Uma equipe de químicos conseguiu agora sintetizar novos ananãis moleculares medicamente significativos, que são difaceis de produzir porque são particularmente sensaveis. O trabalho da equipe foi publicado na revista Nature Catalysis .
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Estruturas de raios-X de cristal aºnico de dois produtos resultantes da reação de cicloadição. Em particular, a esquerda, évisível um sistema de anel condensado aºnico de cinco-quatro-três membros. Adireita, uma estrutura de quatro e seis membros pode ser reconhecida. Os a¡tomos de carbono são mostrados em cinza, a¡tomos de hidrogaªnio em branco, a¡tomos de nitrogaªnio em azul, a¡tomos de oxigaªnio em vermelho e a¡tomos de cloro em verde. Crédito: Universidade de Ma¼nster - Peter Bellotti
Na busca por novos agentes ativos na medicina, as moléculas cujos a¡tomos estãoligados em ananãis estãose tornando cada vez mais importantes. Esses sistemas de ananãis tem propriedades particularmente adequadas para a produção de tais agentes ativos e estãoimpulsionando o desenvolvimento de tratamentos inovadores para tumores malignos, bem como para doenças neurodegenerativas e infecciosas. Uma equipe de químicos chefiada pelo Prof. Frank Glorius da Universidade de Ma¼nster conseguiu agora sintetizar novos ananãis moleculares medicamente significativos, que são difaceis de produzir porque são particularmente sensaveis. O trabalho da equipe foi publicado na revista Nature Catalysis .
Entre os quamicos, especialmente a santese de pequenos sistemas de ananãis a partir dos chamados compostos aroma¡ticos éconsiderada difacil. Além disso, uma quantidade especialmente grande de energia énecessa¡ria para o processo. Um outro obsta¡culo éque a energia tem que ser liberada seletivamente para os materiais de origem, mas não para os produtos sensaveis ao calor. A equipe de Frank Glorius agora desenvolveu uma estratanãgia na qual a luz visível , como fonte de energia barata, ativa um fotocatalisador que impulsiona a reação. O fotocatalisador absorve a luz e transfere sua energia para os materiais de origem. Desta forma, permite que ocorra uma santese altamente eficiente e suave e que não tem, ou quase nenhuma, reações colaterais indesejadas.
"Na³s vemos nosso estudo como um avanço na química de santese", diz o principal autor Dr. Jiajia Ma. "Isso mostra que a energia da luz pode ser usada de maneira direcionada para produzir pequenos sistemas de ananãis. O fato de que, usando diferentes parceiros de reação, podemos produzir diferentes sistemas de ananãis oferece inaºmeras oportunidades para a produção de agentes ativos." Para seus materiais de origem, os químicos usavam apenas matérias-primas baratas e facilmente disponaveis.