uma equipe de pesquisadores da Case Western Reserve University desenvolveu um manãtodo que pode tornar os manãtodos CRISPR ainda mais precisos ose mais promissores.
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)
Proteana Cas9 (branca) associada a CRISPR de Staphylococcus aureus com base no Protein Database ID 5AXW. Crédito: Thomas Splettstoesser (Wikipedia, CC BY-SA 4.0)
A técnica de edição de genes conhecida como CRISPR acelerou a pesquisa biológica e médica na última década, permitindo aos cientistas reparar o DNA de células humanas quase tão simplesmente quanto usar uma tesoura.
A edição de genes ose especialmente o CRISPR, porque éfa¡cil de usar osdeu aos pesquisadores esperana§a de curar doenças genanãticas, incluindo ca¢ncer.
Agora, uma equipe de pesquisadores da Case Western Reserve University desenvolveu um manãtodo que pode tornar os manãtodos CRISPR ainda mais precisos ose mais promissores.
Sua nova técnica, detalhada em um estudo publicado recentemente na revista Nature Communications , combina o CRISPR com um processo quamico que permite que a edição de genes seja localizada e cronometrada com mais precisão.
Essa precisão torna a tecnologia mais eficaz e reduz os efeitos colaterais potenciais, disse Fu-Sen Liang, professor associado de química, que liderou a equipe de pesquisa.
Embora as descobertas ainda sejam preliminares, os pesquisadores, que incluem vários pesquisadores e estudantes de pa³s-doutorado da Case Western Reserve, acreditam que o trabalho pode levar a um tratamento mais eficaz para algumas doena§as, incluindo ca¢ncer.
"O que estamos fazendo éexplorar outra maneira de mudar o resultado do gene, direcionando o RNA com um produto quamico", disse Liang. "Esta nova tecnologia nos da¡ a capacidade de direcionar não apenas o local, mas o momento da alteração - e a capacidade de impedi-la. Isso nunca foi possível antes e acreditamos que pode ser muito importante."
A técnica
CRISPR éum acra´nimo para Clustered Regularly Interspaced Short Palindromic Repeats. A tecnologia transformadora, lana§ada em 2012, usa uma enzima especafica osguiada por RNA, ou a¡cido ribonucleico ospara direcionar, cortar e reparar fitas quebradas ou danificadas de DNA com novo material. O DNA, ou a¡cido desoxirribonucleico, carrega toda a informação genanãtica em humanos e outros organismos.
Os cientistas da Case Western Reserve se concentraram na manipulação do RNA, um polamero com várias funções, incluindo a tradução de informações genanãticas e a regulação da atividade genanãtica. As moléculas de RNA podem ter várias modificações químicas com sequaªncias genanãticas idaªnticas, mas diferentes propriedades e funções.
Ao combinar o CRISPR com seu processo quamico , os cientistas ganharam o controle da localização precisa e do tempo dasmudanças no RNA.
Esse avanço parece ser crítico para entender e controlar os papanãis dessas diferentes versaµes de RNA em processos biola³gicos e doenças fundamentais, disse Liang.
Mais especificamente, Liang e sua equipe usaram a¡cido abscasico (ABA), um horma´nio vegetal comum, e um processo chamado "proximidade induzida quimicamente". Isso lhes permitiu "escrever" ou "apagar" uma característica estrutural chamada m6A em uma área especafica do RNA. Como resultado, eles poderiam efetivamente alternar entre duas versaµes de RNA.
Os cientistas acreditam que a modificação do m6A regula os processos e propriedades fundamentais do RNA, mas também estãodiretamente ligada a várias doenças humanas, disse ele.
A equipe de pesquisa também criou uma maneira de usar a luz ultravioleta para "ligar" o ABA, tornando o processo de edição ainda mais preciso, disse Liang.
"O que torna a pesquisa ainda mais empolgante éque acreditamos que ela pode ser aplicada a outras modificações de RNA, não apenas m6A", disse Liang, "e as funções da grande maioria dessas modificações são totalmente desconhecidas".