O dispositivo implanta¡vel autoalimentado estimula a rápida cicatrização a³ssea e desaparece sem deixar vestagios
Os pesquisadores sabem que a eletricidade pode ajudar a acelerar a cicatrizaa§a£o a³ssea, mas as fraturas
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)
O professor da UW osMadison Xudong Wang segura um dispositivo de eletroestimulação de fratura que ele e seu laboratório projetaram. Quando colocado sobre uma fratura, o dispositivo gera eletricidade a partir do movimento, acelerando a consolidação a³ssea. Crédito: Jason Daley
Em 2017, o quarterback do Green Bay Packers, Aaron Rodgers, quebrou a clavacula direita em um jogo contra o Minnesota Vikings. Normalmente, leva cerca de 12 semanas para uma clavacula cicatrizar completamente, mas em meados de dezembro os fa£s e comentaristas esperavam que o três vezes MVP pudesse se recuperar mais cedo e salvar uma temporada perdida.
O mesmo fez Xudong Wang, professor de ciência de materiais e engenharia da Universidade de Wisconsin-Madison e especialista na criação de dispositivos médicos finos movidos a movimentos . "Comecei a me perguntar se poderaamos fornecer uma nova solução para trazer os atletas de volta ao campo mais rápido do que nunca", disse Wang.
Os pesquisadores sabem que a eletricidade pode ajudar a acelerar a cicatrização a³ssea, mas as fraturas "zapping" nunca pegaram realmente, uma vez que requer a implantação cirúrgica e a remoção de eletrodos alimentados por uma fonte externa.
Uma grande atualização do mesmo conceito de eletroestimulação, a última invenção de Wang não chegou a tempo de ajudar os Packers de 2017 - no entanto, pode ajudar muitos outros, tornando a eletroestimulação uma opção muito mais conveniente para acelerar a cura a³ssea .
Seu dispositivo fino e flexavel éautoalimentado, implanta¡vel e bioreabsorvavel, portanto, uma vez que o osso étricotado novamente, os componentes do dispositivo se dissolvem dentro do corpo.
Wang e seus colaboradores, incluindo Weibo Cai, um professor de radiologia e física médica da UW osMadison, descreveram o novo dispositivo hoje (5 de julho de 2021) na revista Proceedings of the National Academy of Sciences .
O osso éum material piezoelanãtrico, o que significa que produz uma pequena quantidade de eletricidade quando colocado sob tensão. Esses choques de eletricidade estimulam fatores que promovem o crescimento e a cicatrização a³ssea, razãopela qual a eletroestimulação éuma terapia eficaz.
Embora existam estimuladores externos que criam um campo elanãtrico para acelerar a cicatrização indiretamente, a solução ideal éestimular o osso diretamente. Colocar o dispositivo dentro do corpo, no entanto, tem requisitos aºnicos - um dos quais éalimenta¡-lo, de acordo com Wang.
“O caso ideal éque o dispositivo seja autogerado, algo que não existia antesâ€, diz ele.
Para criar o novo dispositivo de eletroestimulação de fratura, ou FED, Wang e sua equipe começam com um nanogerador triboelanãtrico, um dispositivo de pelacula fina comsuperfÍcies microestruturadas que converte a energia meca¢nica produzida por pequenos movimentos em energia elanãtrica . Eles acoplaram o nanogerador a um par de eletrodos para distribuir o campo elanãtrico ao osso. Eles construaram esses componentes ultrafinos, biodegrada¡veis ​​e bioreabsorvaveis em um substrato de poli (a¡cido la¡tico-co-glica³lico), um polamero biocompatavel comumente usado aprovado pela FDA.
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Os testes iniciais dos pesquisadores confirmaram que pequenos movimentos do dispositivo realmente criaram uma estimulação elanãtrica de cerca de 4 volts, que poderia sustentar por mais de seis semanas. Eles então testaram o dispositivo em ratos.
Os animais implantados com o dispositivo se recuperaram completamente de uma fratura da tabia em cerca de seis semanas, muito mais rapidamente do que os animais de um grupo de controle . A densidade mineral e a resistência a flexa£o dos ossos curados também atingiram o mesmoníveldos ossos sauda¡veis ​​nos animais que receberam a eletroestimulação. Apa³s o tratamento, os dispositivos se degradaram e foram absorvidos pelo corpo dos ratos sem complicações e sem necessidade de remoção cirúrgica.
Wang diz que épossível ajustar quanto tempo o estimulador durara¡ dentro do corpo - de semanas a meses - ajustando as propriedades do material bioabsorvavel que reveste o dispositivo.
Eventualmente, Wang gostaria de ampliar o dispositivo de eletroestimulação de fratura para que funcione em humanos. Mas para esses dispositivos com alimentação própria, a fonte de energia pode ser um fator.
“Normalmente, quando alguém tem um osso quebrado, eles precisam restringir seus movimentosâ€, explica ele.
Em outras palavras, alguém usando um elenco pode não produzir energia meca¢nica suficiente para alimentar o nanogerador triboelanãtrico.
"A maneira como um rato se move fornece estimulação constante para o dispositivo, mas para um osso quebrado em um humano que não pode ser movido, isso éum problema", disse Wang.
No entanto, o corpo humano fornece fontes virtualmente infinitas de movimento que podem alimentar o dispositivo de eletroestimulação de fratura se o osso quebrado permanecer ima³vel. "Podemos precisar que o dispositivo responda a outros tipos de fontes meca¢nicas internas, como alterações na pressão arterial", disse Wang, que já estãoolhando para o futuro do FED.
“Sera¡ muito interessante e impactante abordar o desenvolvimento do animal para o humanoâ€, diz ele.
Cai também estãoanimado para continuar o trabalho.
"Nossas colaborações contanuas ao longo da última década foram muito produtivas e altamente sinanãrgicas", disse Cai, que trabalhou com Wang para criar uma bandagem que funciona segundo princapios semelhantes e um dispositivo de perda de peso implanta¡vel , entre outros projetos. "O grupo Wang projeta e fabrica muitos dispositivos intrigantes, e nosso grupo pode testa¡-los in vivo em vários modelos de pequenos animais para estudos subsequentes em grandes animais e tradução clanica potencial."