O novo genoma de referaªncia preenche muitas lacunas que foram deixadas por rascunhos anteriores, especialmente nos centra´meros no meio dos cromossomos e duplicaçaµes em grande escala.
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)
Megan Dennis, professora assistente de bioquímica e medicina molecular na UC Davis School of Medicine e MIND Institute, colaborou em estudos que completam o sequenciamento do genoma humano. Crédito: Karin Higgins/UC Davis
Uma sequaªncia completa do genoma humano foi finalmente publicada por um consãorcio internacional de cientistas. O novo genoma de referaªncia preenche muitas lacunas que foram deixadas por rascunhos anteriores, especialmente nos centra´meros no meio dos cromossomos e duplicações em grande escala.
O trabalho édescrito em uma sanãrie de artigos publicados em 1º de abril na Science pelo Consãorcio Telomere-to-Telomere (T2T). Va¡rios pesquisadores da Universidade da Califórnia em Davis contribuaram para os estudos, incluindo Megan Dennis, professora assistente de bioquímica e medicina molecular na Escola de Medicina da UC Davis e no Instituto MIND, com os alunos de pós-graduação em Genanãtica Integrativa e Gena´mica Daniela Soto e Colin Shew, como bem como Charles Langley, distinto professor de evolução e ecologia na UC Davis College of Biological Sciences, juntamente com sua filha Sasha Langley, cientista do projeto na UC Berkeley.
A sequaªncia original do genoma humano , publicada em 2001, deixou de fora cerca de 8% do DNA, disse Dennis. As áreas omitidas incluaam duplicações quase idaªnticas contendo genes funcionais, bem como centra´meros e tela´meros no meio e na ponta dos cromossomos, respectivamente. Essas áreas contem longas sequaªncias repetidas.
"Estas são regiaµes importantes, mas difaceis de sequenciar", disse Dennis.
Sequenciar um genoma écomo cortar um livro em pedaço s de texto e tentar reconstruir o livro juntando-os novamente. Trechos de texto que contem muitas palavras e frases comuns ou repetidas seriam mais difaceis de colocar no lugar correto do que pedaço s de texto mais exclusivos.
A tecnologia anterior de sequenciamento de DNA são conseguia ler sequaªncias relativamente curtas.
"Um grande salto na tecnologia foi o sequenciamento de longa leitura", disse Dennis. Sequenciadores de nova geração podem decodificar pedaço s muito mais longos, atéum milha£o de pares de bases ou "letras" de DNA. Isso significa que os pedaço s são muito maiores e mais fa¡ceis de montar de volta na sequaªncia original.
"a‰ um divisor de a¡guas", disse Dennis.
Os pesquisadores da UC Davis contribuaram para o projeto realizando alguns dos sequenciamentos de leitura longa com ma¡quinas no Centro de Genoma e analisando variantes e sequaªncias duplicadas.
O novo genoma de referaªncia vem de uma única amostra humana, embora não exatamente de uma pessoa. O DNA veio de uma linha celular derivada de um feixe de células chamado mola hidatiforme. Eles se formam quando um a³vulo no aºtero perde seu pra³prio genoma, mas éfertilizado por um espermatozoide. A canãlula resultante acaba com duas ca³pias idaªnticas de cada cromossomo, ao contra¡rio da maioria das células humanas, que carregam duas ca³pias ligeiramente diferentes. Apesar de sua origem estranha, não hánada que sugira algo fora do comum com o genoma da linhagem celular, disse Dennis.
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O esperma veio de uma pessoa de ascendaªncia europeia. Em contraste, o genoma de referaªncia humano original foi costurado de várias pessoas, criando alguns erros e artefatos.
Explorando o centra´mero
Cerca de 90 por cento da nova sequaªncia realmente vem dos centra´meros dos cromossomos, disse Langley. Estruturalmente distintas e contendo longos trechos de DNA repetitivo, essas regiaµes são notoriamente difaceis de estudar.
"Na³s costuma¡vamos dizer que vocêalertaria os jovens geneticistas para não se aventurarem no centra´mero porque vocênunca sairia", disse Langley.
Mas hoje em dia os centra´meros são um tema quente na biologia. a‰ aqui que a maquinaria que separa os cromossomos pareados durante a meiose osformação de espermatozoides e a³vulos osse liga, um passo fundamental na herana§a. Ele contanãm grandes quantidades de heterocromatina, ou áreas onde o DNA e as proteanas parecem ser mais condensados ​​e compactos.
Os geneticistas conhecem a heterocromatina, vista como manchas escuras nos cromossomos, hádécadas. O pensamento recente sugere que a heterocromatina desempenha um papel importante na forma como os genes são ativados e desativados, deslocando partes do DNA para uma fase diferente do resto do cromossomo, como gotas de a³leo na a¡gua. Isso efetivamente criaria compartimentos no núcleo onde genes específicos poderiam ser ativados ou desativados.
Outro mistério dos centra´meros écomo e por que eles se formam consistentemente no mesmo lugar, porque não háum ca³digo genanãtico especafico para eles. Eles são determinados "epigeneticamente", ou fora do genoma. Basicamente, seus centra´meros estãoonde estãoporque éonde eles estavam no esperma e no a³vulo do qual vocêfoi concebido.
Os Langleys e seus coautores foram capazes de comparar as sequaªncias de centra´meros do novo genoma de referaªncia com outras sequaªncias publicadas, fornecendo evidaªncias de que os centra´meros humanos podem de fato se mover um pouco. Isso foi encontrado em outras espanãcies animais.
"Agora poderemos entender melhor como essas coisas acontecem", disse Langley.
Formula¡rios
Ter a sequaªncia original do genoma humano tem sido uma ferramenta poderosa para descoberta em ciências biomédicas nos últimos 20 anos. A nova referaªncia ajudara¡ os pesquisadores a entender melhor a variação, especialmente nas áreas que não foram bem cobertas antes ou com erros e artefatos, disse Dennis.
"Ele já estãosendo usado para reanalisar genomas coletados pelo Projeto 1000 Genomas, descobrindo e verificando milhares de novas variantes", disse ela. O Projeto 1000 Genomas éuma colaboração internacional para criar um cata¡logo de variação genanãtica humana.
Essas novas variantes genanãticas confirmadas podem, por exemplo, ser associadas a estados de doença e resultados clínicos usando dados de sequenciamento de pacientes, como indivíduos autistas, disse Dennis.
O T2T Consortium inclui 114 cientistas em 33 instituições e écopresidido por Adam Phillippy, NHGRI e Karen Miga, UC Santa Cruz.