O DNA se move de forma constante durante a interfase, fornecendo a s células um sistema robusto de manutenção
Pesquisadores no Japa£o descobriram que o movimento local do DNA dentro das células humanas permanece constante durante a interfase, onde a canãlula cresce e replica seu DNA para a divisão celular. O estudo sugere que esse movimento de DNA em...
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)
O movimento oscilante da cromatina mantanãm-se esta¡vel durante toda a interfase, apesar do aumento da quantidade de DNA e do volume nuclear. Crédito: Shiori Iida & Kazuhiro Maeshima, Instituto Nacional de Genanãtica, ROIS
Pesquisadores no Japa£o descobriram que o movimento local do DNA dentro das células humanas permanece constante durante a interfase, onde a canãlula cresce e replica seu DNA para a divisão celular. O estudo sugere que esse movimento de DNA em estado estaciona¡rio permite que as células realizem tarefas domésticas em ambientes semelhantes durante a interfase.
A equipe, liderada pelo professor Kazuhiro Maeshima, do Instituto Nacional de Genanãtica, ROIS, publicou suas descobertas nesta sexta-feira (3) na Science Advances .
Para caber dentro do núcleo da canãlula, o DNA éorganizado em cromatina, na qual as fitas de DNA são enroladas em grupos de proteanas histonas, como fios em torno de um carretel, para formar estruturas conhecidas como nucleossomos. Os nucleossomos podem então ser dobrados em estruturas ainda mais compactas e formar a cromatina. Pesquisas anteriores mostram que a cromatina estãooscilando continuamente nas células vivas.
Amedida que o ciclo celular progride (ou seja, fases G1, S e G2), onde o DNA do genoma duplica e o núcleo se torna maior, o ambiente nuclear ao redor da cromatina muda drasticamente. Maeshima e colegas do Instituto Nacional de Genanãtica em Mishima, Japa£o, construaram esta questão: Como o comportamento da cromatina muda durante a interfase?
O grupo de Maeshima usou uma técnica de microscopia de luz de alta resolução para observar o comportamento de nucleossomos individuais dentro de células vivas por um tempo muito curto, aproximadamente um segundo.
Maeshima e colegas revelaram que o movimento local da cromatina permanece esta¡vel durante a interfase, embora o DNA do genoma seja duplicado pela replicação do DNA e o núcleo cresa§a. Os pesquisadores também mostraram que o crescimento nuclear sem replicação não afetou o movimento de estado estaciona¡rio da cromatina. Assim, o movimento local da cromatina éindependente de taismudanças nucleares durante a interfase.
"Esta éuma descoberta importante porque o movimento em estado estaciona¡rio permite que as células conduzam suas rotinas, como transcrição de RNA e replicação de DNA, em ambientes nucleares semelhantes", disse o primeiro autor Shiori Iida. "O movimento local da cromatina pode governar a acessibilidade do DNA gena´mico para a busca de alvos ou o recrutamento de uma pea§a de maquinaria. O movimento em estado estaciona¡rio da cromatina fornece um sistema celular robusto no qual as funções do DNA não são afetadas por váriasmudanças nucleares".
“As células podem alterar transitoriamente o movimento da cromatina do estado estaciona¡rio para realizar seus trabalhos ad hoc em resposta a danos no DNA, entre muitas outras tarefasâ€, disse Maeshima. Ele e sua equipe pretendem explorar ainda mais como o movimento do DNA éregulado, quais proteanas estãoenvolvidas no processo de regulação e como o DNA se comporta durante a divisão celular . “Nosso objetivo final éentender como o DNA gena´mico humano dentro da canãlula se comporta para ler as informações genanãticas nelaâ€, disse Maeshima.