcLwS4y0dG4YnRYpDkRJI9kNTihtDZDsk40N2RZGRqa1cM3DTZ8S7IxJjNzIvn8idPogiU1RyJc4TN6oso0oqTJqmMRurx3cVh8mhG2TinLgnWbLwpUb0MuhvNiiymj5Gibsh2TkkiM1Vj1CLvs1K9Y+N9kIFqiXYo1G2eyqQoElQh2bmjmQ4cDWF5w1KRHonyVyOP45SGuPBFDQkIaFAnA6LsSK4KZZ7FLgujcSY5YYqaNRUspWJUS1ES5+h4vG20T6KEhm5odCVk1WExIo3UPUIkkOBRtFHg/8ABwNqENlExIYky9o53lPw2eSJclCQqo3JI5kxQJQrjFidiHyNYjI3jeIlk2RlyTXFi1BT5G7HZeHOkU7tl0RXt4a4H4biuD2IflFL2SjRFjxFo05LonqekXm+MX4c4028clH/ADhFlLbyQSskkmKNs1NO+iOhFE1WHJ4Sw8eiQ39EpCwuMWWKKHp2SgkPCRsZLg5vKaLockxosbxY52ixN2OQhRdmqQVmouToUxu8xdjf0sXC8GJEZtHyDledNpH9laNRexElpxhijsUaGUfGJJZrC4FqL2Karg1ZWyLJO3hojGxQNpwP6t2FldGnGycOBMeYScSUsPllCR0J4WeOhrDLIwcuhtrggrY+BseINIcsIkvurEZEp8YrFUOOGJFC4JSE8JkOSZuOWXhabZHT2rkl2aFWazW4opDjY8RZ0N/ZWExclDEx9YjP/RzGWIiawkVhkZUSlZRGto1ZFc8kEidRiVZ8Y9P2WWOXhu/Qi6NxJIQ48CNiHRL/AASPRCSJO2JkqxeIkYL2bop0jgnLkWrJE9Vs3Cmby/0+xqhCLok7Lo+RvFllERlV52OZTu8Iol+wzohOhqMlY1iI6xtKGXmh+NEFwSQjcXf7Opj/AJH4voRIWGehi8PZEYhi/R//xAAwEAACAQQBAwMDBAICAwEAAAAAARECECExEiAiQQNRYTAycRNAgZFCUCOhM1Jisf/aAAgBAQAGPwL9xB3Ij2tNu14O3yVe5Jgm88jjMkHuYk7nBtkMlWUoaWiTB8iXg7XBNe1ol23aSbcZIp8jc4O02TJsn/W6Pjpn/JmMTabd7ginZlHa5dpJnRnbMPZJo0faYVpNoZnBFLMIliT0zl4s85d/YyzHRFeKWRywSYZM5M6vMmTBj/TwZ0YtM2hZIsiIkhqEcKFozbBEn6nquH8myKIPvMEwTAmJf9k+baRozKMZI2zZl9COKMJWdo63RV/BxgzbfRDZFLm+P9NF82xdJEbqIThGs3wS4qqJqfS+ZFCN4Jqyh/OjKtsmTiswav8ABi+D5FAl9JcllFSp114eSIyhSsGByY/0c9MX5VChQiTVlTUjFRw9KJ9+uJPwO+fA8wTyORKM2xvolqEPjZRvp31QPrwJVqTLwYO47R/6bd58nJkLx0ur3+g6mOrqhs+7zZypq8E+OneLcaSUswRGTtoZ3UtdE2zbmf8A1T9HvWTAl4P4O7/RZ6fm0YIQ6n5vEfSqXVnZHyO2dFC9KZtggTqIWrYMn/HRNXueEZc/klri/dHdb46KaXZ1+nj3RmnqUEHL/E9zGyPJH+gzaHbCO7LHKyL2RTVQoRO2bgc+CGfamcloUbtm6i8M4xBm9Xqf40k+Tl5Hj+CX0YMsim/HphrBTVS8GSLy9HdCMGkRhnsfeztrt31T+CKaYORxVsbJgwRaX/oOXrPHscfTSRkdqUtkvySzNsnJCr97Z31cvFnSnNSIZghatBkisceoj7kTU5IiCfBLIO8dRA+j/kO1WU7umyVUQ3hnabHV5XgfySZXado5Hi7k5owIyfH779T1CffoX/Yos50Keh0vSIRyrh1W2ZOw79HCLTyMmzUnsRSSbtzfb+Rqr+z3R+BUHapJZUxMwcWsESTU/wCRUenpGfNpai+iGfgmzgkzpnJXaStFuDIvrBq0L918I/F82dfmo43myt+T56Y8plSq8kq2DuMXm2UTB2rPg7myH9pxMdHEk3ZbHHg+TJkwsGEhL/JEyQ6Tf8DJ0eI8mLur3G+hcifJFJMk8md/ciVTBJP7mqv36UvcS9jF8aOcx8G1Hud1Tf4RS6NEXxaaW1+DLZ+DFo6kYtIimfYzm/CNWeMEO3dtGSer4u2/uRu2zO+mTlTblX/iPtJpvI2zijX7jhUKKcdC6e2MGarw2TTtEO2rTURScad2eTBHTCONbG5wQKRW/U6ZwTSJVYqKo31QJHwY/romsbTJMmDN+3fk/So35tDOzZmk+0UuWZPg5Uv9vHk4yQN+DRjati1WdHxZcjFok5xaGJrJ31Qj/i/m2BxOjJgyZMWkzbvONJ+LcfJk7SYtJvIpyT74Gieht7+jAo8Dki2Lb6MvPgzskzaatD/br3EvLY6VteT4FVS+iP7vroVEi51H3tnGjtRuR2kf4G4fRnpwNkvdt3SPgToWDRrJo10dx8XhdPjJ31Hkh6J8Xlk9EMnzd41Z1P8AaxdEVL+Tt0yXbNkTbJF4Qn8WzfJMY+bawO3KLTCgxA+Bnpwd5gwdxE4ML/sxTP8AJiKfwd/k7sHk/wCNfzbN5aJi04gjZsl3VNSlHOjX0edFsEL9xPubKU/6MrXT89agpbR27tg0f+9RyM27jdtmL42S1aWdpsybMCmTVtwQvHuaRg41eTtplGjLR3M7TBm0Lo1buwZ0YpJ8mCHdtaGZ0zGLcV/Jsn9pi0E1OCmpWibQ74+5HdSbvgXwLkpMJT7kcY+Tu7mQiSGaM027TUmaTdplG2yEia/6N9PyZeDZMSaj8mP+iKmalGDibM9NPt191Jwp0T4MGNClZNElKpUSQjiRbJiz/YyTHRxYqZaGqjt0KRz/ANkSJ0MUvZCMWl2VR3QiNo9jdsk8r6P+Q7HLMs82yT4MbJbO0UmDZscuZ8GcMypRuCOUm0SzMsXaZpNHI0TT/RhGjRMdyIfTrDGvNtEjHyJRDZ+SPBF8ftMIXsZMCq6e92iD7TuMVwzaNoTq8HFC+LceRMnfhmHfucmEbPa0yZkyjjQZs52bhHHcm4HCki/2kUkchU0vHmTOWLj4EiZItlmlBhJHcfDOcYfQhe8DbvFvYyfaYx0SkZtH1lZSsE6MFPuzJLI6VOTtUW2ZMmz7j5RV+TBsmq0+D2MGyK2zRmP4Mo7cmcCqup17kW7nCJVebdy7Pc+7J/5KSV6k3inLO6Bm7b6/wcqd0mbTxcDdXgxeK6sDi0K09EHFfeZEl+xTak1gj3IXgzZO0HaQ3AoeTt2NRbIkkcV/domUSlkghRaajOTL1aZMo1b7WduDn6mjj4vx2iYu4JrIp/om8NECh5HVMsb68GSIGlgdBmnjST6lU/kig+BeH0f/AKYJJO1Z6OcZJi2b5+rki2DM/k1khW4zbizDMmHk70cVSzK5s/41B3EmGLk+SF66WB1f0ScfcmuqF7EUU7MnbSTpmXaVSaUjV1ZqoiEdmIMM5Vuanolu8dENjpoZnq7T5I8HwZHG0iXfBxezN4dnSRbjiyWiFocKSYMk/sew5epXkfHwNmEUuqkdLN23Z81PsRRg5v3O3LOUdFXoVaZmTsYpWTOlq2R5gVOzlU4MEETafFsK35G63DOSymUz7nx1cnq2Fmyq31OPa+dGCrpk4sjyQ9nxaKcCUsh7IWzczsVXsNP9rk2Sdrwe0CQ52rR0zZzbNnV/6oU4kz/RPk5fbT8kepWfBxVTONKIt8EuyIOdf8HEp1JkiBDnx1KSVaJH1fI7T72h6Y6SOmdGcv3tOjKn5IRJipJnEVKeGYFyMbf7GCOhr4HJgz5JXTK6sGu6o5R9pJyayPm4XgZvpglFEmHI/UjNJyeIO1W5M2YWhvUnuvfokyY0bJY4E5XJEdEEnJ/10R5M21ZkZOL37kHZ6xHqVLkaybJR/wAkv59hz9p8mCGZ+vg2d4uKv/AzFonPRi66P1GsLQnbu39KBWVCIpx8WlmD5MnwOHKG0rwupul4tnBs7cmUfBC6H7mDN3fcGLdyTR2PhULlmlDlwOlOaXb8WXs/2C4xk7mO2RwZJgngjtpJpxV7dMWdVKwYO5R+Tjz14IR31ZHxvj6D8EGu6CXoTS/kmb5Mi9Ok7j4OVLldeGZxVb7kfeQodsdMkVE0k1lceFi+CJHbB+nXkfG+CfU0YWDH1lmDc27tEemr9+zjSJWlHJfcurLwdtKpG/1MHa+35OPpqPkm3aT9BKBsljoVqvTe1ZK8nPUGxRoyRSiGz3fRhGEzjVJy9PK6+4hIwOUQ6opONOUj8nLdoZLH+mcYkgTGvJkmlX4/Xxshq0XTEvJG+mV0asvgdNJPRy5RUiFSdvXy2OPI6mTZHL3vDc3wcK1s7mdhKPcydx/4x1U14PubO700xR2ksVVOjd+XkhGGbI8kEMYqPU0TSx11uGQ0ShwjQqq2SnkyYX5G6dkP60sxsSacO0GbYsl5Mb89GSKcxbNnDNwjuZUlVkwTZsmpjgnphXSOK6E7QtnKrolkDbO7DIp+59DXRnKHV6fgySOnyj8X2Iqz3i7ciqW/JBG6T7rSipVLI63/AATU/wCBIhmLT9WBe3RypWR1VaO0zb9SNDfuYNX0dq6OPgXp0P8ANsWwbIZF+4xeDPgkfQvi2ERUrROiF4INHOqomk7jXUz5OLiGc6Mq3JfyY97yhiqpO5aHLi0P+zFuHuc08lNPq4Jo6KoM7MkP6fLy75IpZFVnxeGTy0fk4u0DMWb6eKGz5658GOmGKfA6av4Mbv27Ed2WdtEIjTJQ6tnOp59jBxopXI7slNFKNQYyrQfgZBxpz7sbJ8Ia8Cfub6YOxSJVYaPuyP3KuSyODPgTzxOMaJSyZwUo+D82pnwKp1dqMfSg4mDNpMnazJgQvUMHKn9ilbsRN4pOTtg+TDFV6dkmhtYVpRxnJHm36rtl5Y27qoyJn6lJy/yq1buO20e1k+l8iq2SLSsXyxdqg7RMjxbJFJCI5cn9FSatkyZO+Wc/RxHgzeK1KJ9NYNRfu3aX9Xi8kjMXjzfGzlbC6GrSfIuRzpMPHQySmTOj8Eje+mOhSdjM25Mki0GLwtjVsWghLLJq+lNN8b//AAzfJ9xjJo2LP8GUSlm8Wj6UqmReDi6otDUfkZjVsDgi8Poxbd1TST0OkdBzeyEz5QjB2o7zFmO0GZMWiClPZIiWOt7IRlnGmpN/kbtN3A6n/Bnf0v06tVDRAp11JPTIM2zsk5enrol9WLy0dtTRFXqGKj3ZFWRO/wAikmimCasEIh/d0/m3Ksf6b3f5uozbLMMkdFdopXEmTJB8CdJxex11VS1b/wBpEoOdS+0eR0PyKfAkiPBgyxZO9tkkWycafJxRLMfRlC9ana+6zpe/BldGD8ClE9ERvo+DPTm0mpQq6Xh+CZ6O95vLPY5XwZ2dwkhLyatjq7cM5xkx0JnOj+jRmyGR7CUxUiIlEeTJk4U6tlwcqfHUhR42ZtPgdWjJBP0UcavtqwNePBgTqXd0I/8AqrZ3aOUGNncoEpOOzFuNSaIPCi2Tt6Z8kNG4JV4s2J1eTshVG7YvnEGDlB+TLM/ahpXxSJ1wYWT3JMjtBxpOBmytU0SJJyc+LR3H/HK93dDo8Qc6dGuhHd56MGd/Vj/Km0VmNX/V9XXhDZB+dEuyor0NmyFsl7EumVtWno2RRo4s+bYtl2nyYtowSYyxNnKmzxl22aGmb6MXiJZLwN01GbODnVUkVcak5IH61UTB3Ukr08fJHqel/Ry9F4+TKKfnZ2Kfk5eBcvT2cuXFGHNkfC1bIzDJqJX0s2wRUShEVKCaKU2fA/fwNjTyqcXTQxcfc5bJjAh9DYnVp+DtMmz7jsG2oKfzki2emVq+SSbcSHofHKvqajGxLwfg+TCt3shELZu0VW5f5M/KIORxnZy8H6fp5kRx9JOn3O/NBNI0NQKfBCO3JlQvdn6XoZ92T6lcMkwNMd4+mn4MdDtLPUH0yJ1HHwfzf5J5EUqfcprS0NTkiTuIFDwjOkRRB3PJK6odvkycbNoa9yEz1KSasDVJjDIPyfJnZvJxpNm+qj8Xwd2SpqmHrp+PJNGiKcGWe5CX5IpfaJxb4vUvkj6kU/QjwN+5VjD1aUSzCOKIagakSMo5eBpEjgybwzlTEDJPyaZym+eqb4EVU1eRwbKqvUeWSZtg5VEIXHbM7tD6PY2UoUWgfwSf8g4v3aHUv4I/s/FvgdKWDDh/JSl/JqBQLkY8Ib9yfH1l72x0d7n4RJLyieJMHGpfye7IjtY+SMZKvc41nF6ZNoItg7nHGytH1k7JEdHcQtDITzaXu2THRyq0RT4M7+hP+RBxgRgqfl3Sr+5eTCdkMeD4RL+poxTI26Id9f2cacGSEQ8kq2DdmqjFKg0THGv2J2Q7ahkIippVD7j/AOhOZZUqTP05vq89Eu8fR5PRxnXgwZvF9E1YMVaMjTJ82pnzbNqK29mx8bOqFzf1ckUI4ocnaQ+uDly/gWLbVsCyKmqqfk7Wn+L5OWTf8ks5U6aHJH0JZK+rJ8E9edEemjjOPgddfVkknkfdgWROCUr+nT7IVoPTkmCF/Nn+DP1XV72hP6Db8ipqR4yJMmnKJiDJ8Dfl25U1QzuHupIkhiWk9nYyX9pVCNYNEXgzu/4MdUW5JdCV56ZZ8EImrZN+TMdEokiCiPCyYqX4tBT+LpFFFPhHBTf5q+tT89HyI7No1afU17DZ3E5J8jVVWBRob8ENR7FMiREycTgcYOPsT40JeSW7e1sCty9jJq3wyOjBNLyR5tFalHOjVtT9DRLZxJe+jOEQuiEQSc/KIp1f2ZTV/d5HDPm/Fap+qiinwQTSSfJyeCUz2MM+T2+RrlJC8EGDXab2ca2fi3uyWhNbQvUShEsXiDlte/VFZL/odP2vwawQ0ShNvJ25vk4+Lcledk668EDyZJtKGqlhEpSxxsmvJFVR8e9s4Zkydm2PlklXafkiCXox0VVslefqoVssm0bMK0omSEPcD5GSaxwbK6l4V/1FTL0ZEdouVn6az0dynompdyOOZdk7YwOprJs1kzTbi7w19eENcsX/AFBelW9mLS9oyj4MmOjt1bLtEZtTT5+vTUn4MnFyQjtF5MowSqfBHkTrXaPj9ppnOnLPtZxqpP03CaIp/on0cP2JVabP0dvyYtFQ/U+B1T1wiKh0vyji/Fssb9iXVgfp1KEdvcvg7lBqTUEiqovq2D83x1aJXTxnAilNZMkr+T4O20GSRpLJkwR4uocFT+vxqfaSqlx8Hbs3u0mEZMEeTehYUe5NMfweTBoxf72ZIOXsduyr566eL7vJKJqclLQ4MnGlZFTXXDtPk/J3Mmk1aCGT5ZqLOqYPjqg1Zv1Hoap10YIg51b8HapPkTZ5kwdyPYyR4H7kMi2WTScir3/YYeBPCOP+PufJ3EQYsvc9yUiaO33Hk2TGCFpX0R5MkI2Vfn6Trf3PR+TOSPRSn4tnYk1kiUTMo9juzfkkQySXXn4M661IjlS4J5YO0zbRJqD4OSwcmalCSoyTBKJRAlslbPm0kDb+0ij9lTrQ/JBkkyYEzKRjBCY/c7Tink5ep6n9GTCRhDbVpJoKvTqzKMPf0UifN5J0PyzkztbQ+W701Us4WSeYFg4wfAn6ekPp51Ihf9iTalEus4cVV8na5RPqOEcqlFJO2tGjdkqWS7wxfNombS1i3J6P/nx+z4VKUVQoE7cUd6yaOKyxzUTLPun8kNQzsxPsZkzePa/FuWNnJP8AkXqUd07up89XHofqeosIjS9rbGnsm8V6MHyjvNGFkkzo5U66f01swbRhE6NR8kVEUOIPkm2BGVm0EwJwTZZvC0R+0zow7Y/s76pMDjI534Mko5QUtDHnKtIl4tyRybj5EvYwYpyTEGDDkyuid9NFH89OVaeK/myZKNZFwrEp0NToyiHab8iKO1nufciCKjuOxEvp3kmqswsjbyuiXbN58/tMPBowM+WP3MroXuhzhkXmlWqaNiinJkhnwTJ3Inkj7jC5VXlwS7ZKWvHQn48j97YtDGpwTOX4IMlVa0YwbO7Zq2z3bJHaWfqU6G/c+TBk2dpo1bJ2k0fd7CRyqISgm2DX7ficmUxo5SQRBndv5G1s4+r/AGKMog+R8XaIYuAptF0JtrJgz1NMlEQZOKWXdzZCpa1bGBVe5FRCeTP3Evqm0FatvF56cEHaU1ers+Fqzi2bR+2kgc1EeSZON59x2zFsC7TlSpnZVjInI+qWpn/odJohFVLpnpUrkdtOTGDNo97Y0dxhm9GTjJs+fp1Oly2rcGQhDo89cwcTkrRBN5T/AGyMk0ncskxkkkheRemssc1HbXaGjluCEoHuKiGcKtMdTjiKUdyhEUNsgycTkz4JIjokVPt0onqU+LYJ8PpyY6H7u7ZCqOXVk7sIbIdp/dpi8naRWsHZmCHhGMsdVS2K0yd6k7DkOpz+BmDi3kmpIUYZFfqaO0zaCKjA7wS+qmoS/wDYgmMEdHvaJmOjHS35IqRHTK0YMmbZM3yYssfueNejFod86G6X4NmVbRypZxqxWNcc3yiKlgn0mRVu69mNNnwduzJgyaE1o+SPPUmiKlsmnV5MkEEq+OmTlGTZ22nwQe19kf6LZuGZqvnRNJyqwcaV/J3HaZUMdSUQJ/5Iaa6JpM9tfuZotk5UObKOjJxZnqmL4ryRyIY1SjYls0Q4Mr+rdts2hk0GcEvBPkUG/wDU4M5Rpp22TRTzH+rC+B1+xyqOTpz4NDXqLYv0tM5EJQfJy8q8NSc+OLKDvp41e6IoX0UmsHcRSjuqbvsiog5Imgzhknk4mEOfJ26IM35ccmx8vBM5Gv8AV50TQ5MnZCO/KMQqbZ/g7pbZhRB/5E2Onnq1NTayJVQdiwTObOmrwfFsnLZI87IZHtb4IRhEVZM9atDxBjMkeeqUTUYySQiU5OFHn2ODf+twx+6NmSJF3dvuj/5IVMscNUVo71MmI5EI76sL5PuMJjpdMED946Mk0vBg7z2+TGSKiKVkapx9HiIhMytFV1fi0YqmzGvLHV5OVBL8/wCu/i9Q7KyFZdD/AAj+BFVkVdCP4H0Prp/NkVXp/FmI/kVlZ/vv/8QAKhABAAICAgICAgIDAQEBAQEAAQARITFBUWFxEIGRoTCxIEDBUOHR8PH/2gAIAQEAAT8h/jUwT1QbzEC5X+JtjXhrcvbFJdY11EkXXqAK8ESbx/8AsQxE2OSWkTEQ0mEBRpylFhbzDUx6bmzlzH4Ijw9zylTVhfDGwAmceoDAsGDqN9s3kinzRPchG0DHEsAcaJtDszEcQz8LNdKDcwQuQqV4TsbxOJdk8xZTGTjNbg1rxzArTBG6K1iXnMrlX3B1iujKM1tcapVxDnN+YcS3plpu0X4Urf8AjzbahoWxUNwaeodSYjZmMh/gsWbJ5LeJcuRMLabmxASG1d4l6+tuWXXfMo6+5qZd+IulznKlsmPDlliLwMJtPAjW2eoO8YlGteMR7ib5ZetN9MJlM+ZpouIGd5wQbkG8zZt5Zv8A1RFHDGYJcPUyEX3jSL6Is7/hllmZuuIRUga6e5yhZZcahbzD3lqw0HqBVtwe5iH+Ic203LGx2DmOUAHqNwMCAyMw29wcWnyTiGWHn/4ty+JQ9oIGQKDxA5Y8y+5RmjMEI6T+orvj4zQjcRUzKx4l6Vxfa2YrnqVzEKB/GGok1aPcW4VdXlmfoTJPeiBd4m0gTYPZKGb4ZXHHaWVMpThm+4TmlVqsJ9DEtbQ6bl2jR1HJHFm0zLBiZV3N9xLloJj2DGLWBxEoZS1Mb1LRwiNTIvUspuUsc1KjOJgjaZTZVkLD0/MSs4jhQtZgwzcvgAxxBpFTRczTcUaWRRs/8MsUQq2b5lBNTO6gcIAQtJnUdLRjEd8w3ATp7jtMH4h5lHzP2svcGCNtPMr5VeiXoR+pnQuFwRu4OMsH8fuAw0tazDaxcMdNd1Lwf+cU0niUsi11txLG36hYloXKBhelTmYWO45URljhmibtSj4D0EWwAecsGYYPE0q5wG2XPgr3B/UWEaqNc+yVNN8TKw7Q3Cm5knMjwzxjyd+YMFcMzGHuaqzk0j0VFH+/qhRjU2pDoDFEftT9Es6TI5mDIf5dESj9VcI0bi8Ig2YBiw67GLZmYYnuFsrbDe8kwlfmPn+5k1iZHRMFnLUWbuIKbIKZl/NoyytMcQwplwGzhjUlXHtHN3MiwbVqc4ZgPXwiRqg53jfxCsszJV6mmIJVeI0asbaTlBLIp5pe7csFHTk/wGGAruoqxGbVM2SBQxANSJfII1wxFOOJcnHiU7lH+9qj0dThmmVnGdSza1A+oGmE4TuZ6cRva7YlNAR0C9rhKMyhmDOtQN5KhtcaIt8wINE2lZtiXS5UJg5hLG3ca5ULKJgRS43Nsr2t4lK5OFQjtLlXiUWFKD2xrjWUVEsZiD0GoIraCrMHuVRG2cIDv8OFJ9BLJ7gzii4uW4I0c8zSEyKa05wQ77v+iPwNMMlxZx8JrUoVm5KJXtlmg9piu4wtGyXTWJoCU4DMaf7hhjNQcGU0FcaigQFdQjMsWfpKdqZESx0jKzIRFjCUM0IN8RhWfBLHbU6JdjHESXhbLBGahcsXLd5joxbiXkOkcdcRWkXN3GPRyysthkl1zNBy9AzG4KWwUNQOGAlXZ3EWzRibajxX0EI43UYwv6IvpjZ5lS+eoLthrjiZfcw6zNUELqWtWI0Ick3IfUCGsTz8cwAlLrkCoVYBHPMoQA8QzoMEstD2jtpedwJ5VEk//YNrJd/3KBwhYC8RXQg6gJkbqHCem9QVE+OpW2xsAgh7s51L7Y8UraRFHPyhJhT0IPp5I8S5R8JWmDmxcxRIBD5lwjj1HW7jXmZxwhuJDBVlOYi1OkomFsy1AtRbBURGNczlExlg5mEpjMqcExJQBuVEWTeE15g2XEzFnqc6ciPppUbYg2RzLlhhlCUOUcdz9vENJc3wHkiHU5xOUfSAY+iNxfcpMmeblc28RAVE9zTyblTjjn9yXQsSneYlVjPMpHLqC2NwY/DKLliv9xSLwywq1OHKUMvUv/YwGhruGAMuaUZiSg598VH5vBAWcFVcZANJv1kGhAVej4TSDMsaljN14hlV1I7HM4QQ9RjsO5XhNlWlNWTX/UbZDDAXubx1wwQVR7n44ko1hwPEVy5Zg6WBrUpQfES+msS6i8QgDiW4blm/3EYNag8guyZj80uDzAoG8AZJwREodeYV/I3LVB1MG2t7jyGnmWgW2It5TiPEOEjiUI/pLUoEuK24nYVM5TUBrASvNQEqU3EcnEJqo7gUM/U4oAms1LCvqVPg5lj/AGiAsGiEJFHSMEQ+5aKhwZjwTqLbVZ54nCekarpeoTYYnn9ROU1eyCwSQ/MDy4ox20FvEwWBOMwIc5RKpW2UzZ7xkcdExcrNHjcPIvceHSEqtZktDgnMbIrdhUv8ILnnio7tJrtKyMOeFRUQX56jx0GUzYU5smMlOajt19Q2sORm4FK3jUNWNb9GK6pyhUd+SD2L4TAtLGB8BArKkLRYwtARaSLrZham745i02rJ9wtgYaMuuY8KlOAhrM9y6j1AYJkjI7lBo4YVoqu5vB9kNPPUpGluIJawNYhcKjXMO2V1NQU1/sNodjKQrGlRb5hzeZi4rMdQ4CXUt9waPxSuQ4lClvmLHBnMsRaMEpXML2y161MhhzLVzKTcyyVaKME6yR0iV5lM0OYTXPmITKphkZsXKCMldwnRc09jmYUYxYnaq5ilZyMpLZYh6ZjSs5Yqq5i1eYgtDGdQcdOcwcd1zFkZdRhNGCxRX3lQnDqL1xOJaaYZEiQrsjGpNkq6idhabcQgrAxm1CAux/KXSrm6Ja1d1VQEsbwg1GvgwUlDKB9JhRr+ZZFm6WcpiVIEWgvDEY9LMK3A4WLmD/2C5F1Gb48wWVMngSlwG8oPdCotkVtz7ixN/WbAYekvfAOUU7kYIBVMRkrubzqa08xvkTB7hBac4S5IvzF4a2YN0cQqFF7l4ay7iC0vGGJsIQ206lgyklYiD/VHMyR/BMvdK42rmdGSjjPKKHSksDLv6HErMkSXFJbiOJ7jLKuox1wzCzYFTDxACcR2zNHdMqRcRZXdTlX1C4cWHuKlOUyQOZbpTcRRf7TBUyi2uZSreIOBAi3uoSflhd4lmlHMiNXPxEwe4ZDuDy34iidxo29S1mK/1hbMnHkqEwj9pgUE6IVdRrdCzGBSBOvuIMupsKNolWzkicLZsuct5jrAv8TIhVrslEq+MwQjmlq31KCf/I30d2FTdQ7IyOs2u+5gqWc18BonUky9S9SeoJAPPCUxxcAqyVM5ASHcwES2dxhi5WDcw4lxe3qCNm+Kk3SJuArcy5zOkoe4D5TxfmO0DCNocaQGijmGU/ZGaiephKdS4hCKFwFtQ5lA85TbUg7bt6nNCozhUAJLTnArqWOjzKWawotTszEO3WYQi4A4jvKpkq7Sml8SxX+rvC0YOpiOTLGUH5mFcRhAxKdpVpgim7jW6m4DKH0yYkxNrQrHCYcRUNVcIsWHPUEUGyaBCoZhVR1QHgmOw6jcSDWs+Y5pSoASkZwFWi7OdzbPcVF7b4GeckcgsSomDRVEGwW4hpNeIM5zOWbIPInSoZ6ueJi9oPsqVs9TLdSjjxHwI0MtYbi2nsIpO40LlzbTKIx6ggLwltr3KHbUcoa4gMKGYaIlRPYlheBnLkamYW7xFuLrpjnE0iz4FOeY/W9s1QKvmYqssdIwu4UlyLgcxPL6la93xLHNMBAJWn/TpfiMSxGidIQcUswoNBflGSpTcOhS1MM1lmNVDDUwr0rcbMwXSFU2qNLUNj9S2gzC4U7uGii9TI+jcMARIP6ImAXPEIRsBG6hJqLmabjK3BtqsxsxRzLWnEotrU7VHY4jfJglROjELyCZmdxsWqRlu5lCypgS/LKpVp1M7T/WZFXcc0QIlm9xlqODDGh/yZMGYXpUyCykwbFzMkGBq5ZRjljVcZjo2RqtwHYCuIC7jPQhmS3pI2fM4oiytvxCt9fAGsYzS3eRzBjpl2XcDBsWdNGiNtr/AKS6QMkxRgZSuWkFleTTF+oVFHyJQ9WI3ZXcoXQgFkEOLsEx8dgPKN2jLSzLTMJaRsihmrtuJd3E8fUUKwxLqWeHuCkDtBqDv9xMbO4xF56ioasYV4jcAMXTCVpFjRZzKAJEFRThKQubNy0qk9RCA0eplpX6lzbRqX23EEec4QkEbOrDbD2Rq5HcWMwvJG1D/SIyvSOy6y8IFZzBMLO5Z4m2B3glHWPqFLtMozAgepayMBWZZqAn80w3a4iFgiiXZhityqcsyXzLLbLIApjs4itSjkOJsu4ytV/GhoDuWIK/nuYKKJWAiQDlg7Jp0AtPTBF03ZB+MFy7jEIWxTHlGG+BqeFXco6TSO+IgG9SpqL5OcIiUShPbkmTKIY+0zw7eiZKuJd3uK83MWGO45i4LqA3tcy4OZku5asXG+i+kBuoN4MKla5qVnhK24FAPuCq1XcCqqdxVtp5muyqUtMZL8UXtpwhuXdxoRRGnF5RpbdzFV1PuCWaf/S1Dqp9SpYR0FscDVwfgrmZCBBhS5hLHCojilHJAqBzD9yrvoyyGU3YFeFnhqK8IGYwtoInxwQG7giqYaTLtKywwy0rg/ngLYH/AFKBlAC2Uw/cOahKwzRBobeKE/8AGOUGJRkcstH2Sgo+LQw5pkgRazSJcRDCRvbC0sdpvGi6nxGIOlY5tDB+6xhTjqUNDME4Ll2kJ6lZyPJAlZD1Ej2lpl9JVRg84maR6GdNflmlI9ZgXcmrEPEzukVYoVVRzBoYgYrQ8dQ4LfZ6gIWKEXLdTCXmxLCZeIP7ap0zgDfAzMFIzIniWGcuo7VszoVuMgjcoc7npDPEqonJHQQLLhhncvZAYBUCtTky2ZIKjWE8oeg5ZYudxpuOLjqqzl2/cuBcNS2sGKME0ZuZUbhZruUv5gaPcN2YOcy9BFaMoc2CS2sx7cSjpgeIs6iUdvuOV30mStcw3LZ5hHYR9E/7Lkgw3EUt8wKloUKgBZiMpeZwwsI55JV2DphPaM4+txh/2ZWlMDHFaiVwrqKVH1cdpa7lS1Qcw5Kk5gsAp6qOqtMMRuLUygaQN5cL4l1vV3GIS1bcpN1RFyqqHQQk9iYgyvpShsItxFs2X+IAS5TdTJeNxC/AhdL2bY/+gxnjMb2SlvMi4UvtOajDiyhmlWSjKDAoMzJ1Fj4MiG4Zu0MuWv1AKdQFK5RXT6itvMqvBhjSUFgrUpDNQkyprEEPDzMjMSYtkANqWLF2wOI47hMd/wAlCRdpccQFkfNSzKD9x5m6cSyx+pZph8QwDMYvUql2alEGMYhVdnVQrll2FiO8BmDr9fGgtEUvuaCh4gCGlmG77eagrSwHl9ziqoZGdwVSOyO/9Fx1dlS9q6IfU+kvB4+P4EX0LFa7zKGn7lQNvLNcDvMfuGXK2ghRqe0V0cEEHIIObhgYBXxKClYiUJNByeZh7+5QqrzCAj7IUyQ2fems8KQ4gMqDGnD4mddhvNTKa5YSfQlv9dKwz6I5KVs3KD6cOagwyRa1CuDLK2UDSNTyzSBuNjxGqvEq3dxPJKCr+9xpaGyYg+kKWXMtnFbc1UbtMsXH3BNrg3f29wHVwZ/kYXS5ffErKt3Ba1Mna+WobqBXmYba2MaaeIAtgS3w4lGzB4gBMGW4DmZBlcK2gDKAKEWTwkeGPrwVfcGgquUqsMmIqrN+oej6iStPEJFgQrDTuXRDUbs83BqBHiOOkQq/li+0S9jbRCbrDiCqV0TElrqMLcpfS12jFHGIssbBK3I2QIMCiFeN9QWXZAgTNkq7kbBmuZYgX4uYO7xLMNOiAdZQyr+5dWKa7jfqF1u5hhFbzMlwJu9IB9L3M1ymdEXGh+5ViL/iPYvV8x65Wj+ZZ+Igrfuylds3HcXEmomxgI6J7KHC/JbcoWtbepd3lcCty7gqZzLL1KXP8lgqLFcsqqKnjDiFT3RiLGJL1TA4Nwz3QBSZKwwXC2XamrjmM3lHUArFP3MnIO5dpuUre5hhLL1GThLaOJhX2JRPbrE9w4lxrN3Ni7OvMuJtiCjyJ9yMQEeJag+pZdvc0iAgTN14ICqaw5vE2tXPuVhgMWsyVLJwZBlkzLMgMzIO/E3imo5PxTuMKOESN3OxGcKSpyO5nBiGwxB4ScMNhhMxVaZtVMcZJ9suF7OoshjOwfcoIVO4oYR1bKGrLzMtiIfUIhcHqf11AUw+ZYVcsVI9AzLOvp8Ou7KLlGQsZZ4I7McQC+NRxrUr2Gcy7stzMbDFkMvGBnOblkHOoxeN/wCPi7lKCJRVLljUbDM9SiZKxGbIWTgmaLYQMIO4lIDHkKuptNrK0opVkx2zmoQAIOG6CZRo2jiLDY4l6cy02EtIHhY+C2Gtk4EotRxeRIYOKji1A6IOTuE2yfccKCbj0EHPJ1ABwsMAreGD2gs4j5zEW4Wu5SGIgtSuTUUMxNxStaLVk7hjYY6IltLu5tBcILRHyhlr9yzn9SmyzuVCokR1nMTSFi5k9xl3Dg4dsTncPKw4hFq4oCXDCppM6rfcbpG+YnLCp+NcpwTHUw3yhGWvJE/UrQy6ZtSpcuJUEQ8xY4nQSTGHVZQrHqFDqELikVKkds2/jVCaE+IC6grbXUKYTYTqElUdzYb6jmi9WSqlPDOaLO51qpcnXNSzwqzNFffRoxKuzUFEC5rqZ73F0gV+G4S+7BCLaEQ9r5uJ9OARxipYYfmMF6LhYZcpCqFIek7iKdvMUM2O5bjq45nhiV4JS5IetS4XvhGNCMeY6LtEpWRGicDERcvuLpNOYdCb6YQEDd3UWUcLlyum4qgezMzU7BmJHNTADqYOJwq+EAqOolYCwoTBGpdZnG6j0qaXcwQUWOA3GWpdTmaTBMQi8VeKUypKFVi9iszyENFRA4hMLGjzPPsMzmNcQei8yoOagcDUCbySjr7jv+PaaiaWaguRTE1UZVH/AASZvQt8SyCdHLC7d3GVhtrmG0RWGyTlJbEUy2MJpmGR5jSyyS8US2Cy9wJJhLZYax8e5aVnjtLOhQd7jOsA/wBVHEywxY65iVTDnmLpWC1NhIw0WbDtMEtgqt1HJx5aXpMsdSpguUUNkgHuM1OeMLrdtN6il/DDiYBWvEKVtEteOpfIKzKagn9T7GNDc02zvyw8waYMP3MQ7h2mHowLhiFSLiZyg4e5kqgtVRyxE6I97SG4YSMx7ih6A5gIZxyMbcHUGnQ5alLe01ZzE7Dd8wHauIoX57mUHbFmGZ73yRv3y+oRqyZtR/5RQyWlINsRoNTk3Bp9xOAXiM+HiXPhDcWYQIpxLMnZL2yZ4wFzsw3L+9RNWbmXuBwjoMyJlco7C9srz4CD9/ECqFKJ4C1KiGy9ymKW5nsEQymBQzsZi2VDNEImoToIg1s9xIVOMIBV5WaMgpQGswMOTwSjc0X77TzNF6RN/mylqKC2CbP0Q1kVFYZc0LhsTzblhWEjgczFMTFnZqOqUkNTOEaOA0RUwri0ARpgwUoMsVFZ2gHEbExOIgzgtUllU9pCjFXCVMHhyRWOb1WSbn/4jgm+oct05cplb1bGHgptmLVt6ZaZI93gQdtsrb+UEQTw+pYZNliQ1YeYqiU0TBPSh8u5qdk6GepXFeEoYOJxgrNRY4RL8MzmawnetfAScsxcq2l9tURljmVzZAQDgJZDVQzSKW6xOIq8Qrl5iuzhipY1bjIGzPmWBQciV73DwTiWt6SIim+UtesSwctkbLjYyyCPAMRqzx5Mm7lsOYLzlF3FesbRLcRStJzGshayZlR/SB3RcxsUOfiOzV+FOQJLhAf9YWwzNmYPGrIKu41aq3cALS5e7gY5rNRPmBV0Ko5ngZTnYsgatZy94TAeo+TnylvrDmexCNtUpf5c5dTcp2ZUrHiCJ2mJdgTJpURkWaq5RUTATddRJfJ9S9ZDAPc9oQo7lKlt3MYrxfmNaVEpO3iJcHMdvWgeqOgIahh5B4nUKQ0TDbqWnRJpDRh9I4Jkm2YMalsas4RV5mJZzhEdVbblBdjkStBMOMzNTAnEOMpQiswF05ZsYr3EHDJdbrcpWZQcXUBab9SqKN7p+XubAidkE6gb2LlEFGJblKg2fqWrEacxU43LVlxJsyzyMaYE8MsuIv8AMRqYhLboQscxc6lTJPpMKu/Mvt8RqydAD3LPrDNt6jk8u9yyTScQVxHBcqHtsdSMeoba7gp/zf8ABoRtmmEJVUzFq8uZQtbtmWBU0M+mJrV01Go/cM4CecvZqWPlA5j0w2zMEsXiZOoup2Pg1D9S+agi4W2CcYb7TsKxGeJx5PUXp7lt9xgVzUz5qYHOZvCAdw3GlRN6epzlzKdFXFXZw0LI48+oNUVe5cxqfawyW+IB05LG6FRLWlqK7EM0MHomWKGrniJ01CBjzNs+Kn9AiVG/CKZk45I+WHUC2KjVnJWIFRUrmLwqcqnqHMA3cVWh4czOFnmaOXN/DCIjjBltLS+IbMuSPzAQVvd6lodIF15HUsR+IMTcGbpC4HbEu4kY10MrX2cRVTKuLgasZitmz/N+QtghgzMUbH4iRR7l9oQ+bPJAoiJ7jd+yIArymINO47Kr41RKhNaY40uZSxL+0tpCcmYLqZg2RTirYXLSGh38A6BD5YYt8DuJP70DF/UDUGHn4OsEvc0vuHEZR7PHDcJRu25a22/F2IZIRt4uLANXqAyQ4lkhuJaJadIW0HpKhT1coBAlGAepzcMsOQQndZZKNazEznStR7H0IBlLjuP4fDUswM8y+y5R/wBdKBee41LKIrtLwcxvVlyxdpkFdCXqcTlaWicRRtdPUSgE48zwGBLiZ3W/UcJVuy7hYF+Zs2fuavZUyuCOcRz1DZ5lF8ylviMNcx/iauEgVnCFQdEbTbRqIxlqZR7g2S1Qi4Q2wpWmoIUCmHTEPgS05xIYLbwl61Od0QpYpMhglkuE2lA5hkKQWCslqNnPiegcQFsuJe9ZzEDkb6l/YjbB8kQKJmFiwkBT1KJati/DAy/1YjmDOwkVbTOszB4jEs5h4Aw97mOKJfQtNTMjLPfZH2jlhM9rSQ9nMAS9Nw7bwRBCtkJo0uWC5jbC9DLJexLLncWiuYckt4IlRitynYjRxFDDtGvDQrXCuYAIg3ZObp2xUt3xKLpYFAlGcsi8io6DMduriUrbiXKjN5ipgXHCVnmWoBHmDnMFP8NDw5hANMEa4ibzf6lm9QxzJuWLO1VLil3KjnuXBN9RYRelxCO4qXrL8UGUjliivmVVlRzcYoF5xEMvwjzKgFFtZc8Bw5i2XMUnML5MQWO5rqEG6hDTC+I8TKF5U9xpm49BFRhseEQmFx7C7+AuoWeYZhzwl1mEzVFVg11EUauAOnoQVyKuIQy9wzzaVhZ1eiXet0yhCATh3Gn3LygwN11DTlisJ/8AsQwq5E2sEsUu2jiIG8Sk+pCLYXFrW4O8seINRqJGK+4ZVcL7hAS4joRM4uWdwGnMS1o5mJ5hAm+NcQoUhxNFgXXbKaHUKA7uXRXvibx5JlMopU8Ym739QBqbfwololrExcsp5QH6KNYzxApbozNzm2SgK7g5YdGHDAyuOA3My/iJXScl4gtkspuXpNwRuaHECJXL5iJMsM7cXz/czL4ghLnCw2I2hUEeg7qW0kxPfuFmrqBAmFWBcZxrgIbi3xCGIBPbD7L4ifKjgilHCrVdDArJuxQyNbXWLUDmMCPJlRDTcBhRxM2lQI+4mTQWf1AJ4dRKPKjH5Yxncwzp+SJYq5fZjZFA3ahoyS9WXioLbqc/A05lhp9zHQDQOAsSmg+0uTlBi5mLmQbdwza8iFg9EbbrtG0qdqiEZHvEZDNblhNdJkQjJhesTELTUR2C8xRXFwgYLhdj+Ch7MAUcBUC06TOeBMhMlLubu0OLTG4IbFxV6QNbyTJdtUwYjlPZhmLLOXc4CO9TFO2BjaMGoW2zPcX/AALQId+ZCwcka2F5CXKRrzG4XBkslrMTHBmZIt+GoL4blWDzKNcYS9zIbo3LqCJnxDHsdQsRgRKiJ/ZATS4R5Y74XiJqysCwOecnEIlxuMYZNyrWx6jyZHGZQYCuILF/oSzc5Q+CZCtRbnPicQAeRlXHuO4YnIDAkD49cTDFSsW3BAepiDmo43BDe7hDa3EEHTuWDHNrxK7cu4bODzUIJrmpd6P/ABMRNyHY9rCJs5ZnVk40TN1R/BQveZFNiYNaiuvCXvH+543oIRfQm+LbvL04QBXHAqeiwZ+IEzM8yN5gGozEG2ZHg1KpTODqimxbB6qDluczIj8CYhNe5zcwYtHEVpIGXjUFhsYo3ua6g8xoI8DJmbmGeUoRzNnI8RJQaju34omRgQuBXUd/aPPuKBlwkJoq5nZSWGcJK31A3ubbmJThOsFqphjfKGCqBhJgLY4MQmEXPUGYr3dDK26mbW5anmbbgVaPILBlTorOeY1CtR7/AESih3iCgy1MOZSxAMGWJtxL5bo5l4Voj3tMwRROEF+HUU8k0v5YfaZlZd4gr/JB1ieUKfBuVbzWY60C3JcxuU8RCxxHMK7nSh5mMohmHgkbmC7lUEajChfcs1P+Ii+Z7jl8RaK2SnwIZJRamDL4uDq4VjIDQH9Rpjg0xvOIUz17gqzUxYReJaF3DC25DNPULazeoS4il8HwJdUxmFSspd5SwAMDIKKzEwFPUUpcas8xbHBHvLdwy9mXP3oBSANdHMQbJ3G8jCFxZZ0SpOGaFvMaNSiSxqfgYlOITgf6lyNnqV0p/qekM3KGOcRghGM1wIuS9y1kEPeA9oAb9xkTbxM+/EOVYziOTDdmDdwjNeUsBmGJwuo9X+WNJVwPEUFbNYlQtiokWI81qJefjjLz0oTLqzFYS27HiPjK0t+2xjU65DxNPiNUcoh1SxUhKhghpctws4g2qh3pSGAoeBqB8SBktwZhgAWAo6uJl+JiPMuCFQBT3BDnN1L/AP8Ao+OGqfRmdWJgxLDGtE0M8Jb0swUmP1DPBszO637i6rUBYaTJd9QXSp+GyBroFjYZYiMFw2qhkLNjL/LRoOY+MHiaAxEl4Aa0x9eHE3thj1FEKWrnAVXuVjxKDeHXUThw8x4A9IrmxeIQDWNJC24ndxbE8q1i2cayx2CuYSiVHZtuYCy3C5bm1cpxc7+olLMYuYEcjgTsP8tsVxgTJGRxUYoP5uZCgklUEx6nQ29zii8OUYaNbhUaOvSo1qNSqdUzL8PMc7+02pWZ+GNpAvlM2iPJ8T0VMtuQeNQFlmUF2NkxyjZ0jOBjCp5lxa+iVVD0irrUGFkgJje3A75gCDXUVduZ+SKlrir4V/cTQTmFmMhbcc3tUDZ3Eqn78zC7Eue9S84i4rmFBdMxwUg37Mx4iQU3cXvcvjxADEH54yTEnZmHcZFywnbF0cpZVj3CoouK5in2hNgVlKqEq0Me/hyj7UrIPOPdMVY/GpRyS5dsYvCK5I1Guf0gOXoHiNxyYFfdS+Uu/wAjySGoQo7nGftKRgANr8RwFDd7iaRwzuYdo7jc1BEvwJkRYMy0uTp1MIF9kZoeqSuuGyai9oSLw6iCBFrAfuNoIEyftF2EzKFkAIeY3HecwsRb7L1K7ahXdPBl1AruPvmbtBB0gceI8fqV7+0qoBqJC5LXEpPCZ7YNnURAWW5hX8ysWcvpuPECL5qymsLxKFX4j3puZ2L4IkqL4mAnSYY6SmDRyTlgDbjdeowssYcqEYpT3MmX4iQz8cBLYfSVDI4zCCiv8yzrHiU7NblICVSEVQrucKVFGLhXwr4iudIjAzNorDBTiwq4+JRZcNXL4la2eJllq4EM/wCaC8M0S0Ma3F//ANwQCww35jqXD/8AKWt6gLq7mEOOzme8cQUmy/MJq3gO5YFbiU4mXTwgouPMeAW8MsPRg6mhWviylwgz8OhUOM7qiNX1BOBuPq9TIszeYILpqJbGtsFXZCZzyzsDmPe0avlYkmiWG5SvswbQ7W5UivDiZ3i2iLot3RbjuNN1aNSnJrz3BUDwTJacGXuK7yhMReouTFBTjiU5hMbldIw+Yr8QiDzob9bqZxHTMu+eCGc9TgtE28GmWvO/iKpLzDxRwOopiS41h9oVpA+ssPV8YPEPMezpkcS35DtQscdIqCe1QtA9Ucr2pkuAlNGV6j0vSO4wS3zLFHmG/Dm5VFSWDWxqwfiVH+orf8/ErFQ0hfKjiyTISyVElkcMJzAsAzTgaqWo2mLjMheZ1XiVzxBibwMzrmKqpINkiQ1M2SL2RK3cRmA4hJI1WYp2orC1mTJ0jBXIuUFojqEsR7gog0ZGMpxyTNJuFIiIompeYZTOXPMRFqe5ljWeCMjpKXWsR3DdXLBnG7mE7gtKO45YmClw2H2NEd9XpCaAniH5tJTBmWq6ZUaZk7WNLkvKb/qXZ3lPu5W2VqWBMUWuLlNVclRwLqWHaUX6SXXdHMuSJcNyiKGtwXdoFzq2MeGMTbNzNSQ9DOhDPGbiFTSMez0E2yP2zFxTAschHNYm5HqZILWa8zhqolqltOj/ADYUzFs6l2XTGEcGC4KuWsxirlfTBFupfZjjhIsgODBLF5gsHUHGI2LMwTxKzCZzB03XhgUgaq1ctc4jsPeDMJ4Ydqw/KKYDwiggHcdO1dQ1cFe/MWyzUTlTdghE8G2iYSqm5du2bZ9RoAC5QX3NMuFniXCmNjvpHhy66lLbEcErE6p7OpkyFx78eEd20hwq1tlcHkIzBuYJvAm+Yq7RRjSDqAY3bNhUMd/MVq76YKXuDWolWyg6rCFS8Rn2xpT1iBlhQTGTMCC1fc8fgxwy83TgXdySBrw8ymLfdy8U0ltRHaMGA4JcRmXG8ERHJ1OVFS+WPIhZgtc43Ll/z2hTGEco+pV3xAUzExuKcGZoc9y9LM08S244alrPWvEoEBnuIcAXxMWuQSUgtuWWx9InYXwzypll/RDUV5S9sMb01DkFw5gnSvBKLLwgpqXLGOIgt3FWqPvczhBcYpcLqYqQvMGMZEwZi7VFVbuXWWZdnmZkkDQcIPO8TO2zMhFuiXdMS1GeGoBtTlH3ASiyC3sS4CVShX9SzBZEFhMZVvJ5mAzSPgi2feWIAMBQsza3UD95ZhtgRyzEN7PMJ1C8TJcTuEIOYtv0lqsNOUTZZUlzH3Lc1sviE/6DAlVZsbJlqptTGbve5sKpirpMhaScralir2l+cv8AB2NfAUw5iVZC8EMXSBStwgO6WzNrlVL5jgrjDUENziFAHFVL1ADYkqhg8RFYB7lgh6TPnshS0l/crssMMscgeJUusVic6WL6cgdKXiBQLddzZENX3GlXHcxtk6zK23h+ZQlVmKtyGqlqhcyv0htKlM0qx4nMr4KZew0kMBEHMy2loCSrdmYkBkF8zLlDpKUZ21Mh2eYOhQhotvwkbLmYIsTDj4yrwljzUzeJs7Yt3oGGUKU5Slxyl53JVyGIbFTLECrZi6lKXyJYTzqGnd1dz2NzLfL6h9tCWF8wASgxwdo0RJuaMXMI1zCAPEttbj//AH6x0/gHwzXFTLmIWleoptWdMYvBnqBZah6hwpe1MTADqXT2h53qL+38RC8rzCqy9svUoVtmWH1EQqDFwtFTjgy6qVWA3BaR4TK48SqwlCrhV7CBOsHiAAb1FNvDGodsevUWsTk3wLFk5EqZrczoagEvmYgJwCLjqChF6aRV2ZbDgXcd0XvcC0QWUO3dESGHeJwXBtjfUgpZmImanUuQW43ctgRA4lyGELfDCBNAXxMKoStxv4yxjM2FVCMQBTEEAhjsj3FRbvT3DRQw7jGAdS1qr6guUGzgww2cahFJhZ3ELp4IbAX7jUTk5lljI1zM/wAHR/FaYuWrWGhWuUixq+4XgHmcjnpZryzD8wtH7mFF3AMOYzaMVMWkwylZzE21pi1GlZYk4pJ5teGNk0xMw9RqFPPUE2J6US4uubQIUtxEW21LxFni8xRasyxQ3UMCfl8RArOScZQ0usStQRbhE7uI1rMrdQz0evgJ80xtVzPombu2XRLI8SlHuLao9PMwF76IsrRMOdhKjvj1L6GnEzncec5g5iIuX8AydS4R99ymqwBjngj3Pxckp8mHJmPVAFRFCVnEJ42LBmcn1EA1eImmLV1Ny3L5OZSg3Nckw3UQQgWzbxLhqduIB39pcqRmHB/IZ9wLTw8S9UWd9wOEicrLIvnzcv5G4xdjiC6zAXzDA/CLILqDQFtnxAo6NHqM/qEKEwDcYbhVTBiZ0x0VDfs6l+HJTQHepSnaS60ZnCAZgI2o4VEMbe4csglYMbiIpbqCmAuY1cituOYwzqbZma3iUs3UoZqInHuHCkqvN8TetX7iY7ZQLdzn3MSFsyiUM5lvgsoyyEDfgEoBBIZxXJ9Efhaa+I2CoCBdsu1i1eDQaJSWcVA0d2UQDgtK6M8psFPqGpQyxlAZi1LDS8wQ+3xGpgHbDoiWhUN1fJHrd/yV8pUNIJYlRDase4vKZl+kweS9y7B2RLwUyCyiLDJCcH10SzoHcA1w4ZQlz4YGBbVCV7s7hLlPqVwOSiDGWZNq2p4CTrJ17jgFtWQXleRhQsGWIoTWipTBecZ4hG3G5e/RmpqZhg0DL8AbbLZWu4vQZtVTCt0zka4jT1MthiZNxK6nMAyPpLijDmWF4hwgaot1FtPENW8pdKmmPVXOOdGoaI+VTHmlmIBAX1Kf6hKEBHequKOBZcyjOHmLO5alwZy0MslEe8JrKY4iRo+Rj2TTmLZ0wqepkj/3lVFo1FWdHEVDsJctTvmW6cJRnf1MU8yooIXP8gsvMUMxQzD3yx0NxbSBn05i1dtfB1m9ufMsUU4Kl1svqNG6PLUcGy5+XjE2PggAZ53HvG5d3NlZL8RTBaojAXGBBRs3OasEGhXcV1eio5gm5U729QHbgqYeuh8k9fFjcp0lMG6mHCLWNVqF1b9o5Cy6emARg8Syr6TrWYag+qiXeHiGC92IWuoBM0O/cbSAzRMgXTjuWxsvcUfiCCnMocJXUFzKzSUrUbWxGyZidCZ1OSaU3U1gt4wRbazMCnUpu3oS3q2E5EdVHE37lHbVKJ2leIbuLl8VHkY6QkdLpIzM5X5lq5Z/cSurVbiisncxTO9zvD1BJmNQLfmR3b+T9qM1aMTCZyMqHBxGfiEmEZgTZbKhqLUtkK/qMJ0BzBYUTeobfWKPMBVFOJUB8T0JiZ7KLiZZrqjtYQGzHLqF7LmEUagFdTZwJdAyyutu+JtXKqMvFSo7xCDKdTOkO4vogmeIrYPqCA3llz+iWN0lkOPLtF1iuiM/E3L1Fw5jT6mPcitNRrDULRBvHKPuVfUoGYHEzVhiboTfM7xLRFpKvczBhbcytYB4LGDUtx0LHEoM3cJeVySr+hhcebl6jVcq4g39ol4ZilGbM/8AkvVJBydxerwS0E8RA1NsyQVUp7GkWqdsf5MQwZsvKNOEolg/qVXqxDUUO2VtBbAfEaVau9wjpbTCuxdywltfuaSviNcBXiU4PRNhswzB9wagBuL1x+0w8TbhjlQcQjG60QDqxALvMKFprFQGW7THReoqvfxUor5E7mFHLS8RmN5UuchpNFQQtBWw9oQosXK6rIRrAEORLpbLwQMsqEbuJXoqskrWlXxExDiYpUWXCynkHmc3iB7ZQ1MmopsICM6j64DRmF3EU0Q7OY0yYYEupU4uZoFzia7ViDQtlytHBZdDJjpXEqBmjDc1R9zNm4W/NMAcJSij14nMQ1adR5bxmZO5XLgHDLetfzWpL/UB0FsTFFysjJSrLNRmqIRTCTNRuWhxhfldwgUCmViYwl11NxvtvMvbCPgdxUYIQCXz1HRcynWHSylN+Crv6pU6qJRdlgRizBqblYmXFRIVG6ohJSS4FeYRF5zNa3U13HcCKVxKZtjTDwuOoAytEXh+Aisfq9wKdFiyuOqY6bamQC+zqYssivUwqB3HXgYIFmI2HbBXUsscLWVCswbaMZhuOFwuFNEDHVS7KZekVyV3Us1egjmIv3LjYeIBAD3KlXbLhzeHmbUlteR3K83BuX4L4sUSrRquy+Yji99xNjnj4oWM18MtVLBqXE3Z3Fv+d/7hDLm4hbGaZUxg54I3T1L/AGQsUiFavFQlB7RvMI+lslcBSTx2LSUV+0ekeZZ7CJi5oj8QKAoU0yh3yKzUAFRjBFRz3AqVylla4gQYnEX4flExRtxM/doHKe8Qd+Y6csTXZxG+hKlok8rKhRVxEVZhUjR5inQrxUtYLcsdjqeZHcoyK9xbwfEEc3oXF9hibbImozm5+GsoSNWbuYMPVQhzeLOqeJvUi8fCMoS+mIAg6zzL6aEIFskMp5hoo0aN2nVTdQ9VLiUGzruWxfqKYj6S42HhNhhnVj1tiZ0fcuhx75hq+Iyv+hsTitGbvDzMpYIhmBorZeGJvl5itq1y7mVKbldwCWPtF2qMEBdzjiH1ezmVhGMEUB0KZSG/uX6tQVI1xF4CoGuIoTiOrIm5gXpErw2kBuiXOyCHwMlVmDMqgyLAlXmUd7h02qXUgBzGCvNGvTvEs3AshfaNI23RGNjjLN6f1EyonEW4+yAsqQUK5zMQtLE111StVDM1MJ8KoOQUa9wAgZx4TBZshEJRbjxKBBrvDs6zuUwgGiWsEzfcIKOg4JVhV3llWadzD25iUxrMNo4f3MKuILZwsLNEYm8LnIXuV8A8SgLrcfmRiUS/lAzEasHSFTWJt/ooFB14mB51FBMS4HKyx+CYGlGJQhStwUGHB1EBqvV1U3ae5hijrKMTIhSy3CKyXm4nZaN7WCTMdKF7QWzeIXvz3xO0SOitVyRbbYwLMA04ZUYAM7mQDC8QcfD8BuVFspPuS9uWGdawO2OZHCIV0wJheoCnDSQVIuNFfCcDPvuNcS1KOK8nMvgx0ws2tzQpu2MpWoLsvK+ZYH2rqWg4iplIjpkZqWKLTLAu1m4lNWeOYLvY/cohZRdfsHHn3Ko3kDE2e8YyTmY7MZkCEaIBpM5iqVbvGZWqyTEFwxYRHyKYVmk2HF6hb4grdUdAwOEFYn+lSu3DNiweo5N2RFRXtMV3JoVEpSoc1Lip+6WOk2HrUM5VmfsMCGbrEWgU6mYEoLTKWW/i/wBo5hnAThav+0TOs3UbHlY3NWp3nEuLvsn/AN5Zsw+El1zE9UdsK5PMrdEahlyBKG1UW3DOIDMCnMohmTiOG7JVA1zBq8H9RFByGYwM8Jqx2lnNxyxQsidTSCZhurCcuqEWNYtuXZevHczNwNQenTLcYLQ9xvemc3TUu7NDuN3bMeW+oGWYU4lHG9S05qACU7MOtTqJl9qeog4mDTD1fwHSniVFaDUwYJwiW/CARbymbf8Ap7ycxljSfctRbjUHiGHF3PUUuu3DDpTncQNGPccKcEtBNMWlEUDUqXsvV9ytkyYQ+hK1dpE2RdS42ziZgLdbjExvkijTiKg05cy+BZldSkbEB0x8NIPu86mVJ9TXDKLViEtseJzbKQ3Yd/hhC+E4pDfgRkCK1U4EmgsEMV3FoJfMbKxqJhlMQgrIyvYcRDEc5GNfKoqt6TJpUrtI7DowCJZbi0ayRoxcwDrcPa1gLhtMRNquOdidiU82JqcPiss+kFoqHJEoXgtgG7S+BDzHFgXKpTH7ntAovJN7KWZRja2QJv8A1DbcOo3As/iBKGu4+5HRMh0MdwSMu4+0czNdxAnSlJYD9Q3YTXaLQhOalaw3fcFwZQAAPcMzxx3Fi8mLdRgaPMduWIWN6jwjUtiCmmNeTE9D0S24hFU0zAViJfxDw+CyXob1NQw8Shso9fyhf6hM28QKepYqwV3xE+iEocuGKnxA7aLg8IgH0TLvda1K2aK43USyWvxqDU7moJcwuRdT8iGyL/5EaOTUBYstQBSoTYR0cbmmJRHJUsbNTLfKVWMIbw4mBcSv1JtUsaFdxMN5uf8A4aEM04i1NV3L8z6/1FTOFj5usEISgBqXgI01Y4Y6yv1LNh1KssqUi1fEtIaYeR+oFOSccPEpmzGE1epiiL6QdNOKSyMj+50Jfc4LmXue4oWQrGGKIjGhjFCLmgVcV3mBNJYTzHV7nJMS7Sqx9JlncfNcyLYg73eeZdT7IWu3UaCi5yyvl3A4EYTVldhWpwHFmXyHiKq4wOYM5+DH0IXFQUTkUjxNxx9bEbT1NT8EM0DUKczzbgiRIReyEstmCCMBq5XpvURyiVdsfFu4cTloY5wIsub/ANQiUMI61xUOizLV2bR2Xf8AULfKa1hHKw6MA5lasrxFFkPTzB7o+o5bDupbdFKNENizxLG/c7ieJOYd1X+uO0OCD8EqVn0RKR9Rv6EVYN9Rqz+JkruWFGXM1WfU/wCmjRhzBN7n3icRx2S0XMRuKHubrEr5rO4Ux7YD4xssjoxxuFdXUV1iDn0n0HUa1bwylo/2S8VNcSk1GZgWoYSAblqCl7UtVwwtHtIUupUoCPzEsrYF04gVKxUy1LiMVuYVWbqUS6IZkC2hnIiNAKltsxHItRVuGUuP9YimpSxs2ZmXqPcbOLgjnsXNc2YzERSzOYucA3LshFhZJpb4giURRoh+4blK6ildS9MA0DEOWrjRsX3HH7nTGrGvM1vYIshQ5KKcxey4GuNzWCILFyhcZviXqszgfDZwm0eNeY90bvczuWWbTBuCZWN3zDGF7eI1rY5gtNEXRODiIasomm8EQ5jkahXU4iZzKlRKuM5cfENO5Q6nLHEmJIHUwtIvxI4PbFehNx9zOvtBkfSZo69R85Ex7OYmoFmojlFbfxx6xPp8HhIuIYtdy5/1xaygVrRdRZuo+BTME9SjiuBNM7LGLj4jm+JSWw9QcVq6uCOTfMFRN9S3E5juE6FWzNuoMZYmwO4hkJs2XshCgxEJVWBJT2zES0MQDZFayXEARZeoyAAIpwVh0GKsJFg9pTuXAWDg5ifdFKFpnG51wVAJlepV5qbBuWqYmByiNCArhL3dzEriUYgl6Rz3IU1HmTE5TUz+EvXpymdcFgPbFW2oCx2jDlECQ+qbly8zhUpaRB/iMlcassbf7A1BuackQAuW5YfpCBgOfEunPdR6RtjxN5PZW4UHAvmOexF9MuJWc2CgBaqMITigrm8McBZExC5mTPiKmKcaBrgykMncTBMPwmTUJmOLeokFXmOOahijEtZU07RtpjzKoKVyckWZTuEEAbhB1E5+CeltZlHO2bY1Rc7Jegyyka5/SMx+0ou/WK0HmbAUQvwhsDU0sS7STA6JhRTHRRSxVag1K8epW4qdstD8oKxbW4OcKdTfV9R1Zb3FYt/+EMU2qPH02VFIeYCi45IxgXLjKaDiU6qdIGjGB5YYytZl3UtQiYrNh5vpuYU6mCDDPFSwkhh+TzLMcVt8zgqUcyrvDFylCPSSo3WL9xW4xS7z7JcYhy7njEtLvEBSVxiXmCpaTCeMgqsTcOE5YmATHMCqk7ZVyy3cHz/M7W4hQU3DpOJQFvjzHcUCBrhfMLM0bjgFrK1ZogBK7TKcEy2qBYZRQvFdMV8uHiVB67j7yshXZXityqSsYgLFB43GtTHV3H/xiVbhBZIDDbumOdNqc9HccIsyu7givEEDZxwdy9m98DiOoNLCvvGZppMh3MjUdGXU3LOBrIpVTzmI6KdRHKgnbMA6eRFFqtJkDrhhEvR4iAGEGanmMo0VKWxXnqAkfSXVzKflLzMzJ5pyW4I7alH+KpuO9UhTMmHECissJDEdI27HcFwUwa8JOHcKudyvXHmDoHhhwDzEmM3MJyvMspR3LYHhklXHV3DXSjvM/wDlLlwJgSYSrNiJhXqVIF7uIJr3RgmUypC43w53AJj0TpHB5mHPZKOLSyM1X7iwAQJsmzuclTw7iYl3LBcSxjsidI7GsE3kKVguVIo5E0amJDcoBSYwrPIjaOeGYc91zFmEeY2/EW1Sn/JFtVxQuuX8y8z3UsUcN3uXTO4WFwsw4gx6wPOZQJxDtCEoH2ilBBLFVAMNdkzdhohGwpzEZ75RDhqbf+Xr+F/dNE/e+F/XN/X5f9Wbfc/5fF/ZNf18S2YJfvTafu/KNPqf1fJH7/y7Tf0jv/DjNXxm/wBs/e+A/Dp8ft6T9qbY/qJqe/8ADnRD/cP/2gAMAwEAAgADAAAAEPPPPOPBUH+DKGvgFPCBXZvo+/SrZiGM7eq90HvKmSlvPPPPPPPPPPPJYIxp3h7xtXaAgV/sfstch8Tu3iNNprEkkpqa0vPPPPPPPPPPPEHq3xQ6GoqO5ZWtCqjXxC4JAhIth0mMIA8EK+atPPPPPPPPPPOM6uo7EJbyh/mGdgHBBsDLRIMgMwACEnIOMwEewEPPPPPPPPPOMrlNNLdiEvvt/GGFE/KIlV+4iEspVO0BUGoZiUsuPPPPPPPPPKAolpklwTe8DoqvS8Ti7YBEZcU7lkJiSZkDf5pCxiHPPPPPPPPPAkMTMTf2+zFqP+1aiCD61Yqy6vu/DUuaeQ1FNQ2VEc/PPPPPPONJvXr9kjJjGY2RknzZ1ItV6AjA/BFpGozOzzkXeq54XvOvvPPLLOO+p1ouB93QtOkUt+vmss6lutg8ThJyu8fGcqiPjSGigvvPPMrJlcrjI2zfzMbG11rUQJzWEPzLHqjBG/paR7YnPDTIzjvPPPKiFXsWdUVLJ3KTOPuV8G2o22joiAmUcQmJ4V30sanZla6iPPPPKkgz4Vwjgoe1rPyJR3RY+PIdD4edQGzcMejHL2Kt2eVOukOsvPKvghor4fu/LYVbP9DRcOugfW8oYGLd4aghAEo7PAWSS424AAFsos0txeqYRnQkekiStSXTmej8Fr0yitja4bDEqVQa95LVaMAwlqqinCS0IHJeARLiuLTZCg8TMRTNgvUDdI3WkYkpeswlTB7CAwPDgO0gaO4SV9BqX18t5x0zC4iXYvwIdCnEEzsSHV8gLUa5ikgBvKBR4uLPQNMzZPEVOtWIYjddbUlUDdeIEF/mev74rOpDTfVc0vPALCEKIqiPjyCUk/Ao/WtiVN74xNL2K7U+7km63J5Mghp+HQivPADUt9umZKV4LNyuWpznW2FQNqL1xXkVYVe1rGR85iAxwN+9hvPB9Nbcnu4wb2/qsUJlaSm5kWRrwnUukkh7pwGnopmD9CfoeA1PPORzNnwTN5KnGxhfCEK3PwI0VkQFivZc5JLckVWKxha1RCNT/PPAlYrPRQeY/J5DkW1h4Z7SweAKGtQFVlUCPEKjKZPmLQ1XdDvPPFkn8dDwtcMz8+7K2DGcgEgfFHyD1jML3g4PACddkF041i5WPPPPFL2+w6e3dD/24n1TzbvrbK80YucaqXatai7u2qilkygw0svPPPMh4z4uUdAEH7fHZosrQ7orPmX/ABzZOn386cGwOti+I7htNbzzyJba2rhj5APp87YSRHptBolJksNMRYCHyif9d/8AieDzzAVo8888ADfrC34I1UoDLGPm84ZDwp7xeI4r6cNcH1xnfumB2n92WU8888OOOgquofVNYTknUacLyDT5eRIkEn67WeIa6mC2HbFVDCyW88888888kGw1rLpzMYQUtUooaH8O72m2lRZgLLt1l1wRkAIwYU8888888865/wAsFc+8AyCq8aB3TydWGcNwa1OuHkK4uYjAsYS8VvPPPPPPPOHPVpd2r+Xd5rSKLRBGiceagQiru8medk5s1pngFQvPPPPPPPPKgsd6VvcG7u9Q5uLSK/WJ8NOIlXfn6CgyaggvPCgnvPPPPPPPPKAieacCP+zXV3vo3o+sTliFhEjmraxL4moggvPPHPPPPPPPPPPIAIwPw3PHP3owPPvAoAPQwPgnnwwfvAIwQPvvPPPPPPPPPP/EACERAQEBAAMAAwEBAQEBAAAAAAEAERAhMSBBUTBAYXGB/9oACAEDAQE/EPi45x3nyTeDeUGzWyGSfV5J3hv3CXV3Tb3eQxJs79S3/GuSa3XDpy7ztvGW/qHcP7PflqBvqe4JHXCTDnLM/wAYRZsQONY8u7uy3LY4z8izfOW0vxO0dvjnfA2n92COVlh6+DkZ5G7wuQkGTwm/A7Dx6tnIg6j9lZnQu3H/AAbEXUFe71FvKpbUaiWR3jVsscYtm6WxM+5bZd9h2a31LrJSQZ1Mc/rbdvIb9w9bwT4ksYUlsdxIPtgacHGzRLbSXsMassTe5ZsaO7MurNLL1eN4z+i3SfrGewfuzI7Ww8L1d7FgE9bMdgnYeCOUgDpdCwtfDPu1j4JeM9xvQ7h/m2j1JvcXSXUaxZwm2WpZdxh3YwPkTgdc6RAz5Z3ZHUj+Gxy8OrS3TGww2dXcb8HjN1GCWyHBg4NSxxlvz7L4aZwnUP8AENs+RPqRsSDuFj9WwZYeuVsB1O/qGDhYskjjfi1nIrLfeM7vUmHkaPiyz5q4yGLsXmIHrg/i6GQQLcjZu5gMkQC3k5BtonDR5Ow98dQ28h2OnV2sRbYt35jxuySW7INswYcPcLl3nfOZDJZL1e8ltjA3/kdoOuBy3je4dn3hnbxObe2F5HsfJjy9j2LLe77nfqzqbp7G/JdcZ8Fk9iWk8J4gcktOvsgjBBPka7jqTbMk+iYTpDrvkD+KyG2J4HGW9jn8OnqXe2GWDWSOTi/G3sl9DPsF+p1Oe2/k9wy28DbO7yfE5WPxxtsWcbwxAO4d7nh6hnuTIIIHB/FaNt+EksgtITi9Wy9yOJPDAs48u8l1Z1HzyDsdeyzyNkEuS8E+2XZrEnc4I31xlnBLstujDOA1h1DYVsBRszsctkdFpD8vqHWbOpTHwjHfwAl+ISCe85xpxteLpltalu0PSHfCZ3O34ntZZy2wG9vC+/k9ECvUGScDwrtwGUMO8nHqc9jUcZjnA1y6j7tNHpiGFke4d9eQXqGcdc/toEnCxeyNmR9Id9lQt+A8YPIG7u4ty2xl+y7nMkSvdiTvqOBl9iaobZT6gBDZll21er04Xi7F4ER81epm7HOXZhJ31etgrvw3hwxrh6+GWTIY6ZF1ZolhFe+GO4vUpWPVjrPax5aHqABY3CyYTQ5Gi2dx14C9dTwu7Zct0kR0jgB38M74H0nTyFjZNMjr4OWXSxg5PHaC29hJu9e5R1A37YOrVyF4WwJ7AMN+TkOYSvs3urRlBhk9rdjy0vuXqTDSM9g/gO0mWy6WXy7zDhcn7y2HG2SQYtnhW7DY7IzLO7R7LtzP/Iwdz3U5wsi3vihBxhyy6PBeo71HzXLeejpfuzj3qB7ghkduJGzlIIR5LNbtss7vfRKZbd2w+1jyPWsxepnt37m7hPT1BZkfPs5ayFZUZ7RgWcMu80u8lA1i0PLq8S7ttll5aMslj2doeyKxs2Cy2WO5XqO3O5TiK1Z4A7M5erbdj59mP+3SXTAW33GDCNzuzx0eWa2HwL8LX1McYV6g7rO8lnsTesk51LSfqhoqlay3eGGHjLIQ/gU7I13I7Y8vpvotLBPAOw87OMLvf+X2LRtLY8sLLHqXe27OoQX1Bk/lqSbPZKBLrhik6Qw9x3wkH8TtnAzZ9t/8hsN6guxAONzqbyODvt51J3Sy+wSx27+4F3byeHcjlLHbw7tGLCJMbpLjf6Hr/nE1y12yyuQ8JE5BwuSYEed8vGBB3PngQnycxjbJELIJcvrZb/Puyd2JsPb06tWog4W7vRMWN4rSzYI+QQ11B++durqXWXaL0bLLqOOxdOv6VvvbdlsvcXiTvBcOr/s5BkdZaTdHXt9qATHPV3vDN7IE5rbdvbNs5Z1Bn9N/YN0vDh0hbO+EfqVLsF6kl527Qncd8NnCi6w8QkWASuwOQtr7+PVn9Uswhk2BYHG98Jt0vWz5eQ45DD3D3jHfvCdS7fakZtZ4ZZAH+X6lYMDgHVmW57L+Qy8a4IjqND4o27MmW/dsOTcYe/8AKXlfkT5PH74PL64+pvF65feT5E8Gfb7/ALf/xAAhEQEBAQEBAQEAAwEBAQEAAAABABEhMRBBIDBRYXFAkf/aAAgBAgEBPxD+L1hDzAd+qz2Igr9sGEvwfkOYZ8ciTBg7dMZ1glft7mzEnz4yyBk1/iH+14QNFu/FNk4fwyVfGp234JJg9YxxnEvi9e4kuxy4Y2xt/wA+Px+DSVwmf7pZkvlgjSydj/eB2j2MNYyiFo3/AA+8b/yyvbQNnyPmfAD6h+/Qsuk8hgYP7g2OS+GOwhjE1goxYW1rMseR0k+InLj4RHr80vEjU0x7ADGe4GEhPCwYg8XeMDcnmHtw9/uw+bsFIEbRDwzUxibQ2ntk8inGD9kjQWu5CyxLR2bn4RpiMiHCbNLvBTkDhH2X6xeJnpP2WzP7QGJBASiBZOsWhpHsGWdkXLZ2xOk5zZktsKWFhJJNvbZ/RdpIfnf+QOzdeZHRjyE2ZltZhCwmTjnsMP6yaC7PTcflxd21kmE/mV4un5wIbJ8uQ8QTpeDbSCl1Y/bmCEw3Ux21Mbxjshl8nDFl5ft22fqPkp7ZQXJfIVD+oMkWqZYtmGww+STFux7yzvzZtgJJxdoTWy9l3JX0QtlufB16yx2DL8S2GFMkhagZs/guRn0/2VdY4/zYZdIboWh2esGQgsXY8mOJ42jL/kOFi8EBRj6WBy2GhadNuy21uUHZ7sYuFgW3mGD6sC5Dk6hR0koAdhrsn8tW2x3i/BgOkd5IuzncsDNhe7euyH5847CcJT/iQ6M+0J4T4QWfkFlIgxhBMzD5wyTInkcCoDyJGeMCwpaeMVd/iSdJA35uOPZ/U49h3bpoxy6bZhMryTzyP9R+oDqMnGEZ+ToSBG4RDVgsCQKwjHXbbkjovAzxhSriDbY+p6ckfYfU84S8xvTBvJupXj/EtHyLsKMtMYH2NxJ/5gtmQbLKEU2AZDPhfBPHLZbDhH+xPIXkN4QPYPMzuctzLhPYI4w7CGWBgjfiuuowdgPLUDIOzi7YBbTFbfGfSR7v/wArQgXSQNbkQsj4bhy9chQpZ/6MwIFlnzjPhpbIScGTGRA26ksW87DhHxF/LLuBMGN4mUXXFhnV7BwvxLbf2Q5OsH8V8TpmWExFhcetoBOeNjGNJr10uB+IBy4ZFlg5Zk4sgSc2j4X7rfhK/l+zAWTW4pu4bwLfRLWQJA0l/IdYFwiLaaQlyH58I+tnefU2KGsyPYvTc/IA2W9uuSHZD8idMssC3exw2QfDR2wJ254wr2U+57FmZJ+eWA1uYXFtrS1lOHlk7NTsZdhrSfQkerPULOi/kzefCPj8Xfhto78DMkrS5k18t7A9gzLbHFrdtiJ/lJ/Z/wBZi7f+x0DPtM2/aV3LbkG2JfsvyWlseORTh8SzPq3Gb9leyPdmkF27OQ22/wADrkY/IB8N+Rb348h5avzi2TSIcZnCWtI5jvkV18sW2duPGSOPCWfrIC2kfqyaWGLQ/wCx2/g3tsMLyGki7bvwmfxNxNdw+pjHGx7M0+T4k4Ikn+z5MEchJ05G56TtmnfYVYArAuW7n5A8gkJ208+Yxj8gwP8AkNh+BvIYxhtjGTpZFtndlaTtkefXmeSv+5iNGyoQnY48tGychLBGjYN3sjRM/wBsiq7L7HLSiONtB58bMzA9+KF5gXkTK2s7dIvQW+N0zr4z63+/hrMOJFeRnIGFX37rqfYw9v8ACB9XnJb58hoiJk7ESRMJ0h9pnfkghBnvyZckPJAw94S3PJIBKYs3MJJAvLfUyxt3OWqT1pdqwPpIz/6J02g8+UJiUsuHLq/w5+WMXWfCefgiMyzSORg+Nno3WYuxpkiTvsaOl1KNmhzfOc7tDYAf2DIOoNRMeSpEPbODYEHuJwFn35h24R4ZUsdSHW3n8T86PJHD9lvqIsIJiI1d/IS0bVGdvG1+AsPIPy73eFx7E7tgwKnC6wGAG297E8sezOmzOS5iwd2HBJwDqRbEFge2Dly5e8gw/jlxbC/LcIOhaMbLiXtgeR5Zp0t1g5C524WhC2CsbThPS042UbcJZHM7BHZwljkYZCYJ7a9bfhZstCzZEllyTTSR2BXLgk/kGrRbdtdM86xDapa8SM4NgOk3/ICv94chCSWnWHZOQcxgCIgxgZB18yFqHWDA9tYJjMaBA92B5E25f8QWBkTjv8y57J9wv8y7GMYKiKH9XsGFjx7K7Kffg/GOwm1SdcZB5ce5cey7GrPUThlAXsW4PMJr1t/LbJkO2hJkIIMEAcgzCf4ZBHPbTkvwnS/CW5szzt6Dl4N6+KzAWCX+HluMJbuTtsIf7L7aDLvhawi4UoZG2B/LCBAm9LVv5Z4IVRB21fBxhFu7P8SPmFh1tXse/OiTy5Fz6TebL/l6khLsTpyR71ZcjDpGrvwdEanvYS0YOTMtdNmwQtKCXA3y70kQTLlwvUA5DH+e2/DBkvYEs+2ICZ+iwsflrG/kpaEmScLf7c51RM8J65Kr5yMeRviAbmXu1lyfxLpkoLxgtMi+zHYzy9Iflx2T+phtd5GyOORZllos2F+wRhwkTb978dNjmQO3S3bWxba1jnbQ7D0lF7flz4/qXd2a9lgIEBCNhjy2/C27GT/UwHt5cYKtknPljxLzlyyLmFs7ebeazP2wPLQjDD2Fo7ZcLiz4n8WOYo9tm7bdOjddQMyRmQBeswpGzGX+tIU+BeS08Sc8gbjGQm5A/t+Ba2INkwdu1Ae3TkOTo+dsiH5BaXS04+SHixm52XlrZd/hln9m2AkjiryfJ+ISkPZ5aOlvZW7cPbaZYHZIh7jD/sPwQ6SymEqT72YrNsyD/wCTMuiVeNp2/KIjh8YHbh7cjjYpRnZC/svMh5DO2/fXJ7hhbyB+Xjs6WT7Hv/xk37eiPS/PyxF+/R4vc+Xv483r437M8Xr6+pn2/Z/t/8QAKhABAAICAgIBBAICAwEBAAAAAQARITFBUWFxgZGhsfDB0TDhEEDxIFD/2gAIAQEAAT8Q/wAdAuhntFbzBLPsjgUl1FGE/wDlKAuNmWbBwd/vUMZguqdxHSg0OD1KyiowshBUqYN5ITyCxbgmzpvJtUd8SzWYDM0q7qo8CsENt3E+iQvjcwmQhM+ZnbcaqIKulnIeYgUVZR1BcIp6VLYtq2arzM01jZK0t6AdS9VXymo77wH5TISBobPiCdaIGnjEEtUbU49zYgK2X+ItAci+/ceVUFVH2lrGUAj7joVi+Y2hoDA6PUVYvIto9w601jwMqosxTUcLYtUsv7/MogqBdqiuIXFFBCO8ucXKKyyTuWuil21PIAxq4AgHJipmFRLLdELZ2jSpuURSu9wBELkN/EIUDrbio8U1qSsxqN5LMeplQuT3Kwwqm8XGdoHrmIs86/wP/dI1h7RCgorHuCRJedEryJgpdx8lTZRlgEVdsUwVaf8AkLZVolGXdR2gI2ort5mwQ0b5+JzicxnxUIjCAqVivMD71M1ZMGQ9y547C4+tLpjNfiMdhXXPpLYzRCVp6cwdQoNZYAPt6E4PiZlRa6XTcOJQWjP0m6hAiVnq/r9JaHleKoeUB8VO9XnJ/MMQFVJYEVgqUqKT1EtdZrmJlK6GWYl3I4SXDHd2XqCF2eTcGCJxsOpVBbVZQ/eOU1hBVTGwoyXuVER3HTqKgnxBKrOHWoQIYbrzBHZe6NzYr+KMf3ARgrbNRFNVOYYHce2xkduIrBTYuIzJYmhw8y5MPJ1DmsKrOZfDOGV3GFJg0qLEBDoBhpgKqq8LWFGgNbKg5TsLiCBSb/8AonEf+7k1Uhs0ek1NjZNdF9pXg+jIy2egGKQzmv8AMsl0NWjK26Pf/AORFwHM2JxeP25d6TgVklYjAtUEvjy3XUuGmFaqAgYiOoA644Z+sO61OL1BbNCo0Q8lTLa/EUO4ovz+/MsGJsZjbDmELxruuVuQbMI8zCWqXsgyHsWz6QAy0NsHqE6FVfmaijdXKLcXKAGQCJlFTWHSWZhv3G1tC5tm2nBKi92Mxmws62kt96S8QQmNC2tVqCAqj/uXRFN1x9YbAlJafiXp2WqdTOq5WdRwswGrshBIpavNw3gcrHLL4a8Ex6scwiKQ4HRKXWj0xYEGiua9xjoBTyv6i4UtdDqGFlMF3l8wYVQnMqFuXMKEQU251r1UfGYY8vcbIzLx1+3EKi4NkQyH/J/xx/3QtCCxOlgCuFoQ07KvV33/ABCMDloKlybp5g5Q98xoUfFiKpNlYcsVrKn1QXSWCgMtEvheqra0ZS9yyrehz8oRbAy/wIy0cujbO6Hd9dxK2P8A2mcRwLu8etYvD9o7EbevEufiWBKGqgMt4jhVQFtn4gqOcpavL7lQ2kln9QUT9KkjVjFwb2A2plVXxfEvFwqRKUAxrlHcLUZvPcO1LdczCDbmuJUOUv4iUiwycR9q1TKDdvdy5HVmmphOBNcsxlKDW4L00smcu5vdNg6viBhrNtZisrA3AaicESjkKCWFaCsPMTlywlUBbxljuZ2l+/zGvTq3N538TLS2LqIoY+Ii5OYuEdC8uvEUKu5l0aSlMLFQzgyEBnlWKuUUeJZeIgDd0C6ucQoommZwBTvRHhWHqI0n/wAP/brm1cvgLOHiBzDGxmPrluBAlrdEvhS8XoYgUXQ6PUWmiLliWYCYjWGAtuOHbltv+osYJwWjGYyL3bLJgS09BitwYQYxKgDGZRAU7iIREJLMd9xNBG23cQlEIDQGF0oYAGZ4IQlxceRWTA7lCuMByf3Mt5AwxuYFjmkqM2VNmYV8hT5ghczDWf6goB2DqA4FYHPnERQlolOYr3AQqr02QJSo1fEVmvapVhZqMJBHb5l6121MQVUmimWrKZpgKN0LrgvNsXBJze5QK/hLVta5aIaBaZXiPCQY1GbheOoLBa8VLjNXeWUQuOLNxBbq9epdlAoBx8vMEZWtuypsVnEeE7lxuyuJkSXuDgzUGs4ExUqCiIahrLBHVH7xMvVFY46qWy3yWX9vmV5A3fP6QAodGHbUbcRFnHx/8P8A2utcEW5mrmFEBku46wWwlbmXD0xOCuW8yioo35hdjJgbezgV1BASwVs7YNOjRV8zk5JMO1hXbqJOSjdksSiNY3AFNJwQACwdwxXmPMTRV89zF880QJbmoINqU9xScn3Mhu1gIjb+vowdCKCmFbR9pvDRQzIvTufE4txLwJiIJg0owgkLSZg2WMs8CIYIDP5HEBsPMvBLHGJeq2v0hoER3cZMBgYFZWdWkKsgCmbeCDUaou3fiAdXDeuoiQzXSXRTHT66gSihg53KOS8jmA2L+EXSomRvcCaPDMduRvctVqWI7K+DBHRt7sN8oKxWYrVJOIuFuuo2c7xccI5iZC4A3mysy+/At6MbiytTkdeYM+DJzkrP/spcS1FNw6QUEhCAL6gC133MlBaILr/h/wC06HqMvFfExxRWWsy74BZ8SyM2ctsvgKeIg5uvMyq2aPCMt0cvrtgcBr1zqpQ30OIUISlc1LQAXFmouLE7epgGXkzAQWUviY/AOTQQZaC5mttncLuu2Irmm5Qlty17msbgkjq5wKKIYc7PvGTiVGYyiDmnLGFBXBBXEI12dyy4G3nuZQt1YagqQVLHGpi1ruVr7AUrKRRBZZcfGt9QbqwnEFdAqwvEHVoiFO2cvEFmVQHb3DKqSlTJCqzRb2y+FAZaivIkun3PeN/3R1KjQJMSsvLd9QhvJhdPiEbQtikqo0Oy0jhTdtbiSqFaXFvu3DjUQbvUS71CUwXVwfNrVWvVxIMdtWZpsz5iXFQRFsDAw2UwzRgRq2WnHmZ6QH21FFEa7QMMN8Bi4Jcs/uKp4xeGYvaCuWGOW6X0MQQHEXRDN45iUx/7ZiRTubVBlOADmzMEqClxnXuFdlQ1j6zERerSU8a10t5ZkIU0VtxqkoGjBMbgcgZf+zOYWYWouYhQtWOmDaUFNmQi8KmCPSoK6thAqkgpWXI3KQa1yMdUKF4mV7h1gm2AorrEpVExQTGi7W9f8ZKMDADjcOVbyTkzUqSgVo2xdI8J0YlokD9fWFiDBFcblvVHAm4GaqncSE3iWxSu40W2KdQOPmG7VnG3a+PBC2Vd6RjEXUC8y7U0LW4rowRahz15JTUKvUGu+QylaXQ69dRwFrSix8ssArbzCEF4Z58RFqaDX2nEbHZUUE71riihkoKa+Y8IWbu7JTNp3tWJGH04EWCieNGEywl5GotVZ0U/EAQ5hBeODLjD7gRDoeVdLAnomvUtCYZDr1FJgL0bhMagOeZfa2yqLxxEVAUDDmNYiT0g7AcZIQDDqEbKU8Y1GVH/AHESmEwqYA5g3L5tr+uJXiGsMvm4BGGaote4VTvhW6i15xk4iYEHCt/+zLpVpcywVsrhHxhbRtiwALAf3mJ1HK3PeqVxUWs8s67PzGhLRlITOhsRE2N3UezWJbUEfMoLvxLFOCqE2+NdZYBqjLLaT4hml5d7U+d/SLZBMkXhQBhe5kaxaHcM7F3Xcswi1gsLOFcVdRLFoJCotO02FsFkrkt9iUnIL8vBKnuuJQNfMsvh7T6aifBDry8jbKyhv0qKsWQN6llWl/P9zAUpkYAMa4g7luAaWvcbAVRG47Zu2zhHIUKteo66j7O4cVO6iv5uKYBUpo0DxmCPLeBh5myD9g/txBZcQFFcQ9emTVqiaaZPiIritmfKbpVRH96ju8XrhE0V1Tli0wApu+JX49sY+0s1BB5r3BBO0pj88V+ZYlatk3FPkXh+I91gwaFylAgtDbLNscFlyPpWWLFmC2mIyHH/AGQtxAj8zVvmouzsKqoqNotjzAVNbRFdD4xHbpSi+JejcbwxUuHDstwjVexuu6l5lNnDLOMaUN7IUsBnK5ZgZWbI8xs21dX1BjwaatB18xFVibPqWA6gbZLAdIeZlzv7Q3cy0rxGeH3uD8SwsDBizzCRrS95JvgKo5PfqOqVtBPzFgj2LpuCVqyJrMSGu5wTCahiKVC3aOaZka6gFFU4DM0gEEtvUvC4AV6HxNEdBm0EgGLKXZcv5noGrxUQ3Cq4u/ERoC4WY+seBXHEEIOSqbgwROQ4IUEpZT9vvM/24XDKmLrEr7ShI2EpZrMYEKVRKuUhmajJUGFAxxb4gRoOEf3uFbK4dLBZkaxjPMDngdJxMDzAtB38Diq57i8ZFvBmJIRX8yyMLUBSIWV1/UtlG0FgftRrRZfuIvVV8kW6uxzHgjpsJb0CaeyYQoV5QsQfuInYtjhEd6jsPiOhS7sQrUwONxQ9MLbjiIpprR4gJPMKb9Rw0Dct7X/2C6bACwmTcFKbqXKmrsKgA2UeTcsCylXUbULq8cyhLxPEaBVCmv2I1Vt1fcCiM6V33cS0ujBO+pwAwV+ZYBbYE7Eqm0h38lmbiKXK4c3ULBL2zLKptm5Tkru45L1A01T6igUDku9wgiKT4iwbq/L6RVahpkmt0OkN1FHbMNVMnO+0MUi5UFDvUUKPICIyC3WiDgTht2+I1sW0QoYYnFwYf+QgqEZRXfhibloq+nuNxiKs43EKyzS8NqKGWNBRPOf9TeQvEasRK2HcIjA2lWyjVa2qcRcQzI0/1BUJSrz0RGaNGVwjQWhy6lKtYLsQ5WiqNaixzvWSKaWyCmG6uRhzHTL6vC4VngC/wh3V0EzXiCrKxV6jIIVpSlDxI0AVKnW8rRNCwe6z5jOxKgHr8Q4RWrLhGxj9Pl8RKwoO41EEr2/ScXppHIr7wLGFkZK8M3RZ0MP0I9zX+FuodMeGY+ghykGatCzV+frCAG8/9cIvbcOfx9481trYfLBRYsjbqtGYXBrBiyIvoDNEqMADEuMMPJGRMjIvUMXrEvqE3a3Z1U2M9sR8TCKXIUPruADjSgqGCFDdXDhoKRlJQADfMbcPLG4dUFGnuPm23U1BBS32l57sKcw4Kzs6JmEwGHVeY0yhWGcYjWHku5O5gBmTphrQF6lLaxcMRaOBz6ghBfJzA6AF4b83GYZNENVfozAOntL9b6OMRauaC/URQpwWVX7UoThhqrzLEq9bJbQoyCblIsrBTHpEUh1iBEDSZ1ELBMjGSru8p4OAOJaqsANMyXVtJB0q8NwlquLW9VGMZQtHMpSiYD+Ynk8AYdbGdrUTdqTNZZXaqr3HjqtqPvLhuo60jrSYWz9X6xuYcODiHUVAgMG9ZTUxmqlTR+koY1VCMlscalidCk4P37wyC8qpf9y1at0j9ZcSJzF09xgYXjxCMYryM0x2FtzV4qMzrFO4lKX9Yo3/ANapPMoMFU8Hv6Yj8lntMBXMFNwJccV8wxk/Ew9oFxMmlsv5jumC4TLZxBFJ3l7qh7z0R3CXA3UpGJs2n9S6iXkjqU3nRfymRE+NeBl9KMIm5QU6MERviWWw8MbrNSggaxbcuW2qmh3BbT5svmMGEmVzBYIGzPEdNXW7rjuI5CrBcMQVs+9yldZ8bj1A0mYBiUuKmEBkTQgqY2gsqXadutx6BbxabiOFzWR8xEWDZhqGGwO1qyZzx1j9YEylG8wAbBMepRA03nlhwxLkqUwAVtAv5iA28EvVVxGwqVYBZTfmUKpjZUcjTplwwG4rcKxuOStUwXBBFGgxEaqmjdNGMRK0hi8HzcHjm2y+dwdSbS8r1BCFG8FTCHaG4vVKpPHmZUd9Yj5YM4iQdnIu4gsQ0vUYSBbvtjtC7HC5Z8GrUMDlhGjy+JVYpT1rxCwJ9oOY0rygekpnNXnqKzB6VfEDCzjgMyifbyrS8YOsYY+DinbGIyrvt8ksV/1ShssuALsFDiOiu2Tz1KwNjmM4o8dxkE8IHtWKqRvZ4lzIVnxCm0w5fEsauTTGrBC0ppdEer6g58sDoy83HrAOyWjcxiXAURoitfIcXELL4u9QbDWisXGXAviiB1yLb9Iq+0q19NQuwfufMzXDeoPWW6Y42EpuPCzAVkICQ8q1LyqkOYOEu6JR4o1lCKkXRM4Jg4sgfiIGIVGjzKjLw6fmBYZwGsYYmWEVwPtlZ2XtLlrClrUN1qrvay+u9U0VWyojglpaCgUV5fENqUusfeIdQKfgfmAGViDRqWHpam+IBA4+sdaYHbKBoK+kwYtpbhlk5Y9vECup0gLk0yzFN2B/Myy/6jMG/EykRdxVLTiMFVtzHY0abhUNTCrit4VHcMSntIGwnJeIENunEzgtC5K9fMdJlMvfd2d9SsB8OYVK2sQkA+BkdMpwOgxXUaX0adnxBuVeIJwgwViLlbozOeITkKY6/wCmMA5gzZioZdo/iJJtuUU1bOKCJ5QFwhBdHZQQkx9moiXSA3ZBAB8kypBvcVB1X0l6wmfLV1FpqucXHDKr4jZNmBe5uLF4WGi6TRzEXlN9TlobMlQgNYphfEughziq4TIHLtI/ErlTGWA27SyIhW2BxQ3i2WdJQvUsyNhvDBk/ZczmQtHOIjNchrUIVCWiGAHUxmJZxF5NxeWU6YwWqzrUVE3sxKYrX1e4lz5aiLbi6wQo0a40xiRTsOIW+G1QxoDQzJQxsU3+sIeaFN+0opS2C6hIpBC7HqplMMmsXmZleHENLKJnLEWiqYcBODRLouhYO5rEFB/UrYCq5I5tg3KweA6mXr2HMb7mMRrVRtCXlVWGqjwYVlOYstLYH8wtaBx3L88Bf5pgWMxFlf8AAhJTnIksTnnBBRSblQUocsddXnc3G71LZYDu8RbE60G58l+0rVYh4bu1Xj+5cDJvsJ3VY93Kj/0MsGpeAN5KJh085zCFpoy+ZaOHXuYwA8QVGXfRDHGQ8XxKIryE1DzxMFc91FcGGipDZAV5YDues3BpV1nuBVZ9/eMLuM0sH1lFD4lhk9PECG79XKFjoxLwvQlnXzEHDuPtCdqm/UZTlCgWXuL1Rc1VvzExQFPuBJgcqs/EUgnGIrwcxrv7c2qCwWa5w0LoHUuhyBDEMm+wcE0IyXxFROmnjzG4INqogAIOzUyyXbRdSwcxrXPuK8sC9L/McbrchqVdRxe7Hwl34fETtmhNLOA7kczSF0U9/wDkT5GKrEwyDCOoVSvOH+SZB674wmOEB6/iP0KW26V/uK0xdtLsl5zjYIYiNovIyxVal6YvEvHllJdIBATfcYrZcmcw1en+4lu1wy9NrTZFLdh1LVgaVepZcptibJx5lrBDteITAm8qj0fhC6ZgiqL2UnrUQtt+2DYLxF4lmAsdnMqYwCxgMSS0dsCij+ggh7PmP6lwsRoZaoDmsXDwLy+CVqKltZiMBnxFVP8An+KgFZneNExDhutxIi4N8TKHK5dwyIq4xFs4dIWwXjyQ2SUm1/alwsp0cPMCDdqUmeOee4GGh0jUC6LooOCOFu2OfEFAaDTtjCY07qDBZsNRiwhHbjEbXlikli1xzuV4bpUyCUgXXsigFYbdBAghOBG8w8pyszsSt8EtVvixFNfhgDHqpemXyx3OzFXGqVPgaZX+VWLLBsaCjbCFQN1zGcxyuXMXLziDgLFV17gc3PT6QcO3jULCFG3FE5rEhuHp4PLf1gkVUVFnFHM3h3HQlqglg3nzCEkOAWMQhTGaNS1uFV/uXoDwq4dALDILAi8JiVUGlsxMJZ8A16mPK2JRKi+FIBqzgG7j0XTYhiF/DxAB7YzmO03etEI+brEblYpe18xWkHONyqNUcXxMknmybiPFkV4OiwgUT0x9TPc7ulm7UxX5l9qXMQO1XXEBBt9ZI7S1wlwF1gOGZxqXVB4O4BouJnmAzZCyx8McC5VWGI/WouADVFj7EbaxsriLgAZait9sRKf8rAHMwKDW2IW5d1t5glmmiPhVZHPqbZZuWRM43FK4Th6mEFdjfPES1VAKriGC9VlrfmVuM3xHDatMZWWQbS7cS2GJyRqIkJi2PTHjkcKiJFGlGgNylS4yo7j6Be+oFAvCsyfGQtXUIIBprA1AzjNpeYLbbQ1EA+gHxEKCMAoIDCL3jiIhTA3LjzDaAlfMmIwFV04Q64sDyyuqNmVkPYkFotfmWCN9h+sQVEtVYjYtV6IwVXSFEraBBBbhBxFNj7qaxGBqoBahm9TdRPGagEUjXOKjaxfK2mCijsQAzmj8cRYEVrw+eZXgLStweLjQCF9XHSUBTJx+YoooVW2DjpyVXmqgAkSqLx+3FVwpgmQgiLSqCxog7dMZBqN7jpizhJTw3uoDjpc9wFgEXphpoAFV+JWjtupjhlO4lAzwQgoHpUJiIOkxFjYrx/7FwV8kpqW68keMNsUV6halBgS6hdX0XDL1+9idQki07RAhgCrF45+sDhCtmrP2plKCXxlngQRzMxpi94CZHMYWXJS2TdwNoFshmpn62N55PEdOS4/5AN/SBdCVk8QQpWsYDuspW5WkpsYjeHVVcQsVpyxsAofjOpjBIvJjo4EVsiABXIp+GWAs7Ce4GAPhlliS04L9Eshxcm4hI7S6RLi+tkjuoXuWp2odQBqFYg1Ido5imxq1uWAm90E0mG0i2gxM3Z+4lPwwWG2Z0PStn1iOld9EqjC1ldEWLCJd3L7s7sWOZzMzL8TQo6GkV3HChL9PR6jnl6A8HcEd2l6HiW6Uau4Tol5uNsWXGdTCADSXuLStNFwtIlaKGFKplok/Q7lBVTm6cSu8AudiIDZMZPQBr6+JvUZvSWDRMLmYM6KUNYszTqGwIDAn05lilAJ1UEGlhsn3hntwOCIEcl3A5kr41UE+xrJ5hYrlCMOkW3w+mWs6G5jXP0qUY2pxxClyAHGeCKqSttcRi1jr1BFV628wKQt6uL2I5zFihcavuNnmM8CtTgm2GoBq2gC83R4jbpTYOpm1HQ5YQ21WWpfcdLZCObZs4+cfSCCjPmf/AGAXfpogrFE1L28ZoyQIppqrrEoZ+xzqJIqFUy+SVFAeIKV/5GE9wcEFHJj1DuZ8AX+8Q7WrwYiXw6pqzX8y1DYgjbePmL4FpV9hLimNZdElDolpsfUGDNyiagD75T9YbqI6x2eTiMuCrhZcXXE5L5Jm9lazkxFrFHdZa8ywtW3eGfLKAFDdmPrA13tDSojlbfX2hbFwJU6/0LXiPQDfk8zAprdvtBcTrBi+Jg3rFcVxDtYXXT8RLbpsHD9Y9UODjPUp6KcU6g0C6wCDiEwIXE0NMhqKleJWaxEI4Hd/xKYMarymVFxeBfJDrMLYa/1KSrVmz1ECyj1zCTDm83MxHEWAlFCNloqCL0J+4ISpDOQv3KtiO1fqUfYZCcy4EzeMTBG0zFNr23wPMaDzkhn15hRitVmxFRqaKQ/mVZtoqwfSBMq6hsXFIBlSUrXkBtDGKMJX2h+BQuAAbWQZhHMU3+8orYvJvfLFJg9WYx7KUY/l2ajitXA1zNhC+JSpYOSOJkUDxDqErpgaP7iFFbViW5G3iNfpHHcTYEfBdwybt0cdfMcMAaQ1B1VYV5OY6L2imT4lrzmg4EbsFunI9y+xusNn0hKqF3MSnpD7zGV8nCJXhVV4hKlORXCUVAg2miNZ7/ycAlqKeFcEJFX4Fxy+lXPiIKljeBTGxJalu25oYunFVCgDrgQGUAHRYIHMPBcQiAq0GY86sRv+4jINC3z7jU0MqeYrQGfGoiRrVstmRz4fEvyECtcZ+0yguwAZmfM3jGG7iBNaG2XMS8AWxxbF4ZonD6xQZWqpW4TK8p4dS8Qy25cS5KXSckE6ABd1uMEyWg4CZWaV/tMSTWV5iWgXWTEVIs4aw+5QQGmyn4mUG8j+CBHqXsu+YwBeR/f/AGWFX7uFhBqnC6jy8XbwxPW1qU1UMr9pm0SpBBLt0XuFBItpVuz+I4GBJS79zkFNOoYAKAwfeL9p3ksjY1hiv4gIcybnqWNQuQ8RW9zDu5otWrfLEGNDUzFJtvC3lhhQtrb1csoGRh8wbTtccJ5SnG2oVUU7qNdUUWcTBhyb3FnW5q6cwqCicFU3C9ZO4mQuaPogmghlKt0QTDqXhn+ZhLOvWIJLVwohgpXMeeo2gsNgpFMCovBlgBscjf1frGs55VLIucXohKrLLbsjoZKV0MadjqLT5R/EOBkRnHRATubR+8JRMgqZrSv6Evdz4+8RzLoIlf472/K9QgjgE5lCM5mpWIgaLc9xlhqPLwSvoAAZZVuHiqzMaBvV3L20rPnxFhwlkCQo75lduDe6ieGBaypcgehv6oxIBscenxGgEDqL8pT4/dzjAuE4lmTsYDzGSgtqYojYojlWPRkM1pbLPoZVb57lO3IrLCRXpKLLDMxq6ReFIvykWuHiDpDARkUrJXB1H9xstr9/3BWENIl9vXBqZck1/qWR3HI33vxLIbhyBcwgMUvCMK0Mlq54isy0qqYh2RQKrcEOsKoNPjqIF6OsxHcJ6mIVV3xKoYg2uGWNIl5FQUIXH0e2OKtW0RtFr9wQmPncyB2goBYtTuGzSBRuZq88D49wyNQAl56gJbJ95S1Q1dxNAhzHZwMEFmlrgIltlum/rM4AbLYMAb7NICirnp4inglQfvELsrKdGISd5vLFmqMor5o3ArFGhQxvqraCrl4ZMlKlkjdFJzj68wIGNPDBNCZOJVUGTJnPiK2snAWQOVnkrf8AUM6Zyq3dwePuzFwgRkRtVR90HBguISUKW7YhtjgBqCtxZL14jXQqKK5YC27WF6leWIMDZKmb+soutf49eToVBRZ57YIAFLTct9iraikVbS8P6g1tv4MQ0YtpXRFhSyJ4gFLwItMI4LNsIisy28nzATAve2ASiuxxGVyAC8+4KN88+Yc161QN/MV0XhJqoFasxWvpCn2g1OuwV9JlJX2QcN8U1GrAze+izKK/JPJ8SoApWc+jOWLmiEHDLIbrear5+IcdSXZr+ZX8SyjIajnCKWu+dsqN+DktxAKuNFrlvYw3Zr+IcGYHJj61AwE30kMBAUofzDiAghwRQGLYLPD+Zpkolb8v0lJmyZV8vcz+Dd0PqZDBgh4D7HRj+4gxSrtKb87mbq36VM3CYE7g3sAHP8QyRgsYUmy4qm4HmQoqs6nCj3i5b0OeKi01MP2mFSG2iJz1chDSPtUQmQubimHFnTmMWQZLePEY5Ls+Xcc4YrPEoEYuscZhnZaLMdfmFDTJVaxtKv8ANRg2xEWFq7GGq2XLv4jXPhyO6lIAOCuSY2hdQ2ichkK8wyhTtfiA3i9GSHUG14cMABVlJXMargsYWoyxHNEb+o4fTMxAbCDUDwqaWz9Y/PAOLzUvwHGD8wCRS0Wy4AZy3hlb13/jV1tXxDHt98RabpfOoLLi8vUEWyrWg8ML8A2sPiUHtsC8pziGKS7gE2tWFG1gWplNk/mymJeZLTdQYynovmCKNDHiMHKub7yxOhpm/ccwO8i5+OoNlCv8kGq7AKo6SPxQmICrs9kRalW4/EFdirzxBc2A3pM/1KCU2rdhzKVawPPzLhgt4O38wdIShoNkd7Bb6zLLIVuLW8cgBf1zApEfZ1AOCMLa/SVxfLavENAGpXUKjBaivxEr0tRrk/TUv+iIai6qF71OjXPEtVFxhmwcOCHxkhNepRUNhwdJAzAFhzmIVxX4VMyNrtgKtNeYoDQNVKa9oWRVzSDuyLFoV2LQeJllcP14gQVrWtUx8IrXi5/MOpfFCtZxKorVVdzlDhmEIpby8QmmAMjitxQi8LGXu8moQFWETiLeGbRzGGFrUw3K0symtYwtS2D5zCQcHcZECnEVYzaTdxCkb6BallTvp31ARAJS3P3huMGa/qHWVNL9dwaPZlpcSWirFOoQ2lnD9YT9AB5QFKNyBmKHvIf6iQV1gYYqMBou9epahWjWUqCaDwnMIgF18o7T/iIqL1BHZWTxM+dfpEqvXMp6LQ1FaSGMSg1AKe3uMxBUe3UtRRWV+zuASxyLCHRUoGUhwBeyWLx5gDhnniJA0n1hBVPcz1TWLeYoQnwPcRDi5DcdYvQ5uIMoaicDEamRm24AZMxNcGI3ij5iSsxXhXmUcYYHMA3pwLSs1GxyANFrBEQH7TwuZWixgp18xFKnKxzMvzLe17ZT0Lty5fMqHKmbYMjqxkxC1mKhMD9ZslVCMr4gMtthWyoRRUqtTGycLlvuWBCl2ltxIHUQwQ+9UDVTMZUU4jIFM174iyLHN3zKDGu5UAJTNty13AdkvqVvmXleN/3GuIFnUqSmNj6xaEVg1jiNSV0cozCIZEJPkRc2WxBVbkjDzyITUMN3pz9pULVaV2GDjmNXUFC6qY0ClW6MQWIPoZXCg2WhxmHEG/tBynWCbwWyECwDzuUFOC6dXHGQBvIrcwwssX6WNTYaFD4Ll1eTxmEXIY0B6wlrIj0j0v6w6iJhjnnr6x7S2qGAY1MpPKnHmZxFNrzzOYBroCHIK1DcAjYdEAhgpVrzHQqhq/8AIRxHNxPGpmY6iSqEpNbNTlKvEJVuuTLy3aHsz/H3hk3VeGIKSrYSOtQLWbl82Onh/mNxegqHqhLyw2w5JdhS81LdsmHmUgJTVQlDLJUAaVVBCxjiWJQeJRqqpXa9StgYbz6iqgYLx5h5Jbt30TVmBtd3AdkGzAPEEusAuYtjSr34hWWM0RuVUHe4h0HFMSWIZzqKxQN0OCGoU0PMSGYVVVSiU6ZeZfZQTUB6QWHHHEtHClVcO69Gi9R2uGUu552VRNlt5uUUgUmhbl9umQWVLbSswIy0mXxHatLTsMwSpSKpxMYZpTqBUK/uZl2vDmHZulIHKsVqPmLbzcuy46WXRLvpl6B2wnEeuhzfMqZXSDcfQH0JVEQlpXIExBcN3DN42umv0jlgpNxBDaadEDgjyQxNSJyw8sgt9YitdlWZ+fiN3LxawTKeyA0zLYdBfqjRhMVFl6YBqsWoHzEBQDFDGOZmKxcYgGjNZE2kijVZgOmSRhqWmTzu+kVaKAlnEQ3pxlviBrBGM4CPCbzs/wAhCKzZLgjDIWg5RtCiVOkNjiMXYTSi2HejYvk1EhktrNAdVL69G6PxFa2OANS5ghcsEGGSyNm2BsOXnUKqw57hVaBq5hbyUjqVkb/mVehxzzLqxYFnmXS6OYyeTFSoU4AGWZ4BU1E/DBrmGiALy3nv7Q9IY3vcS+wR0fuphLhX3GoSys5yS4kdKjVOfEqKv1biqP1rU+S8b1GBFLTxUdY4OodonKPPqUJ08zMUzFvEdcxTWq6IxjYvlKQrCh6IiXmFd/Ms6Wu3iZYcKcypLd2TFNTDmLWnUMm/2bhAJsDAU4v+Zbt4kktopZue5UdsFRPTeqK/f24QM6JvG7ItF3ENtO8hMVR8RrkDypi0aecRAUNp2WK0HJri5neYVZigFfMyQ3fHMMEi0L4j1Za4G5oAsZ5lBKZ5vMBUqFL3EwNraYTx94pGk9uvxKIaOllzUPQ7PiAv0d5/8gyqVaRzcvgOGgx1H24aeojHYsWY1csPVjXGd1CeU7G0/qGxZUFdQYVQwgbhzHdYMazL8yVG7zMBlotDHwI+Ylf5AuWGmGmkbM1e4htlGV1L6nMDLhoV4MxN+t6uJFvk8EOSDlIjoCguBDNXzC0AQpu1uPwAy2AeJUqhuKVdkNxfqOm3erzUJCVcXlBT05vcXkOSF279QCW9Mbj9pyNGFCFdhb2sL5y6ozE7bTmCq3KPSPUpWA4VvMoFS8XmZQINspG5e7lCoBzXBEO5eS8x9fWY2tbPEob4lzrVrJuLx2hablPRStwwpspbriG32gv6QY65xCs1BomrFXqUNuOcxH9koAO1Hf0jwRn1cPOnJ1mYYLmRqjzLwg2B24lbt9m/rLYVMs8TgqDcEhrei9y2AGrfEMByxGlx35YntDYIEv2cFmAmNwywr7ZiDHRcLSwYzfiCmrTINDGFcYyXbuBkrOdRWMV+4hVwXImLhciXeogkBPGCZ7HTYQo1UKNw/Ch9QvfuJlptUs0ys1eadQmmdAQa5escoA50uVirhb8Q5AUlAwJtNKusTDCxd3mHSRETV3K0CxoNs+J2wgZvtI4tPsW5xDRwqUZs5lPHoReobVmctv8A+xT/APCmLr1MCflV3/uCnaxwHeIiuyupdruHBO6x5n0LMLKdU2y1dStGSZI/k0lEUWyBDppwwz/AhZArvUIuAX94jS8FOnmIFmOIROysK8dxarPaXt6VZqY5C2F/EUKgWqWV2QwiAuzX8RxjWk58dwkLE5XAYWw7iIF2+sLUefsQsOWqaHzEtWNW+4Q9VzEsqoY8TCYQ7TxxNi9E4KX9ZhMZJ3LOCGW88RHtoqUuPU9RdsSsV36lW7xlynUeiUbLbgw8TDKQhE0LtgkNcd78y5xGhy+onW0UNV+YeBGrOfiHmA3XMAWwORZWKCgKlURmksiaq0YQvVDmosBX+ogNU0NSgoRmwuBecYbJYAK5QkHM9kfQgNa3OG2VDiPeK+CpoKJBf/0jK1fghgodPIiZ3FZuMATihR+3Eoo0A7qGDczQMJduWKYXxGmUDScPMq0qgthDmUJHIIObYBjKwnKsEY4jlaJegwEau42jQtxGd5gP+byvE4qCfmBlKjcNx+bv3C3Bd1ruK0g8fvEFyFaFr47gpQXDk9xMiibdrHsbp5YxAbL/AMaFvJtKMTrbbH11BwG9Gy5iDkWXC42NEs81RgJTquVdSsS+8ssVoVv+EvgsDVj0BnGpRcxPs3GvK8HYwXTX+YtqCuLlDYmfcZVbOpW0hFr7QypFkXAsaYgpR43KneC9dsBPv8tWList25uWHOIqgAj1qayT7U/WAbBbfLuXFy8rh5hAOHUyM8YYlt146mb28QONGMfBAfdggxQ9QEYGQOkowKWbVwS8thmDRk6lFRnPkuWQwGuIFXlN24hLXgupS1mU1Fzl0s1OsGE90ZAZsiAOR2mrzlUNDPGCliFRvJ15uJQoM9DFszPcfMHwYuU6hjb8r3AXFyKv0SxeM8M9RhKsJAp7hlSTAduq1AmKM1IowDXqXl24NpHaK8AgdRHImoh+zQVxGlOleK5luiB6/EFZUavuI7vajLM2JompRkUyLseoZVG6xqDAN9eHw/e4sCBeWkuwQq+1Xn1MqS5M5ZpQcYX9Y5/JSbituQD5gG4KzN+4+KaKjDkdmjliOPWCA9EKKi09GYIdHSVrqWSN25/iWVFH5wSqxabWK1f/ALf+R6T6vmLrxWefiKHrhU54AV5P1iIOcjxj8SjfeQHBCAuXnddSoDZu3csptfSQu+gpysuE4Lrcn2gTRZymowZPCwCEsZaCxdh+YOs13S5TQVpzqXqezvMPgHNxSlXBx+6iUUk3Rv8AMFqV+Hnn4iIGtND7jVTpYO2MWFLq4KWS+sijvMPGyC1uErvG4llro0ePETQW+42J7u4vv0M5IxewPUIoFS2AqSpnNQ0RC93B0KAprRLLFYgViolsJYV1ZKD7YZ5i2QbLdzLeSx6j07hgLelqCvipyxVnM9wyIHnSniCdAFdRGwrk5l5Yle0PlOaKpQ/iViEm44Ii1Xl3mJzPzElUyt9nwd1HwQTylkAHjqULVhmYkjk2R6eLtI1NDTwQGE2C9eZzoIItKoUeYWzVZuoAeW5czAZHyQywO8qJayZbGR/MJjXdq14hg6wGM9xEmo2arqMPEXvEUlWhkZc5Q0CqlwRRGxTUcGtFHk8eIT8jXgc1iIhLWWwHqIRXAK6jiRpl+7IthBqnDxLViIK7g4wMX31HAP0cy4etu4Lacs3LA1/hsLVteINLqBzAolO4pplwl3CMpXraQ5iK1ho5qKmYSPbUdTBRDjMyoV07mQFelVN4hQEyoDkOfE0s/h4YaWluu4IBtdpQQ2MuzxxBqkKaTjq1hTzGimfMQpu2Kadla6nDtyin/NFnTdRwbzruI5UW5i2NQ3UWCLjNTSopo4lZ5MmdRVOKqpaVq4FylBl7HG6hgB5/2lNSvR6huljKVK2lZuEKtip5uN1pMoUVLJAULlZitBZWmhGUfk7jZrC0VmLypXaddy42gvSitfiP2U0o4iOkjZVHEt2S4OVmEYLdGWylub1BjKrtyfzDphhDr3CgL0JqocGXQ0wyYMMXipmtMXDPdi1Sb3GMXubipoXu6iJCNGYOCOR2ErRKxWyADFkHP+JU6NgvFdRUOXgO55kA5mMKUyidMCmRWWbXAr8RrbUBMhg1jHNuG/cX+8sPtKQjXophngLJdotKmaHGcSv1FmeJWAixlaZRXtJV6IXo6A9k54ngnuHVSyeagCm1DcJEVkByXFsquulYuDLIucS0yyi4F0wrNa5v8JTpbdNS4/f+Ail2pPAR0IG/HmDBJHgdSsoFO41Ca5QsFew3Uv5HQ1E3fthSHqVB5Ipf9RycLb+JdQUnqMKOLArMOF5EbgoFpbeEYm9DZKrTrXHMKT2COmARgN5YGVW1bUqa1Lnb2gEbPbhGZeG3ERvn7EGNLfomlumXBszjbfEyR18xxLaShhI4F30xo2WrSgjwUFjO4XTW+oiu4thRl3FBaBuUtB0JWO4AVVPgGo5gki7Hj3MwNlXsjcIG0doY5nscHEcZc1QxCQyrCz6lI8dLl9xFC8Wb9RTYdGMEu+1uXsjfJ5PmJUzw3CcCrOGvvEVI2r0dEqUrKdErLHsYjOu3Yeo2iWVXMIUFjXCHEIF9kGnIvhsuYkk14+YLJBVG4oR9DBFBrFq8stCBUeAxKg8oKpYqEAydwgVLGHmVobiWUGY4w0srxKhTJl3HhRemq/cS2vnIhbfYqijFB3U+c9TOthcJYR2BtY8GAQdpMimVNKmJSIExcckMrSkFi/cG3QAfrmOh1nh3DoIb8fuIniWbfZG4UOyYEUqtLuuvrK3JmO119ZbyBNmMdzdxWIBNA6/weDg+8V0BATNcwGllSBNBWlGMYiH1YUvgo67T8CAgxR7BxAGbC1MxWil2XmcJa61DGuCn6jiUd4DjiUGF1A9+IZe1rZ+CMAWXo2wKlqN53LMjIp7jSBV8wKc5KlVdubZhBp3cQpc4plpQBWWItvMW9Yl6zHeYwxxGwI1wV2jGiwU1dkKyooSqnTYRhnAoZLtIEYhuu5b4UKrfqZwnTgKmsF1S2uJcwC7px5zCnI0rwlbjtoHAdl8MbMNBW9pfgOJ1DHghyItawOkO7BUVoMbOGDntvyOfEtSDAuh7isNFuZWIo0f39ubBh21USWJa5SVRZfb/AIDpigAaYuW6MxejLjN95buDAVokLUB12HLFWWe+YAuzuM+4qFE41A1dkStWG3U0hsShRXNI0Y7ltjLqXyAiBqnOq3FyyC6tGXRQG5S+LgkadcETgJkeTWI5A2toGaj0lzdXj91B5wUDi+pSEuYWnerMrLQgHANTSsgaqf1GTAoql17m+8bMWdxOmCFLp3K69hqNulxV9StwAarGYDaVz/76IjsY3+CJWgGgz/8AYTOKgv3gCZoDOCFc2q4aph+lWcwUJS4DajYOLsHmVBCqA0EJnyBum7IFmelzKlNRFBmVoMY4OIlsVm7CNVarUq4WYW0U5gePozcGnpWOvuFp148xTBVSu5akOC4gQs7ZlGjEV0uaS5IoWxJRwxwxEGKpl5WHlKA9nqUegCwHxqY34W2Gl2sBu+JkJtXEFueaxHHAbXX0gYrbbinEc0FFYilcpOPEvUGBp4lmiMmZku7gskcWHh+4iPd1bo/4plE0fSvmI9oGrNErQtfw5hGnNeoPS6WNZhsdN5YgsNQcSuQbRwwPJycEUDKs2G4LZRyMRNKlpDEQGAQj7x9ShgyhtwLqGiWdwe5vYVvUBgNpUHuJboKc7IbRpHYpDgCOtlFFbW18xkysYFdtE8QzMUo09InMh4SEvN839YaJMWnmYdPJzHARyxuaslqy2IAry4g1t+1BgwtolmTjLZWHgYPjuBDXOe5VqAXlYpmHUUlbG6blJtt6incFU68wgLwb5JfCy15Ja/8AqgALmAAFYPEcJsZpeipfTmH04lgVvXMHl2RpqIDh4xqUqAPmF6VsnDAVCdgl1St0rhItgxqHajQCncHEJoOvmH2ZFNsKuOFKaiqkxVcv9I71QkDogI5W+WFk3kzZGaVfcuAU5zKaFLUbuzcTcRljZSl0wEAviUjrEQlVEGq2wMpfFXHW12ResXQB7MsJUxSnP9Q69VWLHUq4WbviUA5lrB0Ed8OYoL24c5CFAP5CBqXQac3PahrGIHBWCqamVnPczo8zN8xLjLHNkuMKq+R1G0QsJqKl30O47ARb15mSJZt9ZaXBdtSlJnuCHdwSuoJaNFaoghNWMuq6iOQ6aC+5uwbozX+Sity1gcpQmD0cv4lGEeiIAI1h64mgIe+Ya2WtTLkcJ+/MzVF6emLR+epVobxzfqFMAxiB/dQG8G+jxGgFRxRky7paC8v9St/IRcjcTUOUj+Y5rLCIc43MCQW1u+pXCSq6PfmGaW2z/EwQK1dSrpLTY8RwWjAjI7xLBlLVz8Sxtbw9I/HuA21Dt5ouElGf5pTSbQ0eIvWGjME04VnNRwjGx7I//NEHEKC3Mv1xlaprErk2gOLsYLwdIbiIChe6mKEIzUCraXrqWKHItkAKpv3C6rxGrlWwTVHaDhfMTjTyLmUhsDY4xAmcFIGN7jggmILxOBa7i8eJal+WpnjqW4MJ1DXuKhsu4MAw6k5BHTWq5e1DzAc9cRkZLonCoBWCLQTyj+44agtRu3qMSAWxJe10W5CKgFUBiviJWoZvUoVfGWqm0203EMtseiL7OFibArYbeUPrGcAN53BYAJgLqW1QUuSOUlCh8S9uSbIUiIxSVxxBmqyjlRzA0a7Rm01iI49jQaeZygMHWMmJYKy/ugXQRyYjocGc7gRZL36R+c4lacmsNkowlbRVtQyopwmg3Cy/PMXXYNGI3oLBuNFs7xPlD3lr/buErQGC9+pcCl+8Epy6mnB6wqzzEfGynn+0WPoMTPL4g/8AhjXSpyDYKTAQOjR900+YPeO71hNupRp8LwdTAIotNTeiDo7uC2rSzhOI9VQwDYRA1PZLW3rMOHtbTAI0BlTwxkHnUqi1efEIrYG6CISQGJfEJCMx/ruIcAFGJVo3DTljAkEq9rHtfAuP/wAkVOGKhAKOojQURIbD5d4ZSnP6VEeSXQc54jpn5Jg2bZviIARUqCXO3xBLgOa6iCGV9HX3gNViLe/mblp2loyjIn1qWAega1/EzQ8z+IyLBaM34jlYU6lmtkou6CbjkOravNzE4ptMS1g29kVY0rqLaLuX47PiPVFF1VWx6AHdHErDA4KgqhVdpKikEGYqhDlp1GC0FcVywC0sMSgFd0cjO84qCEV5VhrXxLQFPMYEtDTdwipaR5DNSsnqePcUqH2DBGKHFIOKru+pg0pS8f8AqIsFd1qVGKb5uX25CloRc6KgDmDDYtQ6isNZYYuc4JnEBumkFuTMXZ04RGK96xGlEWGxeY40i9I5FltFqHKzGIwcBb4gY3rmEnhwnZEuQW9KepeSg87WBG0JouUGrVuanhxLGHZbCSNtT4Y5yQbbiSFLD2Vi1MSy6O3zEkB6YR/ir9S8oZYrIiBFuc3MlqN4MN2xbOcbi8ACIeZhd3HOoiiyLQMEQ7laQAg7mWwYfEaKslyrAt2ySsVTC1GkRx5uBV5klc0FH1ZgwK7/APolC74mQMbleFC2ogS6C68RjO6rs4Z5AxERhoPINfMQYD3A2IG7uMBtsb4luZGrjHGiV6YlwwpyZ6gsyEAhPeOz4gGrYBdQ5DoOE4YAuFc7D5h462iwSkcrRWYp1Fv7oBAbvMtsEGDPlL6I3NN2b5hXnVouSOEWnmbjBWVjLDVKjJmXIcMDgg9ElBkgw4WskAHvLghhsbL7iouAzRDGYBzcrANutRbDWNVt/am0NGuOdVGPAVizUou7btu8wDoEc1gm8e0oVl3thKl0u3UShgBtOoJBoMozcGcHB1HIoNl1iXZF2c3UyDRqmbomWS6rQSkrHlYzXN0CHC/UQWA1m+ahtKilzcVgaKeGc2DSdy3OAGCZ8K8VBRy0MsXsMceYNyDhU8yiT6Sad7g3cNbggLqaWqjIhgy07jdY3eYJwVprfMQ1WQjMpJUS09QwyIqaWZH5lvhdKa8/6nkHMHrqCTK6KgexfUooZyrXsAMBUJzlpsZnQPhMvDbHQVAlHcIFp1GOpW7y9VAM6lB4JlUFmV1sYlCcy6PvAMl0Bx5iNCtpYVQBneos61/9CoaQMllupZSrLK0g1ArSvnL4IIBLuJhudAYJ9s3jD4TKZpyxkAliYjGrb911LLpngF3MyTCzKZzhNm9s/eI2iyrmFT7V3AYfKtnEBBz5VRr9I4CDXW/XxGVWnOqog6DoEotp5hwIrBXMyMSqisSI7lJVrAN+ZdMvkpVRZuG2NQIivhWDyy8NXliGuxXEs+A63RBAWMu3cUqPC565IZV4/epaPhEXkHtmRksVqNgOGWPAd96lCCpszUW6g8tXBWvfggqXyZvuY41ua68SnQr8nuaW1vv4mD1a1ZUOKWEw1izhCNg0023M0re8MpbIcCv4lKIW0YIZrgS9SlTY23cpeFyZZLt8dXMQHLrcQg1Odapc+G3dTixg+Jci+aNowMGVvLxhiFUdiMGuDllL6Bbaz7+8QW1Jix/cL1DAKw3+Zkxvphp3bVZb+dfWMa7bGMdS0CTJXEPIt2PiAp0aSpXVy1Karh+ZkCMqu+Kx+3G8A7JV+JaLheuswczvS5iQEXyCKxDtzKkNTMurWAH794joOALoYuXJAXldVNkd5gyiKDhlHwc2XbFQK6eiNdg5No95Lq1bPEsH/wCjcu2MQSviFgNFzITRqrmher5roYnMFcajkurJk8QYCyfbd96iKfqs/XxM5iMMK41FAvV0B5lSF6wu3j7xKYZN4eX6xVNathhpkeomlAfczj6nEMaIncuDQ8MQAUOaxeYShbM3M1jc8RhALzUQbRGBsYEhyHo4hGc2jplPhXqmo2FXg6li1hq2o7GChBleQqwuN8JZopvUd7IkdEvhQBCJRWztIdgZNnPUEo4AgxdgbsjZ1tlYYV31FpmsGRqGaG7rPEqxqUNtIo7mfQ2UdECDEg6WIuQa3qaqcKUrzFgwFW4i4gHtRczB5cwmO3QEO6WwAy1bQgE1aNDiHHIF0I1dBzjcRsHNh6k8tYJWoczmggC14ymZTpBviL8ryzFCmM16gC6RyyR3UvWKIjDKOBrLib0tT7RV1ZycmMQC7ha5O48Q2tbj1C6cFdHMo/qupXbA3srG7I+Uoq6PoQRTgZLXZLlM04z4hDFLNmYmAH19/aIfqpOINYdYbuIlostWEHtQ3jBAZchPnUcq1BBf8wDwXLv7ynht1epc1a1OdR3NiVtdwBSlyYBDSmQfxLZDkrl/+0n+oDKWzHIukCX5+OIBPIzzFDU0rpgBWxdROVLHAxbVsPRbWBzHtoTNcSwADgc4lRxSo2oXaRGSlVy0ueHiMMyV1KFyeajsy/XMVEc7sgmAOw2QJdKxg4gLVHlxVwPTfTuM1geYX12o2R2jGtjLutkn6qJ+dsYqC6HIoDlra35mmOSz3E2gWGNWcCsF7ZoPEpjfD6lJFtxHf0I19obY0Ygw42EYXgt5XLG7CtSym3xEgUA1zLPk+JcsgrLjqVgLvXUt7rGGSQssDGTI285PctbwSrwsDesqIZWlMlQ1JZpWKj+BoLT3ceAjm3ki7ViANu8ykVruBoq+W7lzRdR45Y0YjMefUJMiLfEcVouoOUMqEWCBdniCLzNtsSsReUrMD4KhWnT6Qg0XuUIXncQlXcu9QQYPINxO5S64I9jR4ai2beQtg0kSswy4dvtKJVRmAA3jXEWFa1VuY/CBsYqVncBiX4gtcrMqRoXfwe4DVQCjt7jQ9NQvOYyAK7sxl5FjWIOsRCtTjzrTgTmO2RTgVrU7O+CjP0g1SZXXcxaXRVyxgDl5iW23/wC1VODuEqaIatBX3imBotW4I6ZFnfcGRbOU9RA1gvMPGQ9ahBuDKLQFAppzh/uNhJf4uFGkstlJkZDXR/Vwrm52Ch8ytIfXEADI4hCcloYlfCyw2hzLsQs014lTeFXK+ZYQZQOghaWslrRAsAq0uFcxmbYF6+IdRtef2plyDReguC67xVAiOxDh5l1SDkeEtLWMs2e5bEEICfiJwLWBlcqW6OMQFYTgp7MvCygXxX3l8a7h7CnVzIa1imMNaXr7RxCt4qpcBWQoeo9zT1E+SEAY5Ixi/hGRCrbELljS8OqjaQreNxPKLKbIgciLqHHbqd2ythlPL0RCgXwGgmYsl3UtgaRfEGGLby5CaVRMOR6nX4V65jEilYSmM6sbB9zJi3lMQdIhu70S+VpeAiDbqUD++XcesIDxLVA1szVaAVYYGXM4LKSwR/WVIgdeofSm7HqY/wAloyrmbollAeBzEOh8QHNtzjUfoFR7fzBIIN5IyBJgu1hqYI+0FVoEWQi1W6tIJcvpnwV3uJXVqlXvUxhfblGRADdRWBOqLzXM1gLHF1jU3qBfMz57OfUI7B0HR/gFt1rUGkYqUUync/AiPsnzEY8KQB3yuqWc2hHiGFa7tg2rOkGF0t0PcpDpyc+WGb2VrfN5jTqNnHxPvDmELSrXS5aIByYxL6mmrFY6gJ0YEPbL8SxEloyNQaDYNqJgJM1hkDctHteCy/GTD94mbM7beNcwDYpO4Z8yY0rbUQloQevUB7okDQCNAjNlRea8wrJhs5fVRxEuGIhmo2LcGP3qcBE28xwLPYjMwfvEJRfUvPSNwLbSO8QZgZ9TyR9xlWBeItBeXHmUSI1VeJim8F1MkadseR/9QAChwnLBuQK9E1BnxxGsjkWke7TS2XfMROE4l/Ezpg+sGuSNqgNFolcR4IbGDsgNeB5hrYjjOJiFgr4gQFOzEVdt7qPK78iPbLiC+D5hxKPkxLWE8lmdMucKjW5U0Xa8e4moVnnqZ1KnZe4aNxmLYNDiKir3ud3O8wVdSrYxKlOUcTWCYX4hlDMt9viGAVNznxNZXdV/aUpPteP9RXCA+8fi7G7uEMbLq8qZrOevF3x4jwDPBUyq3QFYMy1A3sDe5bTaIbKD3MTqi0MeSLdtwf4BzXTrxKMCsXfczXiWbL3C1xODmKX7tQxfWJcI9aMVnuXPMKQfuY9Wg+XniWix20PxDETPC4ZuXlgqUIClZaYlF20gWgGhitV9oRBWWuDv8SsoGdyBepwXXqBMuBt/uNVRssYzq7VfRjRt4tD7gEqks0vxCEaOF2kG+MflxFOZ0YFg6oxfXH8yqJqFdLmFZmS6MJIXVuG5bgU5C1LeyW39yZyqU1j6w1yh3edwRoD2pKsNEt5WnA6iCXhgBJpflI3w9DKWfIm+abZtMNsooPkkvJeYS7zlzBWy+oZ/0JqaqtF7gJVfhBR2DXuNNtccSz1AdzwGZagT2n4mMagnR+7j/wBvXomFF1gMXcJq+iCaHMuuZYmypOISl+JaRTOY9y5Pl6Ia2Ja4MeJUDU0BBWqxbIxm+g3mIaM3GWuvaXpauKDzx1AqLL43K8g9LCSz3uANSqq18wUQhktTAqEtmf8A1DEjkrLPUpVsbUxQ18zYfpCsar7whmNnEJetUUYg3CMEz5jF1NUmTMpKLjhHUobAf25WyeBmjzFAQsVUf4bhUC2eYOQalgBrw5iARS2rXy9RK9AKgW/bhAVTGjKFWu6gala5MZhQNvBKgkWZ2jyQOmvrMiPBti1Nhuncy44HuXfStxs6+sGbdZafmoWVq8AZs4Za4jLADJoP6yw9ctjTk6i44W9o7duW9A7xGX4lh9SNrlgLJexlhdzCKHNBCdlVWvERTXd2N+SB2yoCnqECy9+P5igmRlzwVHwMZ8kdIeDi8zWQc1xLn5fcRWw5uWgUoqU/9zMKiw3CItbMssGQw78R1L6Au48BXaYQu3Cx2AAiwspvZAoFmgQMmhdHEMBbXZKM/VBCVr2RwK8RmpZochhgNtynQz9pb4UQgNAsDHKjmWjuVI5YgLN1c2O4ogccXL4JbWZcjS9xbK5VABmQgM214i1k6L1FvMqw5dRLNHteD8SshWcxIVG10wytz1cKAq2yeZuACC19oOtS+kKyWR1W5ouBgLl+sCbPjUAhFjF/EStzsxbFVaH9uXFZD6kVCz7xpENk4iu9O8+iXRu6XHogslbOIvrUlBeWHLlbs1H/ABEO1eWrlxXBPCYClyPDmbqGU6Ip4FQ/zBNQpoND1NIJBpdg6agEGawsix5XBcNPbiYQGRZ18S4MUvV9Mx9tAGfT6hYxXLRVHcORczHZlFI4C7JTpAw0VxnFssIM14v/ANi5Wrurlwm8MrbbnDxq5u8Lsn8xlZuAOsQi/A4yEDpU6PT+Yd1HBePOI4Qtsv4IiIuYNTIQOTiPr4ZLUEDMWWlLFU3FqLvxANhsX1LBdW6jYAdwWpcsXiE3Ciz9+IWblOYWVW2ObaU93cUHU4Zll3h5iL6IGpigEBtZ/f6hy+SUGSDJ3fmtEr2u2TqCo0vCNxsGO8sV1NwH4LcSAZ4UxHKGwJ8xunEMgBh0KdHMrtNbJcJbWd6isUsWX9I6BXDwQ5fEC2CCq2Dz5liJQEeZVKuckCMmODiUdC744gDOoyWL/MrOgsLUMu4ddtA9MEWQ+B/7AOjNdR7jtsclq2/1iMQBBGNyI2bKghahoxGoSuMZgZTe1mugXDpmvMI4mt7IALVp+k0O6qU86KH74ZzV8vbH/Hcv5lQB4F2wtqs1gIobwqyBFgOVHZDSRQpHE4GKtokk5CcmckBBSu3EdDz1mYGuMZfPUFLBoGuCXbTcrk4nO3yNY5jWRYCW1nMoJRUlpfH0lyFPIBgIAmgfmGO1UHKYi2AONV3KtFKzxBwxyuqgrk329IOBTe4cZPmL3gkLJbfwz8wqiJ6UDKfbAeYsSAgDVeoqyacumFAqoLKIu7M/7gTOu7cMRrMCjcSlilaoiCBawC1i5AReEKvBxrDEWZebxDBwwo5SCYXu5Jl0W3UE2qFQ+jUXeJkarzAOKacGaxjEItWHMS3TSnP/AJHoo6HO8wJbu5vuNAToRqW6wBWWXUF3zG3KiKCsjL1c4dqM+IKcjllA7UfNMfCjzEjC6G2K5PY1KoAYDqB6A6SrOPRcIZ4qm4JmIUBwS8rXyygTv4lALBzMvBmuJfDlWrLdWZ7SluMHZ4qUkE9V6hjNOyGHKyoYQTLNCanFjj7StwWZIUTPHPMOoHRbEzHAIyeo2HK2OWotFfS8GV72jFOCVKApO2OpbzH/AB3e0ILiqAZmoLQQQvYQrpSKR+sGrl3cACOAYtiVpKRfvBN0W2zvj7wAaG2Eo8vEDzWjKPybUDgq4lW4yteUAOtrGwIN4YaN+Y91wIj3H0gxEoZUYAifrKUM3jeBxKG81cGL/wBTjUUN4PMJqgyJEvMOXLE8Ft+XmYD4yVjqFMmyYzBoIqFyiV9zqJQsDG6ek4YxU5YuxWTKheYUA8dMWRqYDeibmJhRoNC+oXWoowhe7gYGui5ZS2AMicQGuM1orn5mdONGj8xia2RVxbYwHO4uRM06GHKHOxNqfZBw5ALzUu7tf5lGI+GI4MVxmpfooyLcJVXRqHKz6xqmmhwSWPgiWt6itR+kawftK3cdl7lHyfaDuBuCiQiw7jVYOM3/AOwhmGjxLDgdwUFLu2DJAv3lX+Rbf1jUPBKIGbV/SU8Xwh/mG0JLJhIgHQMQYEFrk+5YY+MFZCeCA2w2+nUEbFYy98SydNfwGPZjB/qF4DrEo4gBNYQSPDSpDSBk2q41Dhloq1vj94lvV3fO318RNAbJKqHIELwdQ1YoILb6jsUJa4eJcdn/ACfZ4fagrf75gFScysRkYNKc+ImRa5KSYlXGy4Yei6uhlqojgP38wQiWBmomMgumnECEWbTXtKPQA8veYALFei4bZoyLYeI50r4dQCULYveYTwDYF8v/AKxA2BTx+5j9CQOXGfxHQbeYczWDRGPP8x9pApWpR4VQjxH41TA3TLmgWsBTKTiOSwogiy1dhD/LEGLzcbM6lOIguqK6U3GLRReCYU5jiwq7uIc/kKWHMKlEqODzAFc3eeD6yieDlTBYnucMrnstWGOlLmcPmYTJHGKlrsC42JgUMBgIq8MGoKnI/QwZo8q3UQgDy3CCC1WrQYlOqKwnUDXyCaxkJnXDY8xIuCDdxGW1SITlfUBUWe5lqBcO4cjUIOLCv4ieAB3UaB08EO4QFo0PEEcnMQGssfjVHeTqY2CizX1mEYeHHE2hbeplhZb0kGFCYFwfETtSqgpi0LPk8kvWUYUEfmrhrTCu3dnE5prIxl5NUcEFwqt85mDzVy4HzER1MAv6zsTEft+Zg+qAsCajAzV8fvqbtsbzcX+ReEY52BEN01qGF6ph7iTKXXygbIRbOoFqwyOiZlC8ZSwlY3jWB8xMJkLT4hRQFpgZY0LXkXFYJgMzUStklWxSgsRA2y+mlVh9SOAVlXR4SdDKuQ1/5B16Tur/AHE526Xtyy1mVXVPjxMCkImnzHIGt7Q9Ruws1uNIqtm+o9VMlmnj3GxXMvUv8CaDojKynlNxG7mu4bzmomalQ3begioAwuxJSmELbf2457KsmiNfA6bl4DiaArYwfMEmaDlpagjxaNbfcrKou8r/AKnMBQSoK2HgMSGgIGJuFbC8S/EaBzNjSxbU2kC1CDElaVJfoQMVMrS0AijSqsxKW7K8zSArEQ87bMNQLNbyX9YY2TsNzfVXZERkim5XAXK8kJS7uWFVYzm8xxjUSJywG0IlQ/lZNECdmArbEgQnjLg394Hfy+P3E0Z6UFviV8+wB/mXLu9rvxXcFwBbycQgUyyeIgCGLNit6haoXxiKsp5MxKBaty/QE2hu62DhirApu5YsCuBcrGoBgLu6jvDFd6DX4g8EaD/No2NvPtByKYNkWXPtDB7mIXGHAw+KjxKAAL3llJDY8xGzC4riORNmFlD24N6ecesQDyLgXjjuI5WvtUDbJlV6Xzv7xWgPVLz/ABDES+v4htoR0Ef9SouOUXJ4lFOXa5a4i7HUGvvCxGw3bz8soFkBw1gY8bRSltzAgq5o5M67i4+gRd3v1EWvcZYh2ZduGocOaVMU4W41HgIsTiDBYoVF10OHS0/mIREguzKSkcgsHMQa9AloQxZXwdykC4UtvmAkW63cXVwAG3GeIyLTo2fSZjM3yQ7W/Oj2x8Rg8eM7Y5FJyV+I2ZQSmHpFKYZaz7iKhb1e5jeLZhio9hoBmLfwisKAxE5GFxu+WaMYLCs1mClRVlmZSRQdR2tNhAvmFOzvKGCXrcviWtw3KttRuWRoLV4gp3qtYB3cbgz0tvfxLBwtptg7Byunmb8QbgzNV1iKE6RwznETC0at3BURl2NTKyoA4+keQBpDcQ5FVJk9QruFnAJhB2KQAWwaagSNBb/UJCZMxABDQcF1uKzS8upYv/MRQXrbkioLpQLLhnjWRw5KjXhDyrCVSlDV/EK8byrMA4qFBMOIwFIDJowYBY0DLzVy03cRekZu/wCJSKoBRru47sYfPqZkknC7Xx95s7QGgTOJYVRNlaYhFttdJeBOsYhRrYK7jxcpW5PUBKnB4PUU0VNdvhPmEeamnnRK4bpbUoLiZaJSNeZbmLZgnT/gzH/JIFtW1TjuL+Rhxx7JdpNaqfcsKCN3cJg0l82yoI0paHcZiOAbY0AOyMsDPRYD95VIdUoomGwiyCynJKSOSaIcoy39un8IDQHb3hE0rM+YvQsrkX3HT19EYUiJiZIRqohS0MjNLVHqKyDd9cS3ZWnEIngDBYnUABqtdi/4IrhhVqv4vUMx2SFjKnmPrRlYFL1BK/GzDjlhqlgKjTUEphYuF9pAMzRjyuEa5NBVD+/aLR8q0vFNROgrkFU+Y3MYtOT6xhsXAtVEDgLrMlsUmsncXil4UeYlxFZxiUsorS2yxWAwVpgYdE0KT3MaK5GZeINoO7NDxDZeb9/9BbtWTK6pTOC9w75QoTD6ShbDgz1GSdqJjiWVap/ZBR5GhQ/SMYs7PEVIVaVFhsv0uAaXNZfeZME2AQFRkOXxgZrLfC33MMwkVdLi4Z9K5BzM2UXa0Ivngv8AuEUkZblBgu7cwKitCDi4T1DbfHUXl3Vi6jtM7xCeIQKWUP2j1mxbLGoOtICWTBzBTiMUlWnqXE8xwFoKqXF4/EHl5WvcY2DtHUrO0+Y+Z7Aa8XLUVwLHz5i4LZAcHjESKJq1iA2yxthrF12TKmbo0QxRxA58ys3Gmn5jQSpa81KKx0JtHy1UvdfWOrtSmAO4jqwA7lC7RG2vmKkatBQIqEb+IFtczKlagk0odGoKHbvD06iGyrCoUNApzFX+YhWrGKR/EoiOAKt3xFV3bHKYWRXWvUpqgolP/MOuO6E7l1sKyX9oRhsaZYl1KGzjEOgTQVmXCCZHfpKK7ldXxmDhGKeZR3DuoNwyg4e4q6SZFGcxYwCu1ftTipGrYlsA25goBQ5oxNiYVaX9YpByEMPmLYBX1m3/AKAwPbb4PhNGyOXMo/d6suUKBN5ftEzOGgbJTpJta/MbLAXriWmHB0O2OQoUUPSKyVsorg1xXAfQSwenIaYBOg4DJ3EhS2/XuHJwGr4jAOF5lANzWWqh2hhZ3ctgLaPMBIUMKWxzHOd2Fbx88YmtfXe1LEViw/MswlCuTaiOpYLq4iBeiRXQ5zDaM0zPMyaijReZgGhvmUqLw54iveUJD0F7+xRTR9Gg9xC0Xz/r6wsUDg4+hDh7Nr0xaKBrMEis3xBanOMS6MTi9IuSACBZxw8fEWlbQrSASqpC3+5jiNq2tfH1gxwGEFy+YNJxOOgjg5gOhSykoOIChEYLSLAe5dTHryuD/wCwze+bcuL3Lkngdv7iYiQsqxRyFZhgTzq0wYvcrno6WLiKRw5H0YjuWooWcgUVvLcMVnWS8MChVMvmKBnmbIlGskrGFqMbjoIMjZONS7TAQ2TJI0njmC6tVvRxK3yH9xCgDK9EaEVeF95himgYdXFnIkfcy2lEw7qWZbHjiGlgeT/o3DT18KRBGzhozBWlrfP9TFNGw6RDCNaNQSQKra+7HAAVbKBF8yrFO4VmSLa4gAgXwTP3izFf2PcpWy3jznUUCFoLz1UrJVaMsKC6lQMri4mkwHhDUFIZwHvipUw3Danqpm1obrR/m8R+Ctrp4ZcEbXAzlhQV1BwP8QvImRbI4xfMIUh5IrzAgNKYFMjYQkwMsdCCh2tt6gMQ0Yla8xDa8xUed3lYpbXcslIXEXaUbnO2u7hjMjo1fj6wrqzniNwlLO8+u4QMtxRjyiyKGi3Biu5cypw3JLIAmDdMYwULQt0N8QFJAyxnqYgfgQ9edQSBY1XeYmAtPf8AEBpEPy8xAo1n5jxRcgV2fpMlLOCteZUwCsGvN7jEpWAC0jIAosncFblQXxWpRFoRd8R8wrCOK7hi1rANVmogMfAag0F21BuUAtcShNrQ6mNaCoGYGobNdvEENRxaFAtaN24lsynwTGzdN0yzwfVcrjIIvLAsEocBuWJLrAMykrQszE9EKqFkMzKVnMf+kAHR5RFVcL4yhnYsYZMNsJTAyigXtt/MQVHE/t4mJRtHy6lgFQF8IiTBgcwZXQNkya+3M/7mVwRDbdamCHVMwEUlVDmJJbTxL9gb4RG1WKvWIZlBeKOI4iLgDPf76ilQKhCDuvcCKufBb3HVjYSCWYvwmQhkNx3EObyywtlG2/W5iE9UKRkWZh6y8R9QzgFBLVaAisIlgt3B0VV0iZh6gtbW6qHhRoXsl+m4WLmGin8xH1GtMBmbkgEaH7RGWtd/MwCUghpgSizLAQkiF8IJQSnjmWMiAcZl7VxOxiXEfCz4l5SwKmK8fvMeCFWlZP3MtUsVoH4mW6lolCDiag28njUMgD43CW5A3qHQFVocShyKtx3qDZfPcGLgrXxGGZQhx4iqqXFN7lurdAdRndHttmMwtc5xE5uCjNVGxMCmuYX2M3ioUAh0xnuVQLeagBllMGI7jVtR14+bhF2KfJ7TuCsdxRIk6wdA/wDkEuxbDMUNDheYfVsiRxgV9ShVGgjE30JL4FB1/wBMcwqWgblqDO7gIclQwxyREIXRjMacUDb5lAarM5PvmEOtsNVNRiEgOehhlYigfiBqYXesMfzM+wiljz6ikr4zRqcFDt4ge+yqc/MckigaIjW91y8QiIRaBOSwx3mZ6xVXKsW9R3ax8ycaJfleeLmGT1H2XHC2SjKwDsr1NtRDJX1gAChnBuGuF1iXSnk1wQidqcsQapu9wLYfWDmQWOL/AFgL5RbZLI1Gqi1NVsn4lbTJ5fM2jbuMcvmh3iDzB5GXtS3mLA2M0arv7RIhsCq/LBYwaF3+JiH8558RsJibE3zLi+6DKMRsJaOlKjsv6f1P/Zf4FsBt5OoZWNEOgVTfUVaKxv3ENjvMddQXqAgKmPY09uYgEqwh0mVc1pLamFh2PMZ2KvPEdERoHcWpeBDcQaKSqgwao3FOAVmu4mOV6g6C+hDCyvERFEaKxUDQnombhoYxU18srkLXiOAgzactmkIhVyirEwhYqby/1LUUO7h4bCuX/UXFzGyZJVnFwCFoAOIWZFduf4ibSirw/f8AeZcALdejOa+s10Vbv8onXZtwy9AR5hVKuBZX7UpSa7LuNe25oNqiM0thcXXMZWqAoAv3BD0lYxcbDFoeUfBtBdq/qKFb4PmNSFBRzoyiBYvTxCpeh1jEsLJer4jqN3aC1faZCxP5iSrsop+/mUZt0X/csVayqZPELoA5XDCGtXsPqZdRa88QzGMb6lsDbzO26BW7hVFFkLNQH4sYCHhCOdH5lWNht3BFqu73CijBeLB+kRopko01kgsdLbRGSNgrQ9/ZndA2OoRaBkXyicg4Cm4IzSZRHuBaCHFwwosC6/DEyh6F3BL59xbALUDne4Jcp9sOAY5qJp3EDcBN5qDchM3Lq7k9iAC6oE8VHAFrJioZet8tP7UEA0m0hFtusOaIpZcPUsGwHtlNvA7YbmKZImJlCNHmJkSZ9SyY8Gj5mGYuSoiDOTowJV2RsIMjy3Apax4eIYoEAxDdmZeq4ju51S1Udu9n/UVMuBs658RMw/0v41Cd5GTSwckbAN1XEv5rbNQitu1mAyK8KQ+12zRKnxFjR37imraGleEj5DLVuAKZe9y8QNHuhrJlkrGZWZ0hy7ZWEsMCLJeBiqrHcS9aZCl6l0cVgpzrEuj029oUYvChiFgHdOO4GuCsBW6zhj9zHr+wGB7gGhe+/cMui2jqFAqror+IwqFHNNQCvQ1CbWYAKvqswyrgxhcRBAqcko3bZbojMqq7uI4RtocQVUVrmWGAyD9JQiGPZ+sNl2tl7itK93shk7BKbjlJc/pFRsaYVnEeE4hWxszBuEMnJcvYhUeBAjRzF4bQVt5YGH6HEWoAdVcDgO4iG3OI4Vo4qE42E6nnpFZtMEcl8wQVapeZSVs1TUISvNQZKdz39Y/VXJ1CoWcb3B2/dA+g95jYbCBozAlwQVAxRWlZXjEEei8eoY7FrzFqkc46Y8E3zAUKj3E0DQjpmNXqVAlndG4t/wDVRothGbIlJS7lAKoNP5lGAcjq5SiChMHnMSWAVoF8S90C6P0qWD70VdeCCQclGArUzojjPEVaY5Xv94l8BcI1fxKWc7TTuOmSyhbGoYaOdB5JVOHg0fEsaGgCfmZe8KtVR+7bS+5A1QWcPrANFIoxQQjFsedwI46uUkExI3XMWlANjMviI5z98y3ixWHXUawu6lSomo1emEWeVySxaNZiaFXrcbULQGoX5QtGq1dURYF+JaqUyljtrxAwS+6HILNpQfeQlADRaG5gRC8tRbsc3FRiqjWlkth9CA4Ooyk3paZIZhkNfqRxlrvUXTZoxDFxiHVTFRQU7svicKXnuNCAh51F21OGBtu0bYTsUHAjKyn2uVO6G8O6hCGZHOJZgbKuolowYSQGBnmloQ2qRycRPFGHpFZdLO3rEetaGqYuPMhYaZlC4rdy3XP/ABsa/KKulgxBsUIPHc8vh7gziUHl7gIb8/8AWGm4ohfzUVNFQXdfabwCrt+0sZnCWSwzBEvKLXXF2RzzGICyWw7VAvdFdjqMQEAPKOQWUJg+kymKhHD3LxkD0PFQvWT9P2lCQS9JFiaOUrXiXk9KcRWtx9GNSMYNJxZFi1aGkjYYOV3Mis/uYwsgZIVGkeBLlsViVLrzlm5sq7R7+85cllr/AHLob1UE1y05qo3L8eMyq6mE0DM6mm+pk+unyJgxxf3jbcZogUbB06JXLMCznfDHZJBt2NhQEdfuJm5FhrxFUVHqIVCBzHNQHBWKI67jioNN/eI1LOl6mJQap3Gxt8yvK2F0VbLUCAUGA7ij9FMFZNsQCrimYy6pccf1KhWrpTzHAQ5KPxGqilLdleIKD7vHcYABhefmAO1tgaccsL9teNfEZoElqwrBO86lZdShcanYM6vMNBeOai3/APBFW1EbfWLOZQl2bI211/2EQmInmlTJU5HICvpKBWBkW48wNw0qxp7iNpEsuXmoeAui25d/u4CKYY/u1uFapSmr/vUqqrVGfpCHNssdRmUuNlXYdynBYuX18TdK7eq6jVDH27Pmoduja4HzL7RXq4VF0BgXAwoAqBNuo1Fq167l01FRXt8x9clgFI6CwOK5hLhtduKjpfFDiof9Cs7eLKqlsjRgIURM6xVdwiNIa4JbK13Y1KnqZKaZuBHjcAqHZWZmgtXiJFhqX4ajbm2MYlk6kVuJ+Di4xE8kEj1paqGnRYMQ2hfOxI5wJq7smKBN3tE7NrVbldNa5DAIpXthlhKDYyf6jMFRlXqLDLVjRFy5a4zqITULa0wC39DiUTTbevEOMtUoGmXnaABDQBlO4S46E45Yx5bxCjBVbWv7gI/OopUFFUKjIrT5gBTXymCMFa4iJf8A8KiZmxzTCprYvuvUbQhVZDzBgaZUyxy8MVM6RZNfLxCbF8TTx63Ks2o5NSq8EscvQRZM6xlK5I6qkqOaeLnLhhceFPmZ8FAv7feE1WNytJXaSuJbCkwviapwgoXRCFFLzV1MywPa5ZfC+lqK8sOeqY/3HSNFRs0iBLZPFwIMDaVbzKpi3moxZaqwMZRw23sJSVfuRCKV3VR63YX9JbAeM8x0+DeJbBEOpcFWkmPrDzrOcMEcm9VpgYXpY1BFhemZ7tfuVpYHcND09ttzShcHMQ+56mVoKNdbMFRwvbBCcA9vjj/cRkk6X92KwwXsjei+FOeJUVlck+JnbmtxmCysnmMBaVkywynAUFUQcRQjbH7uGiAsFbPzBrpQrd749ShTIDYItCMiqoidenWA7ZuJncS4EVqy/wD8VJzDq+1QK1gzrzAtBZhZAKMslF3Gw2bgZ9ka6i0QLUBtOrfMRijLEp+qCtEyL+uCj8Miru4J4Jz1TcM8eslP9IzRlkMevzG8uTV1iIWKwG5Xum2zb4hU3lPENqvVwLkeR3/qNMIVublGVDrrGGa7yVCV5hm9sRG1MIPMxhvttRKQQ1KxriVgsqBp5hENYPKBFK8ePcRCNkPCDkm4xxELNtjuAall7Q+ZfU9HUC9l4o8Rlf8AKGFE5IHRYa7awyz2ow04IVBYI58zSAGXf7X2lYC02qolcg3dOYhKeBHYPLNL+YlgFkBztvlcoMjWTRKtm+k4Jf0EZOo6NgMLzMRal2xBxD0njzFULK0LA3csA3sQMdZjJWDgdxtiu5a//jjUxJe7gSqMdP8AcaFCsaJ4iD3FWWFwIAAczHTaD+n1lHdu7jx3C2S+HK3vwRIR2Gae1h473jQ+LhiyVKxR4qKTLK78kuUJcY5+sOz2Fu/EBgDNLahQvoCxrLPqJjurR7AqxnNSxiL15yRgROKOpcSidtMLbpxFSwLSUZ6Llb9HcQrsn6zQE0myJGtLRVlYWIQMPcQehlLIv4imDVYF/UzAr2xCy2fK7ioRgvLM1U2f8Cg1z/zkgHVNnuNBbjGvLHMffmGk/PUbNAR/YjSBLluazCWXrNVCc25Q0lqxZMW/mhNlaXUMj7PMzD3HAlTopqHoIbDmAgcp4TPwwBze4RLGo3TDjIX7xIYcLhrSq/8AyGcQn3s0+/4m33n7Pc+/T9Huft9T7t+CbPia+j/E+1fifYJ+ONPx+Js/eyfb/jP2nZPu/wCGfdf3PtE1e/5n6PqfYTf8f8Dd7T7eavX8T7v+Yb+z8M5+/wDnbdOP+OZ+Cflz9nwT9B4n2z8z79n8f8R0+fxPsn5Zo9E++T7J/E+9Rmfqeo/emh6/mfav5n25+J+ebf8Ab//Z)
Um embria£o humano no laboratório, 9 dias após a fertilização. O hipoblasto (um grupo de células fora do embria£o principal) envia uma mensagem ao embria£o que inicia o desenvolvimento do eixo do corpo cabea§a-cauda. Usando a análise de imunofluorescaªncia, o hipoblasto émostrado em verde - essas células são distribuadas de forma assimanãtrica. Uma cavidade évisível no centro do embria£o marcada pela secreção de podocalixina (vermelha) e acaºmulo de F-actina (branca). Os núcleos são corados de azul. Crédito: Universidade de Cambridge
Os cientistas identificaram eventos moleculares importantes no embria£o humano em desenvolvimento entre os dias 7 e 14 - um dos esta¡gios mais misteriosos, embora craticos, de nosso desenvolvimento.
A segunda semana de gestação representa um esta¡gio crítico do desenvolvimento embriona¡rio , ou embriogaªnese. A falha de desenvolvimento durante este período éuma das principais causas da perda precoce da gravidez. Saber mais sobre isso ajudara¡ os cientistas a entender como isso pode dar errado e a tomar medidas para consertar os problemas.
O período de pré-implantação, antes dos implantes de embriaµes em desenvolvimento no aºtero da ma£e, foi estudado extensivamente em embriaµes humanos no laboratório. No sanãtimo dia, o embria£o deve se implantar no aºtero para sobreviver e se desenvolver. Muito pouco se sabe sobre o desenvolvimento do embria£o humano uma vez que se implanta, porque se torna inacessavel para estudo.
Trabalho pioneiro da professora Magdalena Zernicka-Goetz e sua equipe desenvolveram uma técnica, relatada em 2016, para cultivar embriaµes humanos fora do corpo da ma£e após a implantação. Isso permitiu que embriaµes humanos fossem estudados atéo dia 14 de desenvolvimento pela primeira vez .
Em um novo estudo, a equipe colaborou com colegas do Instituto Wellcome Sanger para revelar o que acontece nonívelmolecular durante este esta¡gio inicial da embriogaªnese. Suas descobertas fornecem a primeira evidência de que um grupo de células fora do embria£o, conhecido como hipoblasto, envia uma mensagem ao embria£o que inicia o desenvolvimento do eixo do corpo cabea§a-cauda.
Professora Zernicka-Goetz no laboratório. Crédito: Universidade de Cambridge
Quando o eixo do corpo comea§a a se formar, a estrutura simanãtrica do embria£o comea§a a mudar. Uma extremidade torna-se comprometida em se desenvolver na extremidade dianteira e a outra na "cauda".
Os novos resultados, publicados hoje na revista Nature Communications , revelam que os sinais moleculares envolvidos na formação do eixo corporal apresentam semelhanças com os dos animais, apesar de diferenças significativas no posicionamento e organização das células.
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"Na³s revelamos os padraµes de expressão gaªnica no embria£o em desenvolvimento logo após ele se implantar no aºtero, que refletem as maºltiplas conversas que acontecem entre diferentes tipos de células conforme o embria£o se desenvolve nesses esta¡gios iniciais", disse a professora Magdalena Zernicka-Goetz no Departamento de Fisiologia, Desenvolvimento e Neurociências da Universidade de Cambridge, e autor saªnior do relatório.
Ela acrescentou: "Esta¡vamos procurando a conversação do gene que permitira¡ que a cabea§a comece a se desenvolver no embria£o e descobrimos que foi iniciada por células no hipoblasto - um disco de células fora do embria£o. Eles enviam a mensagem ao embria£o adjacente células, que respondem dizendo 'OK, agora vamos nos colocar de lado para nos desenvolvermos na extremidade da cabea§a.' "
O estudo identificou as conversas de genes no embria£o em desenvolvimento, sequenciando o ca³digo em milhares de moléculas de RNA mensageiro feitas por células individuais. Eles capturaram o perfil molecular em evolução do embria£o em desenvolvimento após a implantação no aºtero, revelando a perda progressiva de pluripotaªncia (a capacidade das células embriona¡rias de dar origem a qualquer tipo de canãlula do futuro organismo) conforme o destino de diferentes células édeterminado.
"Nosso objetivo sempre foi permitir insights sobre o desenvolvimento do embria£o humano em um prato, para entender como nossas vidas comea§am. Combinando nossa nova tecnologia com manãtodos de sequenciamento avana§ados, investigamos mais profundamente as principaismudanças que ocorrem neste esta¡gio incravel. do desenvolvimento humano, quando tantas gestações infelizmente falham ", disse Zernicka-Goetz.